JP2012131808A5 - - Google Patents
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- Publication number
- JP2012131808A5 JP2012131808A5 JP2012024825A JP2012024825A JP2012131808A5 JP 2012131808 A5 JP2012131808 A5 JP 2012131808A5 JP 2012024825 A JP2012024825 A JP 2012024825A JP 2012024825 A JP2012024825 A JP 2012024825A JP 2012131808 A5 JP2012131808 A5 JP 2012131808A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- composition
- group
- chemical moiety
- clearance rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58607596A | 1996-01-11 | 1996-01-11 | |
| US08/586,075 | 1996-01-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9525384A Division JP2000503301A (ja) | 1996-01-11 | 1997-01-06 | 減少した正味の正電荷を有する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012131808A JP2012131808A (ja) | 2012-07-12 |
| JP2012131808A5 true JP2012131808A5 (enExample) | 2013-04-04 |
Family
ID=24344206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9525384A Pending JP2000503301A (ja) | 1996-01-11 | 1997-01-06 | 減少した正味の正電荷を有する抗体 |
| JP2012024825A Pending JP2012131808A (ja) | 1996-01-11 | 2012-02-08 | 減少した正味の正電荷を有する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9525384A Pending JP2000503301A (ja) | 1996-01-11 | 1997-01-06 | 減少した正味の正電荷を有する抗体 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0873139B1 (enExample) |
| JP (2) | JP2000503301A (enExample) |
| KR (1) | KR100485240B1 (enExample) |
| AT (1) | ATE249243T1 (enExample) |
| AU (1) | AU730388B2 (enExample) |
| CA (1) | CA2242750C (enExample) |
| DE (1) | DE69724761T2 (enExample) |
| ES (1) | ES2206683T3 (enExample) |
| RU (1) | RU2219949C2 (enExample) |
| WO (1) | WO1997025069A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005047903A1 (en) * | 2003-11-07 | 2005-05-26 | Upstate Usa. Inc. | A method for generating antibody conjugates that preserves antigen recognition |
| US20150344580A1 (en) * | 2012-06-05 | 2015-12-03 | Eldar Kim | Human Monoclonal Antibodies Against Human Chemokine Receptor CCR7 |
| KR102090849B1 (ko) | 2012-07-04 | 2020-03-19 | 에프. 호프만-라 로슈 아게 | 공유 결합된 항원-항체 접합체 |
| EP2869837B1 (en) | 2012-07-04 | 2016-09-14 | F. Hoffmann-La Roche AG | Anti-theophylline antibodies and methods of use |
| EP3339328A1 (en) * | 2012-07-04 | 2018-06-27 | F. Hoffmann-La Roche AG | Anti-biotin antibodies and methods of use |
| JP6602304B2 (ja) | 2014-01-03 | 2019-11-06 | エフ．ホフマン−ラ ロシュ アーゲー | 共有結合で連結されたヘリカー−抗ヘリカー抗体コンジュゲートおよびその用途 |
| EP3089759B1 (en) | 2014-01-03 | 2018-12-05 | F. Hoffmann-La Roche AG | Covalently linked polypeptide toxin-antibody conjugates |
| PL3089996T3 (pl) | 2014-01-03 | 2021-12-13 | F. Hoffmann-La Roche Ag | Dwuswoiste przeciwciała przeciw haptenowi/przeciw receptorowi występującemu w barierze krew-mózg, ich kompleksy i ich zastosowanie jako przenośniki wahadłowe występujące w barierze krew-mózg |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| FR2566271B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
| WO1988007553A1 (fr) * | 1987-03-26 | 1988-10-06 | Teijin Limited | Procede de preparation d'un complexe d'anticorps |
| EP0593452A1 (en) * | 1989-11-30 | 1994-04-27 | Mallinckrodt Medical, Inc. | Method for preparing a metal-radionuclide-labelled protein |
| US5194594A (en) * | 1990-09-07 | 1993-03-16 | Techniclone, Inc. | Modified antibodies |
| SE9100142L (sv) * | 1991-01-17 | 1992-07-18 | Bengt Sandberg | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
| US5578287A (en) * | 1992-06-09 | 1996-11-26 | Neorx Corporation | Three-step pretargeting methods using improved biotin-active agent |
| DE69331319T2 (de) * | 1992-06-09 | 2002-08-08 | Neorx Corp., Seattle | Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren |
| JPH0853499A (ja) * | 1994-08-10 | 1996-02-27 | Green Cross Corp:The | キメラ抗体Ｆａｂ断片のオリゴマー体 |
-
1997
- 1997-01-06 AT AT97902867T patent/ATE249243T1/de active
- 1997-01-06 CA CA002242750A patent/CA2242750C/en not_active Expired - Fee Related
- 1997-01-06 ES ES97902867T patent/ES2206683T3/es not_active Expired - Lifetime
- 1997-01-06 DE DE69724761T patent/DE69724761T2/de not_active Expired - Lifetime
- 1997-01-06 EP EP97902867A patent/EP0873139B1/en not_active Expired - Lifetime
- 1997-01-06 KR KR1019980705339A patent/KR100485240B1/ko not_active Expired - Fee Related
- 1997-01-06 RU RU98115277/15A patent/RU2219949C2/ru not_active IP Right Cessation
- 1997-01-06 JP JP9525384A patent/JP2000503301A/ja active Pending
- 1997-01-06 AU AU16939/97A patent/AU730388B2/en not_active Ceased
- 1997-01-06 WO PCT/US1997/000307 patent/WO1997025069A1/en not_active Ceased
-
2012
- 2012-02-08 JP JP2012024825A patent/JP2012131808A/ja active Pending
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