JP2013523705A5 - - Google Patents
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- Publication number
- JP2013523705A5 JP2013523705A5 JP2013501932A JP2013501932A JP2013523705A5 JP 2013523705 A5 JP2013523705 A5 JP 2013523705A5 JP 2013501932 A JP2013501932 A JP 2013501932A JP 2013501932 A JP2013501932 A JP 2013501932A JP 2013523705 A5 JP2013523705 A5 JP 2013523705A5
- Authority
- JP
- Japan
- Prior art keywords
- ester
- physiologically acceptable
- formula
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002148 esters Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 235000000346 sugar Nutrition 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 229930006000 Sucrose Natural products 0.000 claims 8
- 239000005720 sucrose Substances 0.000 claims 8
- 239000002671 adjuvant Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000008163 sugars Chemical class 0.000 claims 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 5
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 238000004108 freeze drying Methods 0.000 claims 3
- 238000007710 freezing Methods 0.000 claims 3
- 230000008014 freezing Effects 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 125000000185 sucrose group Chemical group 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003708 ampul Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000007900 aqueous suspension Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 108700003601 dimethylglycine Proteins 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 1
- CMUNUTVVOOHQPW-LURJTMIESA-N L-proline betaine Chemical compound C[N+]1(C)CCC[C@H]1C([O-])=O CMUNUTVVOOHQPW-LURJTMIESA-N 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1005518.4A GB201005518D0 (en) | 2010-03-31 | 2010-03-31 | Preservation of alum-adjuvanted vaccines |
| GB1005522.6 | 2010-03-31 | ||
| GB1005518.4 | 2010-03-31 | ||
| GBGB1005522.6A GB201005522D0 (en) | 2010-03-31 | 2010-03-31 | Method for preserving alum-adjuvanted vaccines |
| PCT/GB2011/000497 WO2011121305A2 (en) | 2010-03-31 | 2011-03-31 | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523705A JP2013523705A (ja) | 2013-06-17 |
| JP2013523705A5 true JP2013523705A5 (enExample) | 2014-04-24 |
| JP6023696B2 JP6023696B2 (ja) | 2016-11-09 |
Family
ID=43971221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501932A Active JP6023696B2 (ja) | 2010-03-31 | 2011-03-31 | ミョウバンアジュバントおよびミョウバンアジュバント化ワクチンの保存方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9101607B2 (enExample) |
| EP (1) | EP2552410B1 (enExample) |
| JP (1) | JP6023696B2 (enExample) |
| KR (1) | KR101819250B1 (enExample) |
| CN (1) | CN102892409B (enExample) |
| AU (1) | AU2011234268B2 (enExample) |
| BR (1) | BR112012025044A2 (enExample) |
| CA (1) | CA2795050C (enExample) |
| DK (1) | DK2552410T3 (enExample) |
| ES (1) | ES2708989T3 (enExample) |
| GB (1) | GB2499480A (enExample) |
| HU (1) | HUE042330T2 (enExample) |
| WO (1) | WO2011121305A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2499479A (en) * | 2010-03-31 | 2013-08-21 | Stabilitech Ltd | Stabilisation of viral particles |
| WO2011121301A1 (en) | 2010-03-31 | 2011-10-06 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| US9588123B2 (en) * | 2014-04-11 | 2017-03-07 | Surmodics Ivd, Inc. | Compositions and methods for in vitro diagnostic tests including zwitterionic solubilization reagent |
| GB2562241B (en) * | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AR111760A1 (es) * | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| CN113750228B (zh) * | 2021-09-25 | 2024-02-20 | 大连理工大学 | 一种冷冻保护剂在铝佐剂中的应用 |
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| US3927208A (en) | 1973-05-14 | 1975-12-16 | Rit Rech Ind Therapeut | Live bovine adenovirus vaccines, preparation thereof and method of vaccination using them |
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| JPS6013718A (ja) * | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ワクチン |
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| KR101385805B1 (ko) | 2005-11-30 | 2014-04-16 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 신규 펩티드 화합물 |
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| JP2012503637A (ja) | 2008-09-24 | 2012-02-09 | スタビリテック リミテッド | 糖およびポリエチレンイミンを使用するポリペプチドの保存方法 |
| US20110212127A1 (en) | 2008-09-24 | 2011-09-01 | Stabilitech Ltd. | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine |
| CN101670104A (zh) | 2009-09-24 | 2010-03-17 | 浙江大学 | 一种含人参皂甙的油佐剂及其制备方法 |
| GB2499479A (en) | 2010-03-31 | 2013-08-21 | Stabilitech Ltd | Stabilisation of viral particles |
-
2011
- 2011-03-31 JP JP2013501932A patent/JP6023696B2/ja active Active
- 2011-03-31 ES ES11712653T patent/ES2708989T3/es active Active
- 2011-03-31 EP EP11712653.2A patent/EP2552410B1/en active Active
- 2011-03-31 WO PCT/GB2011/000497 patent/WO2011121305A2/en not_active Ceased
- 2011-03-31 KR KR1020127028370A patent/KR101819250B1/ko not_active Expired - Fee Related
- 2011-03-31 US US13/637,828 patent/US9101607B2/en active Active
- 2011-03-31 DK DK11712653.2T patent/DK2552410T3/en active
- 2011-03-31 CA CA2795050A patent/CA2795050C/en active Active
- 2011-03-31 AU AU2011234268A patent/AU2011234268B2/en not_active Ceased
- 2011-03-31 HU HUE11712653A patent/HUE042330T2/hu unknown
- 2011-03-31 GB GB1216472.9A patent/GB2499480A/en not_active Withdrawn
- 2011-03-31 BR BR112012025044A patent/BR112012025044A2/pt not_active Application Discontinuation
- 2011-03-31 CN CN201180014386.6A patent/CN102892409B/zh not_active Expired - Fee Related
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