BR112012006389A2 - agente de depiração peptídica, métodos para produzir um agente de depuração peptídica, e de terapia de pró-droga de enzima direcionada ao anticorpo, e, uso de um peptídeo - Google Patents
agente de depiração peptídica, métodos para produzir um agente de depuração peptídica, e de terapia de pró-droga de enzima direcionada ao anticorpo, e, uso de um peptídeoInfo
- Publication number
- BR112012006389A2 BR112012006389A2 BR112012006389A BR112012006389A BR112012006389A2 BR 112012006389 A2 BR112012006389 A2 BR 112012006389A2 BR 112012006389 A BR112012006389 A BR 112012006389A BR 112012006389 A BR112012006389 A BR 112012006389A BR 112012006389 A2 BR112012006389 A2 BR 112012006389A2
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- enzyme
- clearance
- agent
- producing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nanotechnology (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0916749.5A GB0916749D0 (en) | 2009-09-23 | 2009-09-23 | Peptide cleaning agents |
| PCT/GB2010/001796 WO2011036457A1 (en) | 2009-09-23 | 2010-09-23 | Peptide clearing agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012006389A2 true BR112012006389A2 (pt) | 2016-11-22 |
Family
ID=41327500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012006389A BR112012006389A2 (pt) | 2009-09-23 | 2010-09-23 | agente de depiração peptídica, métodos para produzir um agente de depuração peptídica, e de terapia de pró-droga de enzima direcionada ao anticorpo, e, uso de um peptídeo |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8846861B2 (https=) |
| EP (1) | EP2470216A1 (https=) |
| JP (1) | JP2013505287A (https=) |
| KR (1) | KR20120084298A (https=) |
| CN (1) | CN102665768B (https=) |
| AU (1) | AU2010299643B2 (https=) |
| BR (1) | BR112012006389A2 (https=) |
| CA (1) | CA2774081A1 (https=) |
| GB (1) | GB0916749D0 (https=) |
| IL (1) | IL218713A0 (https=) |
| IN (1) | IN2012DN02241A (https=) |
| MX (1) | MX2012003565A (https=) |
| NZ (1) | NZ598802A (https=) |
| SG (1) | SG179015A1 (https=) |
| WO (1) | WO2011036457A1 (https=) |
| ZA (1) | ZA201201527B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2435510A (en) | 2006-02-23 | 2007-08-29 | Mologic Ltd | Enzyme detection product and methods |
| WO2012021512A2 (en) | 2010-08-10 | 2012-02-16 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| KR102717969B1 (ko) | 2014-02-21 | 2024-10-15 | 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) | 글리코타겟팅 치료제 |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| IL294515A (en) | 2020-01-31 | 2022-09-01 | Avilar Therapeutics Inc | Compounds bind asgpr to degrade extracellular proteins |
| WO2022235699A2 (en) | 2021-05-03 | 2022-11-10 | Avilar Therapeutics, Inc. | Potent asgpr-binding compounds for the degradation of immunoglobulins and other proteins |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6075010A (en) | 1992-06-09 | 2000-06-13 | Neorx Corporation | Small molecular weight ligand-hexose containing clearing agents |
| US4859449A (en) | 1987-09-14 | 1989-08-22 | Center For Molecular Medicine And Immunology | Modified antibodies for enhanced hepatocyte clearance |
| US20030068322A1 (en) | 1988-04-18 | 2003-04-10 | Immunomedics, Inc. | Methods of antibody-directed enzyme-prodrug therapy |
| EP0538268A4 (en) | 1990-05-11 | 1993-05-12 | The University Of Connecticut | Targeted protection from cytotoxins |
| GB9324807D0 (en) | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
| US6172045B1 (en) * | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
| EP0837696B1 (en) | 1995-06-07 | 2010-02-24 | Immunomedics, Inc. | Improved delivery of diagnostic and therapeutic agents to a target site |
| GB9524942D0 (en) * | 1995-12-06 | 1996-02-07 | Aepact Ltd | Drug therapy |
| AU744444B2 (en) * | 1996-10-31 | 2002-02-21 | Karo Bio Ab | Identification of drugs using complementary combinatorial libraries |
| GB9624993D0 (en) * | 1996-11-30 | 1997-01-15 | Aepact Ltd | Tumour therapy |
| US7138103B2 (en) | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US6465612B1 (en) * | 1998-09-23 | 2002-10-15 | The Regents Of The University Of California | Synthetic peptides, conjugation reagents and methods |
| JP2004535560A (ja) * | 2001-04-20 | 2004-11-25 | ザ ユニヴァーシティ オブ ジョージア リサーチファウンデーション， インク． | 活性部位不活性化因子 |
| EP1929073A4 (en) * | 2005-09-27 | 2010-03-10 | Amunix Inc | PROTEIN MEDICAMENT AND ITS USE |
| ATE514711T1 (de) | 2007-10-16 | 2011-07-15 | Toscana Biomarkers S R L | Galactosylierte peptide, deren zubereitung und verwendung zur diagnose von autoimmunerkrankungen |
-
2009
- 2009-09-23 GB GBGB0916749.5A patent/GB0916749D0/en not_active Ceased
-
2010
- 2010-09-23 NZ NZ598802A patent/NZ598802A/xx not_active IP Right Cessation
- 2010-09-23 JP JP2012530331A patent/JP2013505287A/ja active Pending
- 2010-09-23 CN CN201080042526.6A patent/CN102665768B/zh not_active Expired - Fee Related
- 2010-09-23 SG SG2012015806A patent/SG179015A1/en unknown
- 2010-09-23 BR BR112012006389A patent/BR112012006389A2/pt not_active IP Right Cessation
- 2010-09-23 WO PCT/GB2010/001796 patent/WO2011036457A1/en not_active Ceased
- 2010-09-23 IN IN2241DEN2012 patent/IN2012DN02241A/en unknown
- 2010-09-23 MX MX2012003565A patent/MX2012003565A/es not_active Application Discontinuation
- 2010-09-23 KR KR1020127010173A patent/KR20120084298A/ko not_active Withdrawn
- 2010-09-23 CA CA2774081A patent/CA2774081A1/en not_active Abandoned
- 2010-09-23 AU AU2010299643A patent/AU2010299643B2/en not_active Ceased
- 2010-09-23 US US13/497,967 patent/US8846861B2/en not_active Expired - Fee Related
- 2010-09-23 EP EP10757623A patent/EP2470216A1/en not_active Withdrawn
-
2012
- 2012-02-29 ZA ZA2012/01527A patent/ZA201201527B/en unknown
- 2012-03-18 IL IL218713A patent/IL218713A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013505287A (ja) | 2013-02-14 |
| CN102665768A (zh) | 2012-09-12 |
| AU2010299643A1 (en) | 2012-03-22 |
| SG179015A1 (en) | 2012-04-27 |
| IN2012DN02241A (https=) | 2015-08-21 |
| AU2010299643B2 (en) | 2014-06-26 |
| US20130053543A1 (en) | 2013-02-28 |
| WO2011036457A1 (en) | 2011-03-31 |
| MX2012003565A (es) | 2012-08-03 |
| EP2470216A1 (en) | 2012-07-04 |
| GB0916749D0 (en) | 2009-11-04 |
| CA2774081A1 (en) | 2011-03-31 |
| CN102665768B (zh) | 2015-01-21 |
| US8846861B2 (en) | 2014-09-30 |
| NZ598802A (en) | 2013-10-25 |
| KR20120084298A (ko) | 2012-07-27 |
| IL218713A0 (en) | 2012-05-31 |
| ZA201201527B (en) | 2013-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/54 (2017.01), A61K 47/66 (2017.01), B82Y 5 |