KR101368130B1 - Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 - Google Patents

Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 Download PDF

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Publication number
KR101368130B1
KR101368130B1 KR1020127012503A KR20127012503A KR101368130B1 KR 101368130 B1 KR101368130 B1 KR 101368130B1 KR 1020127012503 A KR1020127012503 A KR 1020127012503A KR 20127012503 A KR20127012503 A KR 20127012503A KR 101368130 B1 KR101368130 B1 KR 101368130B1
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methyl
mmol
fluoro
pyran
chloro
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KR20120082927A (ko
Inventor
안나 벨렌 베니토 콜라도
누리아 디아즈 부에조
알마 마리아 지메네즈-아구아도
셀리아 라푸엔테 블랑코
마리아 안젤레스 마르티네즈-그라우
콘셉시온 페드레갈-테르세로
미구엘 앤젤 톨레도 에스크리바노
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020127012503A 2009-11-16 2010-11-12 Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물 Expired - Fee Related KR101368130B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09382245 2009-11-16
EP09382245.0 2009-11-16
US29862810P 2010-01-27 2010-01-27
US61/298,628 2010-01-27
PCT/US2010/056449 WO2011060217A1 (en) 2009-11-16 2010-11-12 Spiropiperidine compounds as orl-1 receptor antagonists

Publications (2)

Publication Number Publication Date
KR20120082927A KR20120082927A (ko) 2012-07-24
KR101368130B1 true KR101368130B1 (ko) 2014-02-27

Family

ID=41800752

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127012503A Expired - Fee Related KR101368130B1 (ko) 2009-11-16 2010-11-12 Ｏｒｌ―１ 수용체 길항제로서의 스피로피페리딘 화합물

Country Status (18)

Country Link
US (1) US20120214784A1 (https=)
EP (1) EP2501704B1 (https=)
JP (1) JP5723381B2 (https=)
KR (1) KR101368130B1 (https=)
CN (1) CN102666550B (https=)
AU (1) AU2010319400B2 (https=)
BR (1) BR112012011710A2 (https=)
CA (1) CA2781041C (https=)
DK (1) DK2501704T3 (https=)
EA (1) EA020391B1 (https=)
ES (1) ES2436241T3 (https=)
HR (1) HRP20130969T1 (https=)
MX (1) MX2012005690A (https=)
PL (1) PL2501704T3 (https=)
PT (1) PT2501704E (https=)
RS (1) RS53017B (https=)
SI (1) SI2501704T1 (https=)
WO (1) WO2011060217A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN106883246B (zh) * 2009-12-04 2020-05-29 桑诺维恩药品公司 多环化合物及其使用方法
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
CA3032141A1 (en) 2016-07-29 2018-02-01 Vadim ALEXANDROV Compounds and compositions and uses thereof
UA125519C2 (uk) 2016-07-29 2022-04-13 Суновіон Фармасьютікалз Інк. Сполуки і композиції і їх застосування
KR20190037305A (ko) 2016-08-10 2019-04-05 바이엘 크롭사이언스 악티엔게젤샤프트 해충 방제제로서의 치환된 2-헤테로시클릴 이미다졸릴-카르복스아미드
IL268694B2 (en) 2017-02-16 2023-10-01 Sunovion Pharmaceuticals Inc Treatment of schizophrenia
DK3589637T3 (da) * 2017-03-02 2021-06-14 Lilly Co Eli Forbindelser, der er anvendelige til inhibering af ROR-GAMMA-T
PL3589638T3 (pl) 2017-03-02 2021-09-27 Eli Lilly And Company Związki użyteczne do hamowania ror-gamma-t
BR112020001433A2 (pt) 2017-08-02 2020-07-28 Sunovion Pharmaceuticals Inc. compostos de isocromano e usos dos mesmos
EA202091945A1 (ru) 2018-02-16 2021-01-18 Суновион Фармасьютикалз Инк. Соли, кристаллические формы и способы их получения
TWI848031B (zh) 2018-12-17 2024-07-11 美商維泰克斯製藥公司 Apol1抑制劑及其使用方法
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
EP3766879A1 (en) 2019-07-19 2021-01-20 Basf Se Pesticidal pyrazole derivatives
CN115734785A (zh) 2020-04-14 2023-03-03 桑诺维恩药品公司 (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症
WO2021252863A1 (en) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and using the same
IL300298B2 (en) 2020-08-26 2025-06-01 Vertex Pharma Inhibitors of apol1 and methods of using same
CN119343353A (zh) * 2022-02-08 2025-01-21 弗特克斯药品有限公司 作为APOL1抑制剂的2-甲基-4',5'-二氢螺[哌啶-4,7'-噻吩并[2,3-c]吡喃]衍生物和其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016913A1 (en) 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders

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Publication number Priority date Publication date Assignee Title
AU2003235912A1 (en) 2002-05-10 2003-11-11 Taisho Pharmaceutical Co., Ltd. Spiro-ring compound
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
CA2563164A1 (en) * 2004-03-29 2005-10-06 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US7655670B2 (en) * 2005-06-02 2010-02-02 Janssen Pharmaceutica N.V. 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016913A1 (en) 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, pp. 3778-3782 (2008-05-16) *

Also Published As

Publication number Publication date
EA020391B1 (ru) 2014-10-30
DK2501704T3 (da) 2013-10-14
EA201290355A1 (ru) 2012-10-30
AU2010319400A1 (en) 2012-06-07
CA2781041C (en) 2015-01-06
CA2781041A1 (en) 2011-05-19
CN102666550A (zh) 2012-09-12
PL2501704T3 (pl) 2014-02-28
ES2436241T3 (es) 2013-12-27
MX2012005690A (es) 2012-06-13
PT2501704E (pt) 2013-12-05
WO2011060217A1 (en) 2011-05-19
EP2501704A1 (en) 2012-09-26
US20120214784A1 (en) 2012-08-23
SI2501704T1 (sl) 2013-11-29
RS53017B (sr) 2014-04-30
AU2010319400B2 (en) 2013-12-19
JP5723381B2 (ja) 2015-05-27
HRP20130969T1 (hr) 2013-11-22
EP2501704B1 (en) 2013-09-18
CN102666550B (zh) 2015-07-15
KR20120082927A (ko) 2012-07-24
JP2013510870A (ja) 2013-03-28
BR112012011710A2 (pt) 2016-03-01

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