CN105358577A - 具有经修饰的糖基化的西妥昔单抗及其用途 - Google Patents
具有经修饰的糖基化的西妥昔单抗及其用途 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/102—Caprine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/12—Immunoglobulins specific features characterized by their source of isolation or production isolated from milk
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201361764446P | 2013-02-13 | 2013-02-13 | |
| US61/764,446 | 2013-02-13 | ||
| PCT/IB2014/000867 WO2014125382A2 (en) | 2013-02-13 | 2014-02-13 | Cetuximab with modified glycosylation and uses thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN105358577A true CN105358577A (zh) | 2016-02-24 |
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| US (1) | US20160002330A1 (enExample) |
| EP (1) | EP2956484B1 (enExample) |
| JP (1) | JP2016513105A (enExample) |
| KR (1) | KR20150145225A (enExample) |
| CN (1) | CN105358577A (enExample) |
| AR (1) | AR094779A1 (enExample) |
| AU (1) | AU2014217569B2 (enExample) |
| BR (1) | BR112015019339A2 (enExample) |
| CA (1) | CA2900915A1 (enExample) |
| IL (1) | IL240442A0 (enExample) |
| MX (1) | MX2015010429A (enExample) |
| TW (1) | TW201444871A (enExample) |
| WO (1) | WO2014125382A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109415441A (zh) * | 2016-05-24 | 2019-03-01 | K·E·格里斯沃尔德 | 抗体及其制备方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501365A1 (en) | 2010-12-30 | 2013-09-16 | Laboratoire Francais Du Fractionnment Et Des Biotechnologies | Glycols as pathogen inactivating agents |
| BR112015019341A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal |
| EP2956003A2 (en) | 2013-02-13 | 2015-12-23 | Laboratoire Français du Fractionnement et des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| JP2016532100A (ja) | 2013-07-05 | 2016-10-13 | ラボラトワール・フランセ・デュ・フラクシオンマン・エ・デ・ビョテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ Ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ Ｅｔ Ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | アフィニティークロマトグラフィーマトリックス |
| US10927384B2 (en) | 2014-04-09 | 2021-02-23 | Dna Twopointo Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| EP3974524A1 (en) | 2015-10-08 | 2022-03-30 | Dna Twopointo Inc. | Dna vectors, transposons and transposases for eukaryotic genome modification |
| WO2017120613A1 (en) * | 2016-01-10 | 2017-07-13 | Sorrento Therapeutics, Inc. | Improved safety for treating cancers with a glycosylated chimeric antibody to egfr |
| KR102376545B1 (ko) * | 2017-08-01 | 2022-03-21 | 삼성디스플레이 주식회사 | 플렉시블 디스플레이 윈도우 |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| WO2022148549A1 (en) | 2020-01-14 | 2022-07-14 | Babylat Gmbh | Apparatus and method for obtaining protein-enriched fractions from breast milk |
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| CN1729298A (zh) * | 2002-11-27 | 2006-02-01 | Gtc生物治疗学公司 | 在乳汁中稳定生成的修饰抗体及其制备方法 |
| CN102292640A (zh) * | 2009-01-22 | 2011-12-21 | 动量制药公司 | 在来源于CHO细胞的糖蛋白产物中的含有半乳糖-α-1,3-半乳糖的N-聚糖 |
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| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| DE60237282D1 (de) | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| ATE464389T1 (de) * | 2002-05-17 | 2010-04-15 | Kyowa Hakko Kirin Co Ltd | Transgene huftiere, die zur produktion von menschlichen antikörpern fähig sind |
| CA2450289A1 (en) * | 2003-03-20 | 2005-05-19 | Imclone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| WO2005111627A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| BRPI0518151A2 (pt) | 2004-10-13 | 2009-06-16 | Ablynx Nv | polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| NZ568433A (en) | 2005-10-21 | 2012-07-27 | Gtc Biotherapeutics Inc | Milk-derived antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
| FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| HRP20150307T1 (hr) * | 2006-09-10 | 2015-04-24 | Glycotope Gmbh | Upotreba ljudskih stanica podrijetlom iz ljudske leukemije za eksprimiranje protutijela |
| WO2008101177A2 (en) * | 2007-02-16 | 2008-08-21 | University Of Virginia Patent Foundation | Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis |
| KR20120101059A (ko) * | 2009-11-11 | 2012-09-12 | 모멘타 파머슈티컬스 인코포레이티드 | 중국 햄스터 유래의 글리코실 전이효소 및 관련 방법 |
-
2014
- 2014-02-13 MX MX2015010429A patent/MX2015010429A/es unknown
- 2014-02-13 BR BR112015019339A patent/BR112015019339A2/pt not_active Application Discontinuation
- 2014-02-13 AU AU2014217569A patent/AU2014217569B2/en not_active Ceased
- 2014-02-13 US US14/767,089 patent/US20160002330A1/en not_active Abandoned
- 2014-02-13 AR ARP140100458A patent/AR094779A1/es unknown
- 2014-02-13 KR KR1020157024950A patent/KR20150145225A/ko not_active Withdrawn
- 2014-02-13 TW TW103104778A patent/TW201444871A/zh unknown
- 2014-02-13 CA CA2900915A patent/CA2900915A1/en not_active Abandoned
- 2014-02-13 CN CN201480018266.7A patent/CN105358577A/zh active Pending
- 2014-02-13 EP EP14732006.3A patent/EP2956484B1/en not_active Not-in-force
- 2014-02-13 WO PCT/IB2014/000867 patent/WO2014125382A2/en not_active Ceased
- 2014-02-13 JP JP2015557534A patent/JP2016513105A/ja active Pending
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2015
- 2015-08-09 IL IL240442A patent/IL240442A0/en unknown
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| CN1729298A (zh) * | 2002-11-27 | 2006-02-01 | Gtc生物治疗学公司 | 在乳汁中稳定生成的修饰抗体及其制备方法 |
| CN102292640A (zh) * | 2009-01-22 | 2011-12-21 | 动量制药公司 | 在来源于CHO细胞的糖蛋白产物中的含有半乳糖-α-1,3-半乳糖的N-聚糖 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109415441A (zh) * | 2016-05-24 | 2019-03-01 | K·E·格里斯沃尔德 | 抗体及其制备方法 |
| CN109415441B (zh) * | 2016-05-24 | 2023-04-07 | 英斯梅德股份有限公司 | 抗体及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016513105A (ja) | 2016-05-12 |
| US20160002330A1 (en) | 2016-01-07 |
| AR094779A1 (es) | 2015-08-26 |
| WO2014125382A3 (en) | 2014-11-06 |
| WO2014125382A2 (en) | 2014-08-21 |
| MX2015010429A (es) | 2016-05-16 |
| BR112015019339A2 (pt) | 2017-08-22 |
| EP2956484B1 (en) | 2018-11-14 |
| AU2014217569A1 (en) | 2015-08-27 |
| KR20150145225A (ko) | 2015-12-29 |
| CA2900915A1 (en) | 2014-08-21 |
| EP2956484A2 (en) | 2015-12-23 |
| AU2014217569B2 (en) | 2018-10-25 |
| TW201444871A (zh) | 2014-12-01 |
| IL240442A0 (en) | 2015-09-24 |
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