JP2013504074A5 - - Google Patents
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- JP2013504074A5 JP2013504074A5 JP2012528364A JP2012528364A JP2013504074A5 JP 2013504074 A5 JP2013504074 A5 JP 2013504074A5 JP 2012528364 A JP2012528364 A JP 2012528364A JP 2012528364 A JP2012528364 A JP 2012528364A JP 2013504074 A5 JP2013504074 A5 JP 2013504074A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- filter membrane
- exhaled breath
- subject
- sampling unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940079593 drug Drugs 0.000 claims description 74
- 239000003814 drug Substances 0.000 claims description 74
- 238000005070 sampling Methods 0.000 claims description 59
- 239000012528 membrane Substances 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 5
- 238000004949 mass spectrometry Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 241000218236 Cannabis Species 0.000 claims 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- 229920003002 synthetic resin Polymers 0.000 claims 4
- 239000000057 synthetic resin Substances 0.000 claims 4
- 238000012360 testing method Methods 0.000 claims 4
- APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 claims 4
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 2
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 claims 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 2
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 2
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 claims 2
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 claims 2
- 229940025084 amphetamine Drugs 0.000 claims 2
- 239000003263 anabolic agent Substances 0.000 claims 2
- KZOKOEQTKWBKOK-XHQKLZHNSA-N azidomorphine Chemical compound O([C@H]1[C@@H](CC[C@H]23)N=[N+]=[N-])C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O KZOKOEQTKWBKOK-XHQKLZHNSA-N 0.000 claims 2
- 229940049706 benzodiazepine Drugs 0.000 claims 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 2
- 229960001736 buprenorphine Drugs 0.000 claims 2
- 229950002698 cathinone Drugs 0.000 claims 2
- PUAQLLVFLMYYJJ-ZETCQYMHSA-N cathinone Chemical compound C[C@H](N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-ZETCQYMHSA-N 0.000 claims 2
- 229960003920 cocaine Drugs 0.000 claims 2
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims 2
- 229960004193 dextropropoxyphene Drugs 0.000 claims 2
- 229960002069 diamorphine Drugs 0.000 claims 2
- 229950002454 lysergide Drugs 0.000 claims 2
- 229960004815 meprobamate Drugs 0.000 claims 2
- 229960001797 methadone Drugs 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 239000000025 natural resin Substances 0.000 claims 2
- 229940127240 opiate Drugs 0.000 claims 2
- 229920005594 polymer fiber Polymers 0.000 claims 2
- 229960004380 tramadol Drugs 0.000 claims 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 229920000642 polymer Polymers 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 238000002470 solid-phase micro-extraction Methods 0.000 description 7
- 239000011324 bead Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000000409 membrane extraction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24075209P | 2009-09-09 | 2009-09-09 | |
| US61/240,752 | 2009-09-09 | ||
| PCT/EP2010/063266 WO2011029889A1 (en) | 2009-09-09 | 2010-09-09 | Drug detection in exhaled breath |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226506A Division JP2015057607A (ja) | 2009-09-09 | 2014-11-06 | 発散された息における薬物検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504074A JP2013504074A (ja) | 2013-02-04 |
| JP2013504074A5 true JP2013504074A5 (enExample) | 2016-06-30 |
| JP5992328B2 JP5992328B2 (ja) | 2016-09-21 |
Family
ID=43037755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528364A Expired - Fee Related JP5992328B2 (ja) | 2009-09-09 | 2010-09-09 | 発散された息における薬物検出 |
| JP2014226506A Pending JP2015057607A (ja) | 2009-09-09 | 2014-11-06 | 発散された息における薬物検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226506A Pending JP2015057607A (ja) | 2009-09-09 | 2014-11-06 | 発散された息における薬物検出 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US8368883B2 (enExample) |
| EP (6) | EP2982980A1 (enExample) |
| JP (2) | JP5992328B2 (enExample) |
| CN (1) | CN102498398B (enExample) |
| AU (1) | AU2010294183B2 (enExample) |
| BR (1) | BR112012005198A8 (enExample) |
| CA (2) | CA2771830C (enExample) |
| DK (1) | DK2765420T3 (enExample) |
| EA (1) | EA023922B1 (enExample) |
| ES (2) | ES2484515T3 (enExample) |
| HU (1) | HUE038136T2 (enExample) |
| MX (1) | MX2012002976A (enExample) |
| NO (1) | NO2765420T3 (enExample) |
| TR (1) | TR201802101T4 (enExample) |
| WO (2) | WO2011029889A1 (enExample) |
| ZA (1) | ZA201201304B (enExample) |
Families Citing this family (88)
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| US20110178420A1 (en) * | 2010-01-18 | 2011-07-21 | Trent Ridder | Methods and apparatuses for improving breath alcohol testing |
| US8368883B2 (en) | 2009-09-09 | 2013-02-05 | Sensa Bues Ab | System and method for detection of analytes in exhaled breath |
| US9228997B2 (en) | 2009-10-02 | 2016-01-05 | Soberlink, Inc. | Sobriety monitoring system |
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| US9417232B2 (en) * | 2009-10-02 | 2016-08-16 | Bi Mobile Breath, Inc. | Sobriety monitoring system |
| US9988691B2 (en) | 2010-07-06 | 2018-06-05 | Deton Corp. | System for airborne bacterial sample collection and analysis |
| US8814804B2 (en) * | 2010-12-13 | 2014-08-26 | Iph, Llc | Interactive blood-alcohol content tester |
| EP2518499B1 (en) | 2011-03-09 | 2015-06-10 | Sensa Bues AB | A portable sampling device and method for drug detection from exhaled breath |
| EP2498091A1 (en) * | 2011-03-09 | 2012-09-12 | Sensa Bues AB | A vehicle interlocking system and method based on detection of analytes in exhaled breath |
| US20120327407A1 (en) * | 2011-06-21 | 2012-12-27 | University Of Georgia Research Foundation, Inc. | Independent Component Analysis of Surface-Enhanced Raman Scattering (SERS) Signals |
| EP2725985A1 (en) * | 2011-07-01 | 2014-05-07 | 3M Innovative Properties Company | A method and apparatus for screening drug offenders |
| US9255842B2 (en) | 2011-07-13 | 2016-02-09 | Thermo Scientific Portable Analytical Instruments Inc. | Heroin detection by raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant |
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