JP2013510582A - 間葉幹細胞の球状集合体 - Google Patents

間葉幹細胞の球状集合体 Download PDF

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JP2013510582A
JP2013510582A JP2012539009A JP2012539009A JP2013510582A JP 2013510582 A JP2013510582 A JP 2013510582A JP 2012539009 A JP2012539009 A JP 2012539009A JP 2012539009 A JP2012539009 A JP 2012539009A JP 2013510582 A JP2013510582 A JP 2013510582A
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mesenchymal stem
protein
cells
stem cells
spheroids
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JP2013510582A5 (cg-RX-API-DMAC7.html
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プロコップ,ダーウィン,ジェイ.
バートッシュ,トーマス,ダブリュ.,ジュニア
イロスタロ,ジョニ
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ザ テキサス エーアンドエム ユニバーシティー システム
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012539009A 2009-11-12 2010-11-12 間葉幹細胞の球状集合体 Pending JP2013510582A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26055909P 2009-11-12 2009-11-12
US61/260,559 2009-11-12
PCT/US2010/056502 WO2011060244A1 (en) 2009-11-12 2010-11-12 Spheroidal aggregates of mesenchymal stem cells

Publications (2)

Publication Number Publication Date
JP2013510582A true JP2013510582A (ja) 2013-03-28
JP2013510582A5 JP2013510582A5 (cg-RX-API-DMAC7.html) 2014-01-09

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JP2012539009A Pending JP2013510582A (ja) 2009-11-12 2010-11-12 間葉幹細胞の球状集合体

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US (1) US20120219572A1 (cg-RX-API-DMAC7.html)
JP (1) JP2013510582A (cg-RX-API-DMAC7.html)
WO (1) WO2011060244A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020067477A1 (ja) * 2018-09-28 2020-04-02 日産化学株式会社 パラクライン因子生産促進用培地添加剤

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110223138A1 (en) * 2009-12-17 2011-09-15 Prockop Darwin J Mesenchymal stem cells that express increased amounts of anti-apoptotic proteins
KR20140096105A (ko) * 2011-11-04 2014-08-04 더 텍사스 에이 & 엠 유니버시티 시스템 중간엽 줄기 세포 및/또는 tsg-6 단백질에 의한 이식 거부의 예방 및 치료
EP2626369A1 (en) * 2011-11-24 2013-08-14 Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Engineered mesenchymal stem cells and their therapeutic use
US20150238532A1 (en) * 2012-07-25 2015-08-27 Albert Einstein College Of Medicine Of Yeshiva University Methods to isolate human mesenchymal stem cells
EP2908910A4 (en) * 2012-10-17 2016-06-29 Texas A & M Univ Sys TREATMENT OF BRAIN DAMAGE OR TRAUMA WITH TSG-6 PROTEIN
WO2014066122A1 (en) * 2012-10-24 2014-05-01 The Texas A&M University System Treatment of tumors with activated mesenchymal stem cells
EP3446708A1 (en) * 2012-12-24 2019-02-27 Cell Ideas Pty Ltd. Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy
KR102161726B1 (ko) 2013-04-12 2020-10-06 사베리오 라프란체스카 이식용 장기의 개선
US9790465B2 (en) 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
US10208287B2 (en) * 2014-05-01 2019-02-19 Iheart Japan Corporation CD82-positive cardiac progenitor cells
EP3142485B1 (en) * 2014-05-12 2021-04-28 Roosterbio, Inc. Ready-to-print cells and integrated devices
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용
SG11201703500XA (en) 2014-10-29 2017-05-30 Corning Inc Perfusion bioreactor platform
JP2017532971A (ja) 2014-10-29 2017-11-09 コーニング インコーポレイテッド 細胞培養集合体を生成するためのマイクロウェル設計および製造
US20170342363A1 (en) * 2014-10-29 2017-11-30 Corning Incorporated Devices and methods for generation and culture of 3d cell aggregates
KR102460969B1 (ko) 2014-10-29 2022-10-31 코닝 인코포레이티드 세포 배양 인서트
WO2017127123A1 (en) 2016-01-21 2017-07-27 Abt Holding Company Stem cells for wound healing
EP3652292B1 (en) 2017-07-14 2025-06-18 Corning Incorporated Cell culture vessel for 3d culture and methods of culturing 3d cells
JP7197557B2 (ja) 2017-07-14 2022-12-27 コーニング インコーポレイテッド 多孔性支持体を有する細胞培養槽
CN111051494B (zh) 2017-07-14 2024-03-29 康宁股份有限公司 用于手动或自动培养基交换的3d细胞培养容器
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
US11912968B2 (en) 2018-07-13 2024-02-27 Corning Incorporated Microcavity dishes with sidewall including liquid medium delivery surface
JP7171696B2 (ja) 2018-07-13 2022-11-15 コーニング インコーポレイテッド 相互接続されたウェルを有するマイクロプレートを備えた流体デバイス
EP3649229B1 (en) 2018-07-13 2021-08-25 Corning Incorporated Cell culture vessels with stabilizer devices
CA3160433A1 (en) * 2019-12-09 2021-06-17 Daewoong Pharmaceutical Co., Ltd. Method for preparation of mesenchymal stem cell from human pluripotent stem cell and mesenchymal stem cells prepared thereby
CN113106059B (zh) * 2021-04-07 2023-08-15 清华大学深圳国际研究生院 一种高迁徙间充质干细胞及其制备方法和应用
CN115590883B (zh) * 2021-07-07 2026-07-17 澳门大学 球体物质在制备静脉注射剂中的应用
CN115354029B (zh) * 2022-08-16 2023-09-01 上海长征医院 神经类器官的制备方法和神经类器官

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070154458A1 (en) * 1999-05-28 2007-07-05 The Gov. of the USA as represented by the Sec. of the Dep. of Health & Human Services, Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
JP2008029757A (ja) * 2006-07-31 2008-02-14 Tokyo Univ Of Science 歯の製造方法
WO2008076556A2 (en) * 2006-11-15 2008-06-26 Massachusetts Eye & Ear Infirmary Generation of inner ear cells
JP2009529886A (ja) * 2006-03-17 2009-08-27 インターサイテックス リミティド 毛嚢生成のための細胞同時培養

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165128A1 (en) * 2008-03-07 2011-07-07 Columbia University In The City Of New York Homing in mesenchymal stem cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070154458A1 (en) * 1999-05-28 2007-07-05 The Gov. of the USA as represented by the Sec. of the Dep. of Health & Human Services, Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
JP2009529886A (ja) * 2006-03-17 2009-08-27 インターサイテックス リミティド 毛嚢生成のための細胞同時培養
JP2008029757A (ja) * 2006-07-31 2008-02-14 Tokyo Univ Of Science 歯の製造方法
WO2008076556A2 (en) * 2006-11-15 2008-06-26 Massachusetts Eye & Ear Infirmary Generation of inner ear cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN5013000162; FRITH: 'DYNAMIC THREE-DIMENSIONAL CULTURE METHODS ENHANCE MESENCHYMAL STEM CELL PROPERTIES 以下備考' TISSUE ENGINEERING: PART C V16 N4, 20091109 *
JPN6015001961; STEM CELLS Vol.25, 2007, p.1761-1768 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020067477A1 (ja) * 2018-09-28 2020-04-02 日産化学株式会社 パラクライン因子生産促進用培地添加剤
CN112805268A (zh) * 2018-09-28 2021-05-14 日产化学株式会社 用于促进旁分泌因子的产生的培养基添加试剂

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WO2011060244A1 (en) 2011-05-19
US20120219572A1 (en) 2012-08-30

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