JP2013126989A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013126989A5 JP2013126989A5 JP2013011673A JP2013011673A JP2013126989A5 JP 2013126989 A5 JP2013126989 A5 JP 2013126989A5 JP 2013011673 A JP2013011673 A JP 2013011673A JP 2013011673 A JP2013011673 A JP 2013011673A JP 2013126989 A5 JP2013126989 A5 JP 2013126989A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- vaccine powder
- nasal
- dry vaccine
- powder formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 35
- 229960005486 vaccine Drugs 0.000 claims 26
- 239000000843 powder Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 241000700605 Viruses Species 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 230000008014 freezing Effects 0.000 claims 4
- 238000007710 freezing Methods 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 241001591005 Siga Species 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 230000009969 flowable effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010069767 H1N1 influenza Diseases 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 206010064097 avian influenza Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 229940078499 tricalcium phosphate Drugs 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32454210P | 2010-04-15 | 2010-04-15 | |
| US61/324,542 | 2010-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Division JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015186488A Division JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013126989A JP2013126989A (ja) | 2013-06-27 |
| JP2013126989A5 true JP2013126989A5 (enExample) | 2014-05-29 |
Family
ID=44798502
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Active JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
| JP2013011673A Pending JP2013126989A (ja) | 2010-04-15 | 2013-01-25 | 鼻内送達のための方法および組成物 |
| JP2015186488A Pending JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
| JP2017139598A Pending JP2017186377A (ja) | 2010-04-15 | 2017-07-19 | 鼻内送達のための方法および組成物 |
| JP2019039165A Active JP6827488B2 (ja) | 2010-04-15 | 2019-03-05 | 鼻内送達のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547369A Active JP5771626B2 (ja) | 2010-04-15 | 2011-04-15 | 鼻内送達のための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015186488A Pending JP2016006119A (ja) | 2010-04-15 | 2015-09-24 | 鼻内送達のための方法および組成物 |
| JP2017139598A Pending JP2017186377A (ja) | 2010-04-15 | 2017-07-19 | 鼻内送達のための方法および組成物 |
| JP2019039165A Active JP6827488B2 (ja) | 2010-04-15 | 2019-03-05 | 鼻内送達のための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9687536B2 (enExample) |
| EP (2) | EP2689785B1 (enExample) |
| JP (5) | JP5771626B2 (enExample) |
| KR (3) | KR102136036B1 (enExample) |
| CN (3) | CN107260689A (enExample) |
| BR (1) | BR112012026116A2 (enExample) |
| CA (2) | CA2993242C (enExample) |
| CU (1) | CU20120148A7 (enExample) |
| ES (1) | ES2874817T3 (enExample) |
| RU (1) | RU2012144612A (enExample) |
| SG (1) | SG184304A1 (enExample) |
| WO (1) | WO2011129120A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260689A (zh) * | 2010-04-15 | 2017-10-20 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
| DK2790758T3 (da) | 2011-12-16 | 2017-11-20 | Indosys Ltd | Kassette til en lægemiddeldosis og tilførselsindretning |
| TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| WO2014186754A2 (en) * | 2013-05-16 | 2014-11-20 | Board Of Regents The University Of Texas System | Dry solid aluminum adjuvant-containing vaccines and related methods thereof |
| CN104208029B (zh) * | 2013-05-30 | 2017-06-06 | 上海医药工业研究院 | 一种鼻用疫苗组合物粉体制剂及其制备方法 |
| CA2923010C (en) | 2013-09-03 | 2022-08-30 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
| US20160228433A1 (en) * | 2013-09-24 | 2016-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal dhe for the treatment of headache |
| IL246456B2 (en) | 2013-12-31 | 2024-06-01 | Access To Advanced Health Inst | Formulations will be assembled into a single vial |
| EP3127550A1 (en) * | 2015-08-07 | 2017-02-08 | HSC Development GmbH | Stabilizing composition for dry formulation of virus |
| WO2017047089A1 (en) * | 2015-09-16 | 2017-03-23 | Shin Nippon Biomedical Laboratories, Ltd. | Vaccine compositions |
| GB201610628D0 (en) * | 2016-06-17 | 2016-08-03 | Mihranyan Albert | New compositions |
| EP3532093A1 (en) * | 2016-09-19 | 2019-09-04 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
| US11022115B2 (en) | 2017-06-02 | 2021-06-01 | Purdue Research Foundation | Controlled variable delivery external gear machine |
| JPWO2019021957A1 (ja) * | 2017-07-25 | 2020-07-09 | 第一三共株式会社 | 点鼻用乾燥粉末医薬組成物 |
| GB201713899D0 (en) | 2017-08-30 | 2017-10-11 | Indosys Ltd | Multi-dose medicament delivery device |
| CA3083953A1 (en) | 2017-12-11 | 2019-06-20 | Board Of Regents, The University Of Texas System | Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration |
| CA3111273C (en) * | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| EP3893877A4 (en) | 2018-12-11 | 2022-09-14 | Satsuma Pharmaceuticals, Inc. | COMPOSITIONS, DEVICES AND METHODS FOR TREATMENT OR PREVENTION OF HEADACHE |
| JP7660514B2 (ja) * | 2019-02-15 | 2025-04-11 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生インフルエンザワクチン組成物及びその調製プロセス |
| EP3698773A1 (en) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination |
| US11621604B2 (en) | 2020-02-16 | 2023-04-04 | Purdue Research Foundation | Integrated electro-hydraulic machine |
| CN114901293B (zh) * | 2020-03-24 | 2024-09-24 | 安炳哲 | 用于预防或治疗幼小的哺乳动物得与黏膜相关的传染性疾病的血清组成物的制造方法、通过该方法制造的血清组成物及其用途 |
| CN113583970B (zh) * | 2021-07-29 | 2023-05-12 | 吉林大学 | 一种用于预防或抗冠状病毒传播、致病的药物及其制备方法 |
| WO2024047351A1 (en) | 2022-09-01 | 2024-03-07 | Therakind Limited | Dry powder medicament delivery device |
| EP4630460A1 (en) * | 2022-12-07 | 2025-10-15 | Daocheng Zhu | Formulation and use of a fusion protein |
| WO2024228212A1 (en) * | 2023-05-01 | 2024-11-07 | Biovet Private Limited | Bio-lumpivaxin formulations and method of preparation thereof |
| WO2024246607A1 (en) * | 2023-05-31 | 2024-12-05 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for enhanced mucosal penetration |
| GB202403611D0 (en) | 2024-03-13 | 2024-04-24 | Therakind Ltd | Improved multi-dose medicament delivery device |
| CN118924744A (zh) * | 2024-07-29 | 2024-11-12 | 复旦大学 | 小分子抑制剂ha15在抗乙型肝炎病毒中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009819A1 (en) * | 1992-11-03 | 1994-05-11 | Secretech, Inc. | Microcrystalline cellulose as an immune adjuvant |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| CN1193745C (zh) * | 2001-02-27 | 2005-03-23 | 国家医药管理局上海医药工业研究院 | 一种鼻用鲑降钙素粉末吸入剂及制备方法 |
| WO2003043574A2 (en) | 2001-11-19 | 2003-05-30 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| AU2003230908A1 (en) | 2002-04-11 | 2003-10-27 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| WO2005058356A2 (en) * | 2003-12-17 | 2005-06-30 | Wyeth | Methods for porducing storage stable viruses and immunogenic compositions thereof |
| US20060292173A1 (en) * | 2004-12-13 | 2006-12-28 | Macadam Donald H | Multibacterial vaccines and uses thereof |
| EP1954308B1 (en) | 2005-09-16 | 2011-09-07 | Merial Ltd. | Stabilizers for freeze-dried vaccines |
| AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
| CN101296705A (zh) | 2005-10-04 | 2008-10-29 | 阿尔克-阿贝洛有限公司 | 固体疫苗制剂 |
| JP2009526526A (ja) | 2006-02-13 | 2009-07-23 | フラウンホーファー ユーエスエー， インコーポレイテッド | インフルエンザ抗原、ワクチン組成物、および関連する方法 |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| ITMI20061117A1 (it) * | 2006-06-09 | 2007-12-10 | Michele Bonanomi | Una composizione farmaceutica per la somministrazione sublinguale di vaccini metodo per la sua preparazione e sui usi |
| EP2068834A2 (en) | 2006-09-08 | 2009-06-17 | Becton, Dickinson & Company | Stable powder formulations of aluma-dsorbed vaccines |
| HUE032422T2 (en) * | 2006-09-29 | 2017-09-28 | Takeda Vaccines Inc | Norovirus vaccine preparations |
| CN101668544B (zh) * | 2006-12-26 | 2013-04-24 | 株式会社新日本科学 | 经鼻投用制剂 |
| DK2829282T3 (en) * | 2007-03-22 | 2018-01-02 | Univ Colorado Regents | Process for preparing an immunologically active adjuvant-linked dried vaccine composition |
| WO2009006299A2 (en) | 2007-06-29 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Multi-particulate systems |
| KR101695800B1 (ko) * | 2008-03-05 | 2017-02-22 | 사노피 파스퇴르 | 항원보강제 함유 백신 조성물의 안정화 방법 |
| CN101601860A (zh) * | 2008-06-13 | 2009-12-16 | 中国科学院过程工程研究所 | 疫苗 |
| RU2011107757A (ru) | 2008-08-01 | 2012-09-10 | Гамма Ваксинс Пти Лимитед (Au) | Вакцины против гриппа |
| JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
| WO2011013003A2 (en) * | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| JP5491119B2 (ja) * | 2009-10-02 | 2014-05-14 | 日東電工株式会社 | 薬物含有微粒子を含む医薬組成物およびその製造方法 |
| AU2012244077B2 (en) | 2010-04-15 | 2015-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Methods and compositions for intranasal delivery |
| CN107260689A (zh) | 2010-04-15 | 2017-10-20 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
-
2011
- 2011-04-15 CN CN201710415508.1A patent/CN107260689A/zh active Pending
- 2011-04-15 ES ES13189570T patent/ES2874817T3/es active Active
- 2011-04-15 EP EP13189570.8A patent/EP2689785B1/en active Active
- 2011-04-15 KR KR1020197006392A patent/KR102136036B1/ko not_active Expired - Fee Related
- 2011-04-15 SG SG2012071841A patent/SG184304A1/en unknown
- 2011-04-15 CA CA2993242A patent/CA2993242C/en active Active
- 2011-04-15 KR KR1020127025573A patent/KR20130083376A/ko not_active Ceased
- 2011-04-15 CA CA2796593A patent/CA2796593C/en active Active
- 2011-04-15 CN CN201180027287.1A patent/CN102933230B/zh active Active
- 2011-04-15 KR KR1020127030060A patent/KR101960102B1/ko active Active
- 2011-04-15 US US13/640,623 patent/US9687536B2/en active Active
- 2011-04-15 CN CN2013100510480A patent/CN103126996A/zh active Pending
- 2011-04-15 WO PCT/JP2011/002225 patent/WO2011129120A1/en not_active Ceased
- 2011-04-15 RU RU2012144612/15A patent/RU2012144612A/ru not_active Application Discontinuation
- 2011-04-15 EP EP11768642.8A patent/EP2558120A4/en not_active Withdrawn
- 2011-04-15 BR BR112012026116A patent/BR112012026116A2/pt not_active IP Right Cessation
- 2011-04-15 JP JP2012547369A patent/JP5771626B2/ja active Active
-
2012
- 2012-10-12 CU CU2012000148A patent/CU20120148A7/es unknown
-
2013
- 2013-01-25 JP JP2013011673A patent/JP2013126989A/ja active Pending
- 2013-03-14 US US13/828,337 patent/US10463723B2/en active Active
-
2015
- 2015-09-24 JP JP2015186488A patent/JP2016006119A/ja active Pending
-
2017
- 2017-07-19 JP JP2017139598A patent/JP2017186377A/ja active Pending
-
2019
- 2019-03-05 JP JP2019039165A patent/JP6827488B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013126989A5 (enExample) | ||
| Kim et al. | Influenza vaccines: Past, present, and future | |
| RU2012144612A (ru) | Способ и композиции для интраназальной доставки | |
| Zheng et al. | Development of universal influenza vaccines based on influenza virus M and NP genes | |
| JP7082703B2 (ja) | ワクチン組成物 | |
| Quan et al. | Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization | |
| Vassilieva et al. | Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature | |
| Saboo et al. | Optimized formulation of a thermostable spray-dried virus-like particle vaccine against human papillomavirus | |
| Lu et al. | Pulmonary vaccine delivery | |
| US20200376111A1 (en) | Vaccine composition | |
| Tonnis et al. | Devices and formulations for pulmonary vaccination | |
| CN106659777A8 (zh) | 免疫原性组合产品 | |
| Dong et al. | Polycationic HA/CpG nanoparticles induce cross-protective influenza immunity in mice | |
| Murugappan et al. | Physical and immunogenic stability of spray freeze-dried influenza vaccine powder for pulmonary delivery: comparison of inulin, dextran, or a mixture of dextran and trehalose as protectants | |
| WO2014103488A1 (ja) | 経鼻インフルエンザワクチン組成物 | |
| Even-Or et al. | Adjuvanted influenza vaccines | |
| JP2012176990A5 (enExample) | ||
| JP2014530010A5 (enExample) | ||
| HRP20181039T1 (hr) | Cjepiva koja sadrže kolesterol i cpg kao jedine molekule koje nose adjuvans | |
| ES2645156T3 (es) | Agente terapéutico inmunológico de acción rápida y prolongada | |
| Tomar et al. | Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination | |
| JP2015533376A5 (enExample) | ||
| Liu et al. | Influenza virosomes supplemented with GPI-0100 adjuvant: a potent vaccine formulation for antigen dose sparing | |
| JP6764408B2 (ja) | Ｈ１ｎ１インフルエンザに対するコンピュータ最適化広反応性抗原の相乗的併用投与 | |
| RU2019113989A (ru) | Лекарственное средство |