JP2013516479A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013516479A5 JP2013516479A5 JP2012548125A JP2012548125A JP2013516479A5 JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5 JP 2012548125 A JP2012548125 A JP 2012548125A JP 2012548125 A JP2012548125 A JP 2012548125A JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5
- Authority
- JP
- Japan
- Prior art keywords
- unsaturated bond
- contain
- branched
- lower alkyl
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29277610P | 2010-01-06 | 2010-01-06 | |
| US61/292,776 | 2010-01-06 | ||
| PCT/US2011/020414 WO2011085126A2 (en) | 2010-01-06 | 2011-01-06 | Methods and compositions of targeted drug development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013516479A JP2013516479A (ja) | 2013-05-13 |
| JP2013516479A5 true JP2013516479A5 (cg-RX-API-DMAC10.html) | 2014-11-06 |
Family
ID=44306150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548125A Pending JP2013516479A (ja) | 2010-01-06 | 2011-01-06 | 標的薬物を開発する方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8618302B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2521551A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2013516479A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20130027080A (cg-RX-API-DMAC10.html) |
| CN (1) | CN102811723A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2011204368B2 (cg-RX-API-DMAC10.html) |
| CA (2) | CA2786289A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX2012007872A (cg-RX-API-DMAC10.html) |
| SG (1) | SG182343A1 (cg-RX-API-DMAC10.html) |
| WO (2) | WO2011085126A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8658170B2 (en) | 2010-01-06 | 2014-02-25 | Joseph P. Errico | Combination therapy with MDM2 and EFGR inhibitors |
| KR20130027080A (ko) * | 2010-01-06 | 2013-03-14 | 에리코, 조셉, 피. | 표적화된 약물 개발 방법 및 조성물 |
| WO2011106226A2 (en) * | 2010-02-23 | 2011-09-01 | Cornell University | Prolylhydroxylase inhibitors and methods of use |
| HUP1000243A2 (en) * | 2010-05-06 | 2012-01-30 | Avidin Kft | 8-hidroxy-quinoline derivatives |
| WO2011146618A1 (en) * | 2010-05-18 | 2011-11-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of human 12-lipoxygenase |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| WO2012012653A1 (en) * | 2010-07-21 | 2012-01-26 | Errico Joseph P | Combination therapy with mdm2 and efgr inhibitors |
| EP2716292B1 (en) | 2011-05-23 | 2017-09-06 | ONCO Biomedical Technology (Suzhou) Co., Ltd | Cdc42 inhibitor and uses thereof |
| EP2723718A1 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| AP2013007331A0 (en) | 2011-06-24 | 2013-12-31 | Amgen Inc | TRPM8 antagonists and their use in treatments |
| CN102503945A (zh) * | 2011-11-28 | 2012-06-20 | 华东理工大学 | 能够抑制表皮生长因子受体的化合物及其应用 |
| US11373734B2 (en) * | 2012-05-18 | 2022-06-28 | Georgetown University | Methods and systems for populating and searching a drug informatics database |
| EP2863920B1 (en) * | 2012-06-20 | 2023-03-22 | Eutropics Pharmaceuticals, Inc. | Quinoline derivatives for use in the tratment of breast cancer |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| EP2922544B1 (en) * | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| AU2014267360B2 (en) | 2013-05-14 | 2018-07-05 | Active Biotech Ab | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors |
| US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| US20160253451A1 (en) * | 2013-10-07 | 2016-09-01 | Korea University | Method of using a water-based pharmacophore |
| AU2014342269B2 (en) | 2013-10-30 | 2020-02-27 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
| CN104016908B (zh) * | 2014-04-03 | 2016-04-20 | 定陶县友帮化工有限公司 | 一种2-氨基-3,5-二氯吡啶的合成方法 |
| CN104402831B (zh) * | 2014-10-24 | 2016-08-17 | 郑州大学 | 含酰脲结构单元的-5-氰基嘧啶衍生物及其制备方法和用途 |
| CN104744439A (zh) * | 2015-02-10 | 2015-07-01 | 南开大学 | 8-羟基喹啉类ntr1小分子拮抗剂及应用 |
| HUP1500098A2 (hu) * | 2015-03-09 | 2016-09-28 | Avidin Kft | 8-hidroxikinolin származékok új enantiomerjei és szintézisük |
| US10624881B2 (en) * | 2015-10-12 | 2020-04-21 | Health Research, Inc. | Methods for inducing apoptosis in cancer cells |
| EP3388419A1 (en) * | 2017-04-12 | 2018-10-17 | Leadiant Biosciences SA | Gli1 inhibitors and uses thereof |
| WO2019043635A1 (en) | 2017-09-01 | 2019-03-07 | Richter Gedeon Nyrt. | COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE |
| US12213978B2 (en) * | 2018-11-15 | 2025-02-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Madrasin-derivative compounds, composition and uses thereof for treating cancer |
| TW202218665A (zh) | 2020-09-21 | 2022-05-16 | 德國阿爾伯特路德維希弗萊堡大學 | 用於治療或預防造血細胞移植後血液科贅瘤(neoplasm)復發之mdm2抑制劑 |
| CN112250637A (zh) * | 2020-10-30 | 2021-01-22 | 中山大学 | 虚拟筛选的化合物在制备抗肿瘤药物中的应用及其药物 |
| CN114195691B (zh) * | 2021-12-16 | 2023-10-20 | 贵州大学 | 一种含酰胺的阿魏酸衍生物及其制备方法和应用 |
| WO2024073624A2 (en) * | 2022-09-28 | 2024-04-04 | The Research Foundation For The State University Of New York | Antiproliferative betti bases and prodrugs thereof |
| CN115572266B (zh) * | 2022-10-24 | 2023-10-03 | 南方医科大学 | 一种蛋白抑制剂、一种试剂组及其应用 |
| CN120463779B (zh) * | 2025-07-10 | 2025-09-19 | 南京农业大学三亚研究院 | 真菌效应子药靶Nep1及基于该药靶的高通量药物分子筛选和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641474A (en) | 1970-05-11 | 1972-02-08 | Rca Corp | Semiconductor mounting structure |
| ES2273688T3 (es) | 1999-04-14 | 2007-05-16 | Dana-Farber Cancer Institute, Inc. | Procedimiento y composicion para el tratamiento de cancer. |
| US6465448B1 (en) | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
| US6931325B2 (en) | 2001-02-07 | 2005-08-16 | Regents Of The University Of Michigan | Three dimensional protein mapping |
| US7514240B2 (en) | 2002-02-05 | 2009-04-07 | Japan Science And Technology Agency | EGR-EGFR complex |
| US6916455B2 (en) | 2002-08-14 | 2005-07-12 | The Regents Of The University Of California | Protein crystallography prescreen kit |
| CA2588273A1 (en) | 2004-11-19 | 2006-05-26 | Bioquanta Corp. | Pf4 pharmacophores and their uses |
| MY153898A (en) | 2005-06-22 | 2015-04-15 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| US7754724B2 (en) * | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
| RU2452492C2 (ru) | 2006-04-05 | 2012-06-10 | Новартис Аг | КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ Bcr-Abl/c-Kit/PDGF-R TK, ДЛЯ ЛЕЧЕНИЯ РАКА |
| WO2007139946A2 (en) | 2006-05-25 | 2007-12-06 | University Of Tennessee Research Foundation | Gpcr ligands identified by computational modeling |
| EP2079699A1 (en) | 2006-07-25 | 2009-07-22 | Envivo Pharmaceuticals, Inc. | Quinoline derivatives |
| US7947712B2 (en) * | 2006-08-23 | 2011-05-24 | Wyeth Llc | 8-hydroxyquinoline compounds and methods thereof |
| US8609649B2 (en) * | 2007-03-20 | 2013-12-17 | Brandeis University | Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases |
| US8183236B2 (en) * | 2007-04-12 | 2012-05-22 | University Of Southern California | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics |
| US8138356B2 (en) * | 2007-10-16 | 2012-03-20 | Angiogeney, Inc. | Chemical inhibitors of inhibitors of differentiation |
| US8119656B2 (en) * | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009117484A2 (en) * | 2008-03-18 | 2009-09-24 | University Of South Florida | Small molecule e2f inhibitor |
| WO2009137597A1 (en) * | 2008-05-06 | 2009-11-12 | The Trustees Of Columbia University In The City Of New York | COMPOUNDS THAT INHIBIT PRODUCTION OF sAPPβ AND Aβ AND USES THEREOF |
| EP2300005A4 (en) * | 2008-05-28 | 2011-07-13 | Us Of America As Represented By The Secretary Of The Army On Behalf Of U S Army Medical Res And Mate | Small-molecule inhibitors of botulinum neurotoxins |
| US8563580B2 (en) * | 2008-09-23 | 2013-10-22 | Georgetown University | Flavivirus inhibitors and methods for their use |
| CN102574805A (zh) | 2009-08-20 | 2012-07-11 | 维福(国际)股份公司 | 新型喹啉铁调素拮抗剂 |
| KR20130027080A (ko) * | 2010-01-06 | 2013-03-14 | 에리코, 조셉, 피. | 표적화된 약물 개발 방법 및 조성물 |
-
2011
- 2011-01-06 KR KR1020127020466A patent/KR20130027080A/ko not_active Withdrawn
- 2011-01-06 CA CA2786289A patent/CA2786289A1/en not_active Abandoned
- 2011-01-06 US US12/986,146 patent/US8618302B2/en not_active Expired - Fee Related
- 2011-01-06 CN CN2011800126057A patent/CN102811723A/zh active Pending
- 2011-01-06 MX MX2012007872A patent/MX2012007872A/es active IP Right Grant
- 2011-01-06 SG SG2012049292A patent/SG182343A1/en unknown
- 2011-01-06 AU AU2011204368A patent/AU2011204368B2/en not_active Ceased
- 2011-01-06 WO PCT/US2011/020414 patent/WO2011085126A2/en not_active Ceased
- 2011-01-06 CA CA2786277A patent/CA2786277A1/en not_active Abandoned
- 2011-01-06 WO PCT/US2011/020418 patent/WO2011085129A2/en not_active Ceased
- 2011-01-06 EP EP20110732163 patent/EP2521551A4/en not_active Withdrawn
- 2011-01-06 EP EP11732160.4A patent/EP2521553A4/en not_active Withdrawn
- 2011-01-06 JP JP2012548125A patent/JP2013516479A/ja active Pending
-
2013
- 2013-12-04 US US14/096,661 patent/US20140163069A1/en not_active Abandoned
- 2013-12-04 US US14/096,618 patent/US9073858B2/en not_active Expired - Fee Related
-
2014
- 2014-01-08 US US14/150,655 patent/US20140179681A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013339167B2 (en) | Novel amine derivative or salt thereof | |
| DK2185515T3 (en) | DERIVATIVES OF 1-PHENYL-2-PYRIDINYLALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | |
| EP3889134B1 (en) | Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof | |
| AU738037B2 (en) | Nicotinamide derivatives | |
| JP4462930B2 (ja) | ピリミジン化合物及びその医薬組成物 | |
| JP5461189B2 (ja) | キナーゼ活性の阻害剤 | |
| JP4831907B2 (ja) | FabI阻害剤 | |
| EP3186245B1 (en) | Mapk inhibitors | |
| JP5947307B2 (ja) | Kcnq2/3調節因子としての置換6−アミノ−ニコチンアミド | |
| CN107709301B (zh) | 吡唑衍生物或其药理学上可接受的盐 | |
| US7932272B2 (en) | Antifungal agent containing heterocyclic compound | |
| JP2009023986A (ja) | 抗癌剤としてのビアリール誘導体 | |
| JP2022519237A (ja) | Dnaポリメラーゼシータ阻害剤としてのアセトアミド誘導体 | |
| WO2014096965A2 (en) | Novel heterocyclic compounds as bromodomain inhibitors | |
| ZA200504973B (en) | Fuse 1,3-dihydro-imidazole ring compounds | |
| TW200920366A (en) | 5-membered heterocyclic compound | |
| TW200841879A (en) | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same | |
| JP2024056742A (ja) | キノリン誘導体から調製される新規な阻害剤 | |
| WO2011035186A1 (en) | Substituted heteroarylamide analogs as mglur5 negative allosteric modulators and methods of making and using the same | |
| US6180650B1 (en) | Heterosubstituted pyridine derivatives as PDE 4 inhibitors | |
| BRPI0617880B1 (pt) | Composto derivado de piridina substituído por heterociclo, composição farmacêutica,medicamento e agente antifúngico que compreende o dito composto e uso do mesmo para prevenire/ou tratar infecção fúngica | |
| JPWO2006016548A1 (ja) | ヘテロ環化合物を含有する新規な抗マラリア剤 | |
| CN103814024B (zh) | 作为溶血磷脂酸(lpa)受体拮抗剂的苄基哌啶化合物 | |
| CA2800521A1 (en) | Fused imidazole derivative | |
| JP2014526526A5 (cg-RX-API-DMAC10.html) |