JP2013522311A5 - - Google Patents
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- Publication number
- JP2013522311A5 JP2013522311A5 JP2013500162A JP2013500162A JP2013522311A5 JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5 JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5
- Authority
- JP
- Japan
- Prior art keywords
- phe
- lys
- arg
- aromatic
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31394510P | 2010-03-15 | 2010-03-15 | |
| US61/313,945 | 2010-03-15 | ||
| US37681310P | 2010-08-25 | 2010-08-25 | |
| US61/376,813 | 2010-08-25 | ||
| PCT/US2011/028543 WO2011116007A1 (en) | 2010-03-15 | 2011-03-15 | Combination therapies using cyclosporine and aromatic cationic peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522311A JP2013522311A (ja) | 2013-06-13 |
| JP2013522311A5 true JP2013522311A5 (https=) | 2014-05-01 |
Family
ID=44649559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500162A Pending JP2013522311A (ja) | 2010-03-15 | 2011-03-15 | シクロスポリンおよび芳香族カチオン性ペプチドを用いた併用療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US8697657B2 (https=) |
| EP (6) | EP3375449A1 (https=) |
| JP (1) | JP2013522311A (https=) |
| WO (1) | WO2011116007A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3090754A1 (en) * | 2009-12-31 | 2016-11-09 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| EP3266462A1 (en) * | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| EP3375449A1 (en) | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| EP2590664B1 (en) * | 2010-07-09 | 2019-03-27 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury |
| CN106913860A (zh) | 2011-09-29 | 2017-07-04 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| EP2788013A4 (en) * | 2011-12-09 | 2015-08-19 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| CN104271146A (zh) * | 2012-03-30 | 2015-01-07 | 康肽德生物医药技术有限公司 | 用于预防和治疗神经病的方法和组合物 |
| JP2014196281A (ja) * | 2012-08-01 | 2014-10-16 | 健輔 江頭 | 医薬組成物 |
| JP2015529655A (ja) | 2012-08-02 | 2015-10-08 | ステルス ペプチドズ インターナショナル インコーポレイテッド | アテローム性硬化症の処置方法 |
| AU2013334788A1 (en) * | 2012-10-22 | 2015-06-04 | Henry Ford Health Systems | Methods for reducing risks associated with heart failure and factors associated therewith |
| JP2016506391A (ja) * | 2012-12-06 | 2016-03-03 | ステルス ペプチドズ インターナショナル インコーポレイテッド | ペプチド治療薬およびその使用方法 |
| ES2755134T3 (es) | 2013-03-01 | 2020-04-21 | Stealth Biotherapeutics Corp | Métodos para el tratamiento de enfermedad mitocondrial |
| US9687519B2 (en) | 2013-03-01 | 2017-06-27 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| EP3586864A1 (en) * | 2013-05-14 | 2020-01-01 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricle remodeling |
| US20140363391A1 (en) * | 2013-06-06 | 2014-12-11 | Demetris Yannopoulos | System and method for administering poloxamers and anesthetics while performing cpr and minimizing reperfusion injury |
| WO2014210062A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
| CA2916977A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| CA2920735A1 (en) * | 2013-08-12 | 2015-02-19 | Stealth Biotherapeutics Corp | Combination therapy for the treatment of ischemia-reperfusion injury |
| US10221213B2 (en) | 2013-12-27 | 2019-03-05 | Stealth Biotherapeutics Corp | Pharmaceutically relevant aromatic-cationic peptides |
| JP2017512762A (ja) * | 2014-03-03 | 2017-05-25 | ステルス バイオセラピューティックス コープ | 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法 |
| EP3502132A1 (en) * | 2014-05-28 | 2019-06-26 | Stealth BioTherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| WO2015183984A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including tocopherol and uses thereof |
| WO2015183995A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| CA2958585C (en) * | 2014-08-21 | 2024-01-09 | Stealth Biotherapeutics Corp | Use of peptide d-arg-2',6'-dmt-lys-phe-nh2 for the treatment of alport syndrome |
| US10683534B2 (en) * | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
| CA2976632A1 (en) * | 2015-02-13 | 2016-08-18 | Stealth Biotherapeutics Corp | Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof and methods of using the same |
| EP3265109B1 (en) | 2015-03-06 | 2020-10-21 | Stealth BioTherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| CA3006698A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| CA3017359A1 (en) | 2016-03-11 | 2017-09-14 | Scott M. Duncan | Crystalline salt forms |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US11325943B2 (en) * | 2017-06-02 | 2022-05-10 | Stealth Biotherapeutics Inc. | Crystalline salt forms of SBT-20 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| US12252554B2 (en) | 2018-12-18 | 2025-03-18 | Stealth Biotherapeutics Inc. | Analogs that target mitochondrial diseases |
| IL284006B2 (en) * | 2018-12-18 | 2024-12-01 | Stealth Biotherapeutics Corp | Mitochondria-targeting peptides |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技(上海)有限公司 | 环孢菌素类似物及其用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5786332A (en) * | 1995-03-06 | 1998-07-28 | Trega Biosciences, Inc. | Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| SE520730C2 (sv) * | 1995-01-20 | 2003-08-19 | Eskil Elmer | Behandling av hjärnischemi och hjärnskador med ett neuroprotektivt läkemedel |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| WO2000051625A1 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| US6593292B1 (en) * | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| EP1599216B9 (en) | 2003-02-04 | 2015-02-11 | Cornell Research Foundation, Inc. | Methods for preventing mitochondrial permeability transition |
| CA3024434A1 (en) * | 2004-01-23 | 2005-08-11 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| WO2005097164A2 (en) * | 2004-04-08 | 2005-10-20 | Novartis Ag | Use of cyclosporins for treatment of cerebral ischemia and brain and spinal cord injury |
| EP2023948A1 (en) * | 2006-05-04 | 2009-02-18 | Michel Ovize | Use of cyclosporin a or melle4-cyclosporin for the treatment of acute myocardial infarction |
| EP2114427B1 (en) * | 2007-01-30 | 2014-06-25 | New York University | Peptides for treatment of conditions associated with nitric oxide |
| EP3741381B1 (en) | 2008-02-26 | 2024-04-24 | Cornell University | A peptide for use for prevention and treatment of acute renal injury |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| EP2376524B1 (en) * | 2008-12-31 | 2017-03-15 | Cypralis Limited | Derivatives of cyclosporin a |
| ES2964555T3 (es) * | 2009-08-24 | 2024-04-08 | Stealth Biotherapeutics Inc | Péptido para uso en la prevención o tratamiento de la degeneración macular |
| EP3266462A1 (en) | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| EP3090754A1 (en) * | 2009-12-31 | 2016-11-09 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| CA2787331A1 (en) | 2010-01-25 | 2011-07-28 | Hazel H. Szeto | Aromatic-cationic peptides and uses of same |
| JP2013521231A (ja) * | 2010-02-26 | 2013-06-10 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション インコーポレイテッド | ミトコンドリア標的化抗酸化剤は機械的人工呼吸誘発性横隔膜機能障害および骨格筋萎縮を防止する |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
-
2011
- 2011-03-15 EP EP18158672.8A patent/EP3375449A1/en not_active Withdrawn
- 2011-03-15 EP EP17150292.5A patent/EP3210615A1/en not_active Withdrawn
- 2011-03-15 EP EP15187915.2A patent/EP3040080A1/en not_active Withdrawn
- 2011-03-15 JP JP2013500162A patent/JP2013522311A/ja active Pending
- 2011-03-15 EP EP14163505.2A patent/EP2808029A3/en not_active Withdrawn
- 2011-03-15 US US13/634,192 patent/US8697657B2/en active Active
- 2011-03-15 WO PCT/US2011/028543 patent/WO2011116007A1/en not_active Ceased
- 2011-03-15 EP EP19162382.6A patent/EP3560508A1/en not_active Withdrawn
- 2011-03-15 EP EP11756870.9A patent/EP2547352A4/en not_active Withdrawn
-
2014
- 2014-02-20 US US14/185,471 patent/US9561258B2/en active Active
-
2017
- 2017-01-03 US US15/397,030 patent/US10702577B2/en active Active
-
2020
- 2020-01-14 US US16/742,806 patent/US20200376074A1/en not_active Abandoned
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