CA2772212A1 - Desferrithiocin polyether analogues and uses thereof - Google Patents
Desferrithiocin polyether analogues and uses thereof Download PDFInfo
- Publication number
- CA2772212A1 CA2772212A1 CA2772212A CA2772212A CA2772212A1 CA 2772212 A1 CA2772212 A1 CA 2772212A1 CA 2772212 A CA2772212 A CA 2772212A CA 2772212 A CA2772212 A CA 2772212A CA 2772212 A1 CA2772212 A1 CA 2772212A1
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- Prior art keywords
- compound
- iron
- group
- salt
- tumors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000004684 trihydrates Chemical class 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Psychology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27509609P | 2009-08-25 | 2009-08-25 | |
| US61/275,096 | 2009-08-25 | ||
| PCT/US2010/002336 WO2011028255A2 (en) | 2009-08-25 | 2010-08-25 | Desferrithiocin polyether analogues and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2772212A1 true CA2772212A1 (en) | 2011-03-10 |
Family
ID=43649837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2772212A Abandoned CA2772212A1 (en) | 2009-08-25 | 2010-08-25 | Desferrithiocin polyether analogues and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120184586A1 (https=) |
| EP (1) | EP2470515A4 (https=) |
| JP (2) | JP5925679B2 (https=) |
| CN (1) | CN102574824B (https=) |
| AU (1) | AU2010290103B2 (https=) |
| CA (1) | CA2772212A1 (https=) |
| IN (1) | IN2012DN02448A (https=) |
| WO (1) | WO2011028255A2 (https=) |
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| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| JP5439193B2 (ja) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
| US8063227B2 (en) | 2008-07-14 | 2011-11-22 | Ferrokin Biosciences, Inc. | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) * | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| US9045440B2 (en) | 2010-05-04 | 2015-06-02 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| TW201338777A (zh) | 2011-12-09 | 2013-10-01 | Ferrokin Biosciences Inc | 用於治療金屬過載之經口調配物 |
| JP6539046B2 (ja) | 2011-12-16 | 2019-07-03 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ４’−デスフェリチオシン類似体の使用 |
| CA2930966A1 (en) * | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| EP3288557A4 (en) * | 2015-04-27 | 2018-11-07 | University of Florida Research Foundation, Inc. | Metabolically programmed metal chelators and uses thereof |
| EP3383415B1 (en) | 2015-12-01 | 2021-03-31 | Cornell University | Use of mitochondrial iron chelators for treatment of chronic obstructive pulmonary disease |
| KR20230004944A (ko) * | 2016-08-05 | 2023-01-06 | 아브페로 파마슈티칼스, 인크. | 금속-매개 상태를 치료하기 위한 투여 요법 |
| JP2021530515A (ja) * | 2018-07-19 | 2021-11-11 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 鉄欠乏症および関連する貧血を治療するためのエンテロバクチンの新規使用のための方法、システムおよび組成物 |
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| BRPI0610644B8 (pt) * | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| US20100137346A1 (en) * | 2006-12-12 | 2010-06-03 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogue actinide decorporation agents |
| JP5439193B2 (ja) * | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
-
2010
- 2010-08-25 US US13/390,951 patent/US20120184586A1/en not_active Abandoned
- 2010-08-25 CN CN201080048025.9A patent/CN102574824B/zh not_active Expired - Fee Related
- 2010-08-25 WO PCT/US2010/002336 patent/WO2011028255A2/en not_active Ceased
- 2010-08-25 JP JP2012526728A patent/JP5925679B2/ja not_active Expired - Fee Related
- 2010-08-25 EP EP10814064.1A patent/EP2470515A4/en not_active Withdrawn
- 2010-08-25 CA CA2772212A patent/CA2772212A1/en not_active Abandoned
- 2010-08-25 AU AU2010290103A patent/AU2010290103B2/en not_active Ceased
-
2012
- 2012-03-21 IN IN2448DEN2012 patent/IN2012DN02448A/en unknown
-
2015
- 2015-03-02 JP JP2015040176A patent/JP2015120742A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20120184586A1 (en) | 2012-07-19 |
| IN2012DN02448A (https=) | 2015-08-21 |
| JP2015120742A (ja) | 2015-07-02 |
| AU2010290103B2 (en) | 2016-07-14 |
| CN102574824B (zh) | 2016-04-27 |
| EP2470515A4 (en) | 2013-04-24 |
| WO2011028255A2 (en) | 2011-03-10 |
| JP2013503160A (ja) | 2013-01-31 |
| WO2011028255A3 (en) | 2011-07-14 |
| JP5925679B2 (ja) | 2016-05-25 |
| EP2470515A2 (en) | 2012-07-04 |
| CN102574824A (zh) | 2012-07-11 |
| AU2010290103A1 (en) | 2012-03-29 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150817 |
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| FZDE | Discontinued |
Effective date: 20181224 |