JP2013529292A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013529292A5 JP2013529292A5 JP2013504084A JP2013504084A JP2013529292A5 JP 2013529292 A5 JP2013529292 A5 JP 2013529292A5 JP 2013504084 A JP2013504084 A JP 2013504084A JP 2013504084 A JP2013504084 A JP 2013504084A JP 2013529292 A5 JP2013529292 A5 JP 2013529292A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antigens
- ocular
- crystallin
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 58
- 102000036639 antigens Human genes 0.000 claims description 58
- 108091007433 antigens Proteins 0.000 claims description 58
- 102000004169 proteins and genes Human genes 0.000 claims description 30
- 108090000623 proteins and genes Proteins 0.000 claims description 30
- 208000010412 Glaucoma Diseases 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 10
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims description 8
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims description 8
- 229940024142 alpha 1-antitrypsin Drugs 0.000 claims description 8
- 108010071690 Prealbumin Proteins 0.000 claims description 7
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims description 6
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims description 6
- 230000009257 reactivity Effects 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 108010067306 Fibronectins Proteins 0.000 claims description 4
- 102000016359 Fibronectins Human genes 0.000 claims description 4
- 238000002493 microarray Methods 0.000 claims description 4
- 108010058432 Chaperonin 60 Proteins 0.000 claims description 3
- 102000009190 Transthyretin Human genes 0.000 claims description 3
- 238000002405 diagnostic procedure Methods 0.000 claims description 3
- 102000004963 gamma-Synuclein Human genes 0.000 claims description 3
- 108090001121 gamma-Synuclein Proteins 0.000 claims description 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 10
- 210000001124 body fluid Anatomy 0.000 claims 9
- 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 claims 8
- 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 claims 8
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 6
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 6
- 108090000099 Neurotrophin-4 Proteins 0.000 claims 6
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 6
- 239000010839 body fluid Substances 0.000 claims 6
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 6
- -1 jo-1 Proteins 0.000 claims 6
- 101710175516 14 kDa zinc-binding protein Proteins 0.000 claims 5
- 102000000412 Annexin Human genes 0.000 claims 5
- 108050008874 Annexin Proteins 0.000 claims 5
- 102000004121 Annexin A5 Human genes 0.000 claims 5
- 108090000672 Annexin A5 Proteins 0.000 claims 5
- 102000004082 Calreticulin Human genes 0.000 claims 5
- 108090000549 Calreticulin Proteins 0.000 claims 5
- 108010059013 Chaperonin 10 Proteins 0.000 claims 5
- 108050001186 Chaperonin Cpn60 Proteins 0.000 claims 5
- 102000052603 Chaperonins Human genes 0.000 claims 5
- 102000004877 Insulin Human genes 0.000 claims 5
- 108090001061 Insulin Proteins 0.000 claims 5
- 229940123924 Protein kinase C inhibitor Drugs 0.000 claims 5
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 5
- 108010012715 Superoxide dismutase Proteins 0.000 claims 5
- 102000004338 Transferrin Human genes 0.000 claims 5
- 108090000901 Transferrin Proteins 0.000 claims 5
- 102000044159 Ubiquitin Human genes 0.000 claims 5
- 108090000848 Ubiquitin Proteins 0.000 claims 5
- 102000003802 alpha-Synuclein Human genes 0.000 claims 5
- 108090000185 alpha-Synuclein Proteins 0.000 claims 5
- 102000013069 gamma-Crystallins Human genes 0.000 claims 5
- 108010079934 gamma-Crystallins Proteins 0.000 claims 5
- 229940125396 insulin Drugs 0.000 claims 5
- 239000003881 protein kinase C inhibitor Substances 0.000 claims 5
- 239000012581 transferrin Substances 0.000 claims 5
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 4
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 4
- 102000003923 Protein Kinase C Human genes 0.000 claims 4
- 108090000315 Protein Kinase C Proteins 0.000 claims 4
- 102100029290 Transthyretin Human genes 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 4
- 101710119265 DNA topoisomerase 1 Proteins 0.000 claims 3
- 102100024607 DNA topoisomerase 1 Human genes 0.000 claims 3
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 3
- 102000016943 Muramidase Human genes 0.000 claims 3
- 108010014251 Muramidase Proteins 0.000 claims 3
- 108010062374 Myoglobin Proteins 0.000 claims 3
- 102000036675 Myoglobin Human genes 0.000 claims 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 3
- 102000004230 Neurotrophin 3 Human genes 0.000 claims 3
- 108090000742 Neurotrophin 3 Proteins 0.000 claims 3
- 102000003683 Neurotrophin-4 Human genes 0.000 claims 3
- 102100033857 Neurotrophin-4 Human genes 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 claims 3
- 229960000274 lysozyme Drugs 0.000 claims 3
- 235000010335 lysozyme Nutrition 0.000 claims 3
- 239000004325 lysozyme Substances 0.000 claims 3
- 229940032018 neurotrophin 3 Drugs 0.000 claims 3
- 229940097998 neurotrophin 4 Drugs 0.000 claims 3
- 150000002978 peroxides Chemical class 0.000 claims 3
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 3
- 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 claims 2
- 108010085238 Actins Proteins 0.000 claims 2
- 102000007469 Actins Human genes 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 2
- 101100518265 Escherichia coli (strain K12) ompC gene Proteins 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 2
- 108010070675 Glutathione transferase Proteins 0.000 claims 2
- 108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 claims 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 2
- 102100039165 Heat shock protein beta-1 Human genes 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 2
- 108010083674 Myelin Proteins Proteins 0.000 claims 2
- 102000005890 Spectrin Human genes 0.000 claims 2
- 108010019965 Spectrin Proteins 0.000 claims 2
- 101100276603 Synechococcus elongatus (strain PCC 7942 / FACHB-805) cysH gene Proteins 0.000 claims 2
- 102000009843 Thyroglobulin Human genes 0.000 claims 2
- 108010034949 Thyroglobulin Proteins 0.000 claims 2
- 102000013127 Vimentin Human genes 0.000 claims 2
- 108010065472 Vimentin Proteins 0.000 claims 2
- 108010055905 alpha-Crystallin A Chain Proteins 0.000 claims 2
- 108010051585 alpha-Crystallin B Chain Proteins 0.000 claims 2
- 102000013640 alpha-Crystallin B Chain Human genes 0.000 claims 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 2
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims 2
- 108091008324 binding proteins Proteins 0.000 claims 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 2
- 210000005012 myelin Anatomy 0.000 claims 2
- 229960002175 thyroglobulin Drugs 0.000 claims 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 2
- 210000005048 vimentin Anatomy 0.000 claims 2
- 101800000263 Acidic protein Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102100031874 Spectrin alpha chain, non-erythrocytic 1 Human genes 0.000 claims 1
- 102000019355 Synuclein Human genes 0.000 claims 1
- 108050006783 Synuclein Proteins 0.000 claims 1
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 108010006620 fodrin Proteins 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000012125 lateral flow test Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 45
- 210000004027 cell Anatomy 0.000 description 41
- 206010030348 Open-Angle Glaucoma Diseases 0.000 description 21
- 201000006366 primary open angle glaucoma Diseases 0.000 description 21
- 210000001742 aqueous humor Anatomy 0.000 description 13
- 230000035899 viability Effects 0.000 description 8
- 239000000090 biomarker Substances 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000003833 cell viability Effects 0.000 description 4
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 description 4
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 description 4
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 description 4
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 102000004899 14-3-3 Proteins Human genes 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 101000723543 Homo sapiens 14-3-3 protein theta Proteins 0.000 description 2
- 206010030043 Ocular hypertension Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 102000006303 Chaperonin 60 Human genes 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000002508 contact lithography Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000005157 neural retina Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34236310P | 2010-04-13 | 2010-04-13 | |
| US61/342,363 | 2010-04-13 | ||
| PCT/CH2011/000077 WO2011127616A1 (en) | 2010-04-13 | 2011-04-13 | Diagnostic methods for glaucoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253808A Division JP6225157B2 (ja) | 2010-04-13 | 2015-12-25 | 緑内障の診断方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529292A JP2013529292A (ja) | 2013-07-18 |
| JP2013529292A5 true JP2013529292A5 (enExample) | 2014-05-29 |
Family
ID=43984128
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504084A Pending JP2013529292A (ja) | 2010-04-13 | 2011-04-13 | 緑内障の診断方法 |
| JP2015253808A Active JP6225157B2 (ja) | 2010-04-13 | 2015-12-25 | 緑内障の診断方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253808A Active JP6225157B2 (ja) | 2010-04-13 | 2015-12-25 | 緑内障の診断方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10175251B2 (enExample) |
| EP (1) | EP2558862B1 (enExample) |
| JP (2) | JP2013529292A (enExample) |
| KR (1) | KR101903193B1 (enExample) |
| CN (1) | CN103003693B (enExample) |
| AU (1) | AU2011241402B2 (enExample) |
| BR (1) | BR112012026219B1 (enExample) |
| CA (1) | CA2795270C (enExample) |
| DK (1) | DK2558862T3 (enExample) |
| ES (1) | ES2712060T3 (enExample) |
| HR (1) | HRP20190278T1 (enExample) |
| HU (1) | HUE042703T2 (enExample) |
| PL (1) | PL2558862T3 (enExample) |
| RU (1) | RU2657515C2 (enExample) |
| TR (1) | TR201902542T4 (enExample) |
| WO (1) | WO2011127616A1 (enExample) |
| ZA (1) | ZA201207935B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140147413A1 (en) * | 2011-02-28 | 2014-05-29 | Dong Feng Chen | Therapies That Target Autoimmunity For Treating Glaucoma And Optic Neuropathy |
| US10842849B2 (en) | 2011-02-28 | 2020-11-24 | The Schepens Eye Research Institute, Inc. | Methods for promoting neuronal outgrowth by insulin-like growth factor binding protein-like 1 (IGFBPL-1) in glaucoma or leber's optic neuropathy |
| US20150019136A1 (en) * | 2012-02-21 | 2015-01-15 | The Regents Of The University Of California | Systems and methods for determining retinal ganglion cell populations and associated treatments |
| ES2759026T3 (es) * | 2013-02-26 | 2020-05-07 | Inst Oftalmologico Fernandez Vega S L | Método para el diagnóstico de glaucoma basándose en la determinación de niveles de proteínas séricas |
| US20170239331A1 (en) * | 2014-10-15 | 2017-08-24 | Rapid Pathogen Screening, Inc. | Formulations for histatin protectives and therapeutics |
| JP6499918B2 (ja) | 2015-05-20 | 2019-04-10 | 株式会社トプコン | 眼科検査支援システム及び眼科検査支援サーバ |
| RU2617066C1 (ru) * | 2016-04-01 | 2017-04-19 | Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ определения показаний к интравитреальному введению цилиарного нейротрофического фактора при лечении заболеваний зрительно-нервного аппарата глаза |
| WO2018106594A2 (en) | 2016-12-05 | 2018-06-14 | The Jackson Laboratory | Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans |
| JP7202609B2 (ja) * | 2017-12-13 | 2023-01-12 | 国立大学法人東北大学 | 視神経障害の診断用バイオマーカー |
| CN108229545B (zh) * | 2017-12-22 | 2021-09-14 | 北京市商汤科技开发有限公司 | 青光眼诊断的方法、装置及电子设备 |
| CA3132333A1 (en) * | 2019-03-04 | 2020-09-10 | The Schepens Eye Research Institute, Inc. | Modulating neuroinflammation |
| CN111856037B (zh) * | 2020-07-31 | 2021-06-22 | 四川大学华西第二医院 | Unc45a与hsp10的比值在pop早期预警、诊断、预后评估中的应用和产品 |
| KR102596340B1 (ko) | 2020-08-25 | 2023-11-02 | 사회복지법인 삼성생명공익재단 | 안질환 시야 손상 예후 예측 시스템 및 방법과 이를 위한 컴퓨터 프로그램 |
| CN113444789A (zh) * | 2021-08-27 | 2021-09-28 | 中国医学科学院北京协和医院 | 青光眼相关生物标志物及其应用 |
| CN114965664A (zh) * | 2022-03-21 | 2022-08-30 | 上海交通大学 | 一种获取泪液代谢指纹谱图的方法及筛选方法 |
| CN118425510B (zh) * | 2024-05-17 | 2024-11-19 | 上海市第一人民医院 | 一种青光眼诊断的生物标志物及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9419267D0 (en) | 1994-09-23 | 1994-11-09 | Unilever Plc | Assay devices |
| RU2187983C2 (ru) | 1998-11-10 | 2002-08-27 | Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Способ диагностики характера течения глаукомы |
| US20020102581A1 (en) * | 1999-02-19 | 2002-08-01 | Hageman Gregory S. | Diagnostics and therapeutics for ocular disorders |
| US20030149997A1 (en) | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
| US7011952B2 (en) * | 2000-02-22 | 2006-03-14 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| DK2026073T3 (en) | 2000-04-29 | 2016-07-25 | Univ Iowa Res Found | Diagnosis and treatment of macular degeneration-related disorders |
| CN1393470A (zh) * | 2001-06-29 | 2003-01-29 | 上海博德基因开发有限公司 | 一种多肽——beta转导素-45.65和编码这种多肽的多核苷酸 |
| ATE526041T1 (de) * | 2001-12-11 | 2011-10-15 | Fibrogen Inc | Verfahren zur hemmung okularer vorgänge |
| CA2493849A1 (en) * | 2002-07-12 | 2004-01-22 | University Of Washington | Methods and systems for extended in vitro culture of neuronal cells |
| EP1552307A1 (en) * | 2002-10-18 | 2005-07-13 | Rescom GmbH | Diagnosis of glaucoma by complex autoantibody repertoires in body fluids |
| US7662389B2 (en) * | 2003-12-17 | 2010-02-16 | Alcon, Inc. | Use of serum amyloid A gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents |
| US7442720B2 (en) * | 2003-12-19 | 2008-10-28 | Omega Bio-Pharma (I.P.3) Limited | Compositions and methods for treating diabetes |
| AU2006272497B2 (en) * | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
| EP1832600A1 (en) * | 2006-03-09 | 2007-09-12 | Max-Delbrück-Centrum Für Molekulare Medizin | Peptides against autoantibodies associated with glaucoma and use of these peptides |
| RU2314535C1 (ru) | 2006-07-05 | 2008-01-10 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по здравоохранению и социальному развитию" | Способ диагностики начальной стадии открытоугольной глаукомы |
| JP2010507069A (ja) * | 2006-07-08 | 2010-03-04 | ユニバーシティー オブ ケンタッキー リサーチ ファンデーション | 肺癌診断アッセイ |
| EP1929937A1 (de) * | 2006-12-07 | 2008-06-11 | F. Hoffmann-Roche AG | Vorrichtung und Verfahren zum Untersuchen von Körperflüssigkeiten |
| RU2371721C2 (ru) | 2007-06-25 | 2009-10-27 | Закрытое акционерное общество "Молекулярно-медицинские технологии" | Устройство для диагностики с использованием биочипов |
| GB0724412D0 (en) * | 2007-12-14 | 2008-02-06 | Ucl Business Plc | Marker |
| KR101188439B1 (ko) * | 2008-04-02 | 2012-10-08 | (주)루미아이제네틱스 | 녹내장 진단용 키트 |
| EP2354792A1 (en) | 2010-02-08 | 2011-08-10 | Biomonitor A/S | Method for detecting anti-drug antibodies |
| KR20100087276A (ko) | 2010-07-21 | 2010-08-04 | (주)루미아이제네틱스 | 녹내장 진단용 키트 |
| KR20100087275A (ko) | 2010-07-21 | 2010-08-04 | (주)루미아이제네틱스 | 녹내장 진단용 키트 |
-
2011
- 2011-04-13 BR BR112012026219A patent/BR112012026219B1/pt active IP Right Grant
- 2011-04-13 AU AU2011241402A patent/AU2011241402B2/en active Active
- 2011-04-13 ES ES11714916T patent/ES2712060T3/es active Active
- 2011-04-13 CA CA2795270A patent/CA2795270C/en active Active
- 2011-04-13 HU HUE11714916A patent/HUE042703T2/hu unknown
- 2011-04-13 EP EP11714916.1A patent/EP2558862B1/en active Active
- 2011-04-13 DK DK11714916.1T patent/DK2558862T3/en active
- 2011-04-13 PL PL11714916T patent/PL2558862T3/pl unknown
- 2011-04-13 RU RU2012147551A patent/RU2657515C2/ru active
- 2011-04-13 TR TR2019/02542T patent/TR201902542T4/tr unknown
- 2011-04-13 WO PCT/CH2011/000077 patent/WO2011127616A1/en not_active Ceased
- 2011-04-13 KR KR1020127029751A patent/KR101903193B1/ko active Active
- 2011-04-13 HR HRP20190278TT patent/HRP20190278T1/hr unknown
- 2011-04-13 JP JP2013504084A patent/JP2013529292A/ja active Pending
- 2011-04-13 US US13/641,009 patent/US10175251B2/en active Active
- 2011-04-13 CN CN201180028608.XA patent/CN103003693B/zh active Active
-
2012
- 2012-10-22 ZA ZA2012/07935A patent/ZA201207935B/en unknown
-
2015
- 2015-12-25 JP JP2015253808A patent/JP6225157B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013529292A5 (enExample) | ||
| DK2558862T3 (en) | DIAGNOSTIC PROCEDURES FOR GLAUCOMA | |
| Reijn et al. | CSF neurofilament protein analysis in the differential diagnosis of ALS | |
| JP2020512550A5 (enExample) | ||
| Kušnierová et al. | Neurofilament levels in patients with neurological diseases: A comparison of neurofilament light and heavy chain levels | |
| JPWO2016163539A1 (ja) | 肝疾患の病態を判別する方法 | |
| WO2006035237A2 (en) | Methods and compositions relating to alzheimer's disease | |
| EP3452830B1 (en) | Assay for the diagnosis of a neurological disease | |
| EP3052939B1 (en) | Kidney disease biomarker | |
| Mukaetova-Ladinska et al. | Alpha-and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes | |
| KR20150140657A (ko) | 자간전증의 진단을 위한 방법 및 조성물 | |
| US12174187B2 (en) | Methods for detecting multiple sclerosis (MS) diagnostic autoantibodies | |
| WO2016029091A1 (en) | Circulating pulmonary hypertension biomarker | |
| JP6252949B2 (ja) | 統合失調症マーカーセット及びその利用 | |
| WO2023214060A1 (en) | Methods for predicting the clinical outcome of patients suffering from chronic obstructive pulmonary disease | |
| CN115209917A (zh) | 用于检测花生过敏的测定法 | |
| US20220170937A1 (en) | Serial biomarker measurement using a comparator approach | |
| CN120334544B (zh) | 鼻咽癌抗体标志物及其应用 | |
| CN120254279A (zh) | 用于青少年抑郁障碍诊断的生物标记物和用途 |