JP2013126989A5 - - Google Patents
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- Publication number
- JP2013126989A5 JP2013126989A5 JP2013011673A JP2013011673A JP2013126989A5 JP 2013126989 A5 JP2013126989 A5 JP 2013126989A5 JP 2013011673 A JP2013011673 A JP 2013011673A JP 2013011673 A JP2013011673 A JP 2013011673A JP 2013126989 A5 JP2013126989 A5 JP 2013126989A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- vaccine powder
- nasal
- dry vaccine
- powder formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 35
- 229960005486 vaccine Drugs 0.000 claims 26
- 239000000843 powder Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 241000700605 Viruses Species 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 230000008014 freezing Effects 0.000 claims 4
- 238000007710 freezing Methods 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 241001591005 Siga Species 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 230000009969 flowable effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010069767 H1N1 influenza Diseases 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 206010064097 avian influenza Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 229940078499 tricalcium phosphate Drugs 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32454210P | 2010-04-15 | 2010-04-15 | |
| US61/324,542 | 2010-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Division JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015186488A Division JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013126989A JP2013126989A (ja) | 2013-06-27 |
| JP2013126989A5 true JP2013126989A5 (enExample) | 2014-05-29 |
Family
ID=44798502
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Active JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
| JP2013011673A Pending JP2013126989A (ja) | 2010-04-15 | 2013-01-25 | 鼻内送達のための方法および組成物 |
| JP2015186488A Pending JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
| JP2017139598A Pending JP2017186377A (ja) | 2010-04-15 | 2017-07-19 | 鼻内送達のための方法および組成物 |
| JP2019039165A Active JP6827488B2 (ja) | 2010-04-15 | 2019-03-05 | 鼻内送達のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Active JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015186488A Pending JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
| JP2017139598A Pending JP2017186377A (ja) | 2010-04-15 | 2017-07-19 | 鼻内送達のための方法および組成物 |
| JP2019039165A Active JP6827488B2 (ja) | 2010-04-15 | 2019-03-05 | 鼻内送達のための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9687536B2 (enExample) |
| EP (2) | EP2558120A4 (enExample) |
| JP (5) | JP5771626B2 (enExample) |
| KR (3) | KR102136036B1 (enExample) |
| CN (3) | CN102933230B (enExample) |
| BR (1) | BR112012026116A2 (enExample) |
| CA (2) | CA2993242C (enExample) |
| CU (1) | CU20120148A7 (enExample) |
| ES (1) | ES2874817T3 (enExample) |
| RU (1) | RU2012144612A (enExample) |
| SG (1) | SG184304A1 (enExample) |
| WO (1) | WO2011129120A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9687536B2 (en) | 2010-04-15 | 2017-06-27 | Shin Nippon Biomedical Laboratories, Ltd. | Methods and compositions for intranasal delivery |
| IN2014DN06108A (enExample) | 2011-12-16 | 2015-08-14 | Indosys Ltd | |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| WO2014186754A2 (en) * | 2013-05-16 | 2014-11-20 | Board Of Regents The University Of Texas System | Dry solid aluminum adjuvant-containing vaccines and related methods thereof |
| CN104208029B (zh) * | 2013-05-30 | 2017-06-06 | 上海医药工业研究院 | 一种鼻用疫苗组合物粉体制剂及其制备方法 |
| CN105579059B (zh) | 2013-09-03 | 2020-07-31 | 佐治亚科技研究公司 | 热稳定的疫苗配制物、工艺和包含疫苗配制物的微针 |
| ES2904570T3 (es) * | 2013-09-24 | 2022-04-05 | Satsuma Pharmaceuticals Inc | Formulación de DHE intranasal para el tratamiento del dolor de cabeza |
| IL310015B1 (en) * | 2013-12-31 | 2025-10-01 | Access To Advanced Health Inst | Single vial formulation |
| EP3127550A1 (en) * | 2015-08-07 | 2017-02-08 | HSC Development GmbH | Stabilizing composition for dry formulation of virus |
| WO2017047089A1 (en) * | 2015-09-16 | 2017-03-23 | Shin Nippon Biomedical Laboratories, Ltd. | Vaccine compositions |
| GB201610628D0 (en) * | 2016-06-17 | 2016-08-03 | Mihranyan Albert | New compositions |
| US20190275136A1 (en) * | 2016-09-19 | 2019-09-12 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
| US11022115B2 (en) | 2017-06-02 | 2021-06-01 | Purdue Research Foundation | Controlled variable delivery external gear machine |
| WO2019021957A1 (ja) * | 2017-07-25 | 2019-01-31 | 第一三共株式会社 | 点鼻用乾燥粉末医薬組成物 |
| GB201713899D0 (en) | 2017-08-30 | 2017-10-11 | Indosys Ltd | Multi-dose medicament delivery device |
| WO2019118393A1 (en) | 2017-12-11 | 2019-06-20 | Board Of Regents, The University Of Texas System | Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration |
| CA3111273C (en) * | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| CN120284965A (zh) | 2018-12-11 | 2025-07-11 | 小蜜橘制药公司 | 用于治疗或预防头痛的组合物、装置和方法 |
| JP7660514B2 (ja) * | 2019-02-15 | 2025-04-11 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生インフルエンザワクチン組成物及びその調製プロセス |
| EP3698773A1 (en) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination |
| US11621604B2 (en) | 2020-02-16 | 2023-04-04 | Purdue Research Foundation | Integrated electro-hydraulic machine |
| BR112022018160A2 (pt) * | 2020-03-24 | 2022-10-25 | Byung Chul Ahn | Método de produção de composição de soro para prevenir ou tratar doenças infecciosas relacionadas à mucosa em mamíferos jovens, composição de soro produzida por ele, e uso da mesma |
| CN113583970B (zh) * | 2021-07-29 | 2023-05-12 | 吉林大学 | 一种用于预防或抗冠状病毒传播、致病的药物及其制备方法 |
| WO2024047351A1 (en) | 2022-09-01 | 2024-03-07 | Therakind Limited | Dry powder medicament delivery device |
| AU2023388890A1 (en) * | 2022-12-07 | 2025-06-26 | Daocheng Zhu | Formulation and use of a fusion protein |
| WO2024228212A1 (en) * | 2023-05-01 | 2024-11-07 | Biovet Private Limited | Bio-lumpivaxin formulations and method of preparation thereof |
| WO2024246607A1 (en) * | 2023-05-31 | 2024-12-05 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for enhanced mucosal penetration |
| GB202403611D0 (en) | 2024-03-13 | 2024-04-24 | Therakind Ltd | Improved multi-dose medicament delivery device |
| CN118924744A (zh) * | 2024-07-29 | 2024-11-12 | 复旦大学 | 小分子抑制剂ha15在抗乙型肝炎病毒中的应用 |
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| WO1994009819A1 (en) * | 1992-11-03 | 1994-05-11 | Secretech, Inc. | Microcrystalline cellulose as an immune adjuvant |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| CN1193745C (zh) | 2001-02-27 | 2005-03-23 | 国家医药管理局上海医药工业研究院 | 一种鼻用鲑降钙素粉末吸入剂及制备方法 |
| WO2003072016A2 (en) | 2001-11-19 | 2003-09-04 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| WO2003086443A1 (en) | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| MXPA06006947A (es) * | 2003-12-17 | 2007-01-26 | Wyeth Corp | Metodos para producir virus de almacenamiento estable y composiciones inmunogenicas de estos. |
| US20060292173A1 (en) * | 2004-12-13 | 2006-12-28 | Macadam Donald H | Multibacterial vaccines and uses thereof |
| SI1954308T1 (sl) | 2005-09-16 | 2011-12-30 | Merial Ltd | Stabilizatorji za liofilizirana cepiva |
| BRPI0616879A2 (pt) * | 2005-10-04 | 2011-07-05 | Alk Abello As | formulação de vacina sólida |
| RU2008117396A (ru) | 2005-10-04 | 2009-11-10 | Альк-Абелло А/С (Dk) | Твердая вакцинная композиция |
| AU2007215080A1 (en) | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Influenza antigens, vaccine compositions, and related methods |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| ITMI20061117A1 (it) * | 2006-06-09 | 2007-12-10 | Michele Bonanomi | Una composizione farmaceutica per la somministrazione sublinguale di vaccini metodo per la sua preparazione e sui usi |
| WO2008079464A2 (en) | 2006-09-08 | 2008-07-03 | Becton, Dickinson And Company | Stable powder formulations of alum-adsorbed vaccines |
| ES2618885T3 (es) * | 2006-09-29 | 2017-06-22 | Takeda Vaccines, Inc. | Formulaciones de vacuna para norovirus |
| JP5415769B2 (ja) * | 2006-12-26 | 2014-02-12 | 株式会社新日本科学 | 経鼻投与用製剤 |
| AU2008231072B2 (en) * | 2007-03-22 | 2013-08-01 | The Regents Of The University Of Colorado | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
| WO2009006299A2 (en) | 2007-06-29 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Multi-particulate systems |
| MX2010008799A (es) * | 2008-03-05 | 2010-09-07 | Sanofi Pasteur | Proceso para estabilizar una composicion de vacuna que contiene adyuvante. |
| CN101601860A (zh) * | 2008-06-13 | 2009-12-16 | 中国科学院过程工程研究所 | 疫苗 |
| MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
| US9101539B2 (en) * | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| GB2472327B (en) * | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
| JP5491119B2 (ja) | 2009-10-02 | 2014-05-14 | 日東電工株式会社 | 薬物含有微粒子を含む医薬組成物およびその製造方法 |
| US9687536B2 (en) * | 2010-04-15 | 2017-06-27 | Shin Nippon Biomedical Laboratories, Ltd. | Methods and compositions for intranasal delivery |
| AU2012244074B2 (en) | 2010-04-15 | 2015-01-15 | Km Biologics Co., Ltd. | Methods and compositions for intranasal delivery |
-
2011
- 2011-04-15 US US13/640,623 patent/US9687536B2/en active Active
- 2011-04-15 CN CN201180027287.1A patent/CN102933230B/zh active Active
- 2011-04-15 BR BR112012026116A patent/BR112012026116A2/pt not_active IP Right Cessation
- 2011-04-15 SG SG2012071841A patent/SG184304A1/en unknown
- 2011-04-15 CN CN201710415508.1A patent/CN107260689A/zh active Pending
- 2011-04-15 ES ES13189570T patent/ES2874817T3/es active Active
- 2011-04-15 CA CA2993242A patent/CA2993242C/en active Active
- 2011-04-15 JP JP2012547369A patent/JP5771626B2/ja active Active
- 2011-04-15 RU RU2012144612/15A patent/RU2012144612A/ru not_active Application Discontinuation
- 2011-04-15 WO PCT/JP2011/002225 patent/WO2011129120A1/en not_active Ceased
- 2011-04-15 KR KR1020197006392A patent/KR102136036B1/ko not_active Expired - Fee Related
- 2011-04-15 CN CN2013100510480A patent/CN103126996A/zh active Pending
- 2011-04-15 CA CA2796593A patent/CA2796593C/en active Active
- 2011-04-15 EP EP11768642.8A patent/EP2558120A4/en not_active Withdrawn
- 2011-04-15 KR KR1020127025573A patent/KR20130083376A/ko not_active Ceased
- 2011-04-15 EP EP13189570.8A patent/EP2689785B1/en active Active
- 2011-04-15 KR KR1020127030060A patent/KR101960102B1/ko active Active
-
2012
- 2012-10-12 CU CU2012000148A patent/CU20120148A7/es unknown
-
2013
- 2013-01-25 JP JP2013011673A patent/JP2013126989A/ja active Pending
- 2013-03-14 US US13/828,337 patent/US10463723B2/en active Active
-
2015
- 2015-09-24 JP JP2015186488A patent/JP2016006119A/ja active Pending
-
2017
- 2017-07-19 JP JP2017139598A patent/JP2017186377A/ja active Pending
-
2019
- 2019-03-05 JP JP2019039165A patent/JP6827488B2/ja active Active
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