JP2013513380A - Ｂ７ｈ６と結合するモノクローナル抗体およびその使用 - Google Patents
Ｂ７ｈ６と結合するモノクローナル抗体およびその使用 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
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- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021503503A (ja) * | 2017-11-16 | 2021-02-12 | アンティジェネシス・リミテッド・ライアビリティ・カンパニーＡｎｔｉｇｅｎｅｓｉｓ ＬＬＣ | リソソーム誘発性免疫原性細胞死のシステムおよび方法 |
| JP2024529526A (ja) * | 2021-12-07 | 2024-08-06 | ヘーフェイ ティージー イミュノファーマ カンパニー リミテッド | Ｂ７ｈ６抗体及びその使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US12492376B2 (en) | 2009-10-29 | 2025-12-09 | The Trustees Of Dartmouth College | T-cell receptor-deficient T cell compositions |
| US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
| CN104926942B (zh) | 2009-12-09 | 2018-09-14 | 国家健康和医学研究院 | 结合b7h6的单克隆抗体及其用途 |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| BR112014005573A2 (pt) * | 2011-09-13 | 2014-11-11 | Deutsches Krebsforsch | Anticorpo monoclonal b7-h6 terapeuticamente ativo contra polipeptídeo b7-h6 |
| US9790278B2 (en) * | 2012-05-07 | 2017-10-17 | The Trustees Of Dartmouth College | Anti-B7-H6 antibody, fusion proteins, and methods of using the same |
| WO2014044799A1 (en) * | 2012-09-21 | 2014-03-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for the diagnosing of inflammatory conditions involving detecting, identifying or assaying for soluble b7-h6 polypeptides |
| EP2711707A1 (en) | 2012-09-21 | 2014-03-26 | Institut Gustave Roussy | Methods and kits for predicting the sensitivity of a subject to chemotherapy |
| WO2017181001A1 (en) * | 2016-04-15 | 2017-10-19 | Trustees Of Dartmouth College | High affinity b7-h6 antibodies and antibody fragments |
| WO2017214433A1 (en) * | 2016-06-09 | 2017-12-14 | Seattle Genetics, Inc. | Combinations of pbd-based antibody drug conjugates with flt3 inhibitors |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN114026122B (zh) | 2019-02-21 | 2024-12-31 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| KR20220151164A (ko) * | 2020-01-17 | 2022-11-14 | 베이진 엘티디 | 항-NKp30 항체 및 이용 방법 |
| CN117321087A (zh) | 2021-03-26 | 2023-12-29 | 先天制药公司 | 包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| MX2023014647A (es) | 2021-06-09 | 2024-01-31 | Innate Pharma | Proteinas de union a nkp46 multiespecificas. |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| CN114395043B (zh) * | 2021-12-07 | 2023-07-11 | 合肥天港免疫药物有限公司 | Ncr3lg1抗体及其应用 |
| CN114395044B (zh) * | 2021-12-07 | 2023-12-29 | 合肥天港免疫药物有限公司 | 重组抗体及其应用 |
| CN114395047B (zh) * | 2021-12-07 | 2023-11-07 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| CN114634574B (zh) * | 2022-04-18 | 2022-12-20 | 先进生物(苏州)有限公司 | 抗B7H6的scFv抗体、其编码基因及其应用 |
| WO2024005422A1 (ko) * | 2022-06-29 | 2024-01-04 | 고려대학교 산학협력단 | Nkp30 결합력이 향상된 b7-h6 변이체 |
| CN120265755A (zh) * | 2022-11-16 | 2025-07-04 | 德国癌症研究公共权益基金会 | 用于疾病治疗的t细胞-nk细胞相互作用抑制剂 |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021503503A (ja) * | 2017-11-16 | 2021-02-12 | アンティジェネシス・リミテッド・ライアビリティ・カンパニーＡｎｔｉｇｅｎｅｓｉｓ ＬＬＣ | リソソーム誘発性免疫原性細胞死のシステムおよび方法 |
| JP7500005B2 (ja) | 2017-11-16 | 2024-06-17 | ヴィスカ・バイオ・インコーポレイテッド | リソソーム誘発性免疫原性細胞死のシステムおよび方法 |
| JP2024529526A (ja) * | 2021-12-07 | 2024-08-06 | ヘーフェイ ティージー イミュノファーマ カンパニー リミテッド | Ｂ７ｈ６抗体及びその使用 |
| JP7776614B2 (ja) | 2021-12-07 | 2025-11-26 | 合肥天港免疫葯物有限公司 | Ｂ７ｈ６抗体及びその使用 |
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| PT2510011E (pt) | 2014-12-12 |
| ES2523472T3 (es) | 2014-11-26 |
| US20150056214A1 (en) | 2015-02-26 |
| CN104926942B (zh) | 2018-09-14 |
| BR112012013975A2 (pt) | 2017-01-10 |
| JP6212181B2 (ja) | 2017-10-11 |
| HRP20141170T1 (hr) | 2015-01-30 |
| CA2783740C (en) | 2020-03-10 |
| CN102741290A (zh) | 2012-10-17 |
| US8822652B2 (en) | 2014-09-02 |
| MX2012006443A (es) | 2012-06-28 |
| EA024629B1 (ru) | 2016-10-31 |
| CN102741290B (zh) | 2015-04-22 |
| EP2510011B2 (en) | 2021-03-31 |
| PL2510011T3 (pl) | 2015-02-27 |
| JP2017031147A (ja) | 2017-02-09 |
| SI2510011T1 (sl) | 2014-12-31 |
| BR112012013975B1 (pt) | 2021-01-12 |
| SMT201400184B (it) | 2015-01-15 |
| EA201270654A1 (ru) | 2013-02-28 |
| US20130004432A1 (en) | 2013-01-03 |
| BR112012013975B8 (pt) | 2021-05-25 |
| IN2012DN04908A (enExample) | 2015-09-25 |
| CA2783740A1 (en) | 2011-06-16 |
| CN104926942A (zh) | 2015-09-23 |
| DK2510011T3 (en) | 2014-12-01 |
| EP2510011A1 (en) | 2012-10-17 |
| RS53667B1 (sr) | 2015-04-30 |
| EP2510011B1 (en) | 2014-09-17 |
| US9663577B2 (en) | 2017-05-30 |
| WO2011070443A1 (en) | 2011-06-16 |
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