JP2013505287A - ペプチドクリアリング剤 - Google Patents

ペプチドクリアリング剤 Download PDF

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Publication number
JP2013505287A
JP2013505287A JP2012530331A JP2012530331A JP2013505287A JP 2013505287 A JP2013505287 A JP 2013505287A JP 2012530331 A JP2012530331 A JP 2012530331A JP 2012530331 A JP2012530331 A JP 2012530331A JP 2013505287 A JP2013505287 A JP 2013505287A
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JP
Japan
Prior art keywords
peptide
enzyme
binding
peptides
peptide according
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Pending
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JP2012530331A
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English (en)
Japanese (ja)
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JP2013505287A5 (https=
Inventor
デイビス，ポール・ジエイムズ
スカウテン，ジエームス・アレクサンデル
Original Assignee
モロジック リミテッド
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Publication of JP2013505287A publication Critical patent/JP2013505287A/ja
Publication of JP2013505287A5 publication Critical patent/JP2013505287A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2012530331A 2009-09-23 2010-09-23 ペプチドクリアリング剤 Pending JP2013505287A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0916749.5A GB0916749D0 (en) 2009-09-23 2009-09-23 Peptide cleaning agents
GB0916749.5 2009-09-23
PCT/GB2010/001796 WO2011036457A1 (en) 2009-09-23 2010-09-23 Peptide clearing agents

Publications (2)

Publication Number Publication Date
JP2013505287A true JP2013505287A (ja) 2013-02-14
JP2013505287A5 JP2013505287A5 (https=) 2013-11-14

Family

ID=41327500

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012530331A Pending JP2013505287A (ja) 2009-09-23 2010-09-23 ペプチドクリアリング剤

Country Status (16)

Country Link
US (1) US8846861B2 (https=)
EP (1) EP2470216A1 (https=)
JP (1) JP2013505287A (https=)
KR (1) KR20120084298A (https=)
CN (1) CN102665768B (https=)
AU (1) AU2010299643B2 (https=)
BR (1) BR112012006389A2 (https=)
CA (1) CA2774081A1 (https=)
GB (1) GB0916749D0 (https=)
IL (1) IL218713A0 (https=)
IN (1) IN2012DN02241A (https=)
MX (1) MX2012003565A (https=)
NZ (1) NZ598802A (https=)
SG (1) SG179015A1 (https=)
WO (1) WO2011036457A1 (https=)
ZA (1) ZA201201527B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2435510A (en) 2006-02-23 2007-08-29 Mologic Ltd Enzyme detection product and methods
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2603520A4 (en) 2010-08-10 2014-02-19 Ecole Polytech ERYTHROCYTE BINDING THERAPEUTICS
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
SG11201606761RA (en) 2014-02-21 2016-09-29 Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance
EP3790577A4 (en) 2018-05-09 2022-04-27 The University of Chicago COMPOSITIONS AND METHODS RELATED TO IMMUNTOLERANCE
WO2021155317A1 (en) 2020-01-31 2021-08-05 Avilar Therapeutics, Inc. Asgpr-binding compounds for the degradation of extracellular proteins
KR20240017423A (ko) 2021-05-03 2024-02-07 아빌라 테라퓨틱스, 인크. 이뮤노글로불린 및 다른 단백질의 분해를 위한 강력한 asgpr-결합 화합물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502071A (ja) * 1995-12-06 2000-02-22 エンザクタ アール アンド ディ リミテッド 薬物療法
JP2001505220A (ja) * 1996-11-30 2001-04-17 エンザクタ、アール、アンド、ディー、リミテッド 腫瘍の治療法
JP2001510453A (ja) * 1996-10-31 2001-07-31 ノヴァロン ファーマスーチカル コーポレイション 相補的組み合わせライブラリーを使用する薬剤の同定
JP2004535560A (ja) * 2001-04-20 2004-11-25 ザ ユニヴァーシティ オブ ジョージア リサーチファウンデーション， インク． 活性部位不活性化因子
JP2005503768A (ja) * 2001-04-03 2005-02-10 イムノメディクス， インコーポレイテッド 二重特異性抗体とともに使用される新規なペプチド型薬剤の製造および使用
JP2006506325A (ja) * 2002-05-17 2006-02-23 イミューノメディクス、インコーポレイテッド 二重特異性抗体ならびにキャリアペプチドと活性薬剤を含むハプテン構築物を用いる薬物プレターゲッティング
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス， インコーポレイテッド タンパク様薬剤およびその使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075010A (en) 1992-06-09 2000-06-13 Neorx Corporation Small molecular weight ligand-hexose containing clearing agents
US4859449A (en) 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance
US20030068322A1 (en) 1988-04-18 2003-04-10 Immunomedics, Inc. Methods of antibody-directed enzyme-prodrug therapy
EP0538268A4 (en) 1990-05-11 1993-05-12 The University Of Connecticut Targeted protection from cytotoxins
GB9324807D0 (en) 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US6172045B1 (en) * 1994-12-07 2001-01-09 Neorx Corporation Cluster clearing agents
ATE458499T1 (de) 1995-06-07 2010-03-15 Immunomedics Inc Verbesserte abgabe von diagnostischen und therapeutischen stoffen an einem zielort
AU6059699A (en) * 1998-09-23 2000-04-10 Regents Of The University Of California, The Synthetic peptides, conjugation reagents and methods
EP2050761B1 (en) 2007-10-16 2011-06-29 Toscana Biomarkers S.r.l. Galactosylated peptides, their preparation and use in autoimmune diseases diagnosis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502071A (ja) * 1995-12-06 2000-02-22 エンザクタ アール アンド ディ リミテッド 薬物療法
JP2001510453A (ja) * 1996-10-31 2001-07-31 ノヴァロン ファーマスーチカル コーポレイション 相補的組み合わせライブラリーを使用する薬剤の同定
JP2001505220A (ja) * 1996-11-30 2001-04-17 エンザクタ、アール、アンド、ディー、リミテッド 腫瘍の治療法
JP2005503768A (ja) * 2001-04-03 2005-02-10 イムノメディクス， インコーポレイテッド 二重特異性抗体とともに使用される新規なペプチド型薬剤の製造および使用
JP2004535560A (ja) * 2001-04-20 2004-11-25 ザ ユニヴァーシティ オブ ジョージア リサーチファウンデーション， インク． 活性部位不活性化因子
JP2006506325A (ja) * 2002-05-17 2006-02-23 イミューノメディクス、インコーポレイテッド 二重特異性抗体ならびにキャリアペプチドと活性薬剤を含むハプテン構築物を用いる薬物プレターゲッティング
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス， インコーポレイテッド タンパク様薬剤およびその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAGSHAWE, K.D.: ""TARGETING: THE ADEPT STORY SO FAR"", CURRENT DRUG TARGETS, vol. 10, no. 2, JPN5012016876, 1 February 2009 (2009-02-01), US, pages 152 - 157, XP008130166, ISSN: 0002973167 *
SHARMA, S.K. ET AL.: ""Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therap", CANCER, vol. Vol.73, No.3 Suppl., JPN6014054379, 1 February 1994 (1994-02-01), pages 1114 - 1120, ISSN: 0002973166 *

Also Published As

Publication number Publication date
MX2012003565A (es) 2012-08-03
EP2470216A1 (en) 2012-07-04
CN102665768B (zh) 2015-01-21
NZ598802A (en) 2013-10-25
IL218713A0 (en) 2012-05-31
US8846861B2 (en) 2014-09-30
KR20120084298A (ko) 2012-07-27
AU2010299643A1 (en) 2012-03-22
CA2774081A1 (en) 2011-03-31
GB0916749D0 (en) 2009-11-04
IN2012DN02241A (https=) 2015-08-21
CN102665768A (zh) 2012-09-12
BR112012006389A2 (pt) 2016-11-22
SG179015A1 (en) 2012-04-27
ZA201201527B (en) 2013-05-29
AU2010299643B2 (en) 2014-06-26
US20130053543A1 (en) 2013-02-28
WO2011036457A1 (en) 2011-03-31

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