JP2013018708A - 水中油型乳化物 - Google Patents
水中油型乳化物 Download PDFInfo
- Publication number
- JP2013018708A JP2013018708A JP2011150794A JP2011150794A JP2013018708A JP 2013018708 A JP2013018708 A JP 2013018708A JP 2011150794 A JP2011150794 A JP 2011150794A JP 2011150794 A JP2011150794 A JP 2011150794A JP 2013018708 A JP2013018708 A JP 2013018708A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- water emulsion
- viscosity
- hyaluronic acid
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007764 o/w emulsion Substances 0.000 title claims abstract description 50
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 37
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 34
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- 150000003839 salts Chemical class 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- -1 hyaluronic acid salt Chemical class 0.000 claims description 42
- 238000002156 mixing Methods 0.000 claims description 25
- 239000004094 surface-active agent Substances 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 238000005191 phase separation Methods 0.000 abstract description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 2
- 229940014041 hyaluronate Drugs 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
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- 238000012360 testing method Methods 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
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- 239000002994 raw material Substances 0.000 description 4
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- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 239000003093 cationic surfactant Substances 0.000 description 3
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
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- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- BODMYPYTCKYRSP-UHFFFAOYSA-N 1,1-dioctylcyclohexane Chemical compound CCCCCCCCC1(CCCCCCCC)CCCCC1 BODMYPYTCKYRSP-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
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- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- DEMBLPGWNXUBIQ-UHFFFAOYSA-N 2-dodecylhexadecan-1-ol Chemical compound CCCCCCCCCCCCCCC(CO)CCCCCCCCCCCC DEMBLPGWNXUBIQ-UHFFFAOYSA-N 0.000 description 1
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 1
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- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
【解決手段】粘度が1000mPa・s以上であり、以下の(A)、(B)、(C)が必須成分として配合された水中油型乳化物。
(A)カチオン化セルロース
(B)ヒアルロン酸、ヒアルロン酸の塩、アセチル化ヒアルロン酸、及び、アセチル化ヒアルロン酸の塩よりなる群から選ばれる少なくとも一種
(C)炭素数5以下のアルコール
【選択図】なし
Description
上記の配合されたカチオン化セルロースと、ヒアルロン酸、ヒアルロン酸の塩、アセチル化ヒアルロン酸、及び、アセチル化ヒアルロン酸の塩よりなる群から選ばれる少なくとも一種は、水相に含まれることになる。この水相に油相が分散した乳化物が、本発明の水中油型乳化物である。
(A)成分:カチオン化セルロース
カチオン化セルロースとしては、例えば、ヒドロキシエチルセルロースに塩化グリシジルトリメチルアンモニウムを付加して得られる4級アンモニウム塩の重合体である塩化O−[2−ヒドロキシ−3−(トリメチルアンモニオ)プロピル]ヒドロキシエチルセルロースが挙げられる。当該カチオン化セルロースは市販されており、例えば、ダウ・ケミカル日本社製「UCARE Polymer JR-30M」、東邦化学工業社製「カチナールHC−200」、東邦化学工業社製「カチナールLC−200」が挙げられる。
(A)成分の水中油型乳化物における配合量の下限は、0.20質量%が好ましく、0.25質量%がより好ましい。また、その上限値は、特に限定されないが、水中油型乳化物を高価としないために、0.55質量%が好ましい。
塩の形態をとるときの(B)成分としては、例えば、ヒアルロン酸ナトリウム、アセチル化ヒアルロン酸ナトリウムとしてのナトリウム塩となった形態である。
(A)成分の配合量に対する(B)成分の配合量の比([(B)ヒアルロン酸、ヒアルロン酸の塩、アセチル化ヒアルロン酸、及び、アセチル化ヒアルロン酸の塩の総配合量]/[(A)カチオン化セルロースの配合量]により算出される比(B)/(A))の下限値は、0.04が好ましく、0.10がより好ましい。また、その上限値としては、0.32が好ましく、0.30がより好ましい。比(B)/(A)が0.04以上0.32以下であれば、水中油型乳化物の製造が容易である。
本発明の水中油型乳化物においては、(C)成分の配合によって、低温環境下に置いた後の油相の分離が抑制される上に、45℃程度の高温環境下に置いたときの粘度低下が抑制される。
この(C)成分としては、例えば、エタノール、グリセリン、エチレングリコール、1,3−ブチレングリコール、及び、1,3−プロパンジオールよりなる群から選ばれる少なくとも一種であってよい。なかでも、低温での経時安定性に優れる点で、グリセリン、1,3−プロパンジオールが好ましい。
(D)成分は、水との相溶性が無いか又は水との相溶性が低いものであり、本発明の水中油型乳化物の水相中に分散させるものである。(D)成分としては、例えば、25℃で液体又は固体の油脂、エステル油、高級アルコール、ロウ、炭化水素、高級脂肪酸、シリコーンが挙げられる((D)成分の具体例は、株式会社薬事日報社から発行されている「日本化粧品原料集2007」などに記載されている。)。(D)成分は、一種又は二種以上が配合されると良い。
本発明の水中油型乳化物には、界面活性剤、防腐剤、香料等の公知の毛髪処理剤原料がさらに配合されていてもよい。
水中油型乳化物に界面活性剤(ノニオン界面活性剤、カチオン界面活性剤、アニオン界面活性剤、及び、両性界面活性剤の一種又は二種以上)を配合する場合、その配合量は、使用者に与える皮膚刺激を抑制するために、10質量%未満が好ましく、5.0質量%未満がより好ましく、1.0質量%未満がさらに好ましく、0.5質量%未満が特に好ましい。なお、使用者に与える皮膚刺激を抑制するには、界面活性剤を配合しないことが最適である。
本発明の水中油型乳化物の粘度は、1000mPa・s以上である。なお、本発明の水中油型乳化物を毛髪処理剤として用いる場合のハンドリング性を考慮すれば、当該水中油型乳化物の粘度は、1500mPa・s以上30000mPa・s以下が良く、2000mPa・s以上20000mPa・s以下が好ましく、2500mPa・s以上10000mPa・s以下がより好ましい。
粘度の調整手法は、例えば、配合される(A)成分又は(B)成分の平均分子量を上げることで(2質量%水溶液の粘度が高い(A)成分を選定又は1質量%水溶液の粘度が高い(B)成分を選定することで)粘度を上げることができ、また、(A)成分及び(B)成分の配合量を多くすることで粘度を上げることができる。また、(A)成分又は(B)成分の平均分子量を下げる(2質量%水溶液の粘度が低い(A)成分を選定又は1質量%水溶液の粘度が低い(B)成分を選定することで)粘度を下げることができ、また、(A)成分及び(B)成分の配合量を少なくすることで粘度を下げることができる。
水中油型乳化物のpHは、特に限定されないが、例えば4.0以上9.0以下であり、毛髪処理剤用途として汎用的なのは5.0以上8.0以下である。
水中油型乳化物の用途は、特に限定されないが、例えば、毛髪処理剤等の化粧品として用いることができ、界面活性剤を少量配合又は配合しないで洗い流さないトリートメントとして用いてもよい。
(A)成分の水溶液を調製し、更に(B)成分以外の原料を(A)成分水溶液に配合した(固形原料については加温溶融させて、配合した。)。その(B)成分以外の原料の配合に伴い、白濁するまでホモミキサーを用いて攪拌条件3000rpmで攪拌した。次に、(B)成分の0.33質量%水溶液を配合して、さらにホモミキサーを用いて攪拌することで水中油型乳化物を得た。ここで、ホモミキサーによる攪拌条件は、5000rpmで5分間とした。以上の製造手順により、pHが5.0〜6.0である実施例の水中油型乳化物等を製造した。
乳化物を調製できたか否かの評価(乳化物調製)は、調製後数時間が経過した後、目視によって確認し、以下のように評価した。
○:乳化物として確認できた。
×:分離(透明層と不透明層の存在が明確な状態、以下同じ。)が確認された。
調製した乳化物等を収容した密栓ガラス管を、下記表1〜4、6に記載の各温度条件における恒温槽内に放置した。外観の経時変化は、目視によって確認し、以下のように評価した。
◎:分離、油の浮き、及び析出物が認められなかった。
○:分離は認められなかったが、僅かに油浮き又は析出物が認められた。
△:分離は認められなかったが、油浮き又は析出物が認められた。
×:分離が認められた。
Claims (5)
- 粘度が1000mPa・s以上である水中油型乳化物であって、
(A)カチオン化セルロース、
(B)ヒアルロン酸、ヒアルロン酸の塩、アセチル化ヒアルロン酸、及び、アセチル化ヒアルロン酸の塩よりなる群から選ばれる少なくとも一種、並びに、
(C)炭素数5以下のアルコール、
が配合された水中油型乳化物。 - 毛髪処理剤として用いられる請求項1に記載の水中油型乳化物。
- 界面活性剤の配合量が10質量%未満、又は、界面活性剤が配合されていない、
請求項1又は2に記載の水中油型乳化物。 - 界面活性剤の配合量が5.0質量%未満、又は、界面活性剤が配合されていない、
請求項1又は2に記載の水中油型乳化物。 - [(B)ヒアルロン酸、ヒアルロン酸の塩、アセチル化ヒアルロン酸、及び、アセチル化ヒアルロン酸の塩の総配合量]/[(A)カチオン化セルロースの配合量]で算出される比(B)/(A)が、0.04以上0.32以下である、
請求項1から4のいずれか1項に記載の水中油型乳化物。
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JP2017066046A (ja) * | 2015-09-28 | 2017-04-06 | 嘉寛 徳留 | ヒアルロナンを含む複合粒子を含有する乳化組成物 |
JP2019189549A (ja) * | 2018-04-24 | 2019-10-31 | 株式会社 資生堂 | とろみ状の水性化粧料 |
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JPH0789823A (ja) * | 1993-09-21 | 1995-04-04 | Shiseido Co Ltd | 乳化組成物 |
JP2006028095A (ja) * | 2004-07-16 | 2006-02-02 | Sunstar Inc | 高粘度毛髪用洗浄剤組成物 |
JP2010150175A (ja) * | 2008-12-25 | 2010-07-08 | Milbon Co Ltd | シャンプー組成物 |
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JP3549995B2 (ja) | 1996-03-12 | 2004-08-04 | 株式会社資生堂 | W/o型乳化組成物及び化粧料 |
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JPH0497000A (ja) * | 1990-08-13 | 1992-03-30 | Yakult Honsha Co Ltd | 洗浄剤 |
JPH0789823A (ja) * | 1993-09-21 | 1995-04-04 | Shiseido Co Ltd | 乳化組成物 |
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JP2017066046A (ja) * | 2015-09-28 | 2017-04-06 | 嘉寛 徳留 | ヒアルロナンを含む複合粒子を含有する乳化組成物 |
JP2019189549A (ja) * | 2018-04-24 | 2019-10-31 | 株式会社 資生堂 | とろみ状の水性化粧料 |
JP7101527B2 (ja) | 2018-04-24 | 2022-07-15 | 株式会社 資生堂 | とろみ状の水性化粧料 |
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