JP2012533618A5 - - Google Patents
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- Publication number
- JP2012533618A5 JP2012533618A5 JP2012521599A JP2012521599A JP2012533618A5 JP 2012533618 A5 JP2012533618 A5 JP 2012533618A5 JP 2012521599 A JP2012521599 A JP 2012521599A JP 2012521599 A JP2012521599 A JP 2012521599A JP 2012533618 A5 JP2012533618 A5 JP 2012533618A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- process according
- carried out
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 8
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 3
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 3
- 229960004117 capecitabine Drugs 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 238000010511 deprotection reaction Methods 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000004820 halides Chemical group 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22797109P | 2009-07-23 | 2009-07-23 | |
| US61/227,971 | 2009-07-23 | ||
| PCT/SG2010/000276 WO2011010967A1 (en) | 2009-07-23 | 2010-07-21 | Process for producing flurocytidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012533618A JP2012533618A (ja) | 2012-12-27 |
| JP2012533618A5 true JP2012533618A5 (enExample) | 2013-07-04 |
Family
ID=43497887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521599A Abandoned JP2012533618A (ja) | 2009-07-23 | 2010-07-21 | フルオロシチジン誘導体の製造プロセス |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110021769A1 (enExample) |
| EP (1) | EP2456778A4 (enExample) |
| JP (1) | JP2012533618A (enExample) |
| KR (1) | KR20120037932A (enExample) |
| CN (1) | CN102858791A (enExample) |
| AR (1) | AR077498A1 (enExample) |
| TW (1) | TW201103550A (enExample) |
| WO (1) | WO2011010967A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103059085B (zh) * | 2011-12-27 | 2015-09-02 | 石药集团中奇制药技术（石家庄）有限公司 | 一种抗癌药物中间体及其制备方法 |
| CN103183713B (zh) * | 2011-12-31 | 2015-08-05 | 沈阳药科大学 | 5-脱氧-d-呋喃核糖氧苷类化合物的制备方法 |
| CN103910773B (zh) * | 2014-04-08 | 2015-11-25 | 宁波美诺华药业股份有限公司 | 卡培他滨杂质的合成方法 |
| CN104628804A (zh) * | 2015-01-30 | 2015-05-20 | 吉林修正药业新药开发有限公司 | 一种卡培他滨杂质乙酰缩合物的合成方法 |
| CN106496294B (zh) * | 2016-09-21 | 2018-10-30 | 齐鲁天和惠世制药有限公司 | 一种制备微粉型卡培他滨的方法 |
| CN107936075A (zh) * | 2017-12-28 | 2018-04-20 | 山东铂源药业有限公司 | 一种卡培他滨中间体的合成方法 |
| CN109651466A (zh) * | 2018-12-20 | 2019-04-19 | 深圳市祥根生物科技有限公司 | 卡培他滨杂质g的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| TW254946B (enExample) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
| BRPI0810067A2 (pt) * | 2007-04-20 | 2014-10-21 | Reddys Lab Ltd Dr | Processo para a preparação de capecitabina |
| EP2164856A1 (en) * | 2007-06-01 | 2010-03-24 | Synthon B.V. | Processes related to making capecitabine |
| KR101013312B1 (ko) * | 2007-11-19 | 2011-02-09 | 한미홀딩스 주식회사 | 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법 |
-
2010
- 2010-07-21 EP EP10802524.8A patent/EP2456778A4/en not_active Withdrawn
- 2010-07-21 JP JP2012521599A patent/JP2012533618A/ja not_active Abandoned
- 2010-07-21 US US12/840,490 patent/US20110021769A1/en not_active Abandoned
- 2010-07-21 CN CN2010800325446A patent/CN102858791A/zh active Pending
- 2010-07-21 WO PCT/SG2010/000276 patent/WO2011010967A1/en not_active Ceased
- 2010-07-21 KR KR1020127000421A patent/KR20120037932A/ko not_active Withdrawn
- 2010-07-23 AR ARP100102691A patent/AR077498A1/es unknown
- 2010-07-23 TW TW099124113A patent/TW201103550A/zh unknown
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