JP2010525063A5 - - Google Patents
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- JP2010525063A5 JP2010525063A5 JP2010506270A JP2010506270A JP2010525063A5 JP 2010525063 A5 JP2010525063 A5 JP 2010525063A5 JP 2010506270 A JP2010506270 A JP 2010506270A JP 2010506270 A JP2010506270 A JP 2010506270A JP 2010525063 A5 JP2010525063 A5 JP 2010525063A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- pharmaceutical composition
- composition according
- compound
- immunodeficient subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000700605 Viruses Species 0.000 claims description 14
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 9
- 241000701027 Human herpesvirus 6 Species 0.000 claims description 5
- 241000829111 Human polyomavirus 1 Species 0.000 claims description 5
- 241000700584 Simplexvirus Species 0.000 claims description 4
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 claims description 3
- 241000700647 Variola virus Species 0.000 claims description 3
- 241000701161 unidentified adenovirus Species 0.000 claims description 3
- 241001115402 Ebolavirus Species 0.000 claims description 2
- 241000711549 Hepacivirus C Species 0.000 claims description 2
- 241001631646 Papillomaviridae Species 0.000 claims description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 208000005871 monkeypox Diseases 0.000 claims description 2
- 241000712461 unidentified influenza virus Species 0.000 claims description 2
- 208000007089 vaccinia Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 13
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 4
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 3
- ZORWARFPXPVJLW-MTFPJWTKSA-N [2-[(2-amino-6-oxo-3h-purin-9-yl)methoxy]-3-hydroxypropyl] (2s)-2-amino-3-methylbutanoate;hydron;chloride Chemical compound Cl.N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 ZORWARFPXPVJLW-MTFPJWTKSA-N 0.000 claims 3
- 229960002963 ganciclovir Drugs 0.000 claims 3
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 229960004983 valganciclovir hydrochloride Drugs 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- YXQUGSXUDFTPLL-LURJTMIESA-N 4-amino-1-[[(5s)-2-hydroxy-2-oxo-1,4,2$l^{5}-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1C[C@@H]1OCP(O)(=O)OC1 YXQUGSXUDFTPLL-LURJTMIESA-N 0.000 claims 2
- VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 229960001997 adefovir Drugs 0.000 claims 2
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 2
- 229960000724 cidofovir Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 229960004556 tenofovir Drugs 0.000 claims 2
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000029483 Acquired immunodeficiency Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701460 JC polyomavirus Species 0.000 claims 1
- 206010029155 Nephropathy toxic Diseases 0.000 claims 1
- 208000031951 Primary immunodeficiency Diseases 0.000 claims 1
- 201000003740 cowpox Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 230000007694 nephrotoxicity Effects 0.000 claims 1
- 231100000417 nephrotoxicity Toxicity 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 description 3
- 208000001203 Smallpox Diseases 0.000 description 2
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000724252 Cucumber mosaic virus Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 241001492478 dsDNA viruses, no RNA stage Species 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 201000006266 variola major Diseases 0.000 description 1
- 201000000627 variola minor Diseases 0.000 description 1
- 208000014016 variola minor infection Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91453207P | 2007-04-27 | 2007-04-27 | |
| PCT/US2008/005322 WO2008133966A1 (en) | 2007-04-27 | 2008-04-25 | Methods of reducing nephrotoxicity in subjects administered with nucleoside |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014233457A Division JP2015063538A (ja) | 2007-04-27 | 2014-11-18 | ヌクレオシドホスホナートが投与された被験者における腎毒性を減少させる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010525063A JP2010525063A (ja) | 2010-07-22 |
| JP2010525063A5 true JP2010525063A5 (https=) | 2013-05-23 |
Family
ID=39523817
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506270A Withdrawn JP2010525063A (ja) | 2007-04-27 | 2008-04-25 | ヌクレオシドホスホナートが投与された被験者における腎毒性を減少させる方法 |
| JP2014233457A Pending JP2015063538A (ja) | 2007-04-27 | 2014-11-18 | ヌクレオシドホスホナートが投与された被験者における腎毒性を減少させる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014233457A Pending JP2015063538A (ja) | 2007-04-27 | 2014-11-18 | ヌクレオシドホスホナートが投与された被験者における腎毒性を減少させる方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20120010170A1 (https=) |
| EP (1) | EP2155257B1 (https=) |
| JP (2) | JP2010525063A (https=) |
| CN (2) | CN102702260A (https=) |
| AU (1) | AU2008246195B2 (https=) |
| CA (1) | CA2685285A1 (https=) |
| ES (1) | ES2609095T3 (https=) |
| MX (1) | MX2009011573A (https=) |
| WO (1) | WO2008133966A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| EP2254582B1 (en) | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| WO2011017253A1 (en) * | 2009-08-03 | 2011-02-10 | Chimerix, Inc. | Composition and methods of treating viral infections and viral induced tumors |
| CN102665729A (zh) * | 2009-10-30 | 2012-09-12 | 奇默里克斯公司 | 用于治疗病毒相关性疾病的方法 |
| WO2011053812A1 (en) * | 2009-10-30 | 2011-05-05 | Chimerix, Inc. | Methods of treating viral associated diseases |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| US9278135B2 (en) | 2010-04-26 | 2016-03-08 | Chimerix Inc. | Methods of treating retroviral infections and related dosage regimes |
| AU2015201895B2 (en) * | 2010-08-31 | 2016-11-17 | Emergent Biodefence Operations Lansing Llc | Phosphonate ester derivatives and methods of synthesis thereof |
| ES2604137T3 (es) * | 2010-08-31 | 2017-03-03 | Chimerix, Inc. | Derivados de éster de fosfonato y métodos de síntesis de los mismos |
| SE1450131A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | DAA-kombinationsbehandling (t.ex. med ABT-072 eller ABT-333)för användning vid behandling av HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| DE112012002748T5 (de) | 2011-10-21 | 2014-07-31 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| ES2874774T3 (es) | 2011-12-22 | 2021-11-05 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
| EP2869823A4 (en) * | 2012-07-03 | 2016-03-16 | Chimerix Inc | METHOD FOR THE TREATMENT OF RETROVIRUS INFECTIONS AND RELATED DOSING PLANS |
| EA201892769A3 (ru) | 2013-03-15 | 2019-08-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Сложные диэфиры ациклических нуклеозидфосфонатов |
| DK2999476T3 (en) | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| BR112017005111B1 (pt) | 2014-09-15 | 2023-02-14 | The Regents Of The University Of California | Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus |
| WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| EP4295853A3 (en) * | 2016-06-28 | 2024-03-06 | Emergent BioDefense Operations Lansing LLC | Formulations of brincidofovir |
| WO2018156879A1 (en) * | 2017-02-23 | 2018-08-30 | Chimerix, Inc. | Treatment of adenovirus with brincidofovir |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| IL318465A (en) | 2022-07-21 | 2025-03-01 | Antiva Biosciences Inc | Compositions and dosage forms for the treatment of HPV infection and HPV-induced neoplasia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60038038T2 (de) * | 1999-12-03 | 2009-02-12 | The Regents of The University of California at San Diego, La Jolla | Phosphonatverbindungen |
| JP2005508945A (ja) * | 2001-10-06 | 2005-04-07 | メリアル リミテッド | Ｃｐｇ配合物及び関連方法 |
| JP2008535862A (ja) * | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| CN100396689C (zh) * | 2006-03-07 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物 |
-
2008
- 2008-04-25 WO PCT/US2008/005322 patent/WO2008133966A1/en not_active Ceased
- 2008-04-25 CA CA002685285A patent/CA2685285A1/en active Pending
- 2008-04-25 US US12/597,046 patent/US20120010170A1/en not_active Abandoned
- 2008-04-25 JP JP2010506270A patent/JP2010525063A/ja not_active Withdrawn
- 2008-04-25 CN CN2012101543928A patent/CN102702260A/zh active Pending
- 2008-04-25 AU AU2008246195A patent/AU2008246195B2/en active Active
- 2008-04-25 EP EP08743275.3A patent/EP2155257B1/en active Active
- 2008-04-25 ES ES08743275.3T patent/ES2609095T3/es active Active
- 2008-04-25 MX MX2009011573A patent/MX2009011573A/es active IP Right Grant
- 2008-04-25 CN CN200880013876A patent/CN101678122A/zh active Pending
-
2014
- 2014-11-18 JP JP2014233457A patent/JP2015063538A/ja active Pending
-
2016
- 2016-04-13 US US15/098,011 patent/US20160303147A1/en not_active Abandoned
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