BRPI0813942B8 - polipeptídeo da enzima conversora de angiotensina 2 (ace2) recombinante, preparação e composição farmacêutica compreendendo o mesmo, processo para a produção do mesmo e usos terapêuticos dos ditos polipeptídeo, preparação e composição - Google Patents

polipeptídeo da enzima conversora de angiotensina 2 (ace2) recombinante, preparação e composição farmacêutica compreendendo o mesmo, processo para a produção do mesmo e usos terapêuticos dos ditos polipeptídeo, preparação e composição

Info

Publication number
BRPI0813942B8
BRPI0813942B8 BRPI0813942A BRPI0813942A BRPI0813942B8 BR PI0813942 B8 BRPI0813942 B8 BR PI0813942B8 BR PI0813942 A BRPI0813942 A BR PI0813942A BR PI0813942 A BRPI0813942 A BR PI0813942A BR PI0813942 B8 BRPI0813942 B8 BR PI0813942B8
Authority
BR
Brazil
Prior art keywords
polypeptide
preparation
ace2
composition
pharmaceutical composition
Prior art date
Application number
BRPI0813942A
Other languages
English (en)
Inventor
Peball Bernhard
Wagner Bettina
Janzek-Hawlat Evelyne
Loibner Hans
Schuster Manfred
Weik Robert
Stranner Stefan
Original Assignee
Apeiron Biologics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP08450052A external-priority patent/EP2108695A1/de
Application filed by Apeiron Biologics Ag filed Critical Apeiron Biologics Ag
Publication of BRPI0813942A2 publication Critical patent/BRPI0813942A2/pt
Publication of BRPI0813942B1 publication Critical patent/BRPI0813942B1/pt
Publication of BRPI0813942B8 publication Critical patent/BRPI0813942B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023—Angiotensin-converting enzyme 2 (3.4.17.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

polipeptídios ace2 recombinantes, seu processo de preparação e seu uso, preparação compreendendo tais polipeptídios, composição farmacêutica. a presente invenção refere-se a um polipeptídio ace2 recombinante, seu processo de preparação e seu uso, assim como preparações compreendendo tal polipeptídio e composições farmacêuticas, sendo que o polipeptídio ace2 esta presente como dímero. o dímero é formado em especial a partir de monômeros glicosilados e empregado para preparação de produtos farmacêuticos com meia-vida prolongada.
BRPI0813942A 2007-06-12 2008-06-12 polipeptídeo da enzima conversora de angiotensina 2 (ace2) recombinante, preparação e composição farmacêutica compreendendo o mesmo, processo para a produção do mesmo e usos terapêuticos dos ditos polipeptídeo, preparação e composição BRPI0813942B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ATA913/2007 2007-06-12
AT0091307A AT505262A1 (de) 2007-06-12 2007-06-12 Rekombinantes ace2 polypeptid
EP08450052.9 2008-04-08
EP08450052A EP2108695A1 (de) 2008-04-08 2008-04-08 Ace2 Polypeptid
PCT/AT2008/000211 WO2008151347A1 (de) 2007-06-12 2008-06-12 Ace2 polypeptid

Publications (3)

Publication Number Publication Date
BRPI0813942A2 BRPI0813942A2 (pt) 2014-12-30
BRPI0813942B1 BRPI0813942B1 (pt) 2019-08-20
BRPI0813942B8 true BRPI0813942B8 (pt) 2021-05-25

Family

ID=39720296

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813942A BRPI0813942B8 (pt) 2007-06-12 2008-06-12 polipeptídeo da enzima conversora de angiotensina 2 (ace2) recombinante, preparação e composição farmacêutica compreendendo o mesmo, processo para a produção do mesmo e usos terapêuticos dos ditos polipeptídeo, preparação e composição

Country Status (35)

Country Link
US (3) US8586319B2 (pt)
EP (3) EP3375872A1 (pt)
JP (1) JP5731193B2 (pt)
KR (2) KR20160054045A (pt)
CN (2) CN101796183A (pt)
AT (1) AT505262A1 (pt)
AU (1) AU2008261591B2 (pt)
BR (1) BRPI0813942B8 (pt)
CA (1) CA2692854C (pt)
CO (1) CO6270265A2 (pt)
CR (1) CR11213A (pt)
CY (2) CY1116873T1 (pt)
DK (2) DK2543724T3 (pt)
DO (1) DOP2009000282A (pt)
EA (1) EA027399B1 (pt)
EG (1) EG27095A (pt)
ES (2) ES2670938T3 (pt)
HK (2) HK1255493A1 (pt)
HR (2) HRP20151120T1 (pt)
HU (2) HUE037877T2 (pt)
IL (1) IL202653B (pt)
LT (1) LT2543724T (pt)
MA (1) MA31472B1 (pt)
MX (1) MX2009013472A (pt)
MY (1) MY180672A (pt)
NO (1) NO2543724T3 (pt)
NZ (1) NZ581704A (pt)
PL (2) PL2155871T3 (pt)
PT (2) PT2543724T (pt)
RS (2) RS54340B1 (pt)
SI (2) SI2543724T1 (pt)
TR (1) TR201808117T4 (pt)
UA (1) UA106869C2 (pt)
WO (1) WO2008151347A1 (pt)
ZA (1) ZA200908751B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
EP2077119A1 (de) * 2007-12-21 2009-07-08 Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. Behandlung von Fibrosen und Lebererkrankungen
AT506632A1 (de) * 2008-04-09 2009-10-15 Apeiron Biolog Forschungs Und Behandlung von tumorerkrankungen
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
MY167814A (en) 2012-04-19 2018-09-26 Opko Biologics Ltd Long-acting oxyntomodulin variants and methods of producing same
CA2876099A1 (en) 2012-08-02 2014-02-06 F. Hoffmann-La Roche Ag Method for producing monomeric and multimeric molecules and uses thereof
BR122020018510B1 (pt) 2012-11-20 2023-03-14 Opko Biologics Ltd Método para aumentar incrementalmente o tamanho hidrodinâmico de um fator de coagulação ativado viia
ES2732282T3 (es) * 2013-01-14 2019-11-21 Apeiron Biologics Ag Polipéptidos de ECA2 modificados
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
ES2893616T3 (es) 2015-06-19 2022-02-09 Opko Biologics Ltd Factores de coagulación de acción prolongada y métodos para la producción de los mismos
AU2017296352A1 (en) 2016-07-11 2019-02-21 Opko Biologics Ltd. Long-acting coagulation factor VII and methods of producing same
US11518788B2 (en) * 2020-07-10 2022-12-06 Avirus, Inc. Methods and compositions for treating and preventing viral infection
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
EP3884957A1 (en) 2020-03-26 2021-09-29 The University of British Columbia Methods for treatment of virus and methods for screening of anti-virus reagent using organoids
WO2021217120A2 (en) * 2020-04-24 2021-10-28 Administrators Of The Tulane Educational Fund Compositions and methods for preventing or reducing the effects of infections by coronaviruses that bind the extracellular domain of the ace2 receptor
CN113667016A (zh) * 2020-05-15 2021-11-19 普米斯生物技术(珠海)有限公司 一种构建冠状病毒抗体的平台
WO2021247675A1 (en) 2020-06-02 2021-12-09 Ngm Biopharmaceuticals, Inc. Coronavirus-binding agents and uses thereof
DE102020207224A1 (de) 2020-06-09 2021-12-09 Christoph Karle Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
EP4171603A1 (en) * 2020-06-25 2023-05-03 Gliknik Inc. Ace2-fc fusion proteins and methods of use
WO2022008642A1 (en) 2020-07-08 2022-01-13 Apeiron Biologics Ag Treatment of sars-cov-2 infection with a combination of targets
US20220025071A1 (en) * 2020-07-10 2022-01-27 Biomolecular Holdings Llc Tetrahedral antibodies
CN116710560A (zh) * 2020-08-21 2023-09-05 西湖大学 工程化ace2寡聚物及其用途
CN112280764A (zh) * 2020-11-18 2021-01-29 通用生物系统（安徽）有限公司 一种新冠重组ace2蛋白在哺乳动物细胞中的生产方法
EP4011387A1 (en) 2020-12-11 2022-06-15 IMBA-Institut für Molekulare Biotechnologie GmbH Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
WO2022159433A1 (en) 2021-01-20 2022-07-28 Singh Biotechnology, Llc Therapeutics directed against coronavirus
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
WO2022207918A1 (en) 2021-04-02 2022-10-06 Apeiron Biologics Ag COVID-19 Therapy
WO2023023424A1 (en) * 2021-08-19 2023-02-23 Phenom Pharmaceuticals, Inc. Compositions and methods for treatment of sars cov-2
CN113897346A (zh) * 2021-09-16 2022-01-07 四川大学 能够提高与SARS-CoV-2 S蛋白亲和力的ACE2突变组合及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989363B1 (en) * 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6610497B1 (en) 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6194556B1 (en) * 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
PT2332582E (pt) * 2002-06-19 2014-01-28 Apeiron Biologics Ag Activação de ace2 para o tratamento de doença cardíaca, pulmonar e renal e de hipertensão
WO2004023270A2 (en) 2002-09-09 2004-03-18 Millenium Pharmaceuticals, Inc. Crystal structure of angiotensin-converting enzyme-related carboxypeptidase
EP1723962A1 (en) * 2005-05-19 2006-11-22 IMBA-Institut für Molekulare Biotechnologie GmbH Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
AT504443B1 (de) * 2006-10-19 2008-11-15 Apeiron Biolog Forschungs Und Verfahren zur bestimmung der aktivität von ace2
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
EP2108695A1 (de) * 2008-04-08 2009-10-14 Apeiron Biologics Forschungs- und Entwicklungsgesellschaft M.B.H. Ace2 Polypeptid
AT506258A1 (de) * 2007-12-18 2009-07-15 Apeiron Biolog Forschungs Und Behandlung inflammatorischer krankheiten
AT506632A1 (de) * 2008-04-09 2009-10-15 Apeiron Biolog Forschungs Und Behandlung von tumorerkrankungen

Also Published As

Publication number Publication date
IL202653B (en) 2018-01-31
AT505262A1 (de) 2008-12-15
US20100310546A1 (en) 2010-12-09
HK1136602A1 (en) 2010-07-02
EP2543724A3 (de) 2013-02-20
NZ581704A (en) 2012-05-25
RS57292B1 (sr) 2018-08-31
NO2543724T3 (pt) 2018-08-18
HK1255493A1 (zh) 2019-08-16
MX2009013472A (es) 2010-06-25
DOP2009000282A (es) 2010-03-31
CN104450654A (zh) 2015-03-25
CA2692854A1 (en) 2008-12-18
DK2155871T3 (en) 2015-11-09
MA31472B1 (fr) 2010-06-01
KR20160054045A (ko) 2016-05-13
MY180672A (en) 2020-12-05
KR20100040809A (ko) 2010-04-21
HUE037877T2 (hu) 2018-09-28
EA201000002A1 (ru) 2010-08-30
ES2550390T3 (es) 2015-11-06
EP3375872A1 (de) 2018-09-19
SI2155871T1 (sl) 2015-11-30
AU2008261591B2 (en) 2014-08-07
CY1120426T1 (el) 2019-07-10
CA2692854C (en) 2017-07-04
EG27095A (en) 2015-05-28
HRP20180856T1 (hr) 2018-08-24
PL2155871T3 (pl) 2015-12-31
US10716833B2 (en) 2020-07-21
ZA200908751B (en) 2010-07-28
JP5731193B2 (ja) 2015-06-10
HRP20151120T1 (en) 2015-11-20
EA027399B1 (ru) 2017-07-31
CO6270265A2 (es) 2011-04-20
BRPI0813942B1 (pt) 2019-08-20
BRPI0813942A2 (pt) 2014-12-30
JP2011519264A (ja) 2011-07-07
EP2155871B1 (de) 2015-08-12
RS54340B1 (en) 2016-02-29
IL202653A0 (en) 2011-08-01
US20180289779A1 (en) 2018-10-11
WO2008151347A1 (de) 2008-12-18
HUE028012T2 (en) 2016-11-28
US8586319B2 (en) 2013-11-19
CY1116873T1 (el) 2017-04-05
CR11213A (es) 2010-04-20
EP2543724B1 (de) 2018-03-21
PL2543724T3 (pl) 2018-08-31
KR101682240B1 (ko) 2016-12-06
DK2543724T3 (en) 2018-05-28
LT2543724T (lt) 2018-06-25
EP2155871A1 (de) 2010-02-24
US20140099297A1 (en) 2014-04-10
PT2543724T (pt) 2018-06-11
PT2155871E (pt) 2015-10-26
EP2543724A2 (de) 2013-01-09
SI2543724T1 (en) 2018-07-31
TR201808117T4 (tr) 2018-07-23
CN101796183A (zh) 2010-08-04
ES2670938T3 (es) 2018-06-04
AU2008261591A1 (en) 2008-12-18
UA106869C2 (uk) 2014-10-27

Similar Documents

Publication Publication Date Title
BRPI0813942B8 (pt) polipeptídeo da enzima conversora de angiotensina 2 (ace2) recombinante, preparação e composição farmacêutica compreendendo o mesmo, processo para a produção do mesmo e usos terapêuticos dos ditos polipeptídeo, preparação e composição
BRPI0510736A (pt) compostos de amido e seu uso como produtos farmacêuticos
BRPI0518022A (pt) compostos de lactam e seu uso como produtos farmacêuticos
ECSP10010735A (es) Compuestos químicos 251
MX352205B (es) Sistemas de expresion.
NZ592509A (en) HLA-A*1101-restricted WTI peptide and pharmaceutical composition comprising the same
BR112016002753A2 (pt) anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos
TW200745103A (en) Substituted 7-azaindazoles, compositions containing them, production process and use
BR112012016330B8 (pt) ativadores de tieno [2, 3-b] piridinadiona de ampk e composição farmacêutica compreendendo os mesmos
BR112012012025A2 (pt) polipeptídeo imunomodulador derivado da interleucina-2, proteína de fusão, composição farmacêutica e usos do polipeptídeo e da proteína de fusão
BRPI0510428A (pt) composições tópicas de metadona e processos para utilização das mesmas
BR112012017054A2 (pt) "análogo de peptídeo de oxintomodulina, seu uso, bem como composição farmacêutica"
PH12014500923A1 (en) Insulinotropic peptide derivative wherein its n-terminal amino acid is modified
UY30824A1 (es) Nuevos derivados de idazolil éster o amida, composiciones farmacéuticas conteniéndolas, procesos de preparacion y aplicaciones.
BRPI0408158A8 (pt) Amilases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las
AR070119A1 (es) Derivados de insulina con perfil tiempo / accion extremadamente retardado
Takagi et al. Discovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity
BR0214044A (pt) Benzamida e heteroarilamida como antagonistas receptores p2x7
CL2012000119A1 (es) Polipeptido f de virus respiratorio sincicial recombinante, composicion inmunogenica que lo comprende, uso para la preparacion de un medicamento para la profilaxis contra dicho virus.
BR112012015740A2 (pt) anticorpos de anti-flt3 e metodos de uso dos mesmos
CR11802A (es) Derivados de indazoles sustituidos con fenilo o piridinilo
CL2008001467A1 (es) Peptidos cilindricos antagonistas de cxcr4 ciclado por lactamas: composicion farmaceutica que los comprenden; y su uso para tratar artitis reumatica, fibrosis pulmonar, infeccion por vih o cancer.
BR112012009432A2 (pt) anticorpo anti-hsv
BR112014015630A8 (pt) fluorometil-5,6-di-hidro-4h-[1,3]oxazinas, seus usos, e composição farmacêutica
BRPI0620431A8 (pt) uso de um poliuretano formador de película, preparação farmacêutica líquida, aplicador e emplastro contendo a referida preparação farmacêutica

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/08/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/06/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF