CA2781824A1 - Bead reader - Google Patents
Bead reader Download PDFInfo
- Publication number
- CA2781824A1 CA2781824A1 CA2781824A CA2781824A CA2781824A1 CA 2781824 A1 CA2781824 A1 CA 2781824A1 CA 2781824 A CA2781824 A CA 2781824A CA 2781824 A CA2781824 A CA 2781824A CA 2781824 A1 CA2781824 A1 CA 2781824A1
- Authority
- CA
- Canada
- Prior art keywords
- beads
- light
- analyte
- detection area
- detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000011324 bead Substances 0.000 title claims abstract description 435
- 238000001514 detection method Methods 0.000 claims abstract description 224
- 239000012491 analyte Substances 0.000 claims abstract description 146
- 238000000034 method Methods 0.000 claims abstract description 84
- 230000003993 interaction Effects 0.000 claims abstract description 23
- 238000005259 measurement Methods 0.000 claims description 22
- 230000003068 static effect Effects 0.000 claims description 15
- 230000000284 resting effect Effects 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 7
- 230000001133 acceleration Effects 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 description 34
- 238000003556 assay Methods 0.000 description 28
- 238000002474 experimental method Methods 0.000 description 27
- 230000008901 benefit Effects 0.000 description 17
- 239000000975 dye Substances 0.000 description 16
- 239000000463 material Substances 0.000 description 15
- 230000003287 optical effect Effects 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 7
- 239000003446 ligand Substances 0.000 description 7
- 238000009826 distribution Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 238000003384 imaging method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 229910052761 rare earth metal Inorganic materials 0.000 description 3
- 150000002910 rare earth metals Chemical class 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 230000005374 Kerr effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003271 compound fluorescence assay Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 229910001172 neodymium magnet Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
- G01N15/0612—Optical scan of the deposits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1046—Levitated, suspended drops
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26487309P | 2009-11-30 | 2009-11-30 | |
| US61/264,873 | 2009-11-30 | ||
| PCT/IL2010/000993 WO2011064778A2 (en) | 2009-11-30 | 2010-11-29 | Bead reader |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2781824A1 true CA2781824A1 (en) | 2011-06-03 |
Family
ID=43513694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2781824A Abandoned CA2781824A1 (en) | 2009-11-30 | 2010-11-29 | Bead reader |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8927294B2 (enExample) |
| EP (1) | EP2507620B1 (enExample) |
| JP (1) | JP2013512450A (enExample) |
| CA (1) | CA2781824A1 (enExample) |
| WO (1) | WO2011064778A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11606147B1 (en) * | 2022-06-06 | 2023-03-14 | Bae Systems Information And Electronic Systems Integration Inc. | Frequency and bandwidth agile optical bench |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014065221A1 (ja) * | 2012-10-22 | 2014-05-01 | ユニバーサル・バイオ・リサーチ株式会社 | 複数種の目的物質を同時に検出又は定量するための分析方法及び分析キット |
| US20140112840A1 (en) * | 2012-10-23 | 2014-04-24 | Wisconsin Alumni Research Foundation | Device For And Method Of Extracting A Fraction From A Biological Sample |
| US10040062B2 (en) | 2014-01-14 | 2018-08-07 | Wisconsin Alumni Research Foundation | Device and method for transferring a target between locations |
| US20160293502A1 (en) * | 2015-03-31 | 2016-10-06 | Lam Research Corporation | Method and apparatus for detecting defects on wafers |
| CN109982778A (zh) * | 2016-09-23 | 2019-07-05 | 阿谢尔德克斯有限公司 | 流体系统及相关方法 |
| ES2956109T3 (es) * | 2018-02-15 | 2023-12-13 | Procisedx Inc | Analizador |
| US10866192B2 (en) * | 2018-10-19 | 2020-12-15 | Endress+Hauser Conducta Gmbh+Co. Kg | Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit |
| MX2022014818A (es) * | 2020-05-25 | 2023-04-03 | Quantum Ip Holdings Pty Ltd | Uso de nanoparticulas magneticas para la deteccion y cuantificacion de analitos. |
| CN115046927A (zh) * | 2022-06-29 | 2022-09-13 | 湖南超亟检测技术有限责任公司 | 一种基于光栅扫描识别的单分子多联检测方法 |
| CN115046928A (zh) * | 2022-06-29 | 2022-09-13 | 湖南超亟检测技术有限责任公司 | 一种基于光栅扫描识别的单分子检测方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172755A (ja) * | 1987-12-28 | 1989-07-07 | Tosoh Corp | 封入済み免疫反応試薬の異常を検出する方法及び装置 |
| CA2164167A1 (en) * | 1994-12-20 | 1996-06-21 | Izak Bahar | Assay normalization method |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| US7428322B2 (en) * | 2004-04-20 | 2008-09-23 | Bio-Rad Laboratories, Inc. | Imaging method and apparatus |
| JP4733433B2 (ja) * | 2005-06-03 | 2011-07-27 | 株式会社日立ソリューションズ | ビーズアレイ用蛍光読取装置及びビーズアレイ用蛍光読取方法 |
| CA2623130C (en) * | 2005-09-21 | 2018-01-09 | Luminex Corporation | Methods and systems for image data processing |
| EP1942334A4 (en) * | 2005-09-28 | 2011-01-12 | Olympus Corp | FLUORESZENZSPEKTRALANALYSEGERÄT |
| EP2038655A2 (en) * | 2006-06-02 | 2009-03-25 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
| US7764361B2 (en) * | 2006-07-27 | 2010-07-27 | Northwestern University | Systems and methods to analyze multiplexed bead-based assays using backscattered light |
-
2010
- 2010-11-29 CA CA2781824A patent/CA2781824A1/en not_active Abandoned
- 2010-11-29 JP JP2012541621A patent/JP2013512450A/ja not_active Ceased
- 2010-11-29 EP EP10795779.7A patent/EP2507620B1/en not_active Not-in-force
- 2010-11-29 US US12/954,955 patent/US8927294B2/en not_active Expired - Fee Related
- 2010-11-29 WO PCT/IL2010/000993 patent/WO2011064778A2/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11606147B1 (en) * | 2022-06-06 | 2023-03-14 | Bae Systems Information And Electronic Systems Integration Inc. | Frequency and bandwidth agile optical bench |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011064778A2 (en) | 2011-06-03 |
| US8927294B2 (en) | 2015-01-06 |
| US20110136250A1 (en) | 2011-06-09 |
| JP2013512450A (ja) | 2013-04-11 |
| EP2507620B1 (en) | 2017-03-22 |
| WO2011064778A3 (en) | 2011-08-04 |
| EP2507620A2 (en) | 2012-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20161130 |