JP2013220104A5 - - Google Patents
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- JP2013220104A5 JP2013220104A5 JP2013097951A JP2013097951A JP2013220104A5 JP 2013220104 A5 JP2013220104 A5 JP 2013220104A5 JP 2013097951 A JP2013097951 A JP 2013097951A JP 2013097951 A JP2013097951 A JP 2013097951A JP 2013220104 A5 JP2013220104 A5 JP 2013220104A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- tyrosine
- hvr
- serine
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001413 amino acids Chemical group 0.000 claims 241
- 235000001014 amino acid Nutrition 0.000 claims 227
- 229940024606 amino acid Drugs 0.000 claims 224
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 84
- 229960004441 tyrosine Drugs 0.000 claims 84
- 235000002374 tyrosine Nutrition 0.000 claims 84
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 76
- 235000004400 serine Nutrition 0.000 claims 76
- 229960001153 serine Drugs 0.000 claims 76
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 74
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 71
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 50
- 108010068086 Polyubiquitin Proteins 0.000 claims 38
- 102100037935 Polyubiquitin-C Human genes 0.000 claims 38
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 37
- 239000004471 Glycine Substances 0.000 claims 36
- 239000004472 Lysine Substances 0.000 claims 34
- 229960003646 lysine Drugs 0.000 claims 34
- 235000018977 lysine Nutrition 0.000 claims 34
- 229960000310 isoleucine Drugs 0.000 claims 30
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 30
- 235000014705 isoleucine Nutrition 0.000 claims 30
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 28
- 235000008729 phenylalanine Nutrition 0.000 claims 25
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 25
- 229960005190 phenylalanine Drugs 0.000 claims 25
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 25
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 24
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 22
- 235000004279 alanine Nutrition 0.000 claims 19
- 229960003767 alanine Drugs 0.000 claims 19
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 17
- 239000004473 Threonine Substances 0.000 claims 17
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 17
- 229960002898 threonine Drugs 0.000 claims 17
- 235000008521 threonine Nutrition 0.000 claims 17
- 239000004474 valine Substances 0.000 claims 17
- 229960004295 valine Drugs 0.000 claims 17
- 235000014393 valine Nutrition 0.000 claims 17
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 16
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 16
- 235000005772 leucine Nutrition 0.000 claims 16
- 229960003136 leucine Drugs 0.000 claims 16
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 14
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 14
- 235000003704 aspartic acid Nutrition 0.000 claims 14
- 229960005261 aspartic acid Drugs 0.000 claims 14
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 14
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 14
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 13
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 13
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 13
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 13
- 235000009582 asparagine Nutrition 0.000 claims 13
- 229960001230 asparagine Drugs 0.000 claims 13
- 229960002449 glycine Drugs 0.000 claims 13
- 235000006109 methionine Nutrition 0.000 claims 13
- 229930182817 methionine Natural products 0.000 claims 13
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 12
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 12
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 11
- 229960002429 proline Drugs 0.000 claims 11
- 235000013930 proline Nutrition 0.000 claims 11
- 239000004475 Arginine Substances 0.000 claims 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 10
- 229960003121 arginine Drugs 0.000 claims 10
- 235000009697 arginine Nutrition 0.000 claims 10
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 9
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 8
- 102000044159 Ubiquitin Human genes 0.000 claims 8
- 108090000848 Ubiquitin Proteins 0.000 claims 8
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 8
- 235000004554 glutamine Nutrition 0.000 claims 8
- 229960004799 tryptophan Drugs 0.000 claims 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 7
- 235000013922 glutamic acid Nutrition 0.000 claims 7
- 239000004220 glutamic acid Substances 0.000 claims 7
- 229960004452 methionine Drugs 0.000 claims 7
- 235000018102 proteins Nutrition 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 6
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 6
- 235000014304 histidine Nutrition 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 4
- -1 tyrosine Amino acid Chemical class 0.000 claims 4
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229960002989 glutamic acid Drugs 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 102100033467 L-selectin Human genes 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229960002743 glutamine Drugs 0.000 claims 2
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000009575 Angelman syndrome Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000029578 Muscle disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000017854 proteolysis Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75108105P | 2005-12-15 | 2005-12-15 | |
| US60/751,081 | 2005-12-15 | ||
| US79398006P | 2006-04-21 | 2006-04-21 | |
| US60/793,980 | 2006-04-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545980A Division JP5358187B2 (ja) | 2005-12-15 | 2006-12-14 | ポリユビキチンを標的とする方法と組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013220104A JP2013220104A (ja) | 2013-10-28 |
| JP2013220104A5 true JP2013220104A5 (https=) | 2013-12-05 |
| JP6143538B2 JP6143538B2 (ja) | 2017-06-07 |
Family
ID=38610006
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545980A Active JP5358187B2 (ja) | 2005-12-15 | 2006-12-14 | ポリユビキチンを標的とする方法と組成物 |
| JP2013097951A Active JP6143538B2 (ja) | 2005-12-15 | 2013-05-07 | ポリユビキチンを標的とする方法と組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545980A Active JP5358187B2 (ja) | 2005-12-15 | 2006-12-14 | ポリユビキチンを標的とする方法と組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7763245B2 (https=) |
| EP (3) | EP1973948B1 (https=) |
| JP (2) | JP5358187B2 (https=) |
| KR (1) | KR101538521B1 (https=) |
| CN (1) | CN103396485B (https=) |
| AR (1) | AR057237A1 (https=) |
| BR (1) | BRPI0620697A2 (https=) |
| CA (1) | CA2633887C (https=) |
| CL (1) | CL2013002738A1 (https=) |
| ES (1) | ES2535856T3 (https=) |
| IL (2) | IL191617A (https=) |
| NO (1) | NO20083127L (https=) |
| RU (1) | RU2008128134A (https=) |
| TW (1) | TWI395753B (https=) |
| WO (1) | WO2007120334A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
| RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
| CA2633887C (en) | 2005-12-15 | 2015-12-22 | Genentech, Inc. | Methods and compositions for targeting polyubiquitin |
| US20070264155A1 (en) * | 2006-05-09 | 2007-11-15 | Brady Michael D | Aerosol jet deposition method and system for creating a reference region/sample region on a biosensor |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| ES2414804T3 (es) | 2008-01-18 | 2013-07-22 | Genentech, Inc. | Métodos y composiciones que se dirigen a la poliubiquitina |
| JP2009278908A (ja) * | 2008-05-22 | 2009-12-03 | Fujifilm Corp | 抗オステオカルシン抗体及びそれを用いた免疫測定方法 |
| ES2594893T3 (es) * | 2009-12-16 | 2016-12-23 | Abbvie Biotherapeutics Inc. | Anticuerpos anti HER2 y sus usos |
| KR20130062264A (ko) * | 2010-04-15 | 2013-06-12 | 제넨테크, 인크. | 항-폴리유비퀴틴 항체 및 사용 방법 |
| ES2684475T3 (es) | 2010-04-15 | 2018-10-03 | Abbvie Inc. | Proteínas que se unen a beta amiloide |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| US9383367B1 (en) | 2010-12-07 | 2016-07-05 | Chunli Liu | Methods of detecting conjugation site-specific and hidden epitope/antigen |
| MX2014001238A (es) | 2011-08-05 | 2014-09-22 | Genentech Inc | Anticuerpos contra poliubiquitina y métodos de uso. |
| EP2758541A1 (en) | 2011-09-23 | 2014-07-30 | Medical Research Council | Ubiquitin chain analysis |
| WO2013056352A1 (en) * | 2011-10-19 | 2013-04-25 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| EP3475298A1 (en) | 2016-06-24 | 2019-05-01 | H. Hoffnabb-La Roche Ag | Anti-polyubiquitin multispecific antibodies |
| KR20190135393A (ko) * | 2018-05-28 | 2019-12-06 | 주식회사 원진바이오테크놀로지 | 폴리유비퀴틴 스캐폴드에 결합된 생체분자들의 선형 멀티머 중합체 및 이의 용도 |
| US11992520B2 (en) | 2018-09-18 | 2024-05-28 | Vanderbilt University | Human monoclonal antibodies to Staphylococcal aureus Isd proteins and uses thereof |
| CN109402036A (zh) * | 2018-11-07 | 2019-03-01 | 河北科技师范学院 | 牛源肠炎沙门菌trxB基因缺失的应用 |
| WO2020102647A1 (en) * | 2018-11-15 | 2020-05-22 | Invenra Inc. | Multivalent receptor-clustering agonist antibody constructs and antigen binding proteins |
| US11332546B2 (en) | 2019-05-21 | 2022-05-17 | The Regents Of The University Of California | Protease inhibitory antibodies and methods of use thereof |
| US20230074615A1 (en) * | 2019-05-21 | 2023-03-09 | The Regents Of The University Of California | Mmp-9 antibodies and methods of use thereof |
| BR112022010445A2 (pt) * | 2019-11-27 | 2022-09-06 | Onegene Biotechnology Inc | Polímero biomolecular multifuncional, multiespecífico, multimérico , método para preparar um polímero biomolecular multifuncional, multiespecífico, multimérico |
| WO2021145946A1 (en) * | 2020-01-13 | 2021-07-22 | Invenra Inc. | Multispecific treg binding molecules |
| EP4192501A1 (en) * | 2020-08-04 | 2023-06-14 | Exelixis, Inc. | Cd47 binding agents and uses thereof |
| WO2023034750A1 (en) | 2021-08-30 | 2023-03-09 | Genentech, Inc. | Anti-polyubiquitin multispecific antibodies |
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