JP2013512281A5 - - Google Patents
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- Publication number
- JP2013512281A5 JP2013512281A5 JP2012542165A JP2012542165A JP2013512281A5 JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5 JP 2012542165 A JP2012542165 A JP 2012542165A JP 2012542165 A JP2012542165 A JP 2012542165A JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- ylamino
- methyl
- tetrazol
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26564809P | 2009-12-01 | 2009-12-01 | |
| US61/265,648 | 2009-12-01 | ||
| US36646910P | 2010-07-21 | 2010-07-21 | |
| US61/366,469 | 2010-07-21 | ||
| US40596810P | 2010-10-22 | 2010-10-22 | |
| US61/405,968 | 2010-10-22 | ||
| PCT/US2010/058597 WO2011068898A1 (en) | 2009-12-01 | 2010-12-01 | Protein kinase c inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512281A JP2013512281A (ja) | 2013-04-11 |
| JP2013512281A5 true JP2013512281A5 (cg-RX-API-DMAC10.html) | 2014-01-23 |
| JP5802677B2 JP5802677B2 (ja) | 2015-10-28 |
Family
ID=43902714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542165A Expired - Fee Related JP5802677B2 (ja) | 2009-12-01 | 2010-12-01 | プロテインキナーゼｃ阻害剤およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110130415A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2507227B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5802677B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2780759A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011068898A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1663242T3 (da) * | 2003-08-07 | 2011-08-01 | Rigel Pharmaceuticals Inc | 2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler |
| CA2801781C (en) | 2010-07-21 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| WO2012075316A2 (en) | 2010-12-01 | 2012-06-07 | Rigel Pharmaceuticals, Inc. | Cyclopropyl mida boronate |
| TWI548621B (zh) | 2011-04-22 | 2016-09-11 | 標誌製藥公司 | 經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法 |
| WO2012174412A2 (en) * | 2011-06-16 | 2012-12-20 | La Jolla Institute For Allergy And Immunology | Compositions targeting pkc-theta and uses and methods of treating pkc-theta pathologies, adverse immune responses and diseases |
| GB201200555D0 (en) * | 2012-01-13 | 2012-02-29 | Univ Birmingham | Peptide |
| US9839671B2 (en) | 2012-01-13 | 2017-12-12 | The University Of Birmingham | Peptide and uses therefor |
| US9321763B2 (en) | 2012-04-04 | 2016-04-26 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
| US8754251B2 (en) | 2012-06-06 | 2014-06-17 | Rigel Pharmaceuticals, Inc. | Cyclopropyl PIDA boronate |
| EP2928891B1 (en) | 2012-12-04 | 2019-02-20 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| US9169249B2 (en) | 2013-03-14 | 2015-10-27 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
| EP3010893B1 (de) | 2013-06-20 | 2019-10-02 | Bayer CropScience Aktiengesellschaft | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| EP3064492B1 (en) * | 2013-10-28 | 2018-12-26 | Sumitomo Chemical Company, Limited | Tetrazolinone compound and application for same |
| NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| WO2015146552A1 (ja) * | 2014-03-28 | 2015-10-01 | 住友化学株式会社 | テトラゾリノン化合物の製造方法 |
| US9399637B2 (en) | 2014-03-28 | 2016-07-26 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| JO3589B1 (ar) * | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| US10059689B2 (en) | 2014-10-14 | 2018-08-28 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| US9513297B2 (en) | 2014-12-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-Jun N-terminal kinase in skin |
| EP3712134B1 (en) | 2014-12-16 | 2023-11-29 | Signal Pharmaceuticals, LLC | Salts of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide |
| US9439888B2 (en) | 2015-01-26 | 2016-09-13 | Rigel Pharmaceuticals, Inc. | Tetrazolones as a carboxylic acid bioisosteres |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| EP3325432B1 (en) | 2015-07-24 | 2020-09-02 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
| EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| EP3383396B1 (en) | 2015-12-04 | 2023-07-12 | Alexion Pharmaceuticals, Inc. | Cerdulatinib and venetoclax for treating non-hodgkin's lymphoma |
| CN106316864A (zh) * | 2016-08-22 | 2017-01-11 | 苏州天马精细化学品股份有限公司 | 4‑甲基‑3‑三氟甲基苯胺的制备方法 |
| EP3544973B1 (en) * | 2016-11-28 | 2021-07-28 | Sumitomo Chemical Company, Limited | Tetrazolinone compounds and its use as pest control agents |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| EP3560913B1 (en) | 2018-04-25 | 2026-07-29 | Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Process for the production of tetrazolinones |
| US10851087B2 (en) | 2018-05-04 | 2020-12-01 | Portola Pharmaceuticals, Inc. | Synthesis of cerdulatinib |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| EP3616724A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with ctm targeting |
| EP3616725A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with polymethine dye targeting |
| WO2025097025A1 (en) * | 2023-11-03 | 2025-05-08 | Evommune, Inc. | Protein kinase c (pkc) theta inhibitor compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136868A (en) * | 1983-11-04 | 1992-08-11 | Fmc Corporation | Herbicidal 1-aryl-4-substituted-1,4-dihydro-5h-tetrazol-5-ones and sulfur analogs thereof |
| JPH0782258A (ja) | 1993-09-14 | 1995-03-28 | Nippon Bayeragrochem Kk | １−置換−テトラゾール−５−オン類の製造方法 |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2002534515A (ja) | 1999-01-13 | 2002-10-15 | ワーナー−ランバート・カンパニー | １−複素環置換されたジアリールアミン |
| JP4460292B2 (ja) * | 2001-10-17 | 2010-05-12 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | ピリミジン誘導体、これらの化合物を含む医薬組成物、その使用及びその調製方法 |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| IL166241A0 (en) * | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
| WO2004043386A2 (en) | 2002-11-08 | 2004-05-27 | Tolerrx, Inc. | Molecules preferentially associated with effector t cells and methods of their use |
| ES2421139T3 (es) | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
| DK1663242T3 (da) * | 2003-08-07 | 2011-08-01 | Rigel Pharmaceuticals Inc | 2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler |
| WO2005020921A2 (en) | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
| KR20060127415A (ko) | 2003-12-24 | 2006-12-12 | 와이어쓰 | 천식의 치료방법 |
| JP2008540436A (ja) * | 2005-05-03 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋキナーゼインヒビターおよびそれらの使用 |
| AU2007257650A1 (en) * | 2006-06-15 | 2007-12-21 | Boehringer Ingelheim International Gmbh | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha |
| CN101903357A (zh) | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| AU2009262068C1 (en) * | 2008-06-27 | 2015-07-02 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| WO2010090875A1 (en) * | 2009-01-21 | 2010-08-12 | Rigel Pharmaceuticals, Inc. | Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases |
-
2010
- 2010-12-01 US US12/958,284 patent/US20110130415A1/en not_active Abandoned
- 2010-12-01 WO PCT/US2010/058597 patent/WO2011068898A1/en not_active Ceased
- 2010-12-01 JP JP2012542165A patent/JP5802677B2/ja not_active Expired - Fee Related
- 2010-12-01 CA CA2780759A patent/CA2780759A1/en not_active Abandoned
- 2010-12-01 EP EP10796518.8A patent/EP2507227B1/en not_active Not-in-force
-
2016
- 2016-09-09 US US15/261,294 patent/US9732070B2/en not_active Expired - Fee Related
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