JP2013510229A - 双性イオン性ポリマーからの自己組織化粒子および関連する方法 - Google Patents

双性イオン性ポリマーからの自己組織化粒子および関連する方法 Download PDF

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JP2013510229A
JP2013510229A JP2012538071A JP2012538071A JP2013510229A JP 2013510229 A JP2013510229 A JP 2013510229A JP 2012538071 A JP2012538071 A JP 2012538071A JP 2012538071 A JP2012538071 A JP 2012538071A JP 2013510229 A JP2013510229 A JP 2013510229A
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copolymer
poly
pcb
plga
center
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JP2013510229A5 (https=
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ジャング、シャオイ
カオ、ジチアン
シュ、ホン
ジャン、レイ
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ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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    • C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
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    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/126—Polymer particles coated by polymer, e.g. core shell structures
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    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
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    • C08F2438/00—Living radical polymerisation
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    • C08J2333/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
    • C08J2333/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen

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  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012538071A 2009-11-06 2010-11-08 双性イオン性ポリマーからの自己組織化粒子および関連する方法 Pending JP2013510229A (ja)

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US25908509P 2009-11-06 2009-11-06
US61/259,085 2009-11-06
PCT/US2010/055887 WO2011057225A2 (en) 2009-11-06 2010-11-08 Self-assembled particles from zwitterionic polymers and related methods

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JP2013510229A true JP2013510229A (ja) 2013-03-21
JP2013510229A5 JP2013510229A5 (https=) 2014-01-09

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US (2) US8617592B2 (https=)
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WO2016093224A1 (ja) * 2014-12-08 2016-06-16 三菱化学株式会社 コア・シェル型ポリマー粒子、水系ポリマーエマルジョン、毛髪化粧料組成物
US9535062B2 (en) 2006-12-29 2017-01-03 University Of Washington Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
JP2019512551A (ja) * 2016-03-23 2019-05-16 フー、チェ−ミン ジャックHU, Che−Ming Jack 薄肉シェル型ポリマーナノ粒子及びその使用
JP2020522534A (ja) * 2017-06-06 2020-07-30 ウェイン ステート ユニバーシティＷａｙｎｅ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ カルニチン由来材料に関する方法および組成物
JP2024500879A (ja) * 2020-12-22 2024-01-10 コーネル ユニヴァーシティー 双性イオン性脂質ナノ粒子組成物およびその使用方法
JP2025536873A (ja) * 2023-04-08 2025-11-12 ロック・バイオメディカル・インコーポレイテッド ポリマーソームによる標的化送達のための方法及び組成物
JP7851666B2 (ja) 2023-04-08 2026-04-27 ロック・バイオメディカル・インコーポレイテッド ポリマーソームによる標的化送達のための方法及び組成物

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CN102905730A (zh) * 2009-11-06 2013-01-30 华盛顿大学商业中心 两性离子聚合物生物缀合物以及相关的方法
WO2013013220A2 (en) 2011-07-20 2013-01-24 University Of Washington Through Its Center For Commercialization Photonic blood typing
JP5977269B2 (ja) * 2013-01-22 2016-08-24 アークレイ株式会社 試料の分析方法及びそれに用いる溶液
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
US20140348754A1 (en) 2013-05-14 2014-11-27 California Institute Of Technology Method of Delivering Therapeutics and Imaging Agents to the Brain by Nanoparticles that Cross the Blood Brain Barrier
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US10150088B2 (en) 2013-11-08 2018-12-11 Tufts University Zwitterion-containing membranes
JP6198713B2 (ja) * 2013-12-20 2017-09-20 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 接合部官能性ブロックコポリマ
WO2016077625A1 (en) * 2014-11-12 2016-05-19 Stayton Patrick S Stabilized polymeric carriers for therapeutic agent delivery
CN104644555A (zh) * 2014-11-18 2015-05-27 中国科学院过程工程研究所 一种避免加速血液清除现象的长循环脂质体、制备方法及应用
JP6997455B2 (ja) * 2015-06-02 2022-01-17 ユニバーシティ・オブ・ワシントン 自立非汚染性ポリマー、それらの組成物、および関連モノマー
JP6914860B2 (ja) 2015-07-01 2021-08-04 カリフォルニア インスティチュート オブ テクノロジー カチオン性粘液酸ポリマー系デリバリーシステム
IL243285A0 (en) 2015-12-22 2016-04-21 Yeda Res & Dev Analogues of lipids and liposomes containing them
US10947338B2 (en) * 2016-03-29 2021-03-16 Lg Chem, Ltd. Block polymer and polymer electrolyte membrane comprising same
DK3570874T3 (da) * 2017-01-17 2023-04-11 Univ Wayne State Zwitterionisk polymer-insulin-sammensætninger og dertil relaterede fremgangsmåder
JP7102423B2 (ja) 2017-02-16 2022-07-19 イェダ リサーチ アンド ディベロップメント カンパニー リミテッド リポソームの薬物送達ビヒクル
WO2019241327A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
CN109503848A (zh) * 2018-11-02 2019-03-22 宜春学院 一种肝癌靶向的纳米递药系统及其制备方法和用途
CN109821031A (zh) * 2019-02-01 2019-05-31 中国医学科学院生物医学工程研究所 羧酸甜菜碱两性离子聚合物氟-19磁共振成像造影剂的合成和应用
CN115298189B (zh) 2019-12-04 2024-08-30 丹塔里股份有限公司 合成治疗性纳米颗粒的方法和组合物
CN111514308B (zh) * 2020-03-10 2023-02-17 西南民族大学 pH诱导电荷翻转型抗菌金纳米棒及其制备方法和应用
US12551434B2 (en) * 2020-05-20 2026-02-17 Wayne State University Zwitterionic polymer particle compositions and related methods
WO2022152141A2 (en) * 2021-01-14 2022-07-21 Suzhou Abogen Biosciences Co., Ltd. Polymer conjugated lipid compounds and lipid nanoparticle compositions
US20250064741A1 (en) * 2021-12-21 2025-02-27 Cornell University Methods for enhanced nucleic acid delivery
WO2023249926A2 (en) * 2022-06-20 2023-12-28 Cornell University Fluorinated zwitterionic polymers and methods of use
EP4458870A1 (en) * 2023-05-04 2024-11-06 Université de Liège Polymer derivatives and their use as lipid nanoparticle modifiers
CN119661825B (zh) * 2023-09-19 2025-11-14 上海交通大学 聚两性离子-胆酸及其合成以及其在药物递送中的应用
WO2025194120A1 (en) * 2024-03-14 2025-09-18 Massachusetts Institute Of Technology Zwitterionic polymer functionalized lipid nanoparticles for delivery of nucleic acids

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