JP2013512450A - ビーズリーダ - Google Patents
ビーズリーダ Download PDFInfo
- Publication number
- JP2013512450A JP2013512450A JP2012541621A JP2012541621A JP2013512450A JP 2013512450 A JP2013512450 A JP 2013512450A JP 2012541621 A JP2012541621 A JP 2012541621A JP 2012541621 A JP2012541621 A JP 2012541621A JP 2013512450 A JP2013512450 A JP 2013512450A
- Authority
- JP
- Japan
- Prior art keywords
- beads
- light
- bead
- analyte
- detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000011324 bead Substances 0.000 title claims abstract description 452
- 238000001514 detection method Methods 0.000 claims abstract description 228
- 239000012491 analyte Substances 0.000 claims abstract description 141
- 238000000034 method Methods 0.000 claims abstract description 93
- 238000003556 assay Methods 0.000 claims abstract description 23
- 230000003993 interaction Effects 0.000 claims abstract description 19
- 238000005259 measurement Methods 0.000 claims description 20
- 230000003068 static effect Effects 0.000 claims description 16
- 230000005284 excitation Effects 0.000 claims description 9
- 230000001133 acceleration Effects 0.000 claims description 6
- 230000000903 blocking effect Effects 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims description 2
- 239000000758 substrate Substances 0.000 abstract description 2
- 239000012530 fluid Substances 0.000 description 34
- 230000003287 optical effect Effects 0.000 description 24
- 230000008901 benefit Effects 0.000 description 17
- 238000012360 testing method Methods 0.000 description 17
- 239000000975 dye Substances 0.000 description 16
- 239000000463 material Substances 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 239000003446 ligand Substances 0.000 description 7
- 238000005286 illumination Methods 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000007837 multiplex assay Methods 0.000 description 3
- 238000000159 protein binding assay Methods 0.000 description 3
- 229910052761 rare earth metal Inorganic materials 0.000 description 3
- 150000002910 rare earth metals Chemical class 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 230000005374 Kerr effect Effects 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003271 compound fluorescence assay Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 229910001172 neodymium magnet Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
- G01N15/0612—Optical scan of the deposits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1046—Levitated, suspended drops
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26487309P | 2009-11-30 | 2009-11-30 | |
| US61/264,873 | 2009-11-30 | ||
| PCT/IL2010/000993 WO2011064778A2 (en) | 2009-11-30 | 2010-11-29 | Bead reader |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013512450A true JP2013512450A (ja) | 2013-04-11 |
| JP2013512450A5 JP2013512450A5 (enExample) | 2014-01-09 |
Family
ID=43513694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541621A Ceased JP2013512450A (ja) | 2009-11-30 | 2010-11-29 | ビーズリーダ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8927294B2 (enExample) |
| EP (1) | EP2507620B1 (enExample) |
| JP (1) | JP2013512450A (enExample) |
| CA (1) | CA2781824A1 (enExample) |
| WO (1) | WO2011064778A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021514051A (ja) * | 2018-02-15 | 2021-06-03 | プロサイズディーエックス インコーポレーテッド | 分析装置 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014065221A1 (ja) * | 2012-10-22 | 2014-05-01 | ユニバーサル・バイオ・リサーチ株式会社 | 複数種の目的物質を同時に検出又は定量するための分析方法及び分析キット |
| US20140112840A1 (en) * | 2012-10-23 | 2014-04-24 | Wisconsin Alumni Research Foundation | Device For And Method Of Extracting A Fraction From A Biological Sample |
| US10040062B2 (en) | 2014-01-14 | 2018-08-07 | Wisconsin Alumni Research Foundation | Device and method for transferring a target between locations |
| US20160293502A1 (en) * | 2015-03-31 | 2016-10-06 | Lam Research Corporation | Method and apparatus for detecting defects on wafers |
| CN109982778A (zh) * | 2016-09-23 | 2019-07-05 | 阿谢尔德克斯有限公司 | 流体系统及相关方法 |
| US10866192B2 (en) * | 2018-10-19 | 2020-12-15 | Endress+Hauser Conducta Gmbh+Co. Kg | Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit |
| MX2022014818A (es) * | 2020-05-25 | 2023-04-03 | Quantum Ip Holdings Pty Ltd | Uso de nanoparticulas magneticas para la deteccion y cuantificacion de analitos. |
| US11606147B1 (en) * | 2022-06-06 | 2023-03-14 | Bae Systems Information And Electronic Systems Integration Inc. | Frequency and bandwidth agile optical bench |
| CN115046927A (zh) * | 2022-06-29 | 2022-09-13 | 湖南超亟检测技术有限责任公司 | 一种基于光栅扫描识别的单分子多联检测方法 |
| CN115046928A (zh) * | 2022-06-29 | 2022-09-13 | 湖南超亟检测技术有限责任公司 | 一种基于光栅扫描识别的单分子检测方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08233817A (ja) * | 1994-12-20 | 1996-09-13 | Behring Diagnostics Inc | 正規化方法 |
| JP2006337257A (ja) * | 2005-06-03 | 2006-12-14 | Hitachi Software Eng Co Ltd | ビーズアレイ用蛍光読取装置及びビーズアレイ用蛍光読取方法 |
| JP2007533994A (ja) * | 2004-04-20 | 2007-11-22 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 画像化の方法および装置 |
| JP2009509270A (ja) * | 2005-09-21 | 2009-03-05 | ルミネックス・コーポレーション | 画像データ処理の方法及びシステム |
| JP2009540270A (ja) * | 2006-06-02 | 2009-11-19 | ルミネックス・コーポレーション | 磁性粒子を使用することと磁界を印加することを含む、１つ又は複数の材料の測定を実施するシステム及び方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172755A (ja) * | 1987-12-28 | 1989-07-07 | Tosoh Corp | 封入済み免疫反応試薬の異常を検出する方法及び装置 |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| EP1942334A4 (en) * | 2005-09-28 | 2011-01-12 | Olympus Corp | FLUORESZENZSPEKTRALANALYSEGERÄT |
| US7764361B2 (en) * | 2006-07-27 | 2010-07-27 | Northwestern University | Systems and methods to analyze multiplexed bead-based assays using backscattered light |
-
2010
- 2010-11-29 CA CA2781824A patent/CA2781824A1/en not_active Abandoned
- 2010-11-29 JP JP2012541621A patent/JP2013512450A/ja not_active Ceased
- 2010-11-29 EP EP10795779.7A patent/EP2507620B1/en not_active Not-in-force
- 2010-11-29 US US12/954,955 patent/US8927294B2/en not_active Expired - Fee Related
- 2010-11-29 WO PCT/IL2010/000993 patent/WO2011064778A2/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08233817A (ja) * | 1994-12-20 | 1996-09-13 | Behring Diagnostics Inc | 正規化方法 |
| JP2007533994A (ja) * | 2004-04-20 | 2007-11-22 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 画像化の方法および装置 |
| JP2006337257A (ja) * | 2005-06-03 | 2006-12-14 | Hitachi Software Eng Co Ltd | ビーズアレイ用蛍光読取装置及びビーズアレイ用蛍光読取方法 |
| JP2009509270A (ja) * | 2005-09-21 | 2009-03-05 | ルミネックス・コーポレーション | 画像データ処理の方法及びシステム |
| JP2009540270A (ja) * | 2006-06-02 | 2009-11-19 | ルミネックス・コーポレーション | 磁性粒子を使用することと磁界を印加することを含む、１つ又は複数の材料の測定を実施するシステム及び方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021514051A (ja) * | 2018-02-15 | 2021-06-03 | プロサイズディーエックス インコーポレーテッド | 分析装置 |
| JP7206570B2 (ja) | 2018-02-15 | 2023-01-18 | プロサイズディーエックス インコーポレーテッド | 分析装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2781824A1 (en) | 2011-06-03 |
| WO2011064778A2 (en) | 2011-06-03 |
| US8927294B2 (en) | 2015-01-06 |
| US20110136250A1 (en) | 2011-06-09 |
| EP2507620B1 (en) | 2017-03-22 |
| WO2011064778A3 (en) | 2011-08-04 |
| EP2507620A2 (en) | 2012-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013512450A (ja) | ビーズリーダ | |
| US9176152B2 (en) | Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics | |
| US7989177B2 (en) | Method and device for ultrasound assisted particle agglutination assay | |
| CN101903758B (zh) | 用于目标颗粒检测的微电子传感器装置 | |
| CN102933967B (zh) | 试样分析装置和试样分析方法 | |
| JP5643825B2 (ja) | 物質決定装置 | |
| JP5295149B2 (ja) | 生体物質分析方法並びにそれに用いられる生体物質分析セル、チップおよび装置 | |
| Tan et al. | High sensitivity automated multiplexed immunoassays using photonic crystal enhanced fluorescence microfluidic system | |
| EP3394597B1 (en) | Optical detection of a substance in fluid | |
| EP1526370A2 (en) | Patient sample classification based upon low angle light scattering | |
| US20120062219A1 (en) | Sensor device for magnetic particles with a high dynamic range | |
| US20220168735A1 (en) | Point of Care Concentration Analyzer | |
| US20130164861A1 (en) | Biological molecule detecting apparatus and biological molecule detecting method | |
| JP2013515956A (ja) | 検体測定装置及び方法 | |
| WO2013099648A1 (ja) | 試料分析装置及び試料分析方法 | |
| JP2016118389A (ja) | 相互作用解析装置 | |
| JP7362336B2 (ja) | 検体中の検出対象を検出又は定量する方法、反応混合液を攪拌する方法、液体媒体の流動を引き起こす方法、添加剤、試薬、および自動分析装置 | |
| WO2018185672A9 (en) | Bio-assay capture surfaces with bleached autofluorescence | |
| JP2002517727A (ja) | 固相、二光子励起および共焦点蛍光検出を用いた生体特異的均一アッセイ | |
| US20240219302A1 (en) | Optical emission biosensing using magnetic beads with a fast aggregation time | |
| Trueb | Enabling and understanding nanoparticle surface binding assays with interferometric imaging | |
| JP2019124521A (ja) | 検出装置および検出方法 | |
| HK1183686A (en) | Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131115 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131115 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140325 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140527 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140814 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141107 |
|
| A045 | Written measure of dismissal of application [lapsed due to lack of payment] |
Free format text: JAPANESE INTERMEDIATE CODE: A045 Effective date: 20150320 |