JP2013230163A5 - - Google Patents
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- Publication number
- JP2013230163A5 JP2013230163A5 JP2013155694A JP2013155694A JP2013230163A5 JP 2013230163 A5 JP2013230163 A5 JP 2013230163A5 JP 2013155694 A JP2013155694 A JP 2013155694A JP 2013155694 A JP2013155694 A JP 2013155694A JP 2013230163 A5 JP2013230163 A5 JP 2013230163A5
- Authority
- JP
- Japan
- Prior art keywords
- strain
- plethiosum
- actinocinema
- actinocinecine
- mutagenesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 5
- 238000002703 mutagenesis Methods 0.000 claims 5
- 231100000350 mutagenesis Toxicity 0.000 claims 5
- OPQNCARIZFLNLF-UHFFFAOYSA-N ansamitocin P-3 Natural products CN1C(=O)CC(OC(=O)C(C)C)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 OPQNCARIZFLNLF-UHFFFAOYSA-N 0.000 claims 4
- OPQNCARIZFLNLF-JBHFWYGFSA-N ansamitocin P3 Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](OC(=O)C(C)C)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 OPQNCARIZFLNLF-JBHFWYGFSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 238000002955 isolation Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
- 241000143227 Actinosynnema pretiosum Species 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- VZUNGTLZRAYYDE-UHFFFAOYSA-N N-methyl-N'-nitro-N-nitrosoguanidine Chemical compound O=NN(C)C(=N)N[N+]([O-])=O VZUNGTLZRAYYDE-UHFFFAOYSA-N 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 229940035429 isobutyl alcohol Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/057,561 | 2002-01-29 | ||
| US10/057,561 US6790954B2 (en) | 2002-01-29 | 2002-01-29 | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009291891A Division JP2010110328A (ja) | 2002-01-29 | 2009-12-24 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013230163A JP2013230163A (ja) | 2013-11-14 |
| JP2013230163A5 true JP2013230163A5 (https=) | 2015-01-15 |
| JP5840656B2 JP5840656B2 (ja) | 2016-01-06 |
Family
ID=27658220
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003564206A Expired - Lifetime JP4485799B2 (ja) | 2002-01-29 | 2003-01-15 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
| JP2009291891A Pending JP2010110328A (ja) | 2002-01-29 | 2009-12-24 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
| JP2013155694A Expired - Lifetime JP5840656B2 (ja) | 2002-01-29 | 2013-07-26 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003564206A Expired - Lifetime JP4485799B2 (ja) | 2002-01-29 | 2003-01-15 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
| JP2009291891A Pending JP2010110328A (ja) | 2002-01-29 | 2009-12-24 | メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6790954B2 (https=) |
| EP (1) | EP1468077B1 (https=) |
| JP (3) | JP4485799B2 (https=) |
| AT (1) | ATE474043T1 (https=) |
| AU (1) | AU2003238752B2 (https=) |
| CA (1) | CA2474639C (https=) |
| CY (1) | CY1111210T1 (https=) |
| DE (1) | DE60333340D1 (https=) |
| DK (1) | DK1468077T3 (https=) |
| ES (1) | ES2348865T3 (https=) |
| NZ (1) | NZ532831A (https=) |
| PT (1) | PT1468077E (https=) |
| SI (1) | SI1468077T1 (https=) |
| WO (1) | WO2003064610A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AU2002311919B8 (en) | 2001-05-11 | 2007-03-22 | Ludwig Institute For Cancer Research Ltd | Specific binding proteins and uses thereof |
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| US7432088B2 (en) * | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
| US20090017140A1 (en) * | 2007-07-09 | 2009-01-15 | Peter Koepke | Maytenus abenfolia extract and methods of extracting and using such extract |
| US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US7879369B2 (en) * | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| DK2644194T3 (en) | 2008-03-18 | 2017-07-03 | Genentech Inc | Combinations of an anti-HER2 antibody-drug conjugate and docetaxel |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US20110165155A1 (en) | 2009-12-04 | 2011-07-07 | Genentech, Inc. | Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1 |
| KR20130009760A (ko) | 2010-02-10 | 2013-01-23 | 이뮤노젠 아이엔씨 | Ｃｄ２０ 항체 및 이의 용도 |
| US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
| TR201908138T4 (tr) | 2015-07-07 | 2019-06-21 | Hoffmann La Roche | Bir anti-her2 antikoru ilaç konjügatı ve bir bcl-2 inhibitörü ile kombinasyon terapisi. |
| CN108330113B (zh) * | 2018-03-08 | 2019-05-28 | 山东省医药生物技术研究中心（山东省病毒研究所） | 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用 |
| US11420981B2 (en) | 2019-04-18 | 2022-08-23 | Indena S.P.A. | Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof |
| CN115322918B (zh) * | 2021-05-11 | 2024-03-29 | 浙江珲达生物科技有限公司 | 一种高产安丝菌素p-3的菌株及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6016236B2 (ja) * | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | 抗生物質ｃ―１５００３ ｐ―３の製造法 |
| JPS5645483A (en) * | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS56102793A (en) * | 1979-12-28 | 1981-08-17 | Takeda Chem Ind Ltd | Preparation of antibiotic c-15003 p-3 |
| JPS626673A (ja) * | 1985-07-04 | 1987-01-13 | Zenkoku Nogyo Kyodo Kumiai Rengokai | パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法 |
| US5250435A (en) | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| US5648261A (en) | 1991-12-17 | 1997-07-15 | Gist-Brocades, N.V. | Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-β, Ψ-caroten-4-one (HDCO) |
| JPH07274978A (ja) * | 1994-04-13 | 1995-10-24 | Bio Kosumosu:Kk | 紅麹色素の製造方法 |
| JP3376859B2 (ja) * | 1996-11-27 | 2003-02-10 | 三菱化学株式会社 | リビトールの製造方法 |
| US6949356B1 (en) | 1999-10-20 | 2005-09-27 | Microbia, Inc. | Methods for improving secondary metabolite production in fungi |
| US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
| US6790954B2 (en) * | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
-
2002
- 2002-01-29 US US10/057,561 patent/US6790954B2/en not_active Expired - Lifetime
-
2003
- 2003-01-15 PT PT03734944T patent/PT1468077E/pt unknown
- 2003-01-15 WO PCT/US2003/000026 patent/WO2003064610A2/en not_active Ceased
- 2003-01-15 NZ NZ532831A patent/NZ532831A/en not_active IP Right Cessation
- 2003-01-15 AT AT03734944T patent/ATE474043T1/de active
- 2003-01-15 DE DE60333340T patent/DE60333340D1/de not_active Expired - Lifetime
- 2003-01-15 CA CA2474639A patent/CA2474639C/en not_active Expired - Lifetime
- 2003-01-15 AU AU2003238752A patent/AU2003238752B2/en not_active Expired
- 2003-01-15 EP EP03734944A patent/EP1468077B1/en not_active Expired - Lifetime
- 2003-01-15 ES ES03734944T patent/ES2348865T3/es not_active Expired - Lifetime
- 2003-01-15 DK DK03734944.6T patent/DK1468077T3/da active
- 2003-01-15 JP JP2003564206A patent/JP4485799B2/ja not_active Expired - Lifetime
- 2003-01-15 SI SI200331875T patent/SI1468077T1/sl unknown
-
2004
- 2004-07-26 US US10/898,169 patent/US7192750B2/en not_active Expired - Lifetime
-
2009
- 2009-12-24 JP JP2009291891A patent/JP2010110328A/ja active Pending
-
2010
- 2010-09-30 CY CY20101100876T patent/CY1111210T1/el unknown
-
2013
- 2013-07-26 JP JP2013155694A patent/JP5840656B2/ja not_active Expired - Lifetime
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