AR077498A1 - Proceso para producir derivados de fluorocitidina - Google Patents
Proceso para producir derivados de fluorocitidinaInfo
- Publication number
- AR077498A1 AR077498A1 ARP100102691A ARP100102691A AR077498A1 AR 077498 A1 AR077498 A1 AR 077498A1 AR P100102691 A ARP100102691 A AR P100102691A AR P100102691 A ARP100102691 A AR P100102691A AR 077498 A1 AR077498 A1 AR 077498A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- fluorocitidine
- derivatives
- produce
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002904 solvent Substances 0.000 abstract 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 abstract 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229960004117 capecitabine Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22797109P | 2009-07-23 | 2009-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077498A1 true AR077498A1 (es) | 2011-08-31 |
Family
ID=43497887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102691A AR077498A1 (es) | 2009-07-23 | 2010-07-23 | Proceso para producir derivados de fluorocitidina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110021769A1 (enExample) |
| EP (1) | EP2456778A4 (enExample) |
| JP (1) | JP2012533618A (enExample) |
| KR (1) | KR20120037932A (enExample) |
| CN (1) | CN102858791A (enExample) |
| AR (1) | AR077498A1 (enExample) |
| TW (1) | TW201103550A (enExample) |
| WO (1) | WO2011010967A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103059085B (zh) * | 2011-12-27 | 2015-09-02 | 石药集团中奇制药技术（石家庄）有限公司 | 一种抗癌药物中间体及其制备方法 |
| CN103183713B (zh) * | 2011-12-31 | 2015-08-05 | 沈阳药科大学 | 5-脱氧-d-呋喃核糖氧苷类化合物的制备方法 |
| CN103910773B (zh) * | 2014-04-08 | 2015-11-25 | 宁波美诺华药业股份有限公司 | 卡培他滨杂质的合成方法 |
| CN104628804A (zh) * | 2015-01-30 | 2015-05-20 | 吉林修正药业新药开发有限公司 | 一种卡培他滨杂质乙酰缩合物的合成方法 |
| CN106496294B (zh) * | 2016-09-21 | 2018-10-30 | 齐鲁天和惠世制药有限公司 | 一种制备微粉型卡培他滨的方法 |
| CN107936075A (zh) * | 2017-12-28 | 2018-04-20 | 山东铂源药业有限公司 | 一种卡培他滨中间体的合成方法 |
| CN109651466A (zh) * | 2018-12-20 | 2019-04-19 | 深圳市祥根生物科技有限公司 | 卡培他滨杂质g的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| TW254946B (enExample) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
| BRPI0810067A2 (pt) * | 2007-04-20 | 2014-10-21 | Reddys Lab Ltd Dr | Processo para a preparação de capecitabina |
| EP2164856A1 (en) * | 2007-06-01 | 2010-03-24 | Synthon B.V. | Processes related to making capecitabine |
| KR101013312B1 (ko) * | 2007-11-19 | 2011-02-09 | 한미홀딩스 주식회사 | 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법 |
-
2010
- 2010-07-21 EP EP10802524.8A patent/EP2456778A4/en not_active Withdrawn
- 2010-07-21 JP JP2012521599A patent/JP2012533618A/ja not_active Abandoned
- 2010-07-21 US US12/840,490 patent/US20110021769A1/en not_active Abandoned
- 2010-07-21 CN CN2010800325446A patent/CN102858791A/zh active Pending
- 2010-07-21 WO PCT/SG2010/000276 patent/WO2011010967A1/en not_active Ceased
- 2010-07-21 KR KR1020127000421A patent/KR20120037932A/ko not_active Withdrawn
- 2010-07-23 AR ARP100102691A patent/AR077498A1/es unknown
- 2010-07-23 TW TW099124113A patent/TW201103550A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102858791A (zh) | 2013-01-02 |
| US20110021769A1 (en) | 2011-01-27 |
| JP2012533618A (ja) | 2012-12-27 |
| KR20120037932A (ko) | 2012-04-20 |
| WO2011010967A1 (en) | 2011-01-27 |
| EP2456778A4 (en) | 2013-05-29 |
| EP2456778A1 (en) | 2012-05-30 |
| TW201103550A (en) | 2011-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |