JP2013507352A5 - - Google Patents

Info

Publication number

JP2013507352A5

JP2013507352A5 JP2012532683A JP2012532683A JP2013507352A5 JP 2013507352 A5 JP2013507352 A5 JP 2013507352A5 JP 2012532683 A JP2012532683 A JP 2012532683A JP 2012532683 A JP2012532683 A JP 2012532683A JP 2013507352 A5 JP2013507352 A5 JP 2013507352A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

pharmaceutically acceptable

acceptable salt

composition according

propargyl

Prior art date

2010-10-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims description 21
• RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 14
• 201000002212 progressive supranuclear palsy Diseases 0.000 claims description 10
• 208000024891 symptom Diseases 0.000 claims description 6
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 4
• 206010003591 Ataxia Diseases 0.000 claims description 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
• 208000019505 Deglutition disease Diseases 0.000 claims description 2
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
• 206010035664 Pneumonia Diseases 0.000 claims description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
• 206010047571 Visual impairment Diseases 0.000 claims description 2
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical group CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 2
• JDBJJCWRXSVHOQ-UHFFFAOYSA-N methanesulfonic acid;n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound CS(O)(=O)=O.C1=CC=C2C(NCC#C)CCC2=C1 JDBJJCWRXSVHOQ-UHFFFAOYSA-N 0.000 claims description 2
• 230000001144 postural effect Effects 0.000 claims description 2
• 208000027765 speech disease Diseases 0.000 claims description 2
• 229940095064 tartrate Drugs 0.000 claims description 2
• 208000029257 vision disease Diseases 0.000 claims description 2
• 230000004393 visual impairment Effects 0.000 claims description 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 238000000034 method Methods 0.000 description 13
• 206010017577 Gait disturbance Diseases 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 229940001133 rasagiline 1 mg Drugs 0.000 description 1