JP2013203729A - コラーゲン産生促進剤 - Google Patents
コラーゲン産生促進剤 Download PDFInfo
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- JP2013203729A JP2013203729A JP2012077771A JP2012077771A JP2013203729A JP 2013203729 A JP2013203729 A JP 2013203729A JP 2012077771 A JP2012077771 A JP 2012077771A JP 2012077771 A JP2012077771 A JP 2012077771A JP 2013203729 A JP2013203729 A JP 2013203729A
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- collagen production
- collagen
- present
- skin
- production promoter
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Abstract
【解決手段】本発明は、sn−グリセロ(3)ホスホコリンを有効成分として含有してなるコラーゲン産生促進剤を提供する。
【選択図】なし
Description
〔1〕sn−グリセロ(3)ホスホコリンを有効成分として含有してなる、コラーゲン産生促進剤。
〔2〕皮膚状態の改善用である、〔1〕に記載のコラーゲン産生促進剤。
〔3〕L−グリシン、L−プロリン及びL−アラニンから選択される少なくとも1種のアミノ酸を更に含有する、〔1〕又は〔2〕に記載のコラーゲン産生促進剤。
〔4〕ビタミンC及び鉄から選択される少なくとも1種の物質を更に含有する、〔1〕〜〔3〕のいずれかに記載のコラーゲン産生促進剤。
上記のsn−グリセロ(3)ホスホコリン(α−GPC)のコラーゲン産生能向上作用を調べるために、以下の実験を行った。
ヒト正常皮膚由来線維芽細胞(CCD−1059SKCC、DSファーマバイオメディカル株式会社)を、10%FBS(fetal bovine serum)を含むDMEM培地で3〜6回継代培養した。次いで、細胞数が1×106個になるようにカルチャースライド(Culture slide:Falcon社製)に調製し、10%FBSを含むDMEM培地で24時間培養して、細胞をスライドに固定させ、更に、細胞周期を合わせるためにDMEM培地のみで24時間培養した。その後、10%FBSを含むMEM培地に交換し、同時にα−GPCを添加して24時間培養して、以下に示す各サンプル群を調製した。
また、コントロールとしてα−GPCを添加しない群、ポジティブコントロールを添加した群を調製した。
1)α−GPC 0.1μM添加群(0.0256μg/ml)
2)α−GPC 1μM添加群(0.256μg/ml)
3)α−GPC 10μM添加群(2.56μg/ml)
4)α−GPC 100μM添加群(25.6μg/ml)
5)コントロール群(α−GPC無添加)
上記(1)で調製した1)〜5)のサンプル群について、次の手順により、コラーゲンの産生量を免疫組織化学的に解析した。
カルチャースライドをPBS溶液で5分間、3回洗浄した後、4%パラホルムアルデヒド溶液を添加して4℃で一晩静置し、サンプルを固定した。0.1%Triton−Xを含むPBS溶液で5分間、3回洗浄後、3%H2O2溶液で5分間、内因性peroxidaseのブロッキングを行なった。次いで、10%標準ヤギ血清(normal goat Serum)を用いて5分間、非特異的反応のブロッキングを行なった。その後、抗ラット1型コラーゲン抗体(Anti−rat type I Collagen抗体(LSL社製)200倍希釈液)を用いて一次抗体の反応を60分間行なった。PBS溶液で5分間、3回洗浄した後、ビオチン標識ヤギ抗ウサギ免疫グロブリン抗体(Biotinylated Goat anti−rabbit immunogloblins抗体(DAKO社製)400倍希釈液)を用いて二次抗体の反応を30分間行った。PBS溶液で5分間、3回洗浄した後、酵素溶液(Horseradish peroxidase−labelled streptavidine−biotine complex(DAKO社製)400倍希釈液)による反応を30分間行った。PBS溶液で5分間、3回洗浄した後、DAB(3,3−Diaminobenzidine,tetrahydrochloride)溶液を5分間反応させ、Peroxidase発色反応を行なった。PBS溶液で5分間、3回洗浄した後、水溶性封入剤で封入して、標本を作製した。得られた標本における陽性反応(I型コラーゲンの発現)箇所における染色強度を、NIH imageソフトを用いて定量化し、画像解析によりI型コラーゲンの産生量を解析した。
一般的にコラーゲン産生促進物質と言われるものは2倍程度の産生量促進能を示せば大きな効果があるとされている。本実験においても2−3倍の産生量促進能を示し、十分な効果を発揮した。更に、0.1μM(2.56×10−8g/ml)という極めて低濃度でも効果が発揮された。
Claims (4)
- sn−グリセロ(3)ホスホコリンを有効成分として含有してなる、コラーゲン産生促進剤。
- 皮膚状態の改善用である、請求項1に記載のコラーゲン産生促進剤。
- L−グリシン、L−プロリン及びL−アラニンから選択される少なくとも1種のアミノ酸を更に含有する、請求項1又は2に記載のコラーゲン産生促進剤。
- ビタミンC及び鉄から選択される少なくとも1種の物質を更に含有する、請求項1〜3のいずれか1項に記載のコラーゲン産生促進剤。
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH072699A (ja) * | 1993-06-17 | 1995-01-06 | Kanebo Ltd | コラーゲン代謝賦活剤 |
JPH07506348A (ja) * | 1992-03-30 | 1995-07-13 | フレイラー エス.エー.ファーマスィーティカル ファイン ケミカルズ | 局所使用に適した脱アシル化グリセロホスホリピド類を含有した化粧料または製薬組成物 |
JPH07194375A (ja) * | 1993-12-28 | 1995-08-01 | Kanebo Ltd | コラーゲン合成促進剤およびコラーゲン代謝賦活剤 |
JP2004501069A (ja) * | 2000-02-25 | 2004-01-15 | クース ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 美容用組成物 |
JP2004536838A (ja) * | 2001-07-07 | 2004-12-09 | バイヤースドルフ・アクチエンゲゼルシヤフト | 乾燥皮膚および健康な皮膚の生理的恒常性における他の負の変化の処置および有効な予防のためのオスモライトを含有する化粧品および皮膚科調製品 |
JP2009155337A (ja) * | 2009-03-31 | 2009-07-16 | Tsujido Chemical Corp | 治療剤 |
JP2009159983A (ja) * | 2009-04-13 | 2009-07-23 | Tsujido Chemical Corp | 食品組成物 |
JP2009203190A (ja) * | 2008-02-28 | 2009-09-10 | Kose Corp | 細胞賦活剤及び老化防止用皮膚外用剤 |
-
2012
- 2012-03-29 JP JP2012077771A patent/JP2013203729A/ja active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07506348A (ja) * | 1992-03-30 | 1995-07-13 | フレイラー エス.エー.ファーマスィーティカル ファイン ケミカルズ | 局所使用に適した脱アシル化グリセロホスホリピド類を含有した化粧料または製薬組成物 |
JPH072699A (ja) * | 1993-06-17 | 1995-01-06 | Kanebo Ltd | コラーゲン代謝賦活剤 |
JPH07194375A (ja) * | 1993-12-28 | 1995-08-01 | Kanebo Ltd | コラーゲン合成促進剤およびコラーゲン代謝賦活剤 |
JP2004501069A (ja) * | 2000-02-25 | 2004-01-15 | クース ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 美容用組成物 |
JP2004536838A (ja) * | 2001-07-07 | 2004-12-09 | バイヤースドルフ・アクチエンゲゼルシヤフト | 乾燥皮膚および健康な皮膚の生理的恒常性における他の負の変化の処置および有効な予防のためのオスモライトを含有する化粧品および皮膚科調製品 |
JP2009203190A (ja) * | 2008-02-28 | 2009-09-10 | Kose Corp | 細胞賦活剤及び老化防止用皮膚外用剤 |
JP2009155337A (ja) * | 2009-03-31 | 2009-07-16 | Tsujido Chemical Corp | 治療剤 |
JP2009159983A (ja) * | 2009-04-13 | 2009-07-23 | Tsujido Chemical Corp | 食品組成物 |
Non-Patent Citations (1)
Title |
---|
JPN6015052781; 日比野英彦: '新規コリン補給素材 グリセロホスホコリン(GPC)' 食品工業 第54巻、第20号, 20111030, 第86頁〜87頁 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020045333A (ja) * | 2018-09-14 | 2020-03-26 | 株式会社ホーマーイオン研究所 | 化粧料 |
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