JP2013179943A5 - - Google Patents
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- JP2013179943A5 JP2013179943A5 JP2013089445A JP2013089445A JP2013179943A5 JP 2013179943 A5 JP2013179943 A5 JP 2013179943A5 JP 2013089445 A JP2013089445 A JP 2013089445A JP 2013089445 A JP2013089445 A JP 2013089445A JP 2013179943 A5 JP2013179943 A5 JP 2013179943A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- influenza
- amino acid
- acid substitution
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000713196 Influenza B virus Species 0.000 claims 39
- 238000006467 substitution reaction Methods 0.000 claims 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 235000001014 amino acid Nutrition 0.000 claims 20
- 238000000034 method Methods 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 230000035772 mutation Effects 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 6
- 239000004473 Threonine Substances 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 6
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 6
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 5
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 5
- 241000282341 Mustela putorius furo Species 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 230000006798 recombination Effects 0.000 claims 3
- 238000005215 recombination Methods 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 208000037798 influenza B Diseases 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37567502P | 2002-04-26 | 2002-04-26 | |
| US60/375,675 | 2002-04-26 | ||
| US39498302P | 2002-07-09 | 2002-07-09 | |
| US60/394,983 | 2002-07-09 | ||
| US41057602P | 2002-09-12 | 2002-09-12 | |
| US60/410,576 | 2002-09-12 | ||
| US41980202P | 2002-10-18 | 2002-10-18 | |
| US60/419,802 | 2002-10-18 | ||
| US42070802P | 2002-10-23 | 2002-10-23 | |
| US60/420,708 | 2002-10-23 | ||
| US45769903P | 2003-03-24 | 2003-03-24 | |
| US60/457,699 | 2003-03-24 | ||
| US46236103P | 2003-04-10 | 2003-04-10 | |
| US60/462,361 | 2003-04-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103852A Division JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013131951A Division JP2013230156A (ja) | 2002-04-26 | 2013-06-24 | インフルエンザウイルスの生産用多重プラスミドシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013179943A JP2013179943A (ja) | 2013-09-12 |
| JP2013179943A5 true JP2013179943A5 (enExample) | 2013-11-21 |
Family
ID=29273967
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587937A Withdrawn JP2005523698A (ja) | 2002-04-26 | 2003-04-25 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2011103852A Expired - Lifetime JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013089445A Pending JP2013179943A (ja) | 2002-04-26 | 2013-04-22 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013131951A Pending JP2013230156A (ja) | 2002-04-26 | 2013-06-24 | インフルエンザウイルスの生産用多重プラスミドシステム |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587937A Withdrawn JP2005523698A (ja) | 2002-04-26 | 2003-04-25 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2011103852A Expired - Lifetime JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013131951A Pending JP2013230156A (ja) | 2002-04-26 | 2013-06-24 | インフルエンザウイルスの生産用多重プラスミドシステム |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8012736B2 (enExample) |
| EP (2) | EP2497826A1 (enExample) |
| JP (4) | JP2005523698A (enExample) |
| KR (2) | KR101229202B1 (enExample) |
| CN (4) | CN103540613A (enExample) |
| AR (2) | AR039465A1 (enExample) |
| AU (2) | AU2003231083A1 (enExample) |
| CA (1) | CA2482946C (enExample) |
| DK (1) | DK1499348T3 (enExample) |
| ES (1) | ES2526191T3 (enExample) |
| TW (2) | TWI347363B (enExample) |
| WO (1) | WO2003091401A2 (enExample) |
Families Citing this family (83)
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| DE60137345D1 (de) * | 2000-04-28 | 2009-02-26 | St Jude Childrens Res Hospital | Dna-transfektionssystem zur erzeugung von infektiösen negativsträngigen rna virus |
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| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US20050158342A1 (en) * | 2003-12-23 | 2005-07-21 | Medimmune, Inc. | Multi plasmid system for the production of influenza virus |
| CN103540613A (zh) | 2002-04-26 | 2014-01-29 | 米迪缪尼有限公司 | 制备流感病毒的多质粒系统 |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| EP1597400B8 (en) | 2003-02-25 | 2013-10-09 | MedImmune, LLC | Methods of producing influenza vaccine compositions |
| JP2006525815A (ja) * | 2003-05-28 | 2006-11-16 | ウィスコンシン・アラムナイ・リサーチ・ファウンデイション | Ｐｏｌｉｉプロモーターおよびリボザイムを有する組換えインフルエンザベクター |
| CA2816222A1 (en) * | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| EP1748790B1 (en) * | 2004-05-24 | 2015-07-15 | MedImmune, LLC | Multi plasmid system for the production of influenza virus |
| EP2530147B1 (en) | 2004-05-25 | 2014-09-10 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
| EP1797189A4 (en) * | 2004-09-02 | 2010-05-19 | Qun Chen | ENCAPSIDATION SYSTEM FOR THE PRODUCTION OF RECOMBINANT VIRUSELY PARTICLES |
| EP2578229B1 (en) * | 2004-09-09 | 2013-07-10 | Novartis Vaccines and Diagnostics GmbH | Decreasing potential iatrogenic risks associated with vaccine antigens |
| EP2272950A3 (en) * | 2004-11-11 | 2011-07-20 | Abbott Biologicals B.V. | Defective influenza virus particles |
| RU2420577C2 (ru) * | 2004-11-11 | 2011-06-10 | Эбботт Байолоджикалз Б.В. | Условно дефектная частица вируса гриппа и способы ее получения (варианты) |
| JP2008520248A (ja) | 2004-11-19 | 2008-06-19 | ウィスコンシン・アラムナイ・リサーチ・ファウンデイション | タンデム転写ユニットを有する組換えインフルエンザベクター |
| KR101316350B1 (ko) * | 2004-12-08 | 2013-10-15 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| CN101189326B (zh) | 2004-12-23 | 2013-06-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
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| ES2527503T3 (es) * | 2005-03-08 | 2015-01-26 | Medimmune, Llc | Virus influenza reordenantes |
| US7959929B2 (en) * | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| CA2613284A1 (en) * | 2005-06-21 | 2007-01-04 | Medimmune Vaccines, Inc. | Methods and compositions for expressing negative-sense viral rna in canine cells |
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| WO2007126810A2 (en) * | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
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| US12419946B2 (en) | 2019-02-07 | 2025-09-23 | Duke University | Stabilized 9 and 10 segmented influenza viruses as a vaccine platform and methods of making and using same |
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- 2003-04-25 CN CN201310365550.9A patent/CN103540613A/zh active Pending
- 2003-04-25 WO PCT/US2003/012728 patent/WO2003091401A2/en not_active Ceased
- 2003-04-25 EP EP20120168901 patent/EP2497826A1/en not_active Withdrawn
- 2003-04-25 EP EP03724208.8A patent/EP1499348B1/en not_active Expired - Lifetime
- 2003-04-25 CN CN038151952A patent/CN1678345B/zh not_active Expired - Fee Related
- 2003-04-25 ES ES03724208.8T patent/ES2526191T3/es not_active Expired - Lifetime
- 2003-04-25 KR KR1020117011414A patent/KR101229202B1/ko not_active Expired - Lifetime
- 2003-04-25 CA CA 2482946 patent/CA2482946C/en not_active Expired - Lifetime
- 2003-04-25 DK DK03724208.8T patent/DK1499348T3/en active
- 2003-04-25 US US10/423,828 patent/US8012736B2/en active Active
- 2003-04-25 CN CN201310364981.3A patent/CN103540568A/zh active Pending
- 2003-04-25 KR KR20047017199A patent/KR101169468B1/ko not_active Expired - Lifetime
- 2003-04-25 AU AU2003231083A patent/AU2003231083A1/en not_active Abandoned
- 2003-04-25 CN CNA038151952A patent/CN1678345A/zh active Granted
- 2003-04-25 JP JP2003587937A patent/JP2005523698A/ja not_active Withdrawn
- 2003-04-28 TW TW099140358A patent/TWI347363B/zh not_active IP Right Cessation
- 2003-04-28 AR ARP030101459 patent/AR039465A1/es active IP Right Grant
- 2003-10-28 TW TW92109896A patent/TWI338047B/zh not_active IP Right Cessation
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2009
- 2009-10-09 AU AU2009225296A patent/AU2009225296B2/en not_active Ceased
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2011
- 2011-05-06 JP JP2011103852A patent/JP5303603B2/ja not_active Expired - Lifetime
- 2011-06-16 AR ARP110102084 patent/AR081941A2/es unknown
- 2011-08-19 US US13/214,110 patent/US8722059B2/en not_active Expired - Lifetime
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- 2013-04-22 JP JP2013089445A patent/JP2013179943A/ja active Pending
- 2013-06-24 JP JP2013131951A patent/JP2013230156A/ja active Pending
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- 2014-03-21 US US14/222,461 patent/US20140220075A1/en not_active Abandoned
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