JP2013510870A5 - - Google Patents

Info

Publication number

JP2013510870A5

JP2013510870A5 JP2012538997A JP2012538997A JP2013510870A5 JP 2013510870 A5 JP2013510870 A5 JP 2013510870A5 JP 2012538997 A JP2012538997 A JP 2012538997A JP 2012538997 A JP2012538997 A JP 2012538997A JP 2013510870 A5 JP2013510870 A5 JP 2013510870A5

Authority

JP

Japan

Prior art keywords

methyl

pharmaceutically acceptable

acceptable salt

fluoro

chloro

Prior art date

2010-11-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• -1 chloro, cyano, cyanomethyl Chemical group 0.000 claims 16
• 150000003839 salts Chemical class 0.000 claims 11
• 150000001875 compounds Chemical class 0.000 claims 10
• 125000001153 fluoro group Chemical group F* 0.000 claims 8
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 239000001257 hydrogen Substances 0.000 claims 6
• OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 5
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
• 125000001309 chloro group Chemical group Cl* 0.000 claims 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
• 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 2
• 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims 1
• ALDFBAMFJCZMRT-UHFFFAOYSA-N 1-[2-[4-[(2-chloro-4,4-difluorospiro[5h-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1N1N=C(C)C(CN2CCC3(CC2)C=2SC(Cl)=CC=2C(F)(F)CO3)=C1 ALDFBAMFJCZMRT-UHFFFAOYSA-N 0.000 claims 1
• QTOTZWFQCWGMHS-UHFFFAOYSA-N 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]methyl]-4,4-difluorospiro[5h-thieno[2,3-c]pyran-7,4'-piperidine] Chemical compound C1=C(CN2CCC3(CC2)C=2SC(Cl)=CC=2C(F)(F)CO3)C(C)=NN1C1=C(F)C=CC=C1F QTOTZWFQCWGMHS-UHFFFAOYSA-N 0.000 claims 1
• RBBAMCYZDBRGRI-UHFFFAOYSA-N 2-chloro-4,4-difluoro-1'-[[1-[2-fluoro-6-(2-methylimidazol-1-yl)phenyl]-3-methylpyrazol-4-yl]methyl]spiro[5h-thieno[2,3-c]pyran-7,4'-piperidine] Chemical compound C1=C(CN2CCC3(CC2)C=2SC(Cl)=CC=2C(F)(F)CO3)C(C)=NN1C1=C(F)C=CC=C1N1C=CN=C1C RBBAMCYZDBRGRI-UHFFFAOYSA-N 0.000 claims 1
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
• 208000019695 Migraine disease Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010033307 Overweight Diseases 0.000 claims 1
• 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
• 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 1
• 206010027599 migraine Diseases 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
• 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 claims 1