JP2013515049A5 - - Google Patents

Info

Publication number

JP2013515049A5

JP2013515049A5 JP2012545493A JP2012545493A JP2013515049A5 JP 2013515049 A5 JP2013515049 A5 JP 2013515049A5 JP 2012545493 A JP2012545493 A JP 2012545493A JP 2012545493 A JP2012545493 A JP 2012545493A JP 2013515049 A5 JP2013515049 A5 JP 2013515049A5

Authority

JP

Japan

Prior art keywords

composition

klh

concentration

present

peptide

Prior art date

2010-12-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 55
• 239000000863 peptide conjugate Substances 0.000 claims 22
• 239000000872 buffer Substances 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 239000004094 surface-active agent Substances 0.000 claims 6
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 5
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 5
• 239000000562 conjugate Substances 0.000 claims 5
• 238000001542 size-exclusion chromatography Methods 0.000 claims 5
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
• 229920000053 polysorbate 80 Polymers 0.000 claims 4
• 229940068968 polysorbate 80 Drugs 0.000 claims 4
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 3
• 239000000539 dimer Substances 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000008057 potassium phosphate buffer Substances 0.000 claims 3
• 239000003125 aqueous solvent Substances 0.000 claims 2
• 125000000600 disaccharide group Chemical group 0.000 claims 2
• 150000002016 disaccharides Chemical class 0.000 claims 2
• 239000012535 impurity Substances 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000008363 phosphate buffer Substances 0.000 claims 2
• 229920000136 polysorbate Polymers 0.000 claims 2
• 229950008882 polysorbate Drugs 0.000 claims 2
• 125000000647 trehalose group Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000002577 cryoprotective agent Substances 0.000 claims 1
• 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 239000013618 particulate matter Substances 0.000 claims 1
• 229920001983 poloxamer Polymers 0.000 claims 1
• 229960000502 poloxamer Drugs 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000004007 reversed phase HPLC Methods 0.000 claims 1
• 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 claims 1
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1