JP2013528229A5 - - Google Patents

Info

Publication number

JP2013528229A5

JP2013528229A5 JP2013514400A JP2013514400A JP2013528229A5 JP 2013528229 A5 JP2013528229 A5 JP 2013528229A5 JP 2013514400 A JP2013514400 A JP 2013514400A JP 2013514400 A JP2013514400 A JP 2013514400A JP 2013528229 A5 JP2013528229 A5 JP 2013528229A5

Authority

JP

Japan

Prior art keywords

composition

glycopeptide

carbohydrate

independently

occurrence

Prior art date

2011-06-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 62
• 230000002163 immunogen Effects 0.000 claims 30
• 150000001720 carbohydrates Chemical class 0.000 claims 26
• 235000014633 carbohydrates Nutrition 0.000 claims 26
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 24
• 108010015899 Glycopeptides Proteins 0.000 claims 18
• 102000002068 Glycopeptides Human genes 0.000 claims 18
• 238000000034 method Methods 0.000 claims 18
• 102000014914 Carrier Proteins Human genes 0.000 claims 11
• 108010078791 Carrier Proteins Proteins 0.000 claims 11
• 125000005647 linker group Chemical group 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 10
• MGSDFCKWGHNUSM-QVPNGJTFSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]([C@H](O)O[C@H](CO)[C@H]2O)NC(C)=O)O[C@H](CO)[C@H](O)[C@@H]1O MGSDFCKWGHNUSM-QVPNGJTFSA-N 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 9
• 239000000568 immunological adjuvant Substances 0.000 claims 9
• 150000003573 thiols Chemical class 0.000 claims 9
• 125000001931 aliphatic group Chemical group 0.000 claims 8
• 229920006395 saturated elastomer Polymers 0.000 claims 8
• 239000003431 cross linking reagent Substances 0.000 claims 7
• 239000001257 hydrogen Substances 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 7
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• 239000004971 Cross linker Substances 0.000 claims 6
• 230000021615 conjugation Effects 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 238000004132 cross linking Methods 0.000 claims 5
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
• 239000002671 adjuvant Substances 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• -1 aryl carboxylic acid ester Chemical class 0.000 claims 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
• 230000001588 bifunctional effect Effects 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 229910052717 sulfur Inorganic materials 0.000 claims 4
• 239000011593 sulfur Substances 0.000 claims 4
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
• 108010033276 Peptide Fragments Proteins 0.000 claims 3
• 102000007079 Peptide Fragments Human genes 0.000 claims 3
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 3
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
• 229920002601 oligoester Polymers 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 125000006239 protecting group Chemical group 0.000 claims 3
• 210000004881 tumor cell Anatomy 0.000 claims 3
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
• 241000894006 Bacteria Species 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 241001467552 Mycobacterium bovis BCG Species 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 241001222774 Salmonella enterica subsp. enterica serovar Minnesota Species 0.000 claims 2
• 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 150000002016 disaccharides Chemical class 0.000 claims 2
• 239000002502 liposome Substances 0.000 claims 2
• 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
• 229930182490 saponin Natural products 0.000 claims 2
• 150000007949 saponins Chemical class 0.000 claims 2
• 150000004043 trisaccharides Chemical class 0.000 claims 2
• WAAXYLYXYLKHJZ-UHFFFAOYSA-N 1-[3-(1-hydroxy-2,5-dioxopyrrolidine-3-carbonyl)phenyl]pyrrole-2,5-dione Chemical group O=C1N(O)C(=O)CC1C(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 WAAXYLYXYLKHJZ-UHFFFAOYSA-N 0.000 claims 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
• 201000009030 Carcinoma Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
• 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
• LVCADWNPBJTXCT-UHFFFAOYSA-N ON1C(CCC1=O)=O.C(C1=CC=CC=C1)(=O)O.C1(C=CC(N1)=O)=O Chemical compound ON1C(CCC1=O)=O.C(C1=CC=CC=C1)(=O)O.C1(C=CC(N1)=O)=O LVCADWNPBJTXCT-UHFFFAOYSA-N 0.000 claims 1
• 108010039918 Polylysine Proteins 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• PZBFGYYEXUXCOF-UHFFFAOYSA-N TCEP Chemical compound OC(=O)CCP(CCC(O)=O)CCC(O)=O PZBFGYYEXUXCOF-UHFFFAOYSA-N 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 229940098773 bovine serum albumin Drugs 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 201000002628 peritoneum cancer Diseases 0.000 claims 1
• 229920000656 polylysine Polymers 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1