BR112012025044A2 - método para conservar adjuvantes de alum e vacinas com adjuvantes de alum - Google Patents

método para conservar adjuvantes de alum e vacinas com adjuvantes de alum

Info

Publication number
BR112012025044A2
BR112012025044A2 BR112012025044A BR112012025044A BR112012025044A2 BR 112012025044 A2 BR112012025044 A2 BR 112012025044A2 BR 112012025044 A BR112012025044 A BR 112012025044A BR 112012025044 A BR112012025044 A BR 112012025044A BR 112012025044 A2 BR112012025044 A2 BR 112012025044A2
Authority
BR
Brazil
Prior art keywords
alum
preserving
adjuvants
adjuvanted vaccines
vaccines
Prior art date
Application number
BR112012025044A
Other languages
English (en)
Inventor
Corteyn Amanda
Drew Jeffrey
Woodward David
Original Assignee
Stabilitech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1005522.6A external-priority patent/GB201005522D0/en
Priority claimed from GBGB1005518.4A external-priority patent/GB201005518D0/en
Application filed by Stabilitech Ltd filed Critical Stabilitech Ltd
Publication of BR112012025044A2 publication Critical patent/BR112012025044A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

método para conservar adjuvantes de alum e vacinas com adjuvantes de alum. método para conservar um adjuvante de sal alumínio durante o congelamento ou secagem compreendendo o congelamento ou secagem de uma suspensão ou solução aquosa compreendendo: (a) um adjuvante de sal alumínio; (b) um composto da fórmula (i) ou uma sal ou éster fisiologicamente aceitável do mesmo ou um composto da fórmula (ii) ou um sal ou éster fisiolagicamente aceitável do mesmo; e (c) opcionalmente, um ou mais açúcares.
BR112012025044A 2010-03-31 2011-03-31 método para conservar adjuvantes de alum e vacinas com adjuvantes de alum BR112012025044A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1005522.6A GB201005522D0 (en) 2010-03-31 2010-03-31 Method for preserving alum-adjuvanted vaccines
GBGB1005518.4A GB201005518D0 (en) 2010-03-31 2010-03-31 Preservation of alum-adjuvanted vaccines
PCT/GB2011/000497 WO2011121305A2 (en) 2010-03-31 2011-03-31 Method for preserving alum adjuvants and alum-adjuvanted vaccines

Publications (1)

Publication Number Publication Date
BR112012025044A2 true BR112012025044A2 (pt) 2016-06-21

Family

ID=43971221

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012025044A BR112012025044A2 (pt) 2010-03-31 2011-03-31 método para conservar adjuvantes de alum e vacinas com adjuvantes de alum

Country Status (13)

Country Link
US (1) US9101607B2 (pt)
EP (1) EP2552410B1 (pt)
JP (1) JP6023696B2 (pt)
KR (1) KR101819250B1 (pt)
CN (1) CN102892409B (pt)
AU (1) AU2011234268B2 (pt)
BR (1) BR112012025044A2 (pt)
CA (1) CA2795050C (pt)
DK (1) DK2552410T3 (pt)
ES (1) ES2708989T3 (pt)
GB (1) GB2499480A (pt)
HU (1) HUE042330T2 (pt)
WO (1) WO2011121305A2 (pt)

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AU2011234264B2 (en) 2010-03-31 2016-02-04 Stabilitech Ltd Excipients for stabilising viral particles, polypeptides or biological material
DK2898890T3 (da) 2010-03-31 2019-11-25 Stabilitech Biopharma Ltd Stabilisering af viruspartikler
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US9588123B2 (en) * 2014-04-11 2017-03-07 Surmodics Ivd, Inc. Compositions and methods for in vitro diagnostic tests including zwitterionic solubilization reagent
GB201406569D0 (en) * 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
AR111760A1 (es) 2017-05-19 2019-08-14 Novartis Ag Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral
CN113750228B (zh) * 2021-09-25 2024-02-20 大连理工大学 一种冷冻保护剂在铝佐剂中的应用

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Also Published As

Publication number Publication date
US20130156797A1 (en) 2013-06-20
EP2552410B1 (en) 2018-10-24
CA2795050C (en) 2018-05-22
GB201216472D0 (en) 2012-10-31
CN102892409B (zh) 2015-12-09
WO2011121305A2 (en) 2011-10-06
KR101819250B1 (ko) 2018-01-16
EP2552410A2 (en) 2013-02-06
CA2795050A1 (en) 2011-10-06
AU2011234268A1 (en) 2012-09-27
WO2011121305A3 (en) 2011-11-24
HUE042330T2 (hu) 2019-06-28
US9101607B2 (en) 2015-08-11
KR20130012956A (ko) 2013-02-05
DK2552410T3 (en) 2019-02-18
JP6023696B2 (ja) 2016-11-09
JP2013523705A (ja) 2013-06-17
ES2708989T3 (es) 2019-04-12
AU2011234268B2 (en) 2015-07-02
CN102892409A (zh) 2013-01-23
GB2499480A (en) 2013-08-21

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