JP2013503882A5 - - Google Patents
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- JP2013503882A5 JP2013503882A5 JP2012528005A JP2012528005A JP2013503882A5 JP 2013503882 A5 JP2013503882 A5 JP 2013503882A5 JP 2012528005 A JP2012528005 A JP 2012528005A JP 2012528005 A JP2012528005 A JP 2012528005A JP 2013503882 A5 JP2013503882 A5 JP 2013503882A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutical composition
- composition according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 6
- -1 9-methoxynonyl Chemical group 0.000 claims description 5
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000003435 aroyl group Chemical group 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- OLYHECNPMKMYII-LXTVHRRPSA-N (2r,3r,4r,5s)-2-(hydroxymethyl)-1-(6-propoxyhexyl)piperidine-3,4,5-triol Chemical compound CCCOCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO OLYHECNPMKMYII-LXTVHRRPSA-N 0.000 claims description 2
- 241000700626 Cowpox virus Species 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- FTSCEGKYKXESFF-LXTVHRRPSA-N N-nonyldeoxynojirimycin Chemical compound CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO FTSCEGKYKXESFF-LXTVHRRPSA-N 0.000 claims description 2
- 241000700618 Vaccinia virus Species 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 241000700647 Variola virus Species 0.000 claims 2
- 241000700629 Orthopoxvirus Species 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 241000700625 Poxviridae Species 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 2
- 0 C***c1c(*)c(*)c(*)c(*)c1I Chemical compound C***c1c(*)c(*)c(*)c(*)c1I 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27225209P | 2009-09-04 | 2009-09-04 | |
| US61/272,252 | 2009-09-04 | ||
| PCT/US2010/047498 WO2011028781A1 (en) | 2009-09-04 | 2010-09-01 | Methods of treating poxviral infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013503882A JP2013503882A (ja) | 2013-02-04 |
| JP2013503882A5 true JP2013503882A5 (https=) | 2014-03-13 |
| JP5575246B2 JP5575246B2 (ja) | 2014-08-20 |
Family
ID=43649619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528005A Expired - Fee Related JP5575246B2 (ja) | 2009-09-04 | 2010-09-01 | ポックスウイルス感染の治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110065753A1 (https=) |
| EP (1) | EP2473493B1 (https=) |
| JP (1) | JP5575246B2 (https=) |
| KR (1) | KR101459530B1 (https=) |
| CN (1) | CN102625801B (https=) |
| CA (1) | CA2772807A1 (https=) |
| ES (1) | ES2485623T3 (https=) |
| WO (1) | WO2011028781A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2753195C (en) | 2009-02-23 | 2015-06-02 | United Therapeutics Corporation | Iminosugars and methods of treating viral diseases |
| IN2014MN02539A (https=) | 2012-06-06 | 2015-07-24 | Unither Virology Llc | |
| KR20150128899A (ko) * | 2013-03-15 | 2015-11-18 | 유니터 바이롤로지, 엘엘씨 | 항박테리아 화합물 |
| KR20160055916A (ko) * | 2013-09-16 | 2016-05-18 | 이머전트 바이롤로지 엘엘씨 | 데옥시노지리마이신 유도체 및 그의 이용 방법 |
| CA2966893C (en) | 2014-11-05 | 2023-10-24 | Emergent Virology Llc | Iminosugars |
| WO2017201030A1 (en) * | 2016-05-16 | 2017-11-23 | Emergent Virology Llc | Methods of treating viral infection |
| US10176965B1 (en) | 2017-07-05 | 2019-01-08 | ICT Integrated Circuit Testing Gesellschaft für Halbleiterprüftechnik mbH | Aberration-corrected multibeam source, charged particle beam device and method of imaging or illuminating a specimen with an array of primary charged particle beamlets |
| US12097454B2 (en) | 2018-08-03 | 2024-09-24 | 3M Innovative Properties Company | Air-filter media including a relofted spunbonded web, and methods of making and using |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| US5144037A (en) * | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
| US5043273A (en) * | 1989-08-17 | 1991-08-27 | Monsanto Company | Phosphorylated glycosidase inhibitor prodrugs |
| US5103008A (en) * | 1989-08-17 | 1992-04-07 | Monsanto Company | Compound, N-butyl-deoxynojirimycin-6-phosphate |
| US4994572A (en) * | 1989-10-12 | 1991-02-19 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| US5200523A (en) * | 1990-10-10 | 1993-04-06 | Monsanto Company | Synthesis of nojirimycin derivatives |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| WO1995022975A1 (en) * | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
| BR9813508A (pt) * | 1997-12-11 | 2000-10-03 | Univ Oxford | Inibição de replicação viral associada com membrana |
| US6689759B1 (en) * | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| US6809083B1 (en) * | 1998-02-12 | 2004-10-26 | Richard A. Mueller | Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections |
| US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB9828474D0 (en) * | 1998-12-24 | 1999-02-17 | British Aerospace | Surface topology inspection |
| JP2002536407A (ja) * | 1999-02-12 | 2002-10-29 | ジー・ディー・サール・アンド・カンパニー | 肝炎ウィルス感染の治療のための置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の使用 |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| ATE234626T1 (de) * | 1999-07-26 | 2003-04-15 | Searle & Co | Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| PT2441467E (pt) * | 2003-01-31 | 2015-10-12 | Sinai School Medicine | Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica |
| US7446098B2 (en) * | 2003-02-18 | 2008-11-04 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiencies |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| GB0501352D0 (en) * | 2005-01-21 | 2005-03-02 | Slingsby Jason H | Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope |
| KR20080056688A (ko) * | 2005-03-16 | 2008-06-23 | 유니버시티 오브 옥스퍼드 | Ｈｉｖ－ｉ용 만노스 면역원 |
| EP2932982B1 (en) * | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
| KR20080031474A (ko) * | 2005-07-27 | 2008-04-08 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 안구 질환의 치료를 위한 열충격의 사용 |
| AU2006272497B2 (en) * | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
| AU2007241622A1 (en) * | 2006-04-24 | 2007-11-01 | Academisch Medisch Centrum | Improved treatment of cystic fibrosis |
| US8975280B2 (en) * | 2006-05-24 | 2015-03-10 | The Chancellor, Masters And Scholars Of The University Of Oxford | Deoxynojirimycin and D-arabinitol analogs and methods of using |
| JP2009545621A (ja) * | 2006-08-02 | 2009-12-24 | ユナイテッド セラピューティクス コーポレーション | ウィルス感染症のリポソーム処置 |
| US20080131398A1 (en) * | 2006-08-21 | 2008-06-05 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
-
2010
- 2010-09-01 CN CN201080048401.4A patent/CN102625801B/zh not_active Expired - Fee Related
- 2010-09-01 CA CA2772807A patent/CA2772807A1/en not_active Abandoned
- 2010-09-01 ES ES10814414.8T patent/ES2485623T3/es active Active
- 2010-09-01 KR KR1020127007710A patent/KR101459530B1/ko not_active Expired - Fee Related
- 2010-09-01 EP EP10814414.8A patent/EP2473493B1/en not_active Not-in-force
- 2010-09-01 JP JP2012528005A patent/JP5575246B2/ja not_active Expired - Fee Related
- 2010-09-01 US US12/873,705 patent/US20110065753A1/en not_active Abandoned
- 2010-09-01 WO PCT/US2010/047498 patent/WO2011028781A1/en not_active Ceased
-
2016
- 2016-05-04 US US15/145,992 patent/US20160243097A1/en not_active Abandoned
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