JP2013515737A - 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法 - Google Patents

精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法 Download PDF

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JP2013515737A
JP2013515737A JP2012546161A JP2012546161A JP2013515737A JP 2013515737 A JP2013515737 A JP 2013515737A JP 2012546161 A JP2012546161 A JP 2012546161A JP 2012546161 A JP2012546161 A JP 2012546161A JP 2013515737 A JP2013515737 A JP 2013515737A
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pyrrolo
dihydro
trans
dione
quinolin
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JP2013515737A5 (enExample
Inventor
デイビッド ピー． リード，
ニール アール． バーンズ，
ジョン シー． ケイン，
クリストファー エー． リー，
ジャン−シェー チェン，
マーティン ピー． レッドモン，
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アークル インコーポレイテッド
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Publication of JP2013515737A publication Critical patent/JP2013515737A/ja
Publication of JP2013515737A5 publication Critical patent/JP2013515737A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012546161A 2009-12-23 2010-12-21 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法 Pending JP2013515737A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28956309P 2009-12-23 2009-12-23
US61/289,563 2009-12-23
PCT/US2010/061625 WO2011079142A2 (en) 2009-12-23 2010-12-21 Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same

Related Child Applications (1)

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JP2015198998A Division JP2016041712A (ja) 2009-12-23 2015-10-07 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法

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JP2013515737A true JP2013515737A (ja) 2013-05-09
JP2013515737A5 JP2013515737A5 (enExample) 2014-02-06

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JP2012546161A Pending JP2013515737A (ja) 2009-12-23 2010-12-21 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法
JP2015198998A Pending JP2016041712A (ja) 2009-12-23 2015-10-07 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法

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US (3) US8552192B2 (enExample)
EP (2) EP2515904A4 (enExample)
JP (2) JP2013515737A (enExample)
KR (2) KR101669707B1 (enExample)
CN (2) CN104910159A (enExample)
AU (2) AU2010336533B9 (enExample)
BR (1) BR112012015656A2 (enExample)
CA (1) CA2785503A1 (enExample)
CO (1) CO6561823A2 (enExample)
HK (1) HK1215025A1 (enExample)
MX (1) MX2012007259A (enExample)
MY (2) MY169232A (enExample)
NZ (2) NZ600800A (enExample)
PH (2) PH12012501293A1 (enExample)
RU (1) RU2556205C2 (enExample)
SG (1) SG181927A1 (enExample)
TW (3) TWI557125B (enExample)
WO (1) WO2011079142A2 (enExample)
ZA (1) ZA201204759B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2014518284A (ja) * 2011-07-07 2014-07-28 アーキュール，インコーポレイティド ピロロキノリニル−ピロリジン−２，５−ジオン製剤及びその調製方法及び使用方法
JP2016041712A (ja) * 2009-12-23 2016-03-31 アークル インコーポレイテッド 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法
JP2016527227A (ja) * 2013-07-16 2016-09-08 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドトロメタミン塩の新規な結晶形
JP2020530497A (ja) * 2017-08-11 2020-10-22 アクチュエイト セラピューティクス インク． ３−（５−フルオロベンゾフラン−３−イル）−４−（５−メチル−５Ｈ−［１，３］ジオキソロ［４，５−ｆ］インドール−７−イル）ピロール−２，５−ジオンの固体形態

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RS51826B (sr) * 2005-02-09 2012-02-29 Arqule Inc. Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera
EP2841069A4 (en) * 2012-04-23 2015-09-02 Arqule Inc HIGHLY PYRROLOCHINOLINYL-PYRROL-2,5-DION AND PYRROLOCHINOLINYL-PYRROLIDIN-2,5-DION AND METHOD FOR THE PRODUCTION THEREOF
CN110806454A (zh) * 2018-08-06 2020-02-18 江苏正大清江制药有限公司 一种盐酸吉西他滨中手性异构体的检测方法
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4319740A4 (en) * 2021-04-07 2025-03-19 Crystalys Therapeutics, Inc. URAT1 INHIBITOR, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

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JP2008530026A (ja) * 2005-02-09 2008-08-07 アーキュール，インコーポレーテッド マレイミド誘導体、医薬組成物、および癌の治療のためのその使用
JP2010530884A (ja) * 2007-06-22 2010-09-16 アークル インコーポレイテッド 癌の治療のための組成物および方法

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
US5760237A (en) * 1995-08-25 1998-06-02 California Institute Of Technology Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary
ATE315017T1 (de) * 2002-07-31 2006-02-15 Firmenich & Cie Verfahren zur racematspaltung einer sclareolid- vorstufe
EP1786772A1 (en) * 2004-09-10 2007-05-23 Wyeth a Corporation of the State of Delaware Process for the scalable synthesis of 1, 3, 4, 9-tetrahydropyranoý3, 4-b¨-indole derivatives
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CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
JP2013515737A (ja) * 2009-12-23 2013-05-09 アークル インコーポレイテッド 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法
EP2841069A4 (en) * 2012-04-23 2015-09-02 Arqule Inc HIGHLY PYRROLOCHINOLINYL-PYRROL-2,5-DION AND PYRROLOCHINOLINYL-PYRROLIDIN-2,5-DION AND METHOD FOR THE PRODUCTION THEREOF

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US20030229026A1 (en) * 1999-12-16 2003-12-11 Al-Awar Rima Salim Agents and methods for the treatment of proliferative diseases
JP2008530026A (ja) * 2005-02-09 2008-08-07 アーキュール，インコーポレーテッド マレイミド誘導体、医薬組成物、および癌の治療のためのその使用
JP2010530884A (ja) * 2007-06-22 2010-09-16 アークル インコーポレイテッド 癌の治療のための組成物および方法

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016041712A (ja) * 2009-12-23 2016-03-31 アークル インコーポレイテッド 精製されたピロロキノリニル−ピロリジン−２，５−ジオン組成物ならびにその調製方法および使用方法
JP2014518284A (ja) * 2011-07-07 2014-07-28 アーキュール，インコーポレイティド ピロロキノリニル−ピロリジン−２，５−ジオン製剤及びその調製方法及び使用方法
JP2016527227A (ja) * 2013-07-16 2016-09-08 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドトロメタミン塩の新規な結晶形
JP2020530497A (ja) * 2017-08-11 2020-10-22 アクチュエイト セラピューティクス インク． ３−（５−フルオロベンゾフラン−３−イル）−４−（５−メチル−５Ｈ−［１，３］ジオキソロ［４，５−ｆ］インドール−７−イル）ピロール−２，５−ジオンの固体形態
JP2023156372A (ja) * 2017-08-11 2023-10-24 アクチュエイト セラピューティクス インク． ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態
JP7424639B2 (ja) 2017-08-11 2024-01-30 アクチュエイト セラピューティクス インク． ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態
US12145943B2 (en) 2017-08-11 2024-11-19 Actuate Therapeutics Inc. Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
JP7778750B2 (ja) 2017-08-11 2025-12-02 アクチュエイト セラピューティクス インク． ３－（５－フルオロベンゾフラン－３－イル）－４－（５－メチル－５Ｈ－［１，３］ジオキソロ［４，５－ｆ］インドール－７－イル）ピロール－２，５－ジオンの固体形態

Also Published As

Publication number Publication date
PH12012501293A1 (en) 2013-01-07
AU2015243015B2 (en) 2017-02-02
KR20160121602A (ko) 2016-10-19
AU2010336533B9 (en) 2015-10-08
CN104910159A (zh) 2015-09-16
RU2556205C2 (ru) 2015-07-10
KR101669707B1 (ko) 2016-10-27
NZ628087A (en) 2016-02-26
KR20120113760A (ko) 2012-10-15
AU2010336533A1 (en) 2012-07-12
WO2011079142A3 (en) 2011-11-24
WO2011079142A2 (en) 2011-06-30
NZ600800A (en) 2014-10-31
US8871933B2 (en) 2014-10-28
EP2515904A4 (en) 2013-07-03
CA2785503A1 (en) 2011-06-30
RU2012131344A (ru) 2014-01-27
CN102834097B (zh) 2015-06-17
US20160024076A1 (en) 2016-01-28
AU2015243015A1 (en) 2015-11-05
ZA201204759B (en) 2014-03-26
US20110160242A1 (en) 2011-06-30
TW201141865A (en) 2011-12-01
US20140031551A1 (en) 2014-01-30
TWI557125B (zh) 2016-11-11
CO6561823A2 (es) 2012-11-15
MY169232A (en) 2019-03-19
TW201542546A (zh) 2015-11-16
CN102834097A (zh) 2012-12-19
PH12014500310A1 (en) 2015-09-28
HK1215025A1 (zh) 2016-08-12
US8552192B2 (en) 2013-10-08
EP2515904A2 (en) 2012-10-31
AU2010336533B2 (en) 2015-09-10
EP3081567A3 (en) 2016-11-16
SG181927A1 (en) 2012-07-30
US9499540B2 (en) 2016-11-22
MY156701A (en) 2016-03-15
EP3081567A2 (en) 2016-10-19
TW201643163A (zh) 2016-12-16
MX2012007259A (es) 2015-05-15
TWI506026B (zh) 2015-11-01
BR112012015656A2 (pt) 2016-05-10
JP2016041712A (ja) 2016-03-31

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