AR066199A1 - Metodo para reducir la concentracion del peptido amiloide beta - Google Patents
Metodo para reducir la concentracion del peptido amiloide betaInfo
- Publication number
- AR066199A1 AR066199A1 ARP080101265A ARP080101265A AR066199A1 AR 066199 A1 AR066199 A1 AR 066199A1 AR P080101265 A ARP080101265 A AR P080101265A AR P080101265 A ARP080101265 A AR P080101265A AR 066199 A1 AR066199 A1 AR 066199A1
- Authority
- AR
- Argentina
- Prior art keywords
- amyloid peptide
- beta amyloid
- protein component
- protein
- concentration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Proteínas de fusion y a su uso en el tratamiento enzimático de pacientes con la enfermedad de Alzheimer. Reivindicacion 1: Una proteína de fusion que tiene la formula M-A, capaz de degradar el péptido amiloide beta en uno o más sitios de escision en dicha secuencia de aminoácidos de péptido amiloide beta, donde M es un componente proteico que prolonga la vida media de la proteína de fusion, y A es un componente proteico que escinde el péptido amiloide beta, donde dicho componente proteico M está conectado covalentemente a la parte del N-término del componente proteico A. Reivindicacion 28: Una composicion farmacéutica capaz de degradar el péptido amiloide beta, que comprende una cantidad farmacéuticamente aceptable de proteína de fusion de acuerdo con cualquiera de las reivindicaciones 1 a 23 conjuntamente con un portador o excipiente farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90847107P | 2007-03-28 | 2007-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066199A1 true AR066199A1 (es) | 2009-08-05 |
Family
ID=39788753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101265A AR066199A1 (es) | 2007-03-28 | 2008-03-27 | Metodo para reducir la concentracion del peptido amiloide beta |
Country Status (12)
Country | Link |
---|---|
US (1) | US20080242590A1 (es) |
EP (1) | EP2139525A4 (es) |
JP (1) | JP2010522559A (es) |
CN (1) | CN101668545A (es) |
AR (1) | AR066199A1 (es) |
AU (1) | AU2008230177B2 (es) |
CA (1) | CA2681404A1 (es) |
CL (1) | CL2008000910A1 (es) |
PE (1) | PE20090225A1 (es) |
TW (1) | TW200907056A (es) |
UY (1) | UY30984A1 (es) |
WO (1) | WO2008118093A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012530498A (ja) | 2009-06-19 | 2012-12-06 | メディミューン,エルエルシー | プロテアーゼバリアント |
WO2011161127A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc | Protease variants of human neprilysin |
WO2011160732A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc. | Protease variants of human neprilysin |
WO2012145428A2 (en) * | 2011-04-21 | 2012-10-26 | Washington University | Altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid |
CN103529182B (zh) * | 2012-07-06 | 2016-03-16 | 中国科学院上海生命科学研究院 | rbo/Efr3a/Efr3b基因或其蛋白在诊断和治疗阿尔茨海默病中的应用 |
EP2832854A1 (en) * | 2013-08-02 | 2015-02-04 | F. Hoffmann-La Roche AG | Method for improving the recombinant expression of a polypeptide by C-terminal fusion to human neprilysin |
EP3027280A1 (en) * | 2013-08-02 | 2016-06-08 | F. Hoffmann-La Roche AG | Therapeutic fusion protein |
EP3147668B1 (en) * | 2014-05-22 | 2019-12-11 | Shimadzu Corporation | Surrogate biomarker for evaluating intracerebral amyloid beta peptide accumulation and method for analysis thereof |
CN109071600A (zh) * | 2016-04-14 | 2018-12-21 | 道健康生活医药株式会社 | 淀粉样蛋白球体(aspd)结合抑制肽以及评价和筛选方法 |
WO2018138709A1 (en) * | 2017-01-30 | 2018-08-02 | National Research Council Of Canada | Blood-brain barrier transmigrating compounds and uses thereof |
US11752216B2 (en) | 2017-03-23 | 2023-09-12 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
CN110241128B (zh) * | 2018-03-07 | 2020-10-02 | 上海大学 | 一种含有cbd的融合基因、细胞系、液态ecm与应用 |
CA3107349A1 (en) | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
CA3107352A1 (en) | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
JP2022526671A (ja) | 2019-04-11 | 2022-05-25 | エンクリアー セラピーズ, インク. | 脳脊髄液の改善の方法ならびにそのためのデバイスおよびシステム |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
HUP0100813A3 (en) * | 1998-02-25 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancing the circulating half-life of antibody-based fusion proteins |
US20020086405A1 (en) * | 2000-09-25 | 2002-07-04 | Inmaculada Silos-Santiago | 56638, a novel human neprilysin protease and uses thereof |
CA2260376A1 (en) * | 1999-02-11 | 2000-08-11 | Universite De Montreal | New metalloproteases of the neprilysin family |
US20030083277A1 (en) * | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
WO2002096460A1 (en) * | 2001-05-30 | 2002-12-05 | Cornell Research Foundation, Inc. | Endopeptidase/anti-psma antibody fusion proteins for treatment of cancer |
US20050118632A1 (en) * | 2003-11-06 | 2005-06-02 | Jian Chen | Polynucleotides and polypeptides encoding a novel metalloprotease, Protease-40b |
EP1934341A1 (en) * | 2005-10-03 | 2008-06-25 | AstraZeneca AB | Fusion proteins having a modulated half-life in plasma |
-
2008
- 2008-03-26 TW TW097110852A patent/TW200907056A/zh unknown
- 2008-03-27 AU AU2008230177A patent/AU2008230177B2/en not_active Ceased
- 2008-03-27 EP EP08741880A patent/EP2139525A4/en not_active Withdrawn
- 2008-03-27 CN CN200880010294A patent/CN101668545A/zh active Pending
- 2008-03-27 JP JP2010500877A patent/JP2010522559A/ja not_active Withdrawn
- 2008-03-27 CA CA002681404A patent/CA2681404A1/en not_active Abandoned
- 2008-03-27 AR ARP080101265A patent/AR066199A1/es not_active Application Discontinuation
- 2008-03-27 WO PCT/SE2008/050346 patent/WO2008118093A1/en active Application Filing
- 2008-03-27 UY UY30984A patent/UY30984A1/es not_active Application Discontinuation
- 2008-03-27 PE PE2008000557A patent/PE20090225A1/es not_active Application Discontinuation
- 2008-03-28 CL CL2008000910A patent/CL2008000910A1/es unknown
- 2008-03-28 US US12/057,464 patent/US20080242590A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
UY30984A1 (es) | 2008-10-31 |
TW200907056A (en) | 2009-02-16 |
CA2681404A1 (en) | 2008-10-02 |
CL2008000910A1 (es) | 2008-11-21 |
PE20090225A1 (es) | 2009-04-19 |
AU2008230177B2 (en) | 2012-05-10 |
AU2008230177A1 (en) | 2008-10-02 |
EP2139525A4 (en) | 2010-08-18 |
US20080242590A1 (en) | 2008-10-02 |
JP2010522559A (ja) | 2010-07-08 |
WO2008118093A1 (en) | 2008-10-02 |
CN101668545A (zh) | 2010-03-10 |
EP2139525A1 (en) | 2010-01-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR066199A1 (es) | Metodo para reducir la concentracion del peptido amiloide beta | |
BRPI0407001A (pt) | Método para aumentar a estabilidade de uma proteìna purificada, uso de uma proteìna ligante sìtio-especìfica ativa, método para aumentar a produção de uma proteìna recombinante e composição farmacêutica | |
CY1118038T1 (el) | Λυοφιλισμενες φαρμακοτεχνικες μορφες θεραπευτικου πεπτισωματος | |
BRPI0408331B8 (pt) | conjugado de proteína, processo para preparação do dito conjugado de proteína, composição farmacêutica e processo para prolongar a meia vida útil in vivo de um polipeptídeo fisiologicamente ativo | |
BR112014007069A2 (pt) | proteínas de fusão para o tratamento de distúrbios metabólicos | |
NO20076239L (no) | Peptidkonjugatpreparater og fremgangsmater for forebygging og behandling av Alzheimers sykdom | |
AR069135A1 (es) | Compuesto de alfa-(n-sulfonamido) acetamida como un inhibidor de produccion de peptido beta amiloide | |
BRPI0519193A2 (pt) | mÉtodo para produzir suspensÕes estÉreis ou liofilisados de complexos peptÍdicos bÁsicos fracamente soléveis, formulaÇÕes farmacÊuticas contendo os mesmos, e aplicaÇço dos mesmos como medicamentos | |
EA200802396A1 (ru) | УЛУЧШЕННЫЕ ДИМЕРЫ sgp130Fc | |
PE20141727A1 (es) | Composiciones, usos y metodos para tratamiento de trastornos y enfermedades metabolicas | |
BRPI0411112A (pt) | proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga | |
DK1877435T3 (da) | Glucagon-lignende peptid 2 (GLP-2)-analoger | |
AR053252A1 (es) | Antiuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos | |
PE20081634A1 (es) | Fab ab pegilado | |
US20130205416A1 (en) | Anti-viral agent | |
AR047729A1 (es) | Anticuerpos terapeuticos que se unen a la apolipoproteina e (apoe) | |
Gibson et al. | Design of peptidyl compounds that affect β-amyloid aggregation: importance of surface tension and context | |
AR051765A1 (es) | Compuestos de moleculas conjugadas con una actividad reforzada de absorcion de celulas | |
AR076977A1 (es) | Proteinas precursoras repetitivas autoensambladas | |
BR112014007675A2 (pt) | tratamento de doença articular degenerativa | |
CY1118930T1 (el) | Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων | |
BRPI0720879A2 (pt) | microvesícula derivada de fermento carreador de fator de tecido (tf), composição e composição farmacêutica que a compreende, processos para a sua manufatura, proteína lipida de fator de tecido (tf) modificado, polinucleotídeo, vetor, célula hospedeira e anticorpo. | |
AR068020A1 (es) | Terapia combinada para el cancer de pancreas usando un peptido antigenico y un agente quimioterapeutico | |
PE20110677A1 (es) | Polimorfo b de la n-(2-aminofenil)-4-[n-(piridin-3-il) metoxicarbonilamino-metil]benzamida (ms-275) | |
BRPI0407533A (pt) | proteìnas de fusão e muteìnas do interferon alfa com propriedades melhoradas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |