JP2013512918A5 - - Google Patents
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- Publication number
- JP2013512918A5 JP2013512918A5 JP2012542186A JP2012542186A JP2013512918A5 JP 2013512918 A5 JP2013512918 A5 JP 2013512918A5 JP 2012542186 A JP2012542186 A JP 2012542186A JP 2012542186 A JP2012542186 A JP 2012542186A JP 2013512918 A5 JP2013512918 A5 JP 2013512918A5
- Authority
- JP
- Japan
- Prior art keywords
- chelating moiety
- molecule
- noda
- attached
- mpaem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 229910052751 metal Inorganic materials 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 6
- 239000012736 aqueous medium Substances 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- 241001481833 Coryphaena hippurus Species 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229910052733 gallium Inorganic materials 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229910052716 thallium Inorganic materials 0.000 claims 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26677309P | 2009-12-04 | 2009-12-04 | |
| US61/266,773 | 2009-12-04 | ||
| US30228010P | 2010-02-08 | 2010-02-08 | |
| US61/302,280 | 2010-02-08 | ||
| US31612510P | 2010-03-22 | 2010-03-22 | |
| US61/316,125 | 2010-03-22 | ||
| US34748610P | 2010-05-24 | 2010-05-24 | |
| US61/347,486 | 2010-05-24 | ||
| US38172010P | 2010-09-10 | 2010-09-10 | |
| US61/381,720 | 2010-09-10 | ||
| US38826810P | 2010-09-30 | 2010-09-30 | |
| US61/388,268 | 2010-09-30 | ||
| PCT/US2010/058724 WO2011068965A1 (en) | 2009-12-04 | 2010-12-02 | Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512918A JP2013512918A (ja) | 2013-04-18 |
| JP2013512918A5 true JP2013512918A5 (enExample) | 2013-12-26 |
| JP5789821B2 JP5789821B2 (ja) | 2015-10-07 |
Family
ID=44115287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542186A Active JP5789821B2 (ja) | 2009-12-04 | 2010-12-02 | タンパク質、ペプチドおよび他の分子の改善されたｆ−１８標識化のための方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8202509B2 (enExample) |
| EP (1) | EP2507254A4 (enExample) |
| JP (1) | JP5789821B2 (enExample) |
| CN (1) | CN102666567B (enExample) |
| AU (1) | AU2010326004B2 (enExample) |
| CA (1) | CA2782223A1 (enExample) |
| IN (1) | IN2012DN03177A (enExample) |
| WO (1) | WO2011068965A1 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563433B2 (en) * | 2007-01-11 | 2009-07-21 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| US20100226884A1 (en) * | 2009-01-20 | 2010-09-09 | Immunomedics, Inc. | Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R) |
| US20160045626A1 (en) * | 2007-01-11 | 2016-02-18 | Immunomedics, Inc. | Methods and Compositions for Improved Labeling of Targeting Peptides |
| US8545809B2 (en) * | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
| US8398956B2 (en) * | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
| US8889100B2 (en) * | 2007-01-11 | 2014-11-18 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| US8709382B2 (en) * | 2007-01-11 | 2014-04-29 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| WO2010011367A2 (en) * | 2008-02-22 | 2010-01-28 | Illinois Institute Of Technology | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using |
| US10189803B2 (en) | 2008-02-22 | 2019-01-29 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| US10556873B2 (en) | 2008-02-22 | 2020-02-11 | Illinois Institute Of Technology | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using |
| US9446995B2 (en) | 2012-05-21 | 2016-09-20 | Illinois Institute Of Technology | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions |
| IN2012DN03177A (enExample) * | 2009-12-04 | 2015-09-25 | Immunomedics Inc | |
| EP2651411B1 (en) * | 2010-12-13 | 2020-09-16 | Immunomedics, Inc. | Methods and compositions for improved f-18 labeling of proteins, peptides and other molecules |
| EP2717985A4 (en) * | 2011-06-09 | 2015-02-25 | Ge Healthcare Ltd | DEVICE AND METHOD FOR DISTILLATION |
| US9757458B2 (en) | 2011-12-05 | 2017-09-12 | Immunomedics, Inc. | Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells |
| GB201201062D0 (en) * | 2012-01-23 | 2012-03-07 | Ge Healthcare Ltd | Radiofluorination method |
| CN104363919A (zh) | 2012-06-01 | 2015-02-18 | Ibc药品公司 | 具有改进的体内稳定性、药物代谢动力学和功效的多聚体复合物 |
| CN102675329B (zh) * | 2012-06-05 | 2014-12-24 | 浙江大学 | 一种正电子发射断层显像剂及其制备方法 |
| US20150191543A1 (en) * | 2012-08-06 | 2015-07-09 | The Regents Of The University Of California | Engineered antibody fragments for targeting and imaging cd8 expression in vivo |
| CN102911256B (zh) * | 2012-11-02 | 2016-06-01 | 厦门大学 | 一种放射性标记的多肽配合物及其制备方法和应用 |
| JP6391095B2 (ja) * | 2012-11-30 | 2018-09-19 | 国立大学法人京都大学 | ポリペプチド及びイメージング方法 |
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd８에의 항원 결합 구조체들 |
| CN103267850B (zh) * | 2013-04-27 | 2015-04-15 | 深圳先进技术研究院 | 用于肿瘤病理诊断的探针及其制备方法和应用 |
| GB201308053D0 (en) * | 2013-05-03 | 2013-06-12 | Ge Healthcare Ltd | Metal complexes and fluorination thereof |
| WO2015051362A1 (en) | 2013-10-04 | 2015-04-09 | Illinois Institute Of Technology | Multifunctional chelators, complexes, and compositions thereof, and methods of using same |
| EP3077407A4 (en) * | 2013-12-03 | 2017-07-19 | Millennium Pharmaceuticals, Inc. | Compounds and compositions for imaging gcc-expressing cells |
| US20150217006A1 (en) * | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| US20160331852A1 (en) * | 2015-05-11 | 2016-11-17 | Memorial Sloan Kettering Cancer Center | Radioligands for pretargeted pet imaging and methods of their therapeutic use |
| US20170007727A1 (en) * | 2015-07-07 | 2017-01-12 | Immunomedics, Inc. | METHODS OF IMAGING WITH Ga-68 LABELED MOLECULES |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| TWI603980B (zh) * | 2015-09-01 | 2017-11-01 | 免疫功坊股份有限公司 | 用以治療病理性血栓的聯合接合物構型藥物 |
| WO2017070752A1 (en) * | 2015-10-29 | 2017-05-04 | The University Of Queensland | Imaging agents |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| CN107312070A (zh) * | 2017-05-03 | 2017-11-03 | 厦门大学附属第医院 | 一种18f标记的pet多肽探针及其制备方法 |
| CN108314678B (zh) * | 2018-01-17 | 2019-11-08 | 浙江大学 | 以磷脂酰丝氨酸为靶点的分子探针及其用途 |
| US12103927B2 (en) | 2018-03-30 | 2024-10-01 | Centre National De La Recherche Scientifique | Pyclen-based macrocyclic ligands, chelates thereof and uses thereof |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| CN112638415B (zh) * | 2018-07-26 | 2024-07-02 | 大有华夏生物医药集团有限公司 | 用于成像的组合物和方法 |
| MX2021008230A (es) * | 2019-01-07 | 2021-08-11 | Astellas Pharma Inc | Conjugado que comprende ligando y fragmento fab de anticuerpo ceacam5. |
| CN113795511B (zh) * | 2019-01-23 | 2024-07-23 | 大有华夏生物医药集团有限公司 | 抗pd-l1双抗体及其用途 |
| US20220259160A1 (en) * | 2019-08-21 | 2022-08-18 | Nihon Medi-Physics Co., Ltd. | Method for producing radioactive metal complex |
| EP4058423A1 (en) * | 2019-11-13 | 2022-09-21 | Duke University | Radiohalogen prosthetic moieties and radiolabeled biomolecules |
| CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
| CA3215787A1 (en) * | 2021-03-31 | 2022-10-06 | Nihon Medi-Physics Co., Ltd. | Radioactive complex of anti-egfr antibody, and radiopharmaceutical |
| JP2024526275A (ja) * | 2021-06-29 | 2024-07-17 | ライフ モレキュラー イメージング リミティド | 放射性金属標識キレート官能基化ターゲティングコンジュゲートの放射線医薬調製のための新規のキット |
| CN113773365A (zh) * | 2021-09-09 | 2021-12-10 | 原子高科股份有限公司 | 生长抑素类似物及其应用 |
| EP4273142A1 (en) | 2022-05-06 | 2023-11-08 | Université de Bretagne Occidentale | Picolinate cyclam palladium chelates and uses thereof |
| WO2024238987A2 (en) * | 2023-05-18 | 2024-11-21 | The Regents Of The University Of California | Labeled oligosaccharides and methods of use |
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| FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| US5446147A (en) * | 1992-04-03 | 1995-08-29 | Trustees Of The University Of Pennsylvania | Fluorinated and iodinated dopamine agents |
| DE69837095T2 (de) * | 1997-09-03 | 2007-11-22 | Immunomedics, Inc. | Fluorierung von proteinen und peptiden für positronemissionstomographie |
| US6071490A (en) * | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US7138103B2 (en) * | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| US7387772B1 (en) * | 1999-06-22 | 2008-06-17 | Immunimedics, Inc. | Chimeric, human and humanized anti-CSAP monoclonal antibodies |
| US7405320B2 (en) * | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
| US6056939A (en) * | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
| DE19846148C2 (de) * | 1998-10-01 | 2002-10-10 | Igor Popov | Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität |
| US6207858B1 (en) * | 1999-03-03 | 2001-03-27 | Idec Pharmaceuticals Corporation | Regioselective synthesis of DTPA derivatives |
| AU785505B2 (en) * | 1999-10-15 | 2009-02-26 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| AU2001245401A1 (en) * | 2000-03-01 | 2001-09-12 | Sumitomo Pharmaceuticals Company, Limited | Hydrazones and analogs as cholesterol lowering agents |
| AU6836301A (en) * | 2000-06-20 | 2002-01-02 | Idec Pharma Corp | Treatment of b-cell associated diseases such as malignancies and autoimmune diseases using a cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination |
| US7011816B2 (en) * | 2001-12-26 | 2006-03-14 | Immunomedics, Inc. | Labeling targeting agents with gallium-68 and gallium-67 |
| US7081452B2 (en) * | 2002-06-03 | 2006-07-25 | The United States Of America As Represented By The Department Of Health And Human Services | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same |
| US7563433B2 (en) * | 2007-01-11 | 2009-07-21 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| US7597876B2 (en) * | 2007-01-11 | 2009-10-06 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| US7993626B2 (en) * | 2007-01-11 | 2011-08-09 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| JP4874090B2 (ja) * | 2003-01-31 | 2012-02-08 | イミューノメディクス、インコーポレイテッド | 治療薬および診断薬を投与するための方法および組成物 |
| EP1660519B1 (en) * | 2003-07-29 | 2014-05-14 | Immunomedics, Inc. | Conjugates comprising 2-[18F]fluoro-2-deoxy-D-glucose and a peptide molecule |
| WO2005077967A1 (en) * | 2004-02-13 | 2005-08-25 | The University Of British Columbia | Radiolabeled compounds and compositions, their precursors and methods for their production |
| DE102004034517A1 (de) * | 2004-07-16 | 2006-02-16 | Covion Organic Semiconductors Gmbh | Metallkomplexe |
| WO2006017619A2 (en) * | 2004-08-06 | 2006-02-16 | The Regents Of The University Of California | Receptor-binding cyclic peptides and methods of use |
| CA2604032C (en) * | 2005-04-06 | 2017-08-22 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| JP2009508090A (ja) * | 2005-08-31 | 2009-02-26 | イムノメディクス， インコーポレイテッド | 予め標的化されたポジトロン放出断層撮影画像化のためのｆ−１８ペプチド |
| TWI303332B (en) * | 2006-08-04 | 2008-11-21 | Largan Precision Co Ltd | Optical lens assembly |
| US7666392B2 (en) * | 2006-09-15 | 2010-02-23 | Siemens Medical Solutions Usa, Inc. | Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins |
| US8153100B2 (en) * | 2007-01-11 | 2012-04-10 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
| CN101568352B (zh) | 2007-01-11 | 2013-08-21 | 免疫医学股份有限公司 | 用于蛋白质、肽和其他分子的改进的f-18标记的方法和组合物 |
| US8398956B2 (en) * | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
| IN2012DN03177A (enExample) * | 2009-12-04 | 2015-09-25 | Immunomedics Inc |
-
2010
- 2010-12-02 IN IN3177DEN2012 patent/IN2012DN03177A/en unknown
- 2010-12-02 JP JP2012542186A patent/JP5789821B2/ja active Active
- 2010-12-02 CA CA2782223A patent/CA2782223A1/en not_active Abandoned
- 2010-12-02 US US12/958,889 patent/US8202509B2/en active Active
- 2010-12-02 WO PCT/US2010/058724 patent/WO2011068965A1/en not_active Ceased
- 2010-12-02 EP EP10835120.6A patent/EP2507254A4/en not_active Withdrawn
- 2010-12-02 AU AU2010326004A patent/AU2010326004B2/en active Active
- 2010-12-02 CN CN201080052555.0A patent/CN102666567B/zh active Active
-
2012
- 2012-05-17 US US13/474,260 patent/US8444956B2/en active Active
-
2013
- 2013-03-26 US US13/850,591 patent/US8617518B2/en active Active
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