JP2013502951A - 薬剤容器 - Google Patents
薬剤容器 Download PDFInfo
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- JP2013502951A JP2013502951A JP2012526018A JP2012526018A JP2013502951A JP 2013502951 A JP2013502951 A JP 2013502951A JP 2012526018 A JP2012526018 A JP 2012526018A JP 2012526018 A JP2012526018 A JP 2012526018A JP 2013502951 A JP2013502951 A JP 2013502951A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
Abstract
Description
ここで一実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、抗体、酵素、抗体、ホルモン、又はオリゴヌクレオチド、若しくは上記の薬学的に活性な化合物の混合物であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの処置、及び/又は、予防に有用であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の処置、及び/又は、予防のための少なくとも一つのペプチドを含み、
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも一つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2;
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2;
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と結合してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Lys6−desPro36[Met(O)14,Trp(O2)25, Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
1:薬剤容器;
2:バッグ;
2.1〜2.n:バッグチャンバ;
3:液体薬剤;
4:排出口;
5:剛体コア;
5.1:バルジ;
6:アクタ材料;
6.1:遠隔セクション;
7:固定点;
8:ガイドロール;
9:ドレインチャンネル;
10:センサ;
11:エネルギ源;
12:インタフェース;
Q:熱;
Claims (17)
- 排出口(4)を有するバッグ(2)を含む液体薬剤(3)用の薬剤容器(1)で、バッグ(2)が、薬剤容器(1)の少なくとも一部がエネルギ源にさらされることにより、圧縮可能であるか又は収縮可能である、薬剤容器(1)であって、剛体コア(5)がバッグ(2)内に配置されることを特徴とする、上記薬剤容器(1)。
- バッグ(2)が、薬剤容器(1)の少なくとも一部が熱源にさらされることにより、圧縮可能であるか又は収縮可能であることを特徴とする、請求項1に記載の薬剤容器(1)。
- バッグ(2)が、熱(Q)にさらされたとき収縮するように構成される熱収縮性材料よりなることを特徴とする、請求項1又は2に記載の薬剤容器(1)。
- アクタ材料(6)が、バッグ(2)の周囲に少なくとも部分的に配置され、アクタ材料(6)が、熱(Q)にさらされたとき、収縮するように構成されることを特徴とする、請求項1又は2に記載の薬剤容器(1)。
- アクタ材料(6)が、別々に加熱され得る数個のセクションを含むことを特徴とする、請求項4に記載の薬剤容器(1)。
- 剛体コア(5)が、バッグ(2)の縦方向に配置されることを特徴とする、請求項1〜5のいずれか1項に記載の薬剤容器(1)。
- 排出口(4)が、中空注射ニードルを受けるためのインタフェースを含むことを特徴とする、請求項1〜6のいずれか1項に記載の薬剤容器(1)。
- アクタ材料(6)が、バッグ(2)と接触せず熱(Q)にさらされるように配置される遠隔セクション(6.1)を含むことを特徴とする、請求項4〜7のいずれか1項に記載の薬剤容器(1)。
- 少なくとも一つのドレインチャンネル(9)が、剛体コア(5)の表面上の少なくとも一つの開口部を排出口(4)に連結する形で、剛体コア(5)に配置されることを特徴とする、請求項1〜8のいずれか1項に記載の薬剤容器(1)。
- バッグ(2)が、少なくとも二つの連続したバッグチャンバ(2.1〜2.n)に細分割され、ここで、剛体コア(5)は各バッグチャンバ(2.1〜2.n)ごとのそれぞれのセグメントを有し、各セグメントは、ドレインチャンネル(9)の少なくとも一つの開口部を有することを特徴とする、請求項9に記載の薬剤容器(1)。
- 各セグメントが、中央バルジ(5.1)を含むことを特徴とする、請求項10に記載の薬剤容器(1)。
- 少なくとも一つのセンサ(10)が、剛体コア(5)に組込まれることを特徴とする、請求項1〜11のいずれか1項に記載の薬剤容器(1)。
- エネルギ蓄積部(11)が、剛体コア(5)に組込まれることを特徴とする、請求項1〜12のいずれか1項に記載の薬剤容器(1)。
- 排出口(4)の反対側の剛体コア(5)の端部が、センサ(10)のデータ及び/又はエネルギ蓄積部(11)からのエネルギを薬剤容器(1)及び少なくとも一つの外部部材間で交換するためのインタフェース(12)として配置されることを特徴とする、請求項12又は13に記載の薬剤容器(1)。
- 請求項1〜14のいずれか1項に記載の薬剤容器(1)及び排出口に配置された患者皮膚に穿刺するための中空ニードルを含む、液体薬剤(3)を送達するための注射配置。
- バルブ及び患者皮膚に穿刺するための中空ニードルが、排出口(4)に配置されることを特徴とする、請求項15に記載の注射配置。
- 請求項1〜14のいずれか1項に記載の薬剤容器(1)を含む、液体薬剤(3)を送達するための吸入配置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09010969.5 | 2009-08-27 | ||
EP09010969 | 2009-08-27 | ||
PCT/EP2010/062153 WO2011023631A2 (en) | 2009-08-27 | 2010-08-20 | Medicament container |
Publications (3)
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JP2013502951A true JP2013502951A (ja) | 2013-01-31 |
JP2013502951A5 JP2013502951A5 (ja) | 2015-01-22 |
JP5788879B2 JP5788879B2 (ja) | 2015-10-07 |
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Application Number | Title | Priority Date | Filing Date |
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JP2012526018A Active JP5788879B2 (ja) | 2009-08-27 | 2010-08-20 | 薬剤容器 |
Country Status (7)
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US (1) | US8465459B2 (ja) |
EP (1) | EP2470242B1 (ja) |
JP (1) | JP5788879B2 (ja) |
CA (1) | CA2771271A1 (ja) |
DK (1) | DK2470242T3 (ja) |
TR (1) | TR201802991T4 (ja) |
WO (1) | WO2011023631A2 (ja) |
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EP3677293A1 (en) | 2009-01-12 | 2020-07-08 | Becton, Dickinson and Company | In-dwelling rigid catheter with flexible features |
US8136779B2 (en) * | 2010-07-27 | 2012-03-20 | Alcon Research, Ltd. | Mounting arrangement for a pressurized irrigation system |
US8795230B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Adjustable height needle infusion device |
US8795234B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Integrated spring-activated ballistic insertion for drug infusion device |
US9950109B2 (en) | 2010-11-30 | 2018-04-24 | Becton, Dickinson And Company | Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion |
US8784383B2 (en) | 2010-11-30 | 2014-07-22 | Becton, Dickinson And Company | Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion |
US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
WO2013076026A1 (en) | 2011-11-22 | 2013-05-30 | Sanofi-Aventis Deutschland Gmbh | Pen-type drug injection device with controller and time lock-out mechanism its drive |
CA3168888A1 (en) | 2013-10-24 | 2015-04-30 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
GB2549531B (en) * | 2016-04-22 | 2018-12-05 | Reckitt Benckiser Finish Bv | A deformable container |
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- 2010-08-20 JP JP2012526018A patent/JP5788879B2/ja active Active
- 2010-08-20 US US13/389,866 patent/US8465459B2/en active Active
- 2010-08-20 CA CA2771271A patent/CA2771271A1/en not_active Abandoned
- 2010-08-20 EP EP10745595.8A patent/EP2470242B1/en active Active
- 2010-08-20 TR TR2018/02991T patent/TR201802991T4/tr unknown
- 2010-08-20 DK DK10745595.8T patent/DK2470242T3/en active
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Publication number | Publication date |
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US8465459B2 (en) | 2013-06-18 |
EP2470242B1 (en) | 2017-12-06 |
JP5788879B2 (ja) | 2015-10-07 |
US20120253282A1 (en) | 2012-10-04 |
WO2011023631A2 (en) | 2011-03-03 |
EP2470242A2 (en) | 2012-07-04 |
WO2011023631A3 (en) | 2011-04-21 |
DK2470242T3 (en) | 2018-03-12 |
TR201802991T4 (tr) | 2018-03-21 |
CA2771271A1 (en) | 2011-03-03 |
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