JP2013522326A - がん幹細胞を標的とするための新規の方法 - Google Patents

がん幹細胞を標的とするための新規の方法 Download PDF

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Publication number
JP2013522326A
JP2013522326A JP2013500247A JP2013500247A JP2013522326A JP 2013522326 A JP2013522326 A JP 2013522326A JP 2013500247 A JP2013500247 A JP 2013500247A JP 2013500247 A JP2013500247 A JP 2013500247A JP 2013522326 A JP2013522326 A JP 2013522326A
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compound
polymorph
cancer
peak
furan
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JP2013522326A5 (cg-RX-API-DMAC7.html
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ジャン ジャ リ,
デイビッド レゲット,
ヤウジー リ,
ウェイ リ,
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ボストン バイオメディカル, インコーポレイテッド
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Publication of JP2013522326A5 publication Critical patent/JP2013522326A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013500247A 2010-03-19 2011-03-21 がん幹細胞を標的とするための新規の方法 Pending JP2013522326A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,886 2010-03-19
US61/315,890 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells

Related Child Applications (1)

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JP2015179115A Division JP6246169B2 (ja) 2010-03-19 2015-09-11 がん幹細胞を標的とするための新規の方法

Publications (2)

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JP2013522326A true JP2013522326A (ja) 2013-06-13
JP2013522326A5 JP2013522326A5 (cg-RX-API-DMAC7.html) 2014-04-17

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EP (1) EP2547205B1 (cg-RX-API-DMAC7.html)
JP (1) JP2013522326A (cg-RX-API-DMAC7.html)
CN (1) CN103025159A (cg-RX-API-DMAC7.html)
AU (1) AU2011227023B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012023660B8 (cg-RX-API-DMAC7.html)
CA (2) CA2946890A1 (cg-RX-API-DMAC7.html)
DK (1) DK2547205T3 (cg-RX-API-DMAC7.html)
ES (1) ES2987670T3 (cg-RX-API-DMAC7.html)
FI (1) FI2547205T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20240658T1 (cg-RX-API-DMAC7.html)
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PL (1) PL2547205T3 (cg-RX-API-DMAC7.html)
RS (1) RS65536B1 (cg-RX-API-DMAC7.html)
RU (1) RU2591823C2 (cg-RX-API-DMAC7.html)
SI (1) SI2547205T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202400193T1 (cg-RX-API-DMAC7.html)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014098049A (ja) * 2010-03-19 2014-05-29 Boston Biomedical Inc がん幹細胞を標的とするための新規の化合物および組成物
WO2015190489A1 (ja) * 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2736563C (en) 2007-09-10 2016-01-26 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
KR20150139955A (ko) 2013-04-09 2015-12-14 보스톤 바이오메디칼, 인크. 암 치료에 사용하기 위한 2-아세틸나프토[2,3-b]푸란-4,9-디온
US10017488B2 (en) 2014-02-07 2018-07-10 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
CN107666906A (zh) 2015-04-17 2018-02-06 波士顿生物医药有限公司 用于治疗癌症的方法
CN107708700A (zh) 2015-04-17 2018-02-16 波士顿生物医药有限公司 用于治疗癌症的方法
TW201717935A (zh) 2015-06-03 2017-06-01 波士頓生醫公司 用於治療癌症的組成物和方法
JP6871919B2 (ja) 2015-06-16 2021-05-19 ナノファギックス エルエルシー 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
WO2017132049A1 (en) 2016-01-20 2017-08-03 Boston Biomedical, Inc. Methods for treating cancer
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CA3062656A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
US10953369B2 (en) * 2018-03-08 2021-03-23 Georgia Tech Research Corporation Spirocentric compounds and polymers thereof
EP3865130A4 (en) 2018-10-12 2022-07-20 1Globe Biomedical Co., Ltd. NEW COMBINATION SOLUTION FOR THE TREATMENT OF CHEMOTHERAPY-REFRACTORY CANCER
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途
CN117350965A (zh) * 2023-10-07 2024-01-05 中国原子能科学研究院 对象内放射性微球的指标预估装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
WO2000044774A2 (en) 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
MXPA02000828A (es) 1999-08-02 2002-07-30 Hoffmann La Roche Nuevos antagonistas retinoiides selectivos.
JP2001097860A (ja) * 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
AU2002307217A1 (en) 2001-03-28 2002-10-15 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
JP2005517637A (ja) * 2001-11-29 2005-06-16 セラコス・インコーポレイテッド 体外フォトフォレーシスおよび/またはアポプトーシス細胞による一定の被験体を前処理するための方法
ATE337014T1 (de) 2002-03-15 2006-09-15 Natimmune As Mannose-bindungsprotein enthaltende pharmazeutische zusammensetzungen
EP1551392A4 (en) * 2002-09-17 2006-09-20 Arqule Inc NEW LAPACHO COMPOUNDS AND APPLICATION METHOD THEREFOR
CL2003002353A1 (es) 2002-11-15 2005-02-04 Vertex Pharma Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
WO2005005601A2 (en) 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
US7745468B2 (en) 2003-12-11 2010-06-29 Board of Regents, University of Texas Systems The Compounds for treatment of cell proliferative diseases
WO2005110477A2 (en) 2004-04-09 2005-11-24 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
RU2007123675A (ru) 2004-11-24 2008-12-27 Новартис АГ (CH) Комбинации ингибиторов jak
EP1853242A4 (en) 2005-02-25 2009-11-18 Univ Michigan LOW MOLECULAR STAT3 INHIBITORS AND THEIR USES
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP2006290871A (ja) * 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
CN101142202A (zh) * 2005-03-16 2008-03-12 太日保日本株式会社 抗癌化合物及其中间体和生产方法
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
WO2007100640A2 (en) 2006-02-21 2007-09-07 The Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
WO2007115269A2 (en) 2006-03-31 2007-10-11 The Board Of Regents Of The University Of Texas System Orally bioavailable caffeic acid related anticancer drugs
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2008094321A2 (en) 2006-10-04 2008-08-07 Universtiy Of South Florida Akt sensitization of cancer cells
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性2−(1−ヒドロキシエチル)−5−ヒドロキシナフト[2,3−b]フラン−4,9−ジオンの製法
WO2009060282A2 (en) 2007-11-06 2009-05-14 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
RU2657750C1 (ru) * 2010-03-19 2018-06-15 Бостон Байомедикал, Инк. Новые способы направленного воздействия на раковые стволовые клетки

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
JP2010539098A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル, インコーポレイテッド 癌治療のための新規の組成物および方法
JP2010539095A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル, インコーポレイテッド 新規のStat3経路阻害剤及び癌幹細胞阻害剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014098049A (ja) * 2010-03-19 2014-05-29 Boston Biomedical Inc がん幹細胞を標的とするための新規の化合物および組成物
WO2015190489A1 (ja) * 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤
JPWO2015190489A1 (ja) * 2014-06-09 2017-05-25 京都薬品工業株式会社 新規抗癌剤
US10005752B2 (en) 2014-06-09 2018-06-26 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent
US10377730B2 (en) 2014-06-09 2019-08-13 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent
JP2019206529A (ja) * 2014-06-09 2019-12-05 京都薬品工業株式会社 新規抗癌剤
US10689355B2 (en) 2014-06-09 2020-06-23 Kyoto Pharmaceuticals Industries, Ltd. Anticancer agent
US11267797B2 (en) 2014-06-09 2022-03-08 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent

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Publication number Publication date
RU2012144420A (ru) 2014-04-27
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
AU2011227023A1 (en) 2012-09-27
SI2547205T1 (sl) 2024-08-30
WO2011116399A1 (en) 2011-09-22
RS65536B1 (sr) 2024-06-28
CA2793527A1 (en) 2011-09-22
EP2547205A4 (en) 2013-08-14
DK2547205T3 (da) 2024-05-27
US20130028944A1 (en) 2013-01-31
EP2547205A1 (en) 2013-01-23
RU2591823C2 (ru) 2016-07-20
US9730909B2 (en) 2017-08-15
CA2946890A1 (en) 2011-09-22
SMT202400193T1 (it) 2024-07-09
EP2547205B1 (en) 2024-03-20
AU2011227023B2 (en) 2015-05-28
US20170319537A1 (en) 2017-11-09
ES2987670T3 (es) 2024-11-15
PL2547205T3 (pl) 2024-07-08
BR112012023660B1 (pt) 2021-05-18
BR112012023660A2 (pt) 2015-09-15
LT2547205T (lt) 2024-06-10
HRP20240658T1 (hr) 2024-08-16
FI2547205T3 (fi) 2024-05-27

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