JP2013513619A5 - - Google Patents
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- Publication number
- JP2013513619A5 JP2013513619A5 JP2012543317A JP2012543317A JP2013513619A5 JP 2013513619 A5 JP2013513619 A5 JP 2013513619A5 JP 2012543317 A JP2012543317 A JP 2012543317A JP 2012543317 A JP2012543317 A JP 2012543317A JP 2013513619 A5 JP2013513619 A5 JP 2013513619A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- heterocycloalkyl
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000004404 heteroalkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000007082 Aβ accumulation Effects 0.000 claims 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000004957 naphthylene group Chemical group 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- NRZNTGUFHSJBTD-HKOYGPOVSA-N COCCOCCOCCOC(/C(/C#N)=C/c1ccc(cc(cc2)N3CCCCC3)c2c1)=O Chemical compound COCCOCCOCCOC(/C(/C#N)=C/c1ccc(cc(cc2)N3CCCCC3)c2c1)=O NRZNTGUFHSJBTD-HKOYGPOVSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28547009P | 2009-12-10 | 2009-12-10 | |
| US61/285,470 | 2009-12-10 | ||
| PCT/US2010/059952 WO2011072257A2 (en) | 2009-12-10 | 2010-12-10 | Amyloid binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513619A JP2013513619A (ja) | 2013-04-22 |
| JP2013513619A5 true JP2013513619A5 (https=) | 2013-08-29 |
| JP5591946B2 JP5591946B2 (ja) | 2014-09-17 |
Family
ID=44146211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543317A Active JP5591946B2 (ja) | 2009-12-10 | 2010-12-10 | アミロイド結合剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8940918B2 (https=) |
| EP (1) | EP2509940B1 (https=) |
| JP (1) | JP5591946B2 (https=) |
| KR (3) | KR102079160B1 (https=) |
| CN (2) | CN103201258B (https=) |
| AU (1) | AU2010327918B2 (https=) |
| BR (1) | BR112012013810B1 (https=) |
| CA (1) | CA2783466C (https=) |
| CY (1) | CY1116487T1 (https=) |
| DK (1) | DK2509940T3 (https=) |
| ES (1) | ES2546063T3 (https=) |
| HR (1) | HRP20150854T1 (https=) |
| HU (1) | HUE027199T2 (https=) |
| IN (1) | IN2012DN05186A (https=) |
| ME (1) | ME02194B (https=) |
| MX (1) | MX347591B (https=) |
| NZ (1) | NZ600459A (https=) |
| PL (1) | PL2509940T3 (https=) |
| PT (1) | PT2509940E (https=) |
| RS (1) | RS54158B1 (https=) |
| RU (1) | RU2517174C2 (https=) |
| SG (1) | SG181561A1 (https=) |
| SI (1) | SI2509940T1 (https=) |
| SM (1) | SMT201500216B (https=) |
| WO (1) | WO2011072257A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013180815A1 (en) * | 2012-05-30 | 2013-12-05 | University Of Tennessee Research Foundation | Compounds for amide-forming reactions |
| US9588129B2 (en) | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
| TW201609183A (zh) * | 2013-10-31 | 2016-03-16 | 康諾普堤克斯公司 | 眼用調配物之製備方法及其用途 |
| AU2013405234B2 (en) * | 2013-11-12 | 2017-08-10 | Cognoptix, Inc. | Method for measuring fluorescence in ocular tissue |
| AU2015231239B2 (en) | 2014-03-19 | 2018-11-29 | Amydis, Inc. | Amyloid targeting agents and methods of using the same |
| CA2960723A1 (en) * | 2014-09-12 | 2016-03-17 | Amydis Diagnostics, Inc. | In vitro compositions comprising human sample and amyloid targeting agent |
| WO2018208709A1 (en) | 2017-05-09 | 2018-11-15 | Warner Babcock Institute For Green Chemistry, Llc | Stilbene derivatives for the treatment of cns and other disorders |
| WO2019232422A1 (en) * | 2018-05-31 | 2019-12-05 | Amydis, Inc. | Compositions and methods for detection of traumatic brain injury |
| CA3118325A1 (en) * | 2018-11-02 | 2020-05-07 | Amydis, Inc. | Phosphate compounds for detecting neurological disorders |
| KR102240400B1 (ko) | 2020-11-19 | 2021-04-15 | 한국원자력연구원 | 베타-아밀로이드 검출용 수용성 화합물 |
| JP2024509927A (ja) * | 2021-03-12 | 2024-03-05 | アミディス， インコーポレイテッド | 誤って折りたたまれたかまたは凝集したタンパク質への結合を介して全身性アミロイドーシスを検出する方法 |
| US20250282723A1 (en) * | 2021-06-16 | 2025-09-11 | The Regents Of The University Of California | Amyloid targeting agents and methods of using the same |
| CN115322165A (zh) * | 2022-09-30 | 2022-11-11 | 镇江百单医疗生物科技有限公司 | 近红外荧光探针成像肝纤维化中亚铁离子的动态波动 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2583614A (en) * | 1950-05-13 | 1952-01-29 | Eastman Kodak Co | Acylated methine dye compounds |
| US2798090A (en) * | 1953-03-02 | 1957-07-02 | Eastman Kodak Co | Process for preparing benzalaniline-3-sulfonic acid compounds |
| US3074971A (en) * | 1959-01-23 | 1963-01-22 | Gen Aniline & Film Corp | alpha-cyanocinnamic acid esters |
| US3149146A (en) * | 1960-03-09 | 1964-09-15 | Gen Aniline & Film Corp | Alpha-cyano-2-alkenoxy-1-naphthaleneacrylic acid esters |
| FR1321641A (fr) | 1962-03-08 | 1963-03-22 | Gen Aniline & Film Corp | Nouvelles compositions absorbantes de rayons ultraviolets |
| BE794010A (fr) * | 1972-01-13 | 1973-05-02 | Du Pont | Colorants cationiques de couleur jaune-vert |
| DE2714653C3 (de) * | 1977-04-01 | 1980-10-30 | Bayer Ag, 5090 Leverkusen | Kationische Styrylfarbstoffe und Verfahren zum Färben mit diesen Farbstoffen |
| DE2942185A1 (de) * | 1979-10-18 | 1981-04-30 | Basf Ag, 6700 Ludwigshafen | Basische farbstoffe |
| JPS5815912A (ja) * | 1981-07-22 | 1983-01-29 | Ss Pharmaceut Co Ltd | 消炎鎮痛剤 |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JPS63163826A (ja) * | 1986-12-26 | 1988-07-07 | Idemitsu Kosan Co Ltd | 有機非線型光学材料 |
| DE3905916A1 (de) * | 1989-02-25 | 1990-08-30 | Basf Ag | Verwendung von derivaten des n-phenyl-3,4,5,6-tetrahydrophthalimids zur desikkation und abszission von pflanzenorganen |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| DE4430691A1 (de) * | 1994-08-30 | 1996-03-07 | Bayer Ag | Elektrolumineszierende Anordnungen und deren Verwendung |
| ATE507203T1 (de) * | 2002-01-18 | 2011-05-15 | Hospital For Sick Children | Verbindungen für die modulation der proliferation von zellen |
| GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| WO2004078144A2 (en) * | 2003-03-05 | 2004-09-16 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| US7517695B2 (en) * | 2004-01-20 | 2009-04-14 | The Curators Of The University Of Missouri | Local flow and shear stress sensor based on molecular rotors |
| WO2005092904A1 (en) * | 2004-03-26 | 2005-10-06 | Hsc Research And Development Limited Partnership | Novel compounds for modulating cell proliferation |
| US20060167057A1 (en) * | 2004-11-16 | 2006-07-27 | Xianqi Kong | Compounds for the treatment of CNS and amyloid associated diseases |
| US7666886B2 (en) | 2005-07-15 | 2010-02-23 | The Regents Of The University Of California | Compounds and methods for the diagnosis and treatment of amyloid associated diseases |
| PL2049253T3 (pl) | 2006-07-31 | 2020-03-31 | Basf Se | Zintegrowany sposób obejmujący uwodornianie za pomocą katalizatorów rutenowych i ich regenerację |
| FR2905009A1 (fr) * | 2006-08-18 | 2008-02-22 | Servier Lab | Methode de criblage de composes aux proprietes anti-amyloide |
| CN101209976B (zh) * | 2006-12-29 | 2012-01-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代的酒石酸衍生物及其用于制备β-分泌酶抑制剂的用途 |
| EP2217930B1 (en) * | 2007-10-24 | 2013-03-06 | Tallinn University Of Technology | Maldi ms-based high-throughput screening method for substances inhibiting aggregation of alzheimer's amyloid beta peptides |
-
2010
- 2010-12-10 MX MX2012006552A patent/MX347591B/es active IP Right Grant
- 2010-12-10 SI SI201030996T patent/SI2509940T1/sl unknown
- 2010-12-10 KR KR1020197027350A patent/KR102079160B1/ko active Active
- 2010-12-10 PL PL10836776T patent/PL2509940T3/pl unknown
- 2010-12-10 RS RS20150537A patent/RS54158B1/sr unknown
- 2010-12-10 ME MEP-2015-118A patent/ME02194B/me unknown
- 2010-12-10 NZ NZ600459A patent/NZ600459A/en unknown
- 2010-12-10 CN CN201080062250.8A patent/CN103201258B/zh active Active
- 2010-12-10 ES ES10836776.4T patent/ES2546063T3/es active Active
- 2010-12-10 KR KR1020187010217A patent/KR20180041767A/ko not_active Ceased
- 2010-12-10 RU RU2012128798/04A patent/RU2517174C2/ru active
- 2010-12-10 CN CN201511023642.4A patent/CN105669597B/zh active Active
- 2010-12-10 EP EP10836776.4A patent/EP2509940B1/en active Active
- 2010-12-10 JP JP2012543317A patent/JP5591946B2/ja active Active
- 2010-12-10 US US13/515,239 patent/US8940918B2/en active Active
- 2010-12-10 AU AU2010327918A patent/AU2010327918B2/en active Active
- 2010-12-10 WO PCT/US2010/059952 patent/WO2011072257A2/en not_active Ceased
- 2010-12-10 PT PT108367764T patent/PT2509940E/pt unknown
- 2010-12-10 IN IN5186DEN2012 patent/IN2012DN05186A/en unknown
- 2010-12-10 KR KR1020127017823A patent/KR101849680B1/ko active Active
- 2010-12-10 BR BR112012013810-3A patent/BR112012013810B1/pt active IP Right Grant
- 2010-12-10 DK DK10836776.4T patent/DK2509940T3/en active
- 2010-12-10 HU HUE10836776A patent/HUE027199T2/en unknown
- 2010-12-10 CA CA2783466A patent/CA2783466C/en active Active
- 2010-12-10 HR HRP20150854TT patent/HRP20150854T1/hr unknown
- 2010-12-10 SG SG2012041919A patent/SG181561A1/en unknown
-
2014
- 2014-12-16 US US14/572,465 patent/US9551722B2/en active Active
-
2015
- 2015-07-13 CY CY20151100606T patent/CY1116487T1/el unknown
- 2015-09-14 SM SM201500216T patent/SMT201500216B/xx unknown
-
2016
- 2016-12-09 US US15/375,006 patent/US20170315137A1/en not_active Abandoned
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