JP2013516479A - 標的薬物を開発する方法および組成物 - Google Patents

標的薬物を開発する方法および組成物 Download PDF

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JP2013516479A
JP2013516479A JP2012548125A JP2012548125A JP2013516479A JP 2013516479 A JP2013516479 A JP 2013516479A JP 2012548125 A JP2012548125 A JP 2012548125A JP 2012548125 A JP2012548125 A JP 2012548125A JP 2013516479 A JP2013516479 A JP 2013516479A
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unsaturated bond
contain
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lower alkyl
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JP2013516479A5 (cg-RX-API-DMAC10.html
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ジョゼフ・ピー・エリコ
ベンジャミン・マグレージ
イグナティウス・ターチ
マシュー・シルス
ジェーン・オング
ジョン・アロッコ
パム・ワインズ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Evolutionary Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2012548125A 2010-01-06 2011-01-06 標的薬物を開発する方法および組成物 Pending JP2013516479A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29277610P 2010-01-06 2010-01-06
US61/292,776 2010-01-06
PCT/US2011/020414 WO2011085126A2 (en) 2010-01-06 2011-01-06 Methods and compositions of targeted drug development

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JP2013516479A true JP2013516479A (ja) 2013-05-13
JP2013516479A5 JP2013516479A5 (cg-RX-API-DMAC10.html) 2014-11-06

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US (4) US8618302B2 (cg-RX-API-DMAC10.html)
EP (2) EP2521551A4 (cg-RX-API-DMAC10.html)
JP (1) JP2013516479A (cg-RX-API-DMAC10.html)
KR (1) KR20130027080A (cg-RX-API-DMAC10.html)
CN (1) CN102811723A (cg-RX-API-DMAC10.html)
AU (1) AU2011204368B2 (cg-RX-API-DMAC10.html)
CA (2) CA2786289A1 (cg-RX-API-DMAC10.html)
MX (1) MX2012007872A (cg-RX-API-DMAC10.html)
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658170B2 (en) 2010-01-06 2014-02-25 Joseph P. Errico Combination therapy with MDM2 and EFGR inhibitors
KR20130027080A (ko) * 2010-01-06 2013-03-14 에리코, 조셉, 피. 표적화된 약물 개발 방법 및 조성물
WO2011106226A2 (en) * 2010-02-23 2011-09-01 Cornell University Prolylhydroxylase inhibitors and methods of use
HUP1000243A2 (en) * 2010-05-06 2012-01-30 Avidin Kft 8-hidroxy-quinoline derivatives
WO2011146618A1 (en) * 2010-05-18 2011-11-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of human 12-lipoxygenase
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
WO2012012653A1 (en) * 2010-07-21 2012-01-26 Errico Joseph P Combination therapy with mdm2 and efgr inhibitors
EP2716292B1 (en) 2011-05-23 2017-09-06 ONCO Biomedical Technology (Suzhou) Co., Ltd Cdc42 inhibitor and uses thereof
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
CN102503945A (zh) * 2011-11-28 2012-06-20 华东理工大学 能够抑制表皮生长因子受体的化合物及其应用
US11373734B2 (en) * 2012-05-18 2022-06-28 Georgetown University Methods and systems for populating and searching a drug informatics database
EP2863920B1 (en) * 2012-06-20 2023-03-22 Eutropics Pharmaceuticals, Inc. Quinoline derivatives for use in the tratment of breast cancer
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EP2922544B1 (en) * 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
AU2014267360B2 (en) 2013-05-14 2018-07-05 Active Biotech Ab N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
US20160253451A1 (en) * 2013-10-07 2016-09-01 Korea University Method of using a water-based pharmacophore
AU2014342269B2 (en) 2013-10-30 2020-02-27 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
CN104016908B (zh) * 2014-04-03 2016-04-20 定陶县友帮化工有限公司 一种2-氨基-3，5-二氯吡啶的合成方法
CN104402831B (zh) * 2014-10-24 2016-08-17 郑州大学 含酰脲结构单元的-5-氰基嘧啶衍生物及其制备方法和用途
CN104744439A (zh) * 2015-02-10 2015-07-01 南开大学 8-羟基喹啉类ntr1小分子拮抗剂及应用
HUP1500098A2 (hu) * 2015-03-09 2016-09-28 Avidin Kft 8-hidroxikinolin származékok új enantiomerjei és szintézisük
US10624881B2 (en) * 2015-10-12 2020-04-21 Health Research, Inc. Methods for inducing apoptosis in cancer cells
EP3388419A1 (en) * 2017-04-12 2018-10-17 Leadiant Biosciences SA Gli1 inhibitors and uses thereof
WO2019043635A1 (en) 2017-09-01 2019-03-07 Richter Gedeon Nyrt. COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE
US12213978B2 (en) * 2018-11-15 2025-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Madrasin-derivative compounds, composition and uses thereof for treating cancer
TW202218665A (zh) 2020-09-21 2022-05-16 德國阿爾伯特路德維希弗萊堡大學 用於治療或預防造血細胞移植後血液科贅瘤(neoplasm)復發之mdm2抑制劑
CN112250637A (zh) * 2020-10-30 2021-01-22 中山大学 虚拟筛选的化合物在制备抗肿瘤药物中的应用及其药物
CN114195691B (zh) * 2021-12-16 2023-10-20 贵州大学 一种含酰胺的阿魏酸衍生物及其制备方法和应用
WO2024073624A2 (en) * 2022-09-28 2024-04-04 The Research Foundation For The State University Of New York Antiproliferative betti bases and prodrugs thereof
CN115572266B (zh) * 2022-10-24 2023-10-03 南方医科大学 一种蛋白抑制剂、一种试剂组及其应用
CN120463779B (zh) * 2025-07-10 2025-09-19 南京农业大学三亚研究院 真菌效应子药靶Nep1及基于该药靶的高通量药物分子筛选和应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008116092A1 (en) * 2007-03-20 2008-09-25 Brandeis University Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases
US20080269213A1 (en) * 2006-08-23 2008-10-30 Wyeth 8-Hydroxyquinoline compounds and methods thereof
WO2009051801A2 (en) * 2007-10-16 2009-04-23 Angiogenex Chemical inhibitors of inhibitors of differentiation
WO2009117484A2 (en) * 2008-03-18 2009-09-24 University Of South Florida Small molecule e2f inhibitor
WO2009137597A1 (en) * 2008-05-06 2009-11-12 The Trustees Of Columbia University In The City Of New York COMPOUNDS THAT INHIBIT PRODUCTION OF sAPPβ AND Aβ AND USES THEREOF
WO2009151972A1 (en) * 2008-05-28 2009-12-17 , The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Materiel Command Small molecule inhibitors of botulinum neurotoxins
JP2009544631A (ja) * 2006-07-25 2009-12-17 エンビボ ファーマシューティカルズ インコーポレイテッド キノリン誘導体
WO2011020886A1 (de) * 2009-08-20 2011-02-24 Vifor (International) Ag Neue chinolin-hepcidin-antagonisten

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641474A (en) 1970-05-11 1972-02-08 Rca Corp Semiconductor mounting structure
ES2273688T3 (es) 1999-04-14 2007-05-16 Dana-Farber Cancer Institute, Inc. Procedimiento y composicion para el tratamiento de cancer.
US6465448B1 (en) 1999-08-13 2002-10-15 Case Western Reserve University Methoxyamine potentiation of temozolomide anti-cancer activity
US6931325B2 (en) 2001-02-07 2005-08-16 Regents Of The University Of Michigan Three dimensional protein mapping
US7514240B2 (en) 2002-02-05 2009-04-07 Japan Science And Technology Agency EGR-EGFR complex
US6916455B2 (en) 2002-08-14 2005-07-12 The Regents Of The University Of California Protein crystallography prescreen kit
CA2588273A1 (en) 2004-11-19 2006-05-26 Bioquanta Corp. Pf4 pharmacophores and their uses
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
US7754724B2 (en) * 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
RU2452492C2 (ru) 2006-04-05 2012-06-10 Новартис Аг КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ ИНГИБИТОРЫ Bcr-Abl/c-Kit/PDGF-R TK, ДЛЯ ЛЕЧЕНИЯ РАКА
WO2007139946A2 (en) 2006-05-25 2007-12-06 University Of Tennessee Research Foundation Gpcr ligands identified by computational modeling
US8183236B2 (en) * 2007-04-12 2012-05-22 University Of Southern California Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics
US8119656B2 (en) * 2007-12-07 2012-02-21 The Board Of Regents Of The University Of Texas System Inhibitors of the influenza virus non-structural 1 protein
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US8563580B2 (en) * 2008-09-23 2013-10-22 Georgetown University Flavivirus inhibitors and methods for their use
KR20130027080A (ko) * 2010-01-06 2013-03-14 에리코, 조셉, 피. 표적화된 약물 개발 방법 및 조성물

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544631A (ja) * 2006-07-25 2009-12-17 エンビボ ファーマシューティカルズ インコーポレイテッド キノリン誘導体
US20080269213A1 (en) * 2006-08-23 2008-10-30 Wyeth 8-Hydroxyquinoline compounds and methods thereof
WO2008116092A1 (en) * 2007-03-20 2008-09-25 Brandeis University Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases
WO2009051801A2 (en) * 2007-10-16 2009-04-23 Angiogenex Chemical inhibitors of inhibitors of differentiation
WO2009117484A2 (en) * 2008-03-18 2009-09-24 University Of South Florida Small molecule e2f inhibitor
WO2009137597A1 (en) * 2008-05-06 2009-11-12 The Trustees Of Columbia University In The City Of New York COMPOUNDS THAT INHIBIT PRODUCTION OF sAPPβ AND Aβ AND USES THEREOF
WO2009151972A1 (en) * 2008-05-28 2009-12-17 , The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Materiel Command Small molecule inhibitors of botulinum neurotoxins
WO2011020886A1 (de) * 2009-08-20 2011-02-24 Vifor (International) Ag Neue chinolin-hepcidin-antagonisten

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN5012015632; ＲＯＸＡＳ-ＤＵＮＣＡＮ，　ＶＩＲＧＩＮＩＡ: 'ＩＤＥＮＴＩＦＩＣＡＴＩＯＮ　ＡＮＤ　ＢＩＯＣＨＥＭＩＣＡＬ　ＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮ　ＯＦ　ＳＭＡＬＬ-ＭＯＬＥＣＵＬＥ　ＩＮＨＩＢＩＴＯＲＳ　以下備考' ＡＮＴＩＭＩＣＲＯＢＩＡＬ　ＡＧＥＮＴＳ　ＡＮＤ　ＣＨＥＭＯＴＨＥＲＡＰＹ Ｖ５３　Ｎ８, 20090615, Ｐ３４７８-３４８６ *
JPN5013002563; ＴＯＭＬＩＮＳＯＮ: 'Ａ　ＣＨＥＭＩＣＡＬ　ＧＥＮＯＭＩＣ　ＡＰＰＲＯＡＣＨ　ＩＤＥＮＴＩＦＩＥＳ　ＭＡＴＲＩＸ　ＭＥＴＡＬＬＯＰＲＯＴＥＩＮＡＳＥＳ　ＡＳ　ＰＬＡＹＩＮＧ　ＡＮ　ＥＳＳＥＮＴＩＡＬ　以下備考' ＣＨＥＭＩＳＴＲＹ　＆　ＢＩＯＬＯＧＹ Ｖ１６, 20090130, Ｐ９３-１０４ *
JPN6014052603; Ｇａｌａｍ，　Ｌａｋｓｈｍｉ　ｅｔ　ａｌ．: 'Ｈｉｇｈ-ｔｈｒｏｕｇｈｐｕｔ　ａｓｓａｙ　ｆｏｒ　ｔｈｅ　ｉｄｅｎｔｉｆｉｃａｔｉｏｎ　ｏｆ　Ｈｓｐ９０　ｉｎｈｉｂｉｔｏｒｓ　ｂａｓｅｄ　ｏｎ　Ｈｓｐ９０-ｄｅｐｅｎｄｅｎｔ　ｒｅｆｏｌｄｉｎｇ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ １５（５）, 2007, ｐ．　１９３９-１９４６ *
JPN6014052604; Ｍｏｙ，　Ｔｅｒｅｎｃｅ　Ｉ．　ｅｔ　ａｌ．: 'Ｈｉｇｈ-Ｔｈｒｏｕｇｈｐｕｔ　Ｓｃｒｅｅｎ　ｆｏｒ　Ｎｏｖｅｌ　Ａｎｔｉｍｉｃｒｏｂｉａｌｓ　ｕｓｉｎｇ　ａ　Ｗｈｏｌｅ　Ａｎｉｍａｌ　Ｉｎｆｅｃｔｉｏｎ　Ｍｏｄｅｌ' ＡＣＳ　Ｃｈｅｍｉｃａｌ　Ｂｉｏｌｏｇｙ ４（７）, 2009, ｐ．　５２７-５３３及びＳｕｐｐｏｒｔｉｎｇ　Ｉｎｆｏｍａｔｉｏｎ *
JPN6014052605; Ｃｏｕｒｎｉａ，　Ｚｏｅ　ｅｔ　ａｌ．: 'Ｄｉｓｃｏｖｅｒｙ　ｏｆ　Ｈｕｍａｎ　Ｍａｃｒｏｐｈａｇｅ　Ｍｉｇｒａｔｉｏｎ　Ｉｎｈｉｂｉｔｏｒｙ　Ｆａｃｔｏｒ　（ＭＩＦ）-ＣＤ７４　Ａｎｔａｇｏｎｉｓｔｓ　ｖｉａ　Ｖｉｒｔｕａｌ　Ｓｃｒｅｅｎｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ ５２（２）, 2009, ｐ．　４１６-４２４ *
JPN7014003556; Ｓｅｒｇｉｅｖ，　Ｉ．　ｅｔ　ａｌ．: 'Ｐｌａｎｔ　ｇｒｏｗｔｈ　ｒｅｇｕｌａｔｉｎｇ　ａｃｔｉｖｉｔｙ　ｏｆ　ｓｏｍｅ　ｎｏｖｅｌ　Ｎ-（６-ｍｅｔｈｙｌｐｙｒｉｄ-２-ｙｌ）-alpha-（８-ｈｙｄｒｏｘｙ-ｑｕｉｎｏｌｉｎ-７-ｙｌ）-ｓ' Ｄｏｋｌａｄｉ　ｎａ　Ｂｕｌｇａｒｓｋａｔａ　Ａｋａｄｅｍｉｙａ　ｎａ　Ｎａｕｋｉｔｅ ５１（５-６）, 1998, ｐ．　６７-７０ *

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