JP2013506692A5 - - Google Patents
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- JP2013506692A5 JP2013506692A5 JP2012532346A JP2012532346A JP2013506692A5 JP 2013506692 A5 JP2013506692 A5 JP 2013506692A5 JP 2012532346 A JP2012532346 A JP 2012532346A JP 2012532346 A JP2012532346 A JP 2012532346A JP 2013506692 A5 JP2013506692 A5 JP 2013506692A5
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- JP
- Japan
- Prior art keywords
- liquid composition
- group
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- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 15
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims description 14
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 claims description 12
- 229960004114 olopatadine Drugs 0.000 claims description 12
- -1 amidoalkyl Chemical group 0.000 claims description 10
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000001188 haloalkyl group Chemical group 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 4
- NFWDMMZPGUFPQE-UHFFFAOYSA-N 4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-8-(6-morpholin-4-ylhexoxy)-1h-quinolin-2-one Chemical compound C=1C(=O)NC2=C(OCCCCCCN3CCOCC3)C(OC)=CC=C2C=1NC1=C(Cl)C=NC=C1Cl NFWDMMZPGUFPQE-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 125000004181 carboxyalkyl group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- IRFHMTUHTBSEBK-QGZVFWFLSA-N tert-butyl n-[(2s)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate Chemical compound C1([C@H](CC=2C=C3C=CC=CC3=NC=2)CNC(=O)OC(C)(C)C)=CC(F)=CC=C1F IRFHMTUHTBSEBK-QGZVFWFLSA-N 0.000 claims description 4
- 230000000172 allergic effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 208000010668 atopic eczema Diseases 0.000 claims description 3
- 230000004968 inflammatory condition Effects 0.000 claims description 3
- UZGKAASZIMOAMU-UHFFFAOYSA-N 124177-85-1 Chemical compound NP(=O)=O UZGKAASZIMOAMU-UHFFFAOYSA-N 0.000 claims description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- RAGZGIJNEIQQOS-UHFFFAOYSA-N O-aminoperoxyhydroxylamine Chemical compound NOOON RAGZGIJNEIQQOS-UHFFFAOYSA-N 0.000 claims description 2
- 125000005354 acylalkyl group Chemical group 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims description 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 2
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 2
- JSPLKZUTYZBBKA-UHFFFAOYSA-N trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24761809P | 2009-10-01 | 2009-10-01 | |
| US61/247,618 | 2009-10-01 | ||
| PCT/US2010/051062 WO2011041640A1 (en) | 2009-10-01 | 2010-10-01 | Olopatadine compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506692A JP2013506692A (ja) | 2013-02-28 |
| JP2013506692A5 true JP2013506692A5 (https=) | 2013-10-03 |
| JP5721722B2 JP5721722B2 (ja) | 2015-05-20 |
Family
ID=43127787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532346A Expired - Fee Related JP5721722B2 (ja) | 2009-10-01 | 2010-10-01 | オロパタジン組成物およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20110082145A1 (https=) |
| EP (1) | EP2482798A1 (https=) |
| JP (1) | JP5721722B2 (https=) |
| KR (1) | KR20120091037A (https=) |
| CN (1) | CN102548536A (https=) |
| AU (1) | AU2010300421B2 (https=) |
| BR (1) | BR112012007091A2 (https=) |
| CA (1) | CA2773483A1 (https=) |
| CL (1) | CL2012000801A1 (https=) |
| MX (1) | MX2012003693A (https=) |
| PH (1) | PH12012500654A1 (https=) |
| RU (1) | RU2012117141A (https=) |
| WO (1) | WO2011041640A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI544922B (zh) * | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| CN103202833A (zh) * | 2012-12-25 | 2013-07-17 | 常州市亚邦医药研究所有限公司 | 一种奥洛他定或其盐的药用组合物及其制备方法 |
| US10758550B2 (en) | 2013-10-04 | 2020-09-01 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
| EP3037094A1 (en) * | 2014-12-23 | 2016-06-29 | Poifa Warszawa SA | Ophthalmic pharmaceutical composition |
| CN110117271A (zh) * | 2018-02-06 | 2019-08-13 | 中国科学院上海药物研究所 | 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
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-
2010
- 2010-10-01 US US12/896,056 patent/US20110082145A1/en not_active Abandoned
- 2010-10-01 EP EP10762842A patent/EP2482798A1/en not_active Withdrawn
- 2010-10-01 MX MX2012003693A patent/MX2012003693A/es not_active Application Discontinuation
- 2010-10-01 CN CN2010800434937A patent/CN102548536A/zh active Pending
- 2010-10-01 JP JP2012532346A patent/JP5721722B2/ja not_active Expired - Fee Related
- 2010-10-01 KR KR1020127008229A patent/KR20120091037A/ko not_active Withdrawn
- 2010-10-01 PH PH1/2012/500654A patent/PH12012500654A1/en unknown
- 2010-10-01 CA CA2773483A patent/CA2773483A1/en not_active Abandoned
- 2010-10-01 WO PCT/US2010/051062 patent/WO2011041640A1/en not_active Ceased
- 2010-10-01 BR BR112012007091A patent/BR112012007091A2/pt not_active IP Right Cessation
- 2010-10-01 RU RU2012117141/15A patent/RU2012117141A/ru not_active Application Discontinuation
- 2010-10-01 AU AU2010300421A patent/AU2010300421B2/en not_active Ceased
-
2012
- 2012-03-30 CL CL2012000801A patent/CL2012000801A1/es unknown
-
2013
- 2013-12-17 US US14/108,432 patent/US20140107121A1/en not_active Abandoned
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