JP2013525262A5 - - Google Patents
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- Publication number
- JP2013525262A5 JP2013525262A5 JP2012547392A JP2012547392A JP2013525262A5 JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5 JP 2012547392 A JP2012547392 A JP 2012547392A JP 2012547392 A JP2012547392 A JP 2012547392A JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- salt
- optionally substituted
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000002249 Diabetes Complications Diseases 0.000 claims 2
- 206010012655 Diabetic complications Diseases 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical group C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 208000001076 sarcopenia Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- AFSPJJIONSZSCB-AWEZNQCLSA-N n-[(2s)-1-[1-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C1=NC2=CC(OCC3CC3)=CC=C2O1 AFSPJJIONSZSCB-AWEZNQCLSA-N 0.000 claims 1
- NQFDYRVHKCXJQP-HNNXBMFYSA-N n-[(2s)-1-[1-[6-(2-cyclopropylethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCCC1CC1 NQFDYRVHKCXJQP-HNNXBMFYSA-N 0.000 claims 1
- ZTQJADDEMCINFS-AWEZNQCLSA-N n-[(2s)-1-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 ZTQJADDEMCINFS-AWEZNQCLSA-N 0.000 claims 1
- MFVUXRRTNVGQNW-HNNXBMFYSA-N n-[(2s)-4-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]butan-2-yl]acetamide Chemical compound C1CC(CC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 MFVUXRRTNVGQNW-HNNXBMFYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010102718 | 2010-04-27 | ||
| JP2010102718 | 2010-04-27 | ||
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
| PCT/JP2011/060616 WO2011136385A1 (en) | 2010-04-27 | 2011-04-26 | Bicyclic compound derivatives and their use as acc inhibitors. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525262A JP2013525262A (ja) | 2013-06-20 |
| JP2013525262A5 true JP2013525262A5 (cg-RX-API-DMAC7.html) | 2014-04-17 |
| JP5693611B2 JP5693611B2 (ja) | 2015-04-01 |
Family
ID=44120718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547392A Expired - Fee Related JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Country Status (24)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2819400A1 (en) | 2010-11-30 | 2012-06-07 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| CA2853221A1 (en) * | 2011-10-24 | 2013-05-02 | Tohru Yamashita | Bicyclic compound |
| US8530460B2 (en) * | 2011-12-19 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8530461B2 (en) | 2011-12-29 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8623860B2 (en) | 2011-12-30 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Azetidine derivatives, pharmaceutical compositions and uses thereof |
| AU2014319990A1 (en) | 2013-09-12 | 2016-02-25 | Pfizer Inc. | Use of acetyl-CoA carboxylase inhibitors for treating acne vulgaris |
| JP6050291B2 (ja) * | 2014-08-07 | 2016-12-21 | 長谷川香料株式会社 | ソラノンの製造方法およびその合成中間体 |
| JP2016079168A (ja) | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
| CN106636402B (zh) * | 2016-12-22 | 2020-09-15 | 中南大学湘雅医院 | 一种判断鼻咽癌放疗敏感性的分子标志物及应用 |
| JP7361584B2 (ja) * | 2018-12-19 | 2023-10-16 | 高砂香料工業株式会社 | アミドの還元によるアミンの製造方法 |
| EP4434520A4 (en) * | 2021-11-19 | 2025-10-29 | Shionogi & Co | PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF HEART DISEASE OR SKELETAL MUSCLE DISEASE |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6944296A (en) | 1995-09-13 | 1997-04-01 | Takeda Chemical Industries Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| CA2372840C (en) | 1999-05-05 | 2008-07-22 | Aventis Pharma Limited | Substituted bicyclic compounds |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| US6930185B2 (en) | 2000-04-28 | 2005-08-16 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| US7229986B2 (en) | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
| AU2001269531A1 (en) | 2000-07-17 | 2002-01-30 | Takeda Chemical Industries Ltd. | Sulfone derivatives, process for their production and use thereof |
| EA200400980A1 (ru) * | 2002-02-27 | 2005-02-24 | Пфайзер Продактс Инк. | Ингибиторы асс |
| JPWO2003104230A1 (ja) | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
| WO2004039365A1 (en) | 2002-11-01 | 2004-05-13 | Takeda Pharmaceutical Company Limited | Agent for preventing or treating neuropathy |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| AU2003284596A1 (en) | 2002-11-22 | 2004-06-18 | Takeda Pharmaceutical Company Limited | Imidazole derivative, process for producing the same, and use |
| WO2004106276A1 (ja) | 2003-05-30 | 2004-12-09 | Takeda Pharmaceutical Company Limited | 縮合環化合物 |
| WO2005030740A1 (ja) | 2003-09-30 | 2005-04-07 | Takeda Pharmaceutical Company Limited | チアゾリン誘導体およびその用途 |
| EP1695961A4 (en) | 2003-12-17 | 2007-10-24 | Takeda Pharmaceutical | UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE |
| BRPI0418148A (pt) | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
| US7585880B2 (en) | 2003-12-26 | 2009-09-08 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
| CA2560111A1 (en) | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
| EP1731505B1 (en) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| JPWO2005108370A1 (ja) * | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP1873144B1 (en) | 2005-04-20 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| GB0511851D0 (en) * | 2005-06-11 | 2005-07-20 | Astrazeneca Ab | Chemical compounds |
| EP1916234B1 (en) | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| JPWO2007013694A1 (ja) | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| WO2007018314A2 (en) | 2005-08-10 | 2007-02-15 | Takeda Pharmaceutical Company Limited | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| US7749997B2 (en) * | 2005-12-22 | 2010-07-06 | Astrazeneca Ab | Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors |
| EP1996567B1 (en) * | 2006-02-15 | 2013-09-18 | AbbVie Inc. | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| RS52307B (sr) | 2006-06-27 | 2012-12-31 | Takeda Pharmaceutical Company Limited | Kondenzovana ciklična jedinjenja |
| EP2298772A1 (en) | 2006-10-18 | 2011-03-23 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| WO2008050821A1 (en) | 2006-10-19 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Indole compound |
| JP2008179621A (ja) * | 2006-12-28 | 2008-08-07 | Taisho Pharmaceutical Co Ltd | 含窒素飽和複素環化合物 |
| EP2128163A1 (en) | 2007-01-25 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Spiro-ring compound |
| US20100016396A1 (en) | 2007-01-29 | 2010-01-21 | Hiroshi Imoto | Pyrazole compound |
| EA200970746A1 (ru) | 2007-02-09 | 2010-02-26 | Такеда Фармасьютикал Компани Лимитед | Конденсированные циклические соединения в качестве частичных агонистов ppar-гамма |
| EP2149550A4 (en) | 2007-04-27 | 2010-08-11 | Takeda Pharmaceutical | NITROGENIC FIVE-GLOSS HETEROCYCLIC COMPOUND |
| EP2157859A4 (en) | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE |
| AU2009228293B2 (en) | 2008-03-26 | 2012-11-08 | Tennor Therapeutics (Suzhou) Limited | Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones |
| AU2009270984A1 (en) | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic Heterocycle Derivatives and methods of use thereof |
| WO2010050445A1 (ja) * | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| JP2010102718A (ja) | 2009-11-27 | 2010-05-06 | Toshiba Corp | 情報処理装置 |
| CA2819400A1 (en) | 2010-11-30 | 2012-06-07 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| WO2012108478A1 (ja) | 2011-02-09 | 2012-08-16 | 武田薬品工業株式会社 | 単環化合物 |
-
2011
- 2011-04-26 WO PCT/JP2011/060616 patent/WO2011136385A1/en not_active Ceased
- 2011-04-26 CA CA2797767A patent/CA2797767A1/en not_active Abandoned
- 2011-04-26 TW TW100114410A patent/TW201206911A/zh unknown
- 2011-04-26 EA EA201291115A patent/EA021698B1/ru not_active IP Right Cessation
- 2011-04-26 BR BR112012027648A patent/BR112012027648A2/pt not_active IP Right Cessation
- 2011-04-26 UY UY0001033354A patent/UY33354A/es not_active Application Discontinuation
- 2011-04-26 SG SG2012086880A patent/SG185759A1/en unknown
- 2011-04-26 US US13/094,015 patent/US8703758B2/en not_active Expired - Fee Related
- 2011-04-26 PH PH1/2012/502347A patent/PH12012502347A1/en unknown
- 2011-04-26 ES ES11722184.6T patent/ES2546130T3/es active Active
- 2011-04-26 MA MA35387A patent/MA34245B1/fr unknown
- 2011-04-26 CN CN201180031899.8A patent/CN103025716B/zh not_active Expired - Fee Related
- 2011-04-26 AR ARP110101434A patent/AR080969A1/es unknown
- 2011-04-26 NZ NZ603777A patent/NZ603777A/xx not_active IP Right Cessation
- 2011-04-26 UA UAA201213528A patent/UA108102C2/ru unknown
- 2011-04-26 AU AU2011246004A patent/AU2011246004A1/en not_active Abandoned
- 2011-04-26 JP JP2012547392A patent/JP5693611B2/ja not_active Expired - Fee Related
- 2011-04-26 EP EP11722184.6A patent/EP2563765B1/en active Active
- 2011-04-26 KR KR1020127030925A patent/KR20130094211A/ko not_active Withdrawn
- 2011-04-26 GE GEAP201112904A patent/GEP20146178B/en unknown
-
2012
- 2012-11-26 CR CR20120598A patent/CR20120598A/es not_active Application Discontinuation
- 2012-11-26 ZA ZA2012/08895A patent/ZA201208895B/en unknown
- 2012-11-27 CO CO12214563A patent/CO6640253A2/es active IP Right Grant
- 2012-11-27 EC ECSP12012311 patent/ECSP12012311A/es unknown
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