JP5836948B2 - 流体薬剤を送達するための配置 - Google Patents
流体薬剤を送達するための配置 Download PDFInfo
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- JP5836948B2 JP5836948B2 JP2012526017A JP2012526017A JP5836948B2 JP 5836948 B2 JP5836948 B2 JP 5836948B2 JP 2012526017 A JP2012526017 A JP 2012526017A JP 2012526017 A JP2012526017 A JP 2012526017A JP 5836948 B2 JP5836948 B2 JP 5836948B2
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- reservoir
- exendin
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
Description
ここで一実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、抗体、酵素、抗体、ホルモン、若しくはオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの治療、及び/又は、予防に有用であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の治療、及び/又は、予防のための少なくとも1つのペプチドを含み、
ここで更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2;
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2;
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセ
ンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と連結してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれかのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
Publishing社,Easton, Pa., U.S.A.,1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
1:薬剤容器;
1.1:リザーバ;
1.2:連結エレメント;
2:注射デバイス;
3:投与装置;
4:ニードル;
5:プランジャ;
Claims (12)
- 分離したリザーバ(1.1)の配列を含む薬剤容器(1)を含む流体薬剤を注射により送達するための装置で、ここで、各リザーバ(1.1)は流体薬剤の定められた充填量を含み、各リザーバ(1.1)は個別に放出可能であり、そしてリザーバ(1.1)は可撓性であって、連結エレメント(1.2)で連結される、該装置であって;装置は更に、リザーバ(1.1)から、連結エレメント(1.2)の下部であって、リザーバ(1.1)の外側に配置されたニードル(4)への流体薬剤の充填量の放出を起動するように設計された放出アクタを含む投与装置(3)を含み、ここで、投与装置は、放出しようとするリザーバ(1.1)を放出アクタ(5)に供給するように設計された、又は放出アクタ(5)を次に放出しようとするリザーバ(1.1)に移動するように設計された輸送装置を含むことを特徴とする、上記装置。
- 放出アクタ(5)が、一つ又はそれ以上のプランジャを含むか、又は圧縮空気を使用することを特徴とする、請求項1に記載の装置。
- 一つのプランジャ(5)が、一つのリザーバ(1.1)にそれぞれ対応している、請求項2に記載の装置。
- 注射デバイス(2)が、投与装置(3)及び少なくとも一つのニードルを含むことを特徴とする、請求項1〜3のいずれか1項に記載の装置。
- 連結エレメント(1.2)は、分離したリザーバ(1.1)を搬送するキャリアエレメントであって、ブリスターパックの形で配置されることを特徴とする、請求項1〜4のいずれか1項に記載の装置。
- リザーバ(1.1)が、同一の充填量を含むことを特徴とする、請求項1〜5のいずれか1項に記載の装置。
- リザーバ(1.1)が、異なった充填量を含むことを特徴とする、請求項1〜5のいず
れか1項に記載の装置。 - リザーバ(1.1)の配列が、一つ又はそれ以上の列のバンドとして、又はレボルバとして配置されることを特徴とする、請求項1〜7のいずれか1項に記載の装置。
- 一つ又はそれ以上の一体化ニードル(4)を特徴とする、請求項1〜8のいずれか1項に記載の装置。
- ニードル(4)は、各リザーバ(1.1)専用であることを特徴とする、請求項9に記載の装置。
- 一つ又はそれ以上のニードル(4)が、非働的に取付けられた第一の位置から起動する第二の位置に回転可能であることを特徴とする、請求項9又は10に記載の装置。
- 各リザーバ(1.1)が、流体薬剤の充填量をニードル(4)に放出するように設計された所定の破壊点を含むことを特徴とする、請求項1〜11のいずれか1項に記載の装置。
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EP09010972 | 2009-08-27 | ||
EP09010972.9 | 2009-08-27 | ||
PCT/EP2010/062152 WO2011023630A2 (en) | 2009-08-27 | 2010-08-20 | Arrangement for delivering a fluid medicament |
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JP2013502950A JP2013502950A (ja) | 2013-01-31 |
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US (1) | US20120253286A1 (ja) |
EP (1) | EP2470240B1 (ja) |
JP (1) | JP5836948B2 (ja) |
CA (1) | CA2771161A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US2392196A (en) * | 1945-02-24 | 1946-01-01 | Arthur E Smith | Syringe |
US4522622A (en) * | 1982-12-23 | 1985-06-11 | Alza Corporation | Multiple fluid pulse dispenser |
US5019048A (en) * | 1990-01-10 | 1991-05-28 | Margolin George D | Unit dose syringe with rotatable needle |
US5286258A (en) * | 1991-03-08 | 1994-02-15 | Habley Medical Technology Corporation | Multipharmaceutical delivery system |
GB9417399D0 (en) * | 1994-08-30 | 1994-10-19 | Scherer Corp R P | Ocular treatment device |
US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
US6585693B1 (en) * | 2001-07-30 | 2003-07-01 | Louis Dischler | Blister syringe with optional bifurcated guard |
WO2008066991A2 (en) * | 2006-08-30 | 2008-06-05 | Arthur Harris | Continuous feed hypodermic syringe with self contained cartridge dispenser |
CA2688689C (en) * | 2007-05-16 | 2015-06-30 | Mystic Pharmaceuticals, Inc. | Combination unit dose dispensing containers |
-
2010
- 2010-08-20 JP JP2012526017A patent/JP5836948B2/ja active Active
- 2010-08-20 WO PCT/EP2010/062152 patent/WO2011023630A2/en active Application Filing
- 2010-08-20 EP EP10745240.1A patent/EP2470240B1/en active Active
- 2010-08-20 CA CA2771161A patent/CA2771161A1/en not_active Abandoned
- 2010-08-20 DK DK10745240.1T patent/DK2470240T3/en active
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EP2470240A2 (en) | 2012-07-04 |
US20120253286A1 (en) | 2012-10-04 |
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EP2470240B1 (en) | 2015-06-03 |
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