JP2016513105A5 - - Google Patents
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- Publication number
- JP2016513105A5 JP2016513105A5 JP2015557534A JP2015557534A JP2016513105A5 JP 2016513105 A5 JP2016513105 A5 JP 2016513105A5 JP 2015557534 A JP2015557534 A JP 2015557534A JP 2015557534 A JP2015557534 A JP 2015557534A JP 2016513105 A5 JP2016513105 A5 JP 2016513105A5
- Authority
- JP
- Japan
- Prior art keywords
- galactose
- glycosylated
- population
- seq
- glycosylated antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 claims 8
- 210000002919 epithelial cell Anatomy 0.000 claims 7
- 238000004113 cell culture Methods 0.000 claims 6
- 210000000481 breast Anatomy 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 235000002198 Annona diversifolia Nutrition 0.000 claims 1
- 241000157302 Bison bison athabascae Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282836 Camelus dromedarius Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241000282842 Lama glama Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764446P | 2013-02-13 | 2013-02-13 | |
| US61/764,446 | 2013-02-13 | ||
| PCT/IB2014/000867 WO2014125382A2 (en) | 2013-02-13 | 2014-02-13 | Cetuximab with modified glycosylation and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016513105A JP2016513105A (ja) | 2016-05-12 |
| JP2016513105A5 true JP2016513105A5 (enExample) | 2017-03-09 |
Family
ID=50980328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015557534A Pending JP2016513105A (ja) | 2013-02-13 | 2014-02-13 | 改変グリコシル化を有するセツキシマブおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160002330A1 (enExample) |
| EP (1) | EP2956484B1 (enExample) |
| JP (1) | JP2016513105A (enExample) |
| KR (1) | KR20150145225A (enExample) |
| CN (1) | CN105358577A (enExample) |
| AR (1) | AR094779A1 (enExample) |
| AU (1) | AU2014217569B2 (enExample) |
| BR (1) | BR112015019339A2 (enExample) |
| CA (1) | CA2900915A1 (enExample) |
| IL (1) | IL240442A0 (enExample) |
| MX (1) | MX2015010429A (enExample) |
| TW (1) | TW201444871A (enExample) |
| WO (1) | WO2014125382A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501365A1 (en) | 2010-12-30 | 2013-09-16 | Laboratoire Francais Du Fractionnment Et Des Biotechnologies | Glycols as pathogen inactivating agents |
| BR112015019341A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal |
| EP2956003A2 (en) | 2013-02-13 | 2015-12-23 | Laboratoire Français du Fractionnement et des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| JP2016532100A (ja) | 2013-07-05 | 2016-10-13 | ラボラトワール・フランセ・デュ・フラクシオンマン・エ・デ・ビョテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ Ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ Ｅｔ Ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | アフィニティークロマトグラフィーマトリックス |
| US10927384B2 (en) | 2014-04-09 | 2021-02-23 | Dna Twopointo Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| EP3974524A1 (en) | 2015-10-08 | 2022-03-30 | Dna Twopointo Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
| WO2017120613A1 (en) * | 2016-01-10 | 2017-07-13 | Sorrento Therapeutics, Inc. | Improved safety for treating cancers with a glycosylated chimeric antibody to egfr |
| US11649291B2 (en) * | 2016-05-24 | 2023-05-16 | Insmed Incorporated | Antibodies and methods of making same |
| KR102376545B1 (ko) * | 2017-08-01 | 2022-03-21 | 삼성디스플레이 주식회사 | 플렉시블 디스플레이 윈도우 |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| WO2022148549A1 (en) | 2020-01-14 | 2022-07-14 | Babylat Gmbh | Apparatus and method for obtaining protein-enriched fractions from breast milk |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| DE60237282D1 (de) | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| ATE464389T1 (de) * | 2002-05-17 | 2010-04-15 | Kyowa Hakko Kirin Co Ltd | Transgene huftiere, die zur produktion von menschlichen antikörpern fähig sind |
| CA2506629A1 (en) * | 2002-11-27 | 2004-06-17 | Gtc Biotherapeutics, Inc. | Modified antibodies stably produced in milk and methods of producing same |
| CA2450289A1 (en) * | 2003-03-20 | 2005-05-19 | Imclone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| WO2005111627A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| BRPI0518151A2 (pt) | 2004-10-13 | 2009-06-16 | Ablynx Nv | polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| NZ568433A (en) | 2005-10-21 | 2012-07-27 | Gtc Biotherapeutics Inc | Milk-derived antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
| FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| HRP20150307T1 (hr) * | 2006-09-10 | 2015-04-24 | Glycotope Gmbh | Upotreba ljudskih stanica podrijetlom iz ljudske leukemije za eksprimiranje protutijela |
| WO2008101177A2 (en) * | 2007-02-16 | 2008-08-21 | University Of Virginia Patent Foundation | Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis |
| EP2389586B2 (en) * | 2009-01-22 | 2018-01-24 | Momenta Pharmaceuticals, Inc. | Galactose-alpha-1,3-galactose-containing n-glycans in glycoprotein products derived from cho cells |
| KR20120101059A (ko) * | 2009-11-11 | 2012-09-12 | 모멘타 파머슈티컬스 인코포레이티드 | 중국 햄스터 유래의 글리코실 전이효소 및 관련 방법 |
-
2014
- 2014-02-13 MX MX2015010429A patent/MX2015010429A/es unknown
- 2014-02-13 BR BR112015019339A patent/BR112015019339A2/pt not_active Application Discontinuation
- 2014-02-13 AU AU2014217569A patent/AU2014217569B2/en not_active Ceased
- 2014-02-13 US US14/767,089 patent/US20160002330A1/en not_active Abandoned
- 2014-02-13 AR ARP140100458A patent/AR094779A1/es unknown
- 2014-02-13 KR KR1020157024950A patent/KR20150145225A/ko not_active Withdrawn
- 2014-02-13 TW TW103104778A patent/TW201444871A/zh unknown
- 2014-02-13 CA CA2900915A patent/CA2900915A1/en not_active Abandoned
- 2014-02-13 CN CN201480018266.7A patent/CN105358577A/zh active Pending
- 2014-02-13 EP EP14732006.3A patent/EP2956484B1/en not_active Not-in-force
- 2014-02-13 WO PCT/IB2014/000867 patent/WO2014125382A2/en not_active Ceased
- 2014-02-13 JP JP2015557534A patent/JP2016513105A/ja active Pending
-
2015
- 2015-08-09 IL IL240442A patent/IL240442A0/en unknown
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