JP2013516501A5 - - Google Patents
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- JP2013516501A5 JP2013516501A5 JP2012549006A JP2012549006A JP2013516501A5 JP 2013516501 A5 JP2013516501 A5 JP 2013516501A5 JP 2012549006 A JP2012549006 A JP 2012549006A JP 2012549006 A JP2012549006 A JP 2012549006A JP 2013516501 A5 JP2013516501 A5 JP 2013516501A5
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- Japan
- Prior art keywords
- pharmaceutical composition
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- nhcor
- item
- Prior art date
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- 229910052736 halogen Inorganic materials 0.000 claims description 48
- 125000005843 halogen group Chemical group 0.000 claims description 32
- 150000001875 compounds Chemical class 0.000 claims description 20
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 20
- 229940127557 pharmaceutical product Drugs 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 150000002367 halogens Chemical group 0.000 claims description 16
- 210000004175 meibomian gland Anatomy 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 230000028327 secretion Effects 0.000 claims description 12
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 210000000744 eyelid Anatomy 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 239000007963 capsule composition Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- -1 elixirs Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000002997 ophthalmic solution Substances 0.000 claims description 2
- 229940054534 ophthalmic solution Drugs 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000007916 tablet composition Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 150000004677 hydrates Chemical class 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 63
- 150000001204 N-oxides Chemical class 0.000 description 13
- 210000001508 eye Anatomy 0.000 description 5
- JNGVJMBLXIUVRD-SFHVURJKSA-N C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O JNGVJMBLXIUVRD-SFHVURJKSA-N 0.000 description 4
- JQFMUAOGKUMGNM-SFHVURJKSA-N C[C@](COc(cc1)cc(F)c1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound C[C@](COc(cc1)cc(F)c1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O JQFMUAOGKUMGNM-SFHVURJKSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 0 *[C@](COc(cc1F)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O Chemical compound *[C@](COc(cc1F)ccc1C#N)(C(Nc(cc1C(F)(F)F)ccc1C#N)=O)O 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29396610P | 2010-01-11 | 2010-01-11 | |
| US61/293,966 | 2010-01-11 | ||
| PCT/US2011/020871 WO2011085385A1 (en) | 2010-01-11 | 2011-01-11 | Methods of treating meibomian gland dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013516501A JP2013516501A (ja) | 2013-05-13 |
| JP2013516501A5 true JP2013516501A5 (https=) | 2014-04-10 |
Family
ID=44259000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549006A Pending JP2013516501A (ja) | 2010-01-11 | 2011-01-11 | マイボーム腺機能障害を治療する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8791158B2 (https=) |
| EP (1) | EP2523556A4 (https=) |
| JP (1) | JP2013516501A (https=) |
| KR (1) | KR20120115380A (https=) |
| CN (1) | CN103002737A (https=) |
| AU (1) | AU2011203832A1 (https=) |
| CA (1) | CA2787114A1 (https=) |
| MX (1) | MX2012008110A (https=) |
| RU (1) | RU2012134351A (https=) |
| WO (1) | WO2011085385A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US20070060988A1 (en) * | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| ES2581765T3 (es) * | 2006-08-24 | 2016-09-07 | University Of Tennessee Research Foundation | Acilanilidas sustituidas y métodos de uso de las mismas |
| US9381183B2 (en) * | 2012-07-18 | 2016-07-05 | Physicians Recommended Nutriceuticals, Llc | Methods for improving the quality of the meibum composition of meibomian glands |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| LT2872482T (lt) | 2012-07-13 | 2020-12-28 | Oncternal Therapeutics, Inc. | Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| WO2014031857A2 (en) | 2012-08-22 | 2014-02-27 | Tearscience, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US10064818B2 (en) * | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| RU2567829C1 (ru) * | 2014-10-22 | 2015-11-10 | Елизавета Геннадьевна Полунина | Способ оценки морфофункционального состояния мейбомиевых желез - биометрия мейбомиевых желез |
| KR101714710B1 (ko) | 2015-09-17 | 2017-03-10 | 고려대학교 산학협력단 | 마이봄샘 압출기 |
| US11040062B2 (en) * | 2016-04-14 | 2021-06-22 | Azura Ophthalmics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| WO2023091439A1 (en) | 2021-11-17 | 2023-05-25 | Lenz Therapeutics, Inc. | Aceclidine derivatives, compositions thereof and methods of use thereof |
| CN116183427A (zh) * | 2021-11-29 | 2023-05-30 | 巴西石油公司 | 用于评估延迟焦化装置的炉的管中的沉积的系统和方法 |
| US11648247B1 (en) | 2021-12-16 | 2023-05-16 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| US12414942B1 (en) | 2024-03-15 | 2025-09-16 | Lenz Therapeutics Operations, Inc. | Compositions, methods, and systems for treating presbyopia |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| ATE28864T1 (de) * | 1982-07-23 | 1987-08-15 | Ici Plc | Amide-derivate. |
| US20050038110A1 (en) * | 2000-08-24 | 2005-02-17 | Steiner Mitchell S. | Selective androgen receptor modulators and methods of use thereof |
| US7622503B2 (en) * | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US20070173546A1 (en) * | 2000-08-24 | 2007-07-26 | Dalton James T | Selective androgen receptor modulators and method of use thereof |
| US6838484B2 (en) * | 2000-08-24 | 2005-01-04 | University Of Tennessee Research Foundation | Formulations comprising selective androgen receptor modulators |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US6998500B2 (en) * | 2000-08-24 | 2006-02-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) * | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| IL154425A0 (en) * | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| US7919647B2 (en) * | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8445534B2 (en) * | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US7645898B2 (en) * | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| JPWO2002022585A1 (ja) * | 2000-09-14 | 2004-01-22 | 科研製薬株式会社 | テトラヒドロキノリン化合物 |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| AU2003216153B2 (en) | 2002-02-28 | 2008-01-24 | The University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| US7772433B2 (en) * | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| US7705182B2 (en) * | 2002-02-28 | 2010-04-27 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
| US7803970B2 (en) * | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| HRP20040818A2 (en) | 2002-02-28 | 2005-02-28 | University Of Tennessee Research Foundation | Haloacetamide and azide substituted compounds and methods of use thereof |
| JP2005529952A (ja) | 2002-06-17 | 2005-10-06 | ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション | Ｎ架橋選択的アンドロゲン受容体修飾物質及びその使用方法 |
| US20040197928A1 (en) * | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| EP1562906A4 (en) * | 2002-10-15 | 2009-12-02 | Univ Tennessee Res Foundation | HETEROCYCLIC SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD FOR THEIR USE |
| WO2004034978A2 (en) | 2002-10-15 | 2004-04-29 | Gtx, Inc. | Treating obesity with selective androgen receptor modulators |
| CA2502209A1 (en) | 2002-10-15 | 2004-04-29 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
| US20040265916A1 (en) * | 2002-10-15 | 2004-12-30 | Dalton James T. | Method for detecting selective androgen receptor modulators |
| WO2004035739A2 (en) | 2002-10-16 | 2004-04-29 | Gtx, Inc. | Treating androgen decline in aging male (adam)-associated conditions with sarms |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| US20040087810A1 (en) * | 2002-10-23 | 2004-05-06 | Dalton James T. | Irreversible selective androgen receptor modulators and methods of use thereof |
| US8309603B2 (en) * | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| JP4603528B2 (ja) * | 2003-01-13 | 2010-12-22 | ジーティーエックス・インコーポレイテッド | 選択的アンドロゲン受容体の大規模合成 |
| AU2004206909A1 (en) | 2003-01-22 | 2004-08-05 | Gtx Inc. | Treating androgen deficiency in female (ADIF)-associated conditions with sarms |
| WO2005060647A2 (en) | 2003-12-16 | 2005-07-07 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
| US20070082017A1 (en) * | 2004-01-10 | 2007-04-12 | Tseng Scheffer C | Lipid compositions and methods of use |
| PL1753417T3 (pl) | 2004-06-07 | 2012-09-28 | Univ Tennessee Res Found | Selektywny modulator receptora androgenowego i jego zastosowania medyczne |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| US20130034562A1 (en) * | 2004-06-07 | 2013-02-07 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| JP2009506119A (ja) * | 2005-08-31 | 2009-02-12 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 選択的アンドロゲン受容体モジュレーターを用いる腎疾患、熱傷、創傷および脊髄損傷の処置 |
| JP4899625B2 (ja) * | 2006-05-12 | 2012-03-21 | スズキ株式会社 | 鞍乗型不整地走行車両 |
| MX2009000385A (es) | 2006-07-12 | 2009-04-06 | Univ Tennessee Res Foundation | Acil-anilidas sustituidas y metodos de uso de las mismas. |
| BRPI0713198A2 (pt) * | 2006-07-19 | 2012-10-16 | Osurf Ohio State University Res Foundation | modulares seletivos de receptores de androgênio, seus análogos e derivados, e seus usos |
| ES2581765T3 (es) * | 2006-08-24 | 2016-09-07 | University Of Tennessee Research Foundation | Acilanilidas sustituidas y métodos de uso de las mismas |
| BRPI0808410A2 (pt) * | 2007-02-28 | 2015-06-23 | Aciex Therapeutics Inc | Métodos e composições para normalizar secreções da glândula meibomiana |
| US7968603B2 (en) * | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| CN103553966B (zh) * | 2007-09-11 | 2016-09-07 | Gtx公司 | 选择性雄激素受体调节剂的固体形态 |
| HUE024146T2 (en) * | 2008-05-07 | 2016-02-29 | Univ California | Medical filling and enrichment of eye surface lubrication |
-
2011
- 2011-01-11 US US13/004,764 patent/US8791158B2/en active Active
- 2011-01-11 AU AU2011203832A patent/AU2011203832A1/en not_active Abandoned
- 2011-01-11 EP EP11732323.8A patent/EP2523556A4/en not_active Withdrawn
- 2011-01-11 KR KR1020127020961A patent/KR20120115380A/ko not_active Withdrawn
- 2011-01-11 RU RU2012134351/15A patent/RU2012134351A/ru not_active Application Discontinuation
- 2011-01-11 WO PCT/US2011/020871 patent/WO2011085385A1/en not_active Ceased
- 2011-01-11 MX MX2012008110A patent/MX2012008110A/es not_active Application Discontinuation
- 2011-01-11 CA CA2787114A patent/CA2787114A1/en not_active Abandoned
- 2011-01-11 CN CN2011800134439A patent/CN103002737A/zh active Pending
- 2011-01-11 JP JP2012549006A patent/JP2013516501A/ja active Pending
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