JP2013515270A5 - - Google Patents
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- JP2013515270A5 JP2013515270A5 JP2012546198A JP2012546198A JP2013515270A5 JP 2013515270 A5 JP2013515270 A5 JP 2013515270A5 JP 2012546198 A JP2012546198 A JP 2012546198A JP 2012546198 A JP2012546198 A JP 2012546198A JP 2013515270 A5 JP2013515270 A5 JP 2013515270A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- acid
- cancer
- cancerous
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 239000002207 metabolite Substances 0.000 claims 10
- 210000002700 urine Anatomy 0.000 claims 5
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 4
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 4
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims 2
- 239000005639 Lauric acid Substances 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 239000005700 Putrescine Substances 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229940063673 spermidine Drugs 0.000 claims 2
- 229940063675 spermine Drugs 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28920609P | 2009-12-22 | 2009-12-22 | |
| US61/289,206 | 2009-12-22 | ||
| PCT/US2010/061811 WO2011087845A2 (en) | 2009-12-22 | 2010-12-22 | Metabolomic profiling of prostate cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013515270A JP2013515270A (ja) | 2013-05-02 |
| JP2013515270A5 true JP2013515270A5 (enExample) | 2014-01-23 |
Family
ID=44151645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546198A Pending JP2013515270A (ja) | 2009-12-22 | 2010-12-22 | 前立腺癌の代謝学的プロファイリング |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110151497A1 (enExample) |
| EP (1) | EP2517022A4 (enExample) |
| JP (1) | JP2013515270A (enExample) |
| CN (1) | CN102893157A (enExample) |
| WO (1) | WO2011087845A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3812009A1 (en) * | 2012-02-23 | 2021-04-28 | Keio University | Combined anticancer drug sensitivity-determining marker |
| KR101462206B1 (ko) * | 2013-06-26 | 2014-11-20 | 한국과학기술연구원 | 트립토판 대사 변화를 이용한 위암 진단용 기초 정보 제공 방법 |
| JP6222629B2 (ja) * | 2013-08-29 | 2017-11-01 | 花王株式会社 | 排尿障害のバイオマーカー |
| KR101955430B1 (ko) * | 2013-10-11 | 2019-03-11 | 주식회사 씨스퀘어 | 사르코신 대사산물 중 과산화물을 이용한 전립선암 진단 시험지, 그 제조 방법 및 이를 이용한 전립선암 진단에 필요한 정보를 제공하는 방법 |
| BR112017004773B1 (pt) * | 2014-09-10 | 2024-02-27 | Fundação Pio Xii Hospital De Câncer De Barretos Cnpj/Mf | Biomarcadores para avaliação do câncer de mama |
| CN115236166A (zh) * | 2016-05-29 | 2022-10-25 | 深圳市绘云生物科技有限公司 | 肝病相关生物标志物和其使用方法 |
| WO2017213246A1 (ja) * | 2016-06-10 | 2017-12-14 | 株式会社日立製作所 | 尿中代謝物による疾病診断法 |
| JP6280997B1 (ja) * | 2016-10-31 | 2018-02-14 | 株式会社Preferred Networks | 疾患の罹患判定装置、疾患の罹患判定方法、疾患の特徴抽出装置及び疾患の特徴抽出方法 |
| CN106770873B (zh) * | 2017-01-19 | 2019-02-19 | 中国人民解放军第四军医大学 | 一种膀胱癌诊断标志物及其应用和诊断试剂盒 |
| CN108344830B (zh) * | 2017-01-22 | 2020-10-16 | 中国科学院大连化学物理研究所 | 用于诊断前列腺癌的尿样组合标志物及检测试剂盒 |
| KR102077058B1 (ko) * | 2017-09-21 | 2020-02-13 | 연세대학교 산학협력단 | 대사체 프로파일링을 이용한 유방암의 예후 또는 위험도를 평가하는 방법 및 키트 |
| CN108414661B (zh) * | 2018-03-13 | 2020-04-21 | 中国医科大学 | 一种检测生物样品中氨含量的衍生化气相色谱-质谱方法 |
| EP3803390B1 (en) * | 2018-06-01 | 2024-05-01 | Lewis, Ian Andrew | Method for detecting urinary tract infections and sample analysis |
| IT201800007264A1 (it) * | 2018-07-17 | 2020-01-17 | Metodo per la diagnosi in vitro di carcinoma della prostata mediante biomarcatori urinari | |
| KR102405789B1 (ko) * | 2018-08-24 | 2022-06-07 | 고려대학교 세종산학협력단 | 키누레닌 경로 대사체를 포함하는 전립선암 진단용 바이오마커 조성물 |
| EP3629021A1 (en) * | 2018-09-26 | 2020-04-01 | Euroimmun Medizinische Labordiagnostika AG | Diagnosis of a neuroautoimmune disease |
| KR20210030883A (ko) * | 2019-09-10 | 2021-03-18 | 고려대학교 세종산학협력단 | 인돌아민 2,3-이산소화 효소를 포함하는 전립선암 진단용 마커 |
| US20210333280A1 (en) * | 2020-04-23 | 2021-10-28 | YatHing Biotechnology Company Limited | Methods related to the diagnosis of prostate cancer |
| US20230384316A1 (en) * | 2020-10-20 | 2023-11-30 | Baylor College Of Medicine | Multiplex metabolic markers in plasma for early detection of african american prostate cancer |
| WO2022149487A1 (ja) * | 2021-01-07 | 2022-07-14 | 住友化学株式会社 | 前立腺がんの罹患の可能性を検査する方法 |
| CN114324674A (zh) * | 2022-01-21 | 2022-04-12 | 苏州南医大创新中心 | 一种精液中与无精子症有关的分子标志物及其检测方法和应用 |
| CN114487217B (zh) * | 2022-02-14 | 2024-06-25 | 广州市番禺区中心医院 | 一种区分前列腺癌和良性前列腺增生的标志物及试剂盒 |
| CN114544812B (zh) * | 2022-02-18 | 2023-06-30 | 复旦大学附属中山医院 | 一种代谢组合式标志物在诊断哮喘中的应用 |
| CN116465920B (zh) * | 2023-04-03 | 2023-11-10 | 汕头大学医学院 | 用于诊断食管癌的代谢标志物 |
| CN116106535B (zh) * | 2023-04-11 | 2023-08-11 | 南京品生医学检验实验室有限公司 | 生物标志物组合在制备乳腺癌预测产品中的应用 |
| TW202528739A (zh) * | 2023-09-05 | 2025-07-16 | 國立臺灣大學 | 用於前列腺癌的生物標記 |
| DE102023125870A1 (de) * | 2023-09-25 | 2025-03-27 | Numares Ag | Verwendung eines Markersets für die Diagnostik des Prostatakarzinoms |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020139A (en) * | 1995-04-25 | 2000-02-01 | Oridigm Corporation | S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy |
| US6866837B2 (en) * | 1998-06-05 | 2005-03-15 | Mallinckrodt Inc. | Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors |
| US7329489B2 (en) * | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| WO2001078652A2 (en) * | 2000-04-14 | 2001-10-25 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US20050181375A1 (en) * | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
| US20070078093A1 (en) * | 2003-10-16 | 2007-04-05 | The Administrators Of The Tulane Educational Fund | Methods and compositions for treating cancer |
| US20070055456A1 (en) * | 2005-08-31 | 2007-03-08 | Daniel Raftery | NMR method for differentiating complex mixtures |
| WO2007066216A2 (en) * | 2005-12-09 | 2007-06-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Fatty acids profile correlated to the propensity or risk of breast cancer |
| CN101454331A (zh) * | 2006-03-24 | 2009-06-10 | 菲诺梅诺米发现公司 | 有效用于诊断前列腺癌的生物标记，及其方法 |
| US20090075284A1 (en) * | 2006-09-19 | 2009-03-19 | The Regents Of The University Of Michigan | Metabolomic profiling of prostate cancer |
| EP2061899B1 (en) * | 2006-09-19 | 2012-08-29 | Metabolon Inc. | Biomarkers for prostate cancer and methods using the same |
| US20090047269A1 (en) * | 2007-08-16 | 2009-02-19 | The Regents Of The University Of Michigan | Metabolomic cancer targets |
-
2010
- 2010-12-22 JP JP2012546198A patent/JP2013515270A/ja active Pending
- 2010-12-22 CN CN2010800645336A patent/CN102893157A/zh active Pending
- 2010-12-22 EP EP10843575.1A patent/EP2517022A4/en not_active Withdrawn
- 2010-12-22 US US12/976,177 patent/US20110151497A1/en not_active Abandoned
- 2010-12-22 WO PCT/US2010/061811 patent/WO2011087845A2/en not_active Ceased
-
2013
- 2013-03-12 US US13/796,988 patent/US20130261022A1/en not_active Abandoned
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