JP2013509201A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013509201A5 JP2013509201A5 JP2012537194A JP2012537194A JP2013509201A5 JP 2013509201 A5 JP2013509201 A5 JP 2013509201A5 JP 2012537194 A JP2012537194 A JP 2012537194A JP 2012537194 A JP2012537194 A JP 2012537194A JP 2013509201 A5 JP2013509201 A5 JP 2013509201A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- polypeptide
- optionally
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25745809P | 2009-11-02 | 2009-11-02 | |
| US61/257,458 | 2009-11-02 | ||
| US37075210P | 2010-08-04 | 2010-08-04 | |
| US61/370,752 | 2010-08-04 | ||
| PCT/US2010/055131 WO2011053982A2 (en) | 2009-11-02 | 2010-11-02 | Therapeutic nuclease compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016045546A Division JP2016174604A (ja) | 2009-11-02 | 2016-03-09 | 治療用ヌクレアーゼ組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013509201A JP2013509201A (ja) | 2013-03-14 |
| JP2013509201A5 true JP2013509201A5 (https=) | 2013-12-19 |
| JP6199033B2 JP6199033B2 (ja) | 2017-09-20 |
Family
ID=43923071
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537194A Active JP6199033B2 (ja) | 2009-11-02 | 2010-11-02 | 治療用ヌクレアーゼ組成物および方法 |
| JP2016045546A Pending JP2016174604A (ja) | 2009-11-02 | 2016-03-09 | 治療用ヌクレアーゼ組成物および方法 |
| JP2018024633A Active JP7081935B2 (ja) | 2009-11-02 | 2018-02-15 | 治療用ヌクレアーゼ組成物および方法 |
| JP2020127299A Pending JP2021006026A (ja) | 2009-11-02 | 2020-07-28 | 治療用ヌクレアーゼ組成物および方法 |
| JP2020128888A Active JP7237045B2 (ja) | 2009-11-02 | 2020-07-30 | 治療用ヌクレアーゼ組成物および方法 |
| JP2023029040A Active JP7657249B2 (ja) | 2009-11-02 | 2023-02-28 | 治療用ヌクレアーゼ組成物および方法 |
| JP2024228230A Pending JP2025041849A (ja) | 2009-11-02 | 2024-12-25 | 治療用ヌクレアーゼ組成物および方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016045546A Pending JP2016174604A (ja) | 2009-11-02 | 2016-03-09 | 治療用ヌクレアーゼ組成物および方法 |
| JP2018024633A Active JP7081935B2 (ja) | 2009-11-02 | 2018-02-15 | 治療用ヌクレアーゼ組成物および方法 |
| JP2020127299A Pending JP2021006026A (ja) | 2009-11-02 | 2020-07-28 | 治療用ヌクレアーゼ組成物および方法 |
| JP2020128888A Active JP7237045B2 (ja) | 2009-11-02 | 2020-07-30 | 治療用ヌクレアーゼ組成物および方法 |
| JP2023029040A Active JP7657249B2 (ja) | 2009-11-02 | 2023-02-28 | 治療用ヌクレアーゼ組成物および方法 |
| JP2024228230A Pending JP2025041849A (ja) | 2009-11-02 | 2024-12-25 | 治療用ヌクレアーゼ組成物および方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (10) | US20130089546A1 (https=) |
| EP (3) | EP2496691B1 (https=) |
| JP (7) | JP6199033B2 (https=) |
| KR (5) | KR102624939B1 (https=) |
| CN (3) | CN106399276B (https=) |
| AU (4) | AU2010313103B2 (https=) |
| BR (1) | BR112012010202A2 (https=) |
| CA (2) | CA2779615C (https=) |
| CY (3) | CY1119166T1 (https=) |
| DK (3) | DK3202898T3 (https=) |
| ES (2) | ES2626000T3 (https=) |
| HR (2) | HRP20170757T1 (https=) |
| HU (2) | HUE041426T2 (https=) |
| IL (4) | IL297588A (https=) |
| LT (3) | LT3202898T (https=) |
| MX (3) | MX341084B (https=) |
| NZ (1) | NZ813794A (https=) |
| PL (2) | PL2496691T3 (https=) |
| PT (2) | PT2496691T (https=) |
| RS (1) | RS55989B1 (https=) |
| SG (3) | SG10201406801XA (https=) |
| SI (3) | SI2496691T1 (https=) |
| SM (1) | SMT201700248T1 (https=) |
| WO (1) | WO2011053982A2 (https=) |
| ZA (3) | ZA201705246B (https=) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX341084B (es) | 2009-11-02 | 2016-08-05 | Univ Washington | Composiciones de nucleasas terapéuticas y métodos. |
| ES2666303T3 (es) | 2011-04-29 | 2018-05-03 | University Of Washington | Composiciones terapéuticas de nucleasa y métodos |
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| FR2983212A1 (fr) | 2011-11-28 | 2013-05-31 | Lfb Biotechnologies | Aptameres anti-fh, procede pour leur obtention et utilisations |
| US9603907B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Dry powder formulations of dNase I |
| US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| HRP20192080T1 (hr) | 2013-10-31 | 2020-02-07 | Resolve Therapeutics, Llc | Terapeutske fuzije nukleaza-albumine i postupci |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| WO2015077491A1 (en) | 2013-11-20 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| WO2016069889A1 (en) * | 2014-10-31 | 2016-05-06 | Resolve Therapeutics, Llc | Therapeutic nuclease-transferrin fusions and methods |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CA3029627A1 (en) * | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3351263A1 (en) | 2017-01-20 | 2018-07-25 | Universitätsklinikum Hamburg-Eppendorf | Pharmaceutical preparation for treating or preventing tissue adhesion |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| JP6263298B1 (ja) * | 2017-05-09 | 2018-01-17 | 東京瓦斯株式会社 | 検針データの処理システム、その処理プログラム、その処理装置、その処理方法、およびガスメータ |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| DK3668972T3 (da) * | 2017-08-18 | 2025-01-13 | Neutrolis Inc | Konstruerede dnase-enzymer og anvendelse i terapi |
| CA3073537A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| KR20250133482A (ko) | 2018-05-11 | 2025-09-05 | 빔 테라퓨틱스, 인크. | 프로그래밍가능한 염기 편집기 시스템을 이용하여 단일 뉴클레오티드 다형성을 편집하는 방법 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CA3108281A1 (en) | 2018-08-03 | 2020-02-06 | Beam Therapeutics Inc. | Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence |
| IL325846A (en) | 2018-10-08 | 2026-03-01 | Neutrolis Inc | Engineering deoxyribonuclease enzymes for manufacturing and medicine |
| US10988746B2 (en) | 2018-10-08 | 2021-04-27 | Neutrolis, Inc. | Manufacturing and engineering of DNASE enzymes for therapy |
| US11058724B2 (en) | 2018-10-08 | 2021-07-13 | Neutrolis, Inc. | Methods of using DNASE1-like 3 in therapy |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US20220282275A1 (en) | 2018-11-15 | 2022-09-08 | The Broad Institute, Inc. | G-to-t base editors and uses thereof |
| WO2020142740A1 (en) * | 2019-01-04 | 2020-07-09 | Resolve Therapeutics, Llc | Treatment of sjogren's disease with nuclease fusion proteins |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| US11352613B2 (en) | 2019-02-04 | 2022-06-07 | Neutrolis, Inc. | Engineered human extracellular DNASE enzymes |
| WO2020181178A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through thymine alkylation |
| WO2020181195A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenine excision |
| WO2020181193A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenosine methylation |
| WO2020181180A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to c:g base editors and uses thereof |
| WO2020181202A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to t:a base editing through adenine deamination and oxidation |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021030666A1 (en) | 2019-08-15 | 2021-02-18 | The Broad Institute, Inc. | Base editing by transglycosylation |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20230086199A1 (en) | 2019-11-26 | 2023-03-23 | The Broad Institute, Inc. | Systems and methods for evaluating cas9-independent off-target editing of nucleic acids |
| IL294114A (en) * | 2020-01-11 | 2022-08-01 | Univ Yale | Preparations and methods for the treatment, improvement and/or prevention of diseases or disorders caused by or related to dnase1 and/or dnase1l3 |
| EP4100519A2 (en) | 2020-02-05 | 2022-12-14 | The Broad Institute, Inc. | Adenine base editors and uses thereof |
| EP3881862A1 (de) * | 2020-03-18 | 2021-09-22 | Pharis Biotec GmbH | Polypeptid zur therapie von glomerulären nierenerkrankungen und analyse des verlaufes und prognose der abhängigen syndrome |
| EP4143315A1 (en) | 2020-04-28 | 2023-03-08 | The Broad Institute Inc. | <smallcaps/>? ? ?ush2a? ? ? ? ?targeted base editing of thegene |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| EP4161645A4 (en) * | 2020-06-08 | 2023-11-01 | Yale University | COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING COAGULOPATHY AND/OR SEPSIS IN PATIENTS WITH BACTERIAL AND/OR VIRAL INFECTIONS |
| CA3165342A1 (en) | 2020-06-29 | 2022-01-06 | James Arthur Posada | Treatment of sjogren's syndrome with nuclease fusion proteins |
| US12336973B2 (en) | 2020-09-25 | 2025-06-24 | Providence Health & Services—Oregon | Cancer therapeutic compositions and methods targeting DNAse1L3 |
| CA3208612A1 (en) | 2021-02-19 | 2022-08-25 | Beam Therapeutics Inc. | Recombinant rabies viruses for gene therapy |
| JP2024507220A (ja) * | 2021-02-19 | 2024-02-16 | セリピオン, インコーポレイテッド | パラオキソナーゼ融合ポリペプチドならびに関連する組成物および方法 |
| CA3230629A1 (en) | 2021-09-08 | 2023-03-16 | Beam Therapeutics Inc. | Viral guide rna delivery |
| WO2024040083A1 (en) | 2022-08-16 | 2024-02-22 | The Broad Institute, Inc. | Evolved cytosine deaminases and methods of editing dna using same |
| WO2024155745A1 (en) | 2023-01-18 | 2024-07-25 | The Broad Institute, Inc. | Base editing-mediated readthrough of premature termination codons (bert) |
| WO2025147696A1 (en) | 2024-01-05 | 2025-07-10 | Resolve Therapeutics, Llc | Treatment of symptoms associated with sars-cov viral infection or a prior sars-cov viral infection with nuclease agents |
| US12416020B2 (en) | 2024-02-20 | 2025-09-16 | Wyvern Pharmaceuticals Inc. | Plasmid encoding a TLR3 and Fc fusion protein |
| WO2026072421A2 (en) | 2024-09-27 | 2026-04-02 | The Broad Institute, Inc. | Base editing methods and compositions for editing prnp in the treatment of prion disease |
Family Cites Families (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5453269A (en) * | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5559212A (en) | 1988-04-06 | 1996-09-24 | Alfacell Corporation | Frog embryo and egg-derived tumor cell anti-proliferation protein |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5840840A (en) | 1990-04-17 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Selective RNase cytotoxic reagents |
| ES2133285T3 (es) | 1991-04-17 | 1999-09-16 | Medisup Int Nv | Polipeptidos hidrosolubles que tienen una alta afinidad para los interferones alfa y beta. |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5470582A (en) | 1992-02-07 | 1995-11-28 | Syntex (U.S.A.) Inc. | Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles |
| GB9300686D0 (en) | 1993-01-15 | 1993-03-03 | Imp Cancer Res Tech | Compounds for targeting |
| US20030108548A1 (en) | 1993-06-01 | 2003-06-12 | Bluestone Jeffrey A. | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| GB9422383D0 (en) | 1994-11-05 | 1995-01-04 | Wellcome Found | Antibodies |
| US6348343B2 (en) | 1995-02-24 | 2002-02-19 | Genentech, Inc. | Human DNase I variants |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
| BR9606706A (pt) * | 1995-10-16 | 1999-04-06 | Unilever Nv | Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo |
| US6482626B2 (en) | 1996-02-05 | 2002-11-19 | Genentech, Inc. | Human DNase |
| US6716974B1 (en) * | 1996-05-31 | 2004-04-06 | Maine Medical Center Research Institute | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
| US6391607B1 (en) | 1996-06-14 | 2002-05-21 | Genentech, Inc. | Human DNase I hyperactive variants |
| DE69738522T2 (de) | 1996-08-02 | 2009-04-02 | Bristol-Myers Squibb Co. | Ein verfahren zur inhibierung immunglobulininduzierter toxizität aufgrund von der verwendung von immunoglobinen in therapie und in vivo diagnostik |
| US7247302B1 (en) | 1996-08-02 | 2007-07-24 | Bristol-Myers Squibb Company | Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis |
| US6653104B2 (en) | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
| DK0932417T3 (da) | 1996-10-17 | 2003-04-14 | Immunomedics Inc | Non-antigent toxinkonjugat og fusionsprotein af internaliserende receptorsystem |
| WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US20030068623A1 (en) | 1997-06-16 | 2003-04-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20020192659A1 (en) | 1997-09-17 | 2002-12-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6280991B1 (en) | 1997-10-15 | 2001-08-28 | Wisconsin Alumni Research Foundation | Engineered cytotoxic ribonclease |
| US5840296A (en) | 1997-10-15 | 1998-11-24 | Raines; Ronald T. | Engineered cytotoxic ribonuclease A |
| ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1006183A1 (en) | 1998-12-03 | 2000-06-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Recombinant soluble Fc receptors |
| US6239257B1 (en) | 1998-12-30 | 2001-05-29 | Alfacell Corporation | Family of proteins belonging to the pancreatic ribonuclease a superfamily |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PL209392B1 (pl) | 1999-01-15 | 2011-08-31 | Genentech Inc | Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała |
| IL147270A0 (en) | 1999-07-02 | 2002-08-14 | Genentech Inc | Fusion peptides comprising a peptide ligand domain and a multimerization domain |
| US6175003B1 (en) | 1999-09-10 | 2001-01-16 | Alfacell Corporation | Nucleic acids encoding ribonucleases and methods of making them |
| WO2001026608A2 (en) | 1999-10-14 | 2001-04-19 | Ledbetter Jeffrey A | Dna vaccines encoding antigen linked to a domain that binds cd40 |
| GB0029407D0 (en) | 2000-12-01 | 2001-01-17 | Affitech As | Product |
| US7083784B2 (en) | 2000-12-12 | 2006-08-01 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| NZ527283A (en) | 2001-01-29 | 2006-03-31 | Biogen Idec Inc | Modified antibodies and methods of use |
| WO2002096948A2 (en) | 2001-01-29 | 2002-12-05 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| JP4586310B2 (ja) | 2001-07-04 | 2010-11-24 | 株式会社Ihi | セラミックス複合部材の製造方法 |
| US20060040262A1 (en) * | 2002-12-27 | 2006-02-23 | Morris David W | Novel compositions and methods in cancer |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| JP2006502091A (ja) | 2002-03-01 | 2006-01-19 | イミューノメディクス、インコーポレイテッド | クリアランス速度を高めるための二重特異性抗体点変異 |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| CA2489446A1 (en) | 2002-06-14 | 2003-12-24 | Wisconsin Alumni Research Foundation | Ribonuclease zymogen design |
| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| EP1553975B8 (en) | 2002-09-27 | 2023-04-12 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| DK1562972T3 (da) | 2002-10-15 | 2010-12-06 | Facet Biotech Corp | Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese |
| EP1578367A4 (en) | 2002-11-01 | 2012-05-02 | Genentech Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE DISEASES |
| GB2395337B (en) | 2002-11-14 | 2005-12-28 | Gary Michael Wilson | Warning Unit |
| CA2512729C (en) | 2003-01-09 | 2014-09-16 | Macrogenics, Inc. | Identification and engineering of antibodies with variant fc regions and methods of using same |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
| US7067298B2 (en) | 2003-03-31 | 2006-06-27 | Ambion, Inc. | Compositions and methods of using a synthetic Dnase I |
| US7666417B2 (en) * | 2003-04-22 | 2010-02-23 | Fred Hutchinson Cancer Research Center | Methods and compositions for treating autoimmune diseases or conditions |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| AU2004266159A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| GB0324368D0 (en) | 2003-10-17 | 2003-11-19 | Univ Cambridge Tech | Polypeptides including modified constant regions |
| US9296820B2 (en) | 2003-11-05 | 2016-03-29 | Roche Glycart Ag | Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function |
| WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| WO2005063815A2 (en) * | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| EP1697520A2 (en) | 2003-12-22 | 2006-09-06 | Xencor, Inc. | Fc polypeptides with novel fc ligand binding sites |
| RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
| SI1706424T1 (sl) | 2004-01-12 | 2010-01-29 | Applied Molecular Evolution | Variante fc regij |
| US7544487B2 (en) | 2004-02-13 | 2009-06-09 | Immunomedics, Inc. | Fusion proteins containing recombinant cytotoxic RNAses |
| EP1737890A2 (en) | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| WO2005123780A2 (en) | 2004-04-09 | 2005-12-29 | Protein Design Labs, Inc. | Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP2008505853A (ja) | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
| WO2006085967A2 (en) | 2004-07-09 | 2006-08-17 | Xencor, Inc. | OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS |
| EP2471813B1 (en) | 2004-07-15 | 2014-12-31 | Xencor, Inc. | Optimized Fc variants |
| AU2005334481A1 (en) | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
| WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
| DE102005009219A1 (de) | 2005-02-25 | 2006-08-31 | Martin-Luther-Universität Halle-Wittenberg | Ribonuclease-Tandemenzyme und Verfahren zu ihrer Herstellung |
| US20110123440A1 (en) | 2005-03-29 | 2011-05-26 | Genevieve Hansen | Altered Antibody FC Regions and Uses Thereof |
| BRPI0611445A2 (pt) | 2005-05-09 | 2010-09-08 | Glycart Biotechnology Ag | molécula de ligação a antìgeno glicomanipulada, polinucleotìdeo, polipeptìdeo, vetor, célula hospedeira, método para produção, uso e composição farmacêutica |
| EP1910541B1 (en) | 2005-06-16 | 2010-10-20 | Wisconsin Alumni Research Foundation | Cytotoxic ribonuclease variants |
| EP1896579A2 (en) | 2005-06-16 | 2008-03-12 | Wisconsin Alumni Research Foundation | Cytotoxic ribonuclease variants |
| RU2423381C2 (ru) | 2005-07-25 | 2011-07-10 | Трабьон Фармасьютикалз, Инк. | Снижение количества в-клеток с использованием cd37-специфических и cd20-специфических связывающих молекул |
| US20080279850A1 (en) | 2005-07-25 | 2008-11-13 | Trubion Pharmaceuticals, Inc. | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules |
| US7807409B2 (en) | 2005-10-21 | 2010-10-05 | Roche Palo Alto Llc | Method for the recombinant expression of a polypeptide |
| AU2007238034A1 (en) | 2006-04-14 | 2007-10-25 | Trubion Pharmaceuticals Inc. | Binding proteins comprising immunoglobulin hinge and Fc regions having altered Fc effector functions |
| US20100015661A1 (en) | 2006-04-21 | 2010-01-21 | Mab-Factory Gmbh | Antibody-rnase-conjugate |
| GB0611444D0 (en) * | 2006-06-09 | 2006-07-19 | Medical Res Council Technology | Rnase H2 complex and genes therefor |
| NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
| EP1905841A1 (en) * | 2006-09-25 | 2008-04-02 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Trex1 as a marker for lupus erythematosus |
| EP2144930A1 (en) | 2007-04-18 | 2010-01-20 | ZymoGenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| JP2010531137A (ja) | 2007-06-12 | 2010-09-24 | ワイス・エルエルシー | 抗cd20治療用組成物および方法 |
| JP2010532764A (ja) * | 2007-07-06 | 2010-10-14 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | C末端に配置された特異的結合性ドメインを有する結合性ペプチド |
| WO2009015345A1 (en) * | 2007-07-25 | 2009-01-29 | Amgen Inc. | Pharmaceutical compositions comprising fc fusion proteins |
| BRPI0814465B1 (pt) | 2007-07-26 | 2021-11-23 | Novagen Holding Corporation | Proteína de fusão, dímero, método para produzir uma proteína de fusão, linhagem de célula, usos de uma proteína de fusão e de uma composição farmacêutica e composição farmacêutica |
| CA2705542A1 (en) * | 2007-11-13 | 2009-05-22 | Sapphire Energy, Inc. | Production of fc-fusion polypeptides in eukaryotic algae |
| RU2531754C2 (ru) | 2008-04-11 | 2014-10-27 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ,ЭлЭлСи,US | Связывающееся с cd37 иммунотерапевтическое средство и его комбинация с бифункциональным химиотерапевтическим средством |
| CN102224258A (zh) | 2008-09-26 | 2011-10-19 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗、诊断和监测狼疮的方法 |
| BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
| MX341084B (es) | 2009-11-02 | 2016-08-05 | Univ Washington | Composiciones de nucleasas terapéuticas y métodos. |
| TWI529163B (zh) | 2011-01-25 | 2016-04-11 | 陶氏農業科學公司 | 用於製備4-胺基-5-氟-3-鹵素-6-(經取代之)吡啶甲酸酯的方法 |
| EA201370187A1 (ru) | 2011-02-23 | 2013-12-30 | Амген Инк. | Клеточная культуральная среда для уфс воздействия и относящиеся к ней способы |
| MX363013B (es) | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| RS61447B1 (sr) | 2011-04-21 | 2021-03-31 | Glaxo Group Ltd | Modulacija ekspresije virusa hepatitisa b (hbv) |
| ES2666303T3 (es) | 2011-04-29 | 2018-05-03 | University Of Washington | Composiciones terapéuticas de nucleasa y métodos |
| US20140178479A1 (en) | 2011-08-12 | 2014-06-26 | Perosphere, Inc. | Concentrated Felbamate Formulations for Parenteral Administration |
| WO2013180295A1 (ja) | 2012-06-01 | 2013-12-05 | 日本電信電話株式会社 | パケット転送処理方法およびパケット転送処理装置 |
| HRP20192080T1 (hr) | 2013-10-31 | 2020-02-07 | Resolve Therapeutics, Llc | Terapeutske fuzije nukleaza-albumine i postupci |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| CA3029627A1 (en) | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| JP6349003B1 (ja) | 2017-03-17 | 2018-06-27 | 東洋ビーネット株式会社 | 耐熱性ルシフェラーゼ |
-
2010
- 2010-11-02 MX MX2012005062A patent/MX341084B/es active IP Right Grant
- 2010-11-02 DK DK16198956.1T patent/DK3202898T3/en active
- 2010-11-02 HR HRP20170757TT patent/HRP20170757T1/hr unknown
- 2010-11-02 LT LTEP16198956.1T patent/LT3202898T/lt unknown
- 2010-11-02 SG SG10201406801XA patent/SG10201406801XA/en unknown
- 2010-11-02 CN CN201610979041.9A patent/CN106399276B/zh active Active
- 2010-11-02 EP EP10827655.1A patent/EP2496691B1/en active Active
- 2010-11-02 RS RS20170510A patent/RS55989B1/sr unknown
- 2010-11-02 KR KR1020227009207A patent/KR102624939B1/ko active Active
- 2010-11-02 LT LTEP10827655.1T patent/LT2496691T/lt unknown
- 2010-11-02 SG SG10201912571XA patent/SG10201912571XA/en unknown
- 2010-11-02 ES ES10827655.1T patent/ES2626000T3/es active Active
- 2010-11-02 HU HUE16198956A patent/HUE041426T2/hu unknown
- 2010-11-02 KR KR1020127014363A patent/KR101934923B1/ko active Active
- 2010-11-02 SI SI201031462A patent/SI2496691T1/sl unknown
- 2010-11-02 JP JP2012537194A patent/JP6199033B2/ja active Active
- 2010-11-02 CA CA2779615A patent/CA2779615C/en active Active
- 2010-11-02 HU HUE10827655A patent/HUE032166T2/en unknown
- 2010-11-02 DK DK10827655.1T patent/DK2496691T3/en active
- 2010-11-02 SI SI201031820T patent/SI3202898T1/sl unknown
- 2010-11-02 CA CA3091939A patent/CA3091939A1/en active Pending
- 2010-11-02 KR KR1020247000800A patent/KR20240007725A/ko not_active Ceased
- 2010-11-02 MX MX2014013439A patent/MX360465B/es unknown
- 2010-11-02 PT PT108276551T patent/PT2496691T/pt unknown
- 2010-11-02 SG SG10201912573YA patent/SG10201912573YA/en unknown
- 2010-11-02 DK DK18190143.0T patent/DK3460056T3/da active
- 2010-11-02 KR KR1020187037619A patent/KR102118584B1/ko active Active
- 2010-11-02 KR KR1020207015149A patent/KR102378465B1/ko active Active
- 2010-11-02 PT PT16198956T patent/PT3202898T/pt unknown
- 2010-11-02 SM SM20170248T patent/SMT201700248T1/it unknown
- 2010-11-02 PL PL10827655T patent/PL2496691T3/pl unknown
- 2010-11-02 CN CN201080060471.1A patent/CN102770533B/zh active Active
- 2010-11-02 EP EP18190143.0A patent/EP3460056B1/en active Active
- 2010-11-02 WO PCT/US2010/055131 patent/WO2011053982A2/en not_active Ceased
- 2010-11-02 CN CN202110852975.7A patent/CN113528485B/zh active Active
- 2010-11-02 PL PL16198956T patent/PL3202898T3/pl unknown
- 2010-11-02 IL IL297588A patent/IL297588A/en unknown
- 2010-11-02 BR BR112012010202A patent/BR112012010202A2/pt not_active Application Discontinuation
- 2010-11-02 NZ NZ813794A patent/NZ813794A/en unknown
- 2010-11-02 ES ES16198956T patent/ES2702053T3/es active Active
- 2010-11-02 LT LTEP18190143.0T patent/LT3460056T/lt unknown
- 2010-11-02 EP EP16198956.1A patent/EP3202898B1/en active Active
- 2010-11-02 AU AU2010313103A patent/AU2010313103B2/en active Active
- 2010-11-02 SI SI201032038T patent/SI3460056T1/sl unknown
- 2010-11-02 US US13/505,421 patent/US20130089546A1/en not_active Abandoned
-
2011
- 2011-08-03 US US13/197,731 patent/US8841416B2/en active Active
-
2012
- 2012-04-29 IL IL219475A patent/IL219475A0/en active IP Right Grant
- 2012-04-30 MX MX2018013333A patent/MX2018013333A/es unknown
-
2013
- 2013-03-12 US US13/796,730 patent/US20130177561A1/en not_active Abandoned
- 2013-03-13 US US13/799,843 patent/US20130184334A1/en not_active Abandoned
- 2013-03-13 US US13/799,854 patent/US20130183308A1/en not_active Abandoned
-
2014
- 2014-04-22 US US14/258,319 patent/US20140227269A1/en not_active Abandoned
- 2014-10-16 US US14/516,161 patent/US9790479B2/en active Active
-
2016
- 2016-03-09 JP JP2016045546A patent/JP2016174604A/ja active Pending
- 2016-04-06 AU AU2016202135A patent/AU2016202135B2/en active Active
-
2017
- 2017-05-22 CY CY20171100532T patent/CY1119166T1/el unknown
- 2017-08-03 ZA ZA2017/05246A patent/ZA201705246B/en unknown
- 2017-08-17 US US15/679,746 patent/US11306297B2/en active Active
-
2018
- 2018-02-14 AU AU2018201071A patent/AU2018201071B2/en active Active
- 2018-02-15 JP JP2018024633A patent/JP7081935B2/ja active Active
- 2018-09-05 ZA ZA201805962A patent/ZA201805962B/en unknown
- 2018-11-21 IL IL263180A patent/IL263180B/en active IP Right Grant
- 2018-12-12 HR HRP20182102TT patent/HRP20182102T1/hr unknown
- 2018-12-21 CY CY20181101388T patent/CY1121220T1/el unknown
-
2020
- 2020-04-22 AU AU2020202688A patent/AU2020202688B2/en active Active
- 2020-04-28 IL IL274309A patent/IL274309B2/en unknown
- 2020-07-28 JP JP2020127299A patent/JP2021006026A/ja active Pending
- 2020-07-30 JP JP2020128888A patent/JP7237045B2/ja active Active
- 2020-08-21 ZA ZA2020/05216A patent/ZA202005216B/en unknown
- 2020-11-03 CY CY20201101036T patent/CY1123684T1/el unknown
-
2022
- 2022-03-16 US US17/696,364 patent/US12435322B2/en active Active
-
2023
- 2023-02-28 JP JP2023029040A patent/JP7657249B2/ja active Active
-
2024
- 2024-12-25 JP JP2024228230A patent/JP2025041849A/ja active Pending
-
2025
- 2025-08-08 US US19/294,688 patent/US20260035680A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013509201A5 (https=) | ||
| JP2014519809A5 (https=) | ||
| US12152060B2 (en) | Interleukin-2 variants and methods of uses thereof | |
| US20230355728A1 (en) | Peptidic chimeric antigen receptor t cell switches and uses thereof | |
| HRP20170757T1 (hr) | Terapeutski pripravci nukleaze i postupci | |
| JP7663628B2 (ja) | サイトカイン融合タンパク質 | |
| JP2021007390A5 (https=) | ||
| TWI838621B (zh) | 具有經修飾重鏈恆定區之多特異性重鏈抗體 | |
| ES2666303T3 (es) | Composiciones terapéuticas de nucleasa y métodos | |
| JP2020203926A5 (https=) | ||
| EP3201231B1 (en) | Methods of treating systemic lupus erythematosus using a domain antibody directed against cd28 | |
| JP2019536437A5 (https=) | ||
| KR20170074852A (ko) | 대사 장애를 치료하기 위한 조성물 및 사용 방법 | |
| JP2019530430A5 (https=) | ||
| JP7702445B2 (ja) | 免疫調節融合タンパク質 | |
| WO2008138017A2 (en) | Methods and compositions for modifying t cell immune responses and inflammation | |
| EP4438054A2 (en) | Methods and uses of variant icos ligand (icosl) fusion proteins | |
| JP2024503506A (ja) | インターロイキン-2変異体およびその使用 | |
| KR20140135766A (ko) | 종양괴사인자 수용체 융합 단백질 및 이를 이용하는 방법 | |
| WO2022050401A2 (en) | Interleukin-2 muteins and uses thereof | |
| AU2021217373A1 (en) | Method of treating a solid tumor with a combination of an IL-7 protein and CAR-bearing immune cells | |
| EP3268382A1 (en) | Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use | |
| HRP20201752T1 (hr) | Terapeutski pripravci nukleaze i postupci | |
| Choi | New Therapeutic Challenges | |
| WO2008003748A2 (en) | Cd300lg polypeptides and their use in treating autoimmune diseases |