JP2013503160A5 - - Google Patents
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- JP2013503160A5 JP2013503160A5 JP2012526728A JP2012526728A JP2013503160A5 JP 2013503160 A5 JP2013503160 A5 JP 2013503160A5 JP 2012526728 A JP2012526728 A JP 2012526728A JP 2012526728 A JP2012526728 A JP 2012526728A JP 2013503160 A5 JP2013503160 A5 JP 2013503160A5
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- JP
- Japan
- Prior art keywords
- salt
- solvate
- hydrate
- compound according
- item
- Prior art date
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- 239000002184 metal Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 18
- 125000002252 acyl group Chemical group 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 201000004624 Dermatitis Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
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- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
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- 229910052785 arsenic Inorganic materials 0.000 claims description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| US61/275,096 | 2009-08-25 | ||
| PCT/US2010/002336 WO2011028255A2 (en) | 2009-08-25 | 2010-08-25 | Desferrithiocin polyether analogues and uses thereof |
Related Child Applications (1)
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| JP2015040176A Division JP2015120742A (ja) | 2009-08-25 | 2015-03-02 | デスフェリチオシンポリエーテル類似体およびその使用 |
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| JP2013503160A JP2013503160A (ja) | 2013-01-31 |
| JP2013503160A5 true JP2013503160A5 (https=) | 2013-10-03 |
| JP5925679B2 JP5925679B2 (ja) | 2016-05-25 |
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| JP2012526728A Expired - Fee Related JP5925679B2 (ja) | 2009-08-25 | 2010-08-25 | デスフェリチオシンポリエーテル類似体およびその使用 |
| JP2015040176A Pending JP2015120742A (ja) | 2009-08-25 | 2015-03-02 | デスフェリチオシンポリエーテル類似体およびその使用 |
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| JP2015040176A Pending JP2015120742A (ja) | 2009-08-25 | 2015-03-02 | デスフェリチオシンポリエーテル類似体およびその使用 |
Country Status (8)
| Country | Link |
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| US (1) | US20120184586A1 (https=) |
| EP (1) | EP2470515A4 (https=) |
| JP (2) | JP5925679B2 (https=) |
| CN (1) | CN102574824B (https=) |
| AU (1) | AU2010290103B2 (https=) |
| CA (1) | CA2772212A1 (https=) |
| IN (1) | IN2012DN02448A (https=) |
| WO (1) | WO2011028255A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| JP5439193B2 (ja) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
| US8063227B2 (en) | 2008-07-14 | 2011-11-22 | Ferrokin Biosciences, Inc. | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) * | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| US9045440B2 (en) | 2010-05-04 | 2015-06-02 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| TW201338777A (zh) | 2011-12-09 | 2013-10-01 | Ferrokin Biosciences Inc | 用於治療金屬過載之經口調配物 |
| JP6539046B2 (ja) | 2011-12-16 | 2019-07-03 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ４’−デスフェリチオシン類似体の使用 |
| CA2930966A1 (en) * | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| EP3288557A4 (en) * | 2015-04-27 | 2018-11-07 | University of Florida Research Foundation, Inc. | Metabolically programmed metal chelators and uses thereof |
| EP3383415B1 (en) | 2015-12-01 | 2021-03-31 | Cornell University | Use of mitochondrial iron chelators for treatment of chronic obstructive pulmonary disease |
| KR20230004944A (ko) * | 2016-08-05 | 2023-01-06 | 아브페로 파마슈티칼스, 인크. | 금속-매개 상태를 치료하기 위한 투여 요법 |
| JP2021530515A (ja) * | 2018-07-19 | 2021-11-11 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 鉄欠乏症および関連する貧血を治療するためのエンテロバクチンの新規使用のための方法、システムおよび組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0610644B8 (pt) * | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| US20100137346A1 (en) * | 2006-12-12 | 2010-06-03 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogue actinide decorporation agents |
| JP5439193B2 (ja) * | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
-
2010
- 2010-08-25 US US13/390,951 patent/US20120184586A1/en not_active Abandoned
- 2010-08-25 CN CN201080048025.9A patent/CN102574824B/zh not_active Expired - Fee Related
- 2010-08-25 WO PCT/US2010/002336 patent/WO2011028255A2/en not_active Ceased
- 2010-08-25 JP JP2012526728A patent/JP5925679B2/ja not_active Expired - Fee Related
- 2010-08-25 EP EP10814064.1A patent/EP2470515A4/en not_active Withdrawn
- 2010-08-25 CA CA2772212A patent/CA2772212A1/en not_active Abandoned
- 2010-08-25 AU AU2010290103A patent/AU2010290103B2/en not_active Ceased
-
2012
- 2012-03-21 IN IN2448DEN2012 patent/IN2012DN02448A/en unknown
-
2015
- 2015-03-02 JP JP2015040176A patent/JP2015120742A/ja active Pending
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