JP2013522311A5 - - Google Patents
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- Publication number
- JP2013522311A5 JP2013522311A5 JP2013500162A JP2013500162A JP2013522311A5 JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5 JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5
- Authority
- JP
- Japan
- Prior art keywords
- phe
- lys
- arg
- aromatic
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31394510P | 2010-03-15 | 2010-03-15 | |
| US61/313,945 | 2010-03-15 | ||
| US37681310P | 2010-08-25 | 2010-08-25 | |
| US61/376,813 | 2010-08-25 | ||
| PCT/US2011/028543 WO2011116007A1 (en) | 2010-03-15 | 2011-03-15 | Combination therapies using cyclosporine and aromatic cationic peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522311A JP2013522311A (ja) | 2013-06-13 |
| JP2013522311A5 true JP2013522311A5 (https=) | 2014-05-01 |
Family
ID=44649559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500162A Pending JP2013522311A (ja) | 2010-03-15 | 2011-03-15 | シクロスポリンおよび芳香族カチオン性ペプチドを用いた併用療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US8697657B2 (https=) |
| EP (6) | EP3375449A1 (https=) |
| JP (1) | JP2013522311A (https=) |
| WO (1) | WO2011116007A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751763A (zh) * | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
| EP3266462A1 (en) * | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| EP3375449A1 (en) | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| JP6319738B2 (ja) * | 2010-07-09 | 2018-05-09 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 虚血/再灌流障害に続くノーリフローの予防又は処置方法 |
| AU2012315586B2 (en) * | 2011-09-29 | 2017-07-20 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| EP3009141A1 (en) * | 2011-12-09 | 2016-04-20 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| JP6317324B2 (ja) * | 2012-03-30 | 2018-04-25 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 神経障害を予防および処置するための方法および組成物 |
| JP2014196281A (ja) * | 2012-08-01 | 2014-10-16 | 健輔 江頭 | 医薬組成物 |
| HK1210953A1 (en) * | 2012-08-02 | 2016-05-13 | Stealth Peptides International, Inc. | Methods for treatment of atherosclerosis |
| AU2013334788A1 (en) * | 2012-10-22 | 2015-06-04 | Henry Ford Health Systems | Methods for reducing risks associated with heart failure and factors associated therewith |
| EP2928562A4 (en) * | 2012-12-06 | 2016-06-22 | Stealth Peptides Int Inc | PEPTIDE THERAPEUTIC PRODUCTS AND METHODS OF USE |
| CN110339339A (zh) | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| EP3626252A1 (en) | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| CA2912386A1 (en) * | 2013-05-14 | 2014-11-20 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricular remodeling |
| US20140363391A1 (en) * | 2013-06-06 | 2014-12-11 | Demetris Yannopoulos | System and method for administering poloxamers and anesthetics while performing cpr and minimizing reperfusion injury |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| WO2014210062A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| WO2015023680A1 (en) * | 2013-08-12 | 2015-02-19 | Stealth Peptides International, Inc. | Combination therapy for the treatment of ischemia-reperfusion injury |
| JP6626446B2 (ja) | 2013-12-27 | 2019-12-25 | ステルス バイオセラピューティックス コープ | 薬学的に適切な芳香族カチオン性ペプチド |
| HK1231493A1 (zh) * | 2014-03-03 | 2017-12-22 | Stealth Biotherapeutics Corp | 药学上相关的芳香族阳离子肽 |
| WO2015183984A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including tocopherol and uses thereof |
| EP3149035A4 (en) * | 2014-05-28 | 2018-05-16 | Stealth BioTherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| WO2015183995A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| WO2016029027A2 (en) | 2014-08-21 | 2016-02-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of disease |
| US10683534B2 (en) * | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
| CA2976632A1 (en) * | 2015-02-13 | 2016-08-18 | Stealth Biotherapeutics Corp | Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof and methods of using the same |
| US10633415B2 (en) | 2015-03-06 | 2020-04-28 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| CA3006698A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| CN115160402A (zh) | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| CN110914287A (zh) | 2017-04-05 | 2020-03-24 | 隐形生物治疗公司 | Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式 |
| WO2018223032A1 (en) * | 2017-06-02 | 2018-12-06 | Stealth Biotherapeutics Corp. | Crystalline salt forms of sbt-20 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| US12404300B2 (en) | 2018-12-18 | 2025-09-02 | Stealth Biotherapeutics Inc. | Mitochondria-targeting peptides |
| EP3898653A4 (en) | 2018-12-18 | 2022-08-24 | Stealth BioTherapeutics Inc. | ANALOGS TARGETING MITOCHONDRIAL DISEASES |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技(上海)有限公司 | 环孢菌素类似物及其用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5786332A (en) | 1995-03-06 | 1998-07-28 | Trega Biosciences, Inc. | Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| SE520730C2 (sv) * | 1995-01-20 | 2003-08-19 | Eskil Elmer | Behandling av hjärnischemi och hjärnskador med ett neuroprotektivt läkemedel |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| CA2381425A1 (en) * | 1999-08-24 | 2001-03-01 | Cellgate, Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
| SI2656854T1 (sl) * | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| CA2851972C (en) | 2004-01-23 | 2015-06-23 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| US20080194470A1 (en) * | 2004-04-08 | 2008-08-14 | Novartis Ag | Nim811 In Cerebral Ischemia and Brain and Spinal Cord Injury |
| EP2023948A1 (en) * | 2006-05-04 | 2009-02-18 | Michel Ovize | Use of cyclosporin a or melle4-cyclosporin for the treatment of acute myocardial infarction |
| EP2114427B1 (en) * | 2007-01-30 | 2014-06-25 | New York University | Peptides for treatment of conditions associated with nitric oxide |
| DK2262520T3 (en) * | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| US8536114B2 (en) * | 2008-12-31 | 2013-09-17 | Scynexis, Inc. | Macrocycles |
| PL2470191T3 (pl) * | 2009-08-24 | 2014-09-30 | Stealth Peptides Int Inc | Sposoby i kompozycje do profilaktyki lub leczenia stanów okulistycznych |
| EP3266462A1 (en) | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| CN103751763A (zh) * | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
| AU2011207432A1 (en) | 2010-01-25 | 2012-08-02 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP3332795A1 (en) * | 2010-02-26 | 2018-06-13 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
-
2011
- 2011-03-15 EP EP18158672.8A patent/EP3375449A1/en not_active Withdrawn
- 2011-03-15 EP EP15187915.2A patent/EP3040080A1/en not_active Withdrawn
- 2011-03-15 EP EP11756870.9A patent/EP2547352A4/en not_active Withdrawn
- 2011-03-15 WO PCT/US2011/028543 patent/WO2011116007A1/en not_active Ceased
- 2011-03-15 JP JP2013500162A patent/JP2013522311A/ja active Pending
- 2011-03-15 EP EP19162382.6A patent/EP3560508A1/en not_active Withdrawn
- 2011-03-15 EP EP17150292.5A patent/EP3210615A1/en not_active Withdrawn
- 2011-03-15 US US13/634,192 patent/US8697657B2/en active Active
- 2011-03-15 EP EP14163505.2A patent/EP2808029A3/en not_active Withdrawn
-
2014
- 2014-02-20 US US14/185,471 patent/US9561258B2/en active Active
-
2017
- 2017-01-03 US US15/397,030 patent/US10702577B2/en active Active
-
2020
- 2020-01-14 US US16/742,806 patent/US20200376074A1/en not_active Abandoned
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