JP2013213055A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013213055A5 JP2013213055A5 JP2013147555A JP2013147555A JP2013213055A5 JP 2013213055 A5 JP2013213055 A5 JP 2013213055A5 JP 2013147555 A JP2013147555 A JP 2013147555A JP 2013147555 A JP2013147555 A JP 2013147555A JP 2013213055 A5 JP2013213055 A5 JP 2013213055A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- urease
- tumor
- enzyme
- targeting moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39724402P | 2002-07-18 | 2002-07-18 | |
| US60/397,244 | 2002-07-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011161332A Division JP5850561B2 (ja) | 2002-07-18 | 2011-07-22 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015199988A Division JP2016014066A (ja) | 2002-07-18 | 2015-10-08 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013213055A JP2013213055A (ja) | 2013-10-17 |
| JP2013213055A5 true JP2013213055A5 (enExample) | 2014-05-08 |
Family
ID=30771022
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522053A Withdrawn JP2006501196A (ja) | 2002-07-18 | 2003-07-16 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
| JP2011161332A Expired - Fee Related JP5850561B2 (ja) | 2002-07-18 | 2011-07-22 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
| JP2013147555A Withdrawn JP2013213055A (ja) | 2002-07-18 | 2013-07-16 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
| JP2015199988A Withdrawn JP2016014066A (ja) | 2002-07-18 | 2015-10-08 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522053A Withdrawn JP2006501196A (ja) | 2002-07-18 | 2003-07-16 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
| JP2011161332A Expired - Fee Related JP5850561B2 (ja) | 2002-07-18 | 2011-07-22 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015199988A Withdrawn JP2016014066A (ja) | 2002-07-18 | 2015-10-08 | 癌細胞増殖を阻害するためのウレアーゼの使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7211250B2 (enExample) |
| EP (2) | EP2324846B1 (enExample) |
| JP (4) | JP2006501196A (enExample) |
| KR (2) | KR101352826B1 (enExample) |
| CN (1) | CN100577203C (enExample) |
| AU (1) | AU2003250658B2 (enExample) |
| BR (1) | BR0312664A (enExample) |
| CA (1) | CA2492472C (enExample) |
| DK (1) | DK1530482T3 (enExample) |
| ES (1) | ES2443416T3 (enExample) |
| IL (1) | IL166249A (enExample) |
| MX (1) | MXPA05000778A (enExample) |
| NO (1) | NO336811B1 (enExample) |
| NZ (1) | NZ538284A (enExample) |
| PL (1) | PL217626B1 (enExample) |
| PT (1) | PT1530482E (enExample) |
| RU (1) | RU2326691C2 (enExample) |
| SI (1) | SI1530482T1 (enExample) |
| TR (1) | TR200500108T2 (enExample) |
| UA (1) | UA81634C2 (enExample) |
| WO (1) | WO2004009112A1 (enExample) |
| ZA (1) | ZA200500423B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7264800B2 (en) * | 2002-07-18 | 2007-09-04 | Helix Biopharma Corporation | Method and composition for inhibiting cancer cell growth |
| US7672704B2 (en) * | 2002-09-11 | 2010-03-02 | Duke University | Methods and compositions for blood pool identification, drug distribution quantification and drug release verification |
| US7769423B2 (en) * | 2002-09-11 | 2010-08-03 | Duke University | MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting |
| CA2543200A1 (en) * | 2003-10-24 | 2005-05-06 | National Research Council Of Canada | Ligand-pseudoreceptor system for generation of adenoviral vectors with altered tropism |
| IL182956A0 (en) * | 2007-05-03 | 2008-01-20 | Yeda Res & Dev | Glycan modified soluble receptors and binding proteins and their use |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| AU2014252666B2 (en) * | 2013-04-08 | 2017-02-02 | Helix Biopharma Corp. | Use of antibody-urease conjugates for diagnostic and therapeutic purposes |
| NZ733669A (en) * | 2015-01-23 | 2019-03-29 | Helix Biopharma Corp | Antibody-urease conjugates for therapeutic purposes |
| US10640806B2 (en) | 2016-09-24 | 2020-05-05 | Helix Biopharma Corp. | Restoring function of tumour acidified T cells |
| US20180243437A1 (en) * | 2017-01-05 | 2018-08-30 | Heman Lap Man CHAO | Anti-vegfr-2 urease conjugates |
| CN115666571B (zh) * | 2020-05-20 | 2024-11-05 | 美德阿利克斯株式会社 | 含有阿扑吗啡的经皮吸收型制剂 |
| CA3182871A1 (en) * | 2020-06-15 | 2021-12-23 | Kortuc Inc. | Sensitizer for cancer treatment |
| CN113433087A (zh) * | 2021-06-22 | 2021-09-24 | 中南大学 | 一种尿素浓度快速检测方法及检测传感器和应用 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2965725D1 (en) | 1978-07-19 | 1983-07-28 | Patrick Couvreur | Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation |
| US4489055A (en) | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| FR2504408B1 (fr) | 1981-04-24 | 1986-02-14 | Couvreur Patrick | Procede de preparation de particules submicroscopiques, particules ainsi obtenues et compositions pharmaceutiques les contenant |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| EP0092227B1 (en) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
| US4824783A (en) | 1983-12-20 | 1989-04-25 | Enichem S.P.A. | Oxidized sulfur derivatives of diaminophosphinyl compounds as urease inhibitors |
| US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4894443A (en) | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| EP0188256B1 (en) | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4837380A (en) * | 1985-09-30 | 1989-06-06 | Regents Of University Of California | Liposome-calcitonin preparation |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4680333A (en) | 1986-04-14 | 1987-07-14 | National Starch And Chemical Corporation | Removable hot melt pressure sensitive adhesive |
| US4867962A (en) | 1988-02-26 | 1989-09-19 | Neorx Corporation | Functionally specific antibodies |
| CA1340323C (en) | 1988-09-20 | 1999-01-19 | Arnold E. Hampel | Rna catalyst for cleaving specific rna sequences |
| FR2637612B1 (fr) | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
| EP0460607A3 (en) * | 1990-06-05 | 1992-04-01 | Bristol-Myers Squibb Company | Novel monoclonal antibody to novel antigen associated with human tumors |
| US5298399A (en) | 1990-08-10 | 1994-03-29 | Sapporo Breweries Limited | Gene and process for producing a thermostable urease |
| US5140100A (en) | 1990-12-28 | 1992-08-18 | Cedars-Sinai Medical Center | Protein that inhibits production of human choriogonadotropin |
| FR2683159B1 (fr) | 1991-10-31 | 1994-02-25 | Coletica | Procede de fabrication de nanocapsules a paroi a base de proteines reticulees; nanocapsules ainsi obtenues et compositions cosmetiques, pharmaceutiques et alimentaires en comportant application. |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| WO1993020221A1 (en) * | 1992-04-03 | 1993-10-14 | Young Alexander T | Gene therapy using targeted viral vectors |
| US6358490B2 (en) | 1992-06-09 | 2002-03-19 | Neorx Corporation | Three-step pretargeting methods and compounds |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US6290962B1 (en) * | 1992-11-03 | 2001-09-18 | Oravax, Inc. | Urease-based vaccine and treatment for helicobacter infection |
| GB9300875D0 (en) | 1993-01-18 | 1993-03-10 | Ucb Sa | Nanocapsule containing pharmaceutical compositions |
| WO1994018955A1 (en) | 1993-02-22 | 1994-09-01 | Alza Corporation | Compositions for oral delivery of active agents |
| WO1995014093A1 (en) | 1993-05-19 | 1995-05-26 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides |
| JP3872813B2 (ja) | 1994-05-18 | 2007-01-24 | エス.ピー.アイ. シンセティック ペプチデス インコーポレイテッド | ヘテロダイマーポリペプチド免疫原キャリア組成物および方法 |
| GB9417873D0 (en) | 1994-09-06 | 1994-10-26 | Sandoz Ltd | Organic compounds |
| US5886143A (en) | 1994-12-07 | 1999-03-23 | Neorx Corporation | Hepatic-directed compounds and reagents for preparation thereof |
| US6172045B1 (en) | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
| FR2732605B1 (fr) * | 1995-04-07 | 1997-05-16 | Pasteur Merieux Serums Vacc | Composition destinee a l'induction d'une reponse immunitaire mucosale |
| ATE214101T1 (de) * | 1995-09-06 | 2002-03-15 | Austrian Nordic Biotherapeutic | Expression von heterologen genen in menschlichen brustzellen, einschliesslich menschliche brustkarzionomzellen unter der kontrolle von regulatorischen sequenzen von wap oder mmtv |
| AU1846297A (en) | 1996-01-31 | 1997-08-22 | Regents Of The University Of California, The | Method for inhibiting tumor cell growth |
| US6395712B1 (en) | 1996-03-20 | 2002-05-28 | Board Of Regents, The University Of Texas System | Sensitization of HER-2/neu overexpressing cancer cells to chemotherapy |
| JPH1017492A (ja) * | 1996-07-02 | 1998-01-20 | Fuji Yakuhin Kogyo Kk | 腫瘍細胞増殖抑制剤 |
| US5958892A (en) | 1996-07-30 | 1999-09-28 | Board Of Regents, The University Of Texas System | 2-methoxyestradiol-induced apoptosis in cancer cells |
| US5750496A (en) * | 1996-08-12 | 1998-05-12 | Utah State University | Method of controlling cryptosporidium infectons using protease inhibitors |
| EP0824019B1 (en) * | 1996-08-13 | 2002-11-20 | Quest International B.V. | Inhibition or reduction of oral malodour |
| JP2001503396A (ja) | 1996-10-11 | 2001-03-13 | アルザ コーポレイション | 治療用リポソーム組成物および方法 |
| US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| CN1181422A (zh) * | 1996-10-31 | 1998-05-13 | 上海市肿瘤研究所 | 与生长因子受体结合的多肽所构建的基因转移载体 |
| US6180114B1 (en) | 1996-11-21 | 2001-01-30 | University Of Washington | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures |
| US6045774A (en) | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| GB9703633D0 (en) | 1997-02-21 | 1997-04-09 | Imp Cancer Res Tech | Cancer therapy |
| US6190923B1 (en) | 1997-09-05 | 2001-02-20 | David K. Johnson | Diethylenetriamine-N,N′,N″-triacetic acid derivatives |
| FR2772025B1 (fr) | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| US6426086B1 (en) * | 1998-02-03 | 2002-07-30 | The Regents Of The University Of California | pH-sensitive, serum-stable liposomes |
| PT1122262E (pt) * | 1998-10-16 | 2010-01-27 | Otsuka Pharma Co Ltd | Péptidos específicos de zonas neovasculares |
| FR2790405B1 (fr) | 1999-03-02 | 2001-04-20 | Oreal | Nanocapsules a base de polymeres dendritiques |
| AU5646800A (en) | 1999-03-02 | 2000-09-21 | Helix Biopharma Corporation | Card-based biosensor device |
| US6159443A (en) | 1999-04-29 | 2000-12-12 | Vanderbilt University | X-ray guided drug delivery |
| RU2270029C2 (ru) * | 1999-06-25 | 2006-02-20 | Джинентех, Инк. | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО, КОТОРОЕ ОБЛАДАЕТ СПОСОБНОСТЬЮ СВЯЗЫВАТЬ ErbB2 И БЛОКИРОВАТЬ АКТИВАЦИЮ ЛИГАНДОМ РЕЦЕПТОРА ErbB (ВАРИАНТЫ) И КОМПОЗИЦИЯ ДЛЯ ПРИМЕНЕНИЯ ПРИ ЛЕЧЕНИИ РАКА, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО |
| US6307372B1 (en) | 1999-11-02 | 2001-10-23 | Glaxo Wellcome, Inc. | Methods for high throughput chemical screening using magnetic resonance imaging |
| WO2001037721A2 (en) | 1999-11-22 | 2001-05-31 | The Research Foundation Of State University Of New York | Magnetic nanoparticles for selective therapy |
| US20020041898A1 (en) | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
| AU2001280105A1 (en) * | 2000-08-22 | 2002-03-04 | Kyowa Hakko Kogyo Co. Ltd. | Methof of regulating apoptosis and apoptosis-regulatory polypeptide |
| WO2003032814A2 (en) * | 2001-10-16 | 2003-04-24 | Raven Biotechnologies, Inc. | Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof |
-
2003
- 2003-07-16 MX MXPA05000778A patent/MXPA05000778A/es active IP Right Grant
- 2003-07-16 TR TR2005/00108T patent/TR200500108T2/xx unknown
- 2003-07-16 UA UAA200501034A patent/UA81634C2/ru unknown
- 2003-07-16 JP JP2004522053A patent/JP2006501196A/ja not_active Withdrawn
- 2003-07-16 SI SI200332335T patent/SI1530482T1/sl unknown
- 2003-07-16 EP EP10014201.7A patent/EP2324846B1/en not_active Expired - Lifetime
- 2003-07-16 US US10/621,833 patent/US7211250B2/en not_active Expired - Lifetime
- 2003-07-16 PT PT37648508T patent/PT1530482E/pt unknown
- 2003-07-16 CN CN03822307A patent/CN100577203C/zh not_active Expired - Fee Related
- 2003-07-16 AU AU2003250658A patent/AU2003250658B2/en not_active Ceased
- 2003-07-16 KR KR1020117022947A patent/KR101352826B1/ko not_active Expired - Fee Related
- 2003-07-16 RU RU2005104113/15A patent/RU2326691C2/ru active
- 2003-07-16 NZ NZ538284A patent/NZ538284A/en not_active IP Right Cessation
- 2003-07-16 ES ES03764850.8T patent/ES2443416T3/es not_active Expired - Lifetime
- 2003-07-16 WO PCT/CA2003/001061 patent/WO2004009112A1/en not_active Ceased
- 2003-07-16 CA CA2492472A patent/CA2492472C/en not_active Expired - Lifetime
- 2003-07-16 PL PL374675A patent/PL217626B1/pl unknown
- 2003-07-16 KR KR1020057000961A patent/KR20050038005A/ko not_active Ceased
- 2003-07-16 DK DK03764850.8T patent/DK1530482T3/da active
- 2003-07-16 BR BR0312664-1A patent/BR0312664A/pt not_active Application Discontinuation
- 2003-07-16 EP EP03764850.8A patent/EP1530482B9/en not_active Expired - Lifetime
-
2005
- 2005-01-12 IL IL166249A patent/IL166249A/en active IP Right Grant
- 2005-01-17 ZA ZA200500423A patent/ZA200500423B/xx unknown
- 2005-02-15 NO NO20050793A patent/NO336811B1/no not_active IP Right Cessation
-
2011
- 2011-07-22 JP JP2011161332A patent/JP5850561B2/ja not_active Expired - Fee Related
-
2013
- 2013-07-16 JP JP2013147555A patent/JP2013213055A/ja not_active Withdrawn
-
2015
- 2015-10-08 JP JP2015199988A patent/JP2016014066A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013213055A5 (enExample) | ||
| Yin et al. | Strategies targeting PD-L1 expression and associated opportunities for cancer combination therapy | |
| Gerber et al. | Combining antibody–drug conjugates and immune-mediated cancer therapy: what to expect? | |
| CN111194232A (zh) | 用于x射线诱导的光动力学疗法、放射疗法、放射动力学疗法、化学疗法、免疫疗法以及它们的任何组合的纳米级金属有机层和金属有机纳米片 | |
| JP2019501204A5 (enExample) | ||
| CL2011003052A1 (es) | Compuesto 8-(2,4-dimetoxi-pirimidin-5-il)-1-(1-etil-3-metil-1h-pirazol-4-il)-3-metil-1,3-dihidro-imidazo[4,5-c]quinolin-2-ona; su composicion farmaceutica; util en el tratamiento de enfermedades dependientes de la cinasa de lipido y/o de proteina, en el tratamiento de enfermedades proliferativas, tales como tumores y carcinomas de cerebro, riñon, higado, entre otras. | |
| JP2022505041A (ja) | Dnaアルキル化剤及びatr阻害剤を使用する併用療法 | |
| JP2019501873A5 (enExample) | ||
| KR20250053841A (ko) | 암의 치료 및/또는 예방을 위한 의약품 | |
| BRPI0608175A2 (pt) | método de eliminação de população de células heterogêneas ou mistas em tumores, assim como compostos maitansinóides | |
| CN111565742B (zh) | 使用axl诱骗受体治疗转移性癌症的方法 | |
| Choi et al. | A phase I study of nimotuzumab in combination with radiotherapy in stages IIB–IV non-small cell lung cancer unsuitable for radical therapy: Korean results | |
| JP2020505433A5 (enExample) | ||
| RU2016110874A (ru) | Комбинация ингибитора alk и ингибитора cdk для лечения клеточных пролиферативных заболеваний | |
| RU2018105923A (ru) | Способы лечения рака с использованием апилимода | |
| JP2018525358A5 (enExample) | ||
| RU2326691C2 (ru) | Использование уреазы для ингибирования роста раковых клеток | |
| US20220211883A1 (en) | Fap-activated radiotheranostics and uses related thereto | |
| Kim et al. | Combination therapy of cilengitide with belotecan against experimental glioblastoma | |
| Mani et al. | ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo | |
| Mellinghoff et al. | PL3. 1 A phase 1, open-label, perioperative study of ivosidenib (AG-120) and vorasidenib (AG-881) in recurrent, IDH1-mutant, low-grade glioma: results from cohort 1 | |
| US11419894B2 (en) | Modified natural killer cells for the treatment of cancer | |
| WO2016191703A3 (en) | Tumor deliverable iron and protein synthesis inhibitors as a new class of drugs for the diagnosis and treatment of cancer | |
| Dômont et al. | Adjuvant chemotherapy in early-stage non-small cell lung cancer | |
| Choi et al. | Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer |