JP2012532593A - 経口補水液用粉末と混合した凍結乾燥乳酸菌を保存するための製品 - Google Patents
経口補水液用粉末と混合した凍結乾燥乳酸菌を保存するための製品 Download PDFInfo
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- JP2012532593A JP2012532593A JP2012519004A JP2012519004A JP2012532593A JP 2012532593 A JP2012532593 A JP 2012532593A JP 2012519004 A JP2012519004 A JP 2012519004A JP 2012519004 A JP2012519004 A JP 2012519004A JP 2012532593 A JP2012532593 A JP 2012532593A
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- lactic acid
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- oral rehydration
- acid bacteria
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000000843 powder Substances 0.000 title claims abstract description 26
- 241000894006 Bacteria Species 0.000 title claims abstract description 25
- 239000004310 lactic acid Substances 0.000 title claims abstract description 23
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 23
- 239000000310 rehydration solution Substances 0.000 title description 7
- 239000002274 desiccant Substances 0.000 claims abstract description 46
- 239000011888 foil Substances 0.000 claims abstract description 44
- 239000000463 material Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000004806 packaging method and process Methods 0.000 claims abstract description 8
- 239000006041 probiotic Substances 0.000 claims description 14
- 235000018291 probiotics Nutrition 0.000 claims description 14
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 13
- 230000000529 probiotic effect Effects 0.000 claims description 12
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 11
- 229910052782 aluminium Inorganic materials 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 8
- -1 polyethylene Polymers 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 239000005022 packaging material Substances 0.000 claims description 4
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000292 calcium oxide Substances 0.000 claims description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 230000007774 longterm Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 5
- 239000000047 product Substances 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 150000003839 salts Chemical class 0.000 description 15
- 230000035899 viability Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 238000002671 oral rehydration therapy Methods 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 235000011148 calcium chloride Nutrition 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012047 saturated solution Substances 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 235000011147 magnesium chloride Nutrition 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 239000004317 sodium nitrate Substances 0.000 description 2
- 235000010344 sodium nitrate Nutrition 0.000 description 2
- IATRAKWUXMZMIY-UHFFFAOYSA-N strontium oxide Chemical compound [O-2].[Sr+2] IATRAKWUXMZMIY-UHFFFAOYSA-N 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
- 239000004708 Very-low-density polyethylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229920001179 medium density polyethylene Polymers 0.000 description 1
- 239000004701 medium-density polyethylene Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001866 very low density polyethylene Polymers 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
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- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
Description
試験したパラメータ
実施例において、本発明の方法は、加速試験として30℃で、少なくとも12カ月の保存寿命に到達することを目的として、小袋中でORS溶液塩を凍結乾燥L.ロイテリと混合できるかどうかを評価するために試験する。加速試験は、より低い温度では保存時間がより長くなることを意味することが知られている。新しい製造方法は、US20070160789A1に記載の乾燥剤を有する新規のホイル材料の使用を含む。
無水ORS粉末中L.ロイテリのミックスを含む小袋の製造
無水ORS粉末は以下のものを含んでいた:
L.ロイテリ DSM17938: 68.000mg/小袋(約10E+11CFU/g)
グルコース(無水): 3781.000mg/小袋
クエン酸ナトリウム(無水): 866.000mg/小袋
塩化カリウム: 379.000mg/小袋
塩化ナトリウム: 365.000mg/小袋
硫酸亜鉛; 4,000mg/小袋
合計 5463.000mg/小袋
凍結乾燥L.ロイテリDSM17938を経口補水液(ORS)粉末中で30℃、12カ月間保存した場合の安定性試験
L.ロイテリDSM17938粉末商品番号1012 BiobGaia AB、ストックホルム、スウェーデン(製品規格PS137)の生存能力は、経口補水液粉末(Norfoods AB、スウェーデンより入手)中で評価する。無水ORS粉末は例1に従って作製する。テストパラメータは表1に従って実施する。試料は、Lund(スウェーデン)にあるBioGaia ABにおいて、30℃/65%RHの人工気候キャビネット中に保管される。
結果は図1に示す。一体化された乾燥剤と無水ORSを有するホイル中に保存された微生物(図1のグラフ2)は、意外にもORSなしで保存された微生物(図1のグラフ1)とほぼ同じ生存能力を示した。
Claims (17)
- 無水経口補水液粉末と混合した凍結乾燥乳酸菌を含むプロバイオティック製品であって、凍結乾燥乳酸菌と無水経口補水液粉末が、ホイル中に一体化された乾燥剤を有するホイルの中に包装されている、上記プロバイオティック製品。
- ホイルがアルミニウムを含む、請求項1に記載のプロバイオティック製品。
- ホイルがさらにポリエチレン層を含む、請求項2に記載のプロバイオティック製品。
- ホイル材料中に一体化された乾燥剤が酸化カルシウムを含む、請求項1に記載のプロバイオティック製品。
- 凍結乾燥乳酸菌がラクトバチルス・ロイテリ(Lactobacillus reuteri)である、請求項1に記載のプロバイオティック製品。
- プロバイオティック製品を30℃で12カ月保存後に、5×10E+09CFU/gのラクトバチルス・ロイテリ(Lactobacillus reuteri)で開始した場合、少なくとも10E+07CFU/gのラクトバチルス・ロイテリ(Lactobacillus reuteri)が存在する、請求項1に記載のプロバイオティック製品。
- 12カ月の保存後に少なくとも10E+08CFU/gのラクトバチルス・ロイテリ(Lactobacillus reuteri)が存在する、請求項6に記載のプロバイオティック製品。
- 12カ月の保存後に少なくとも10E+09CFU/gのラクトバチルス・ロイテリ(Lactobacillus reuteri)が存在する、請求項7に記載のプロバイオティック製品。
- 水分に感受性の製品を生存可能に保存するための製品であって、水分に感受性の製品と混合するための無水経口補水液粉末と、水分に感受性の製品及び無水経口補水液粉末のための包装材料とを含み、包装材料が、ホイルの層内に組み入れられた化学的乾燥材料を含む、上記製品。
- 水分に感受性の製品が生存能力のある凍結乾燥乳酸菌を含む、請求項9に記載の製品。
- ホイルがアルミニウムを含む、請求項9に記載の製品。
- ホイルがさらにポリエチレン層を含む、請求項11に記載の製品。
- 生存能力のある凍結乾燥プロバイオティック乳酸菌を長期保存する方法であって、
a)無水経口補水液粉末を用意することと、
b)凍結乾燥乳酸菌を無水経口補水液粉末と混合することと、
c)凍結乾燥乳酸菌と無水経口補水液粉末の混合物を、ホイルの層中に組み入れられた化学的乾燥材料を含むパッケージの中に包装することと、
d)シールが破れないようにパッケージをシールすることと、
を含む上記方法。 - ホイルがアルミホイルを含む、請求項13に記載の方法。
- ホイルがさらにポリエチレン層を含む、請求項14に記載の方法。
- ホイル材料中に一体化された乾燥剤が酸化カルシウムを含む、請求項13に記載の方法。
- 凍結乾燥乳酸菌がラクトバチルス・ロイテリ(Lactobacillus reuteri)である、請求項13に記載の方法。
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US27056609P | 2009-07-10 | 2009-07-10 | |
US61/270,566 | 2009-07-10 | ||
US12/803,758 US20110014324A1 (en) | 2009-07-10 | 2010-07-06 | Product for the storage of freeze-dried lactic acid bacteria mixed with oral rehydration solution |
US12/803,758 | 2010-07-06 | ||
PCT/EP2010/059856 WO2011003995A1 (en) | 2009-07-10 | 2010-07-09 | Product for the storage of freeze-dried lactic acid bacteria mixed with a powder for an oral rehydration solution |
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JP2012532593A true JP2012532593A (ja) | 2012-12-20 |
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US (2) | US20110014324A1 (ja) |
EP (1) | EP2451298B1 (ja) |
JP (1) | JP5608227B2 (ja) |
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AU (1) | AU2010270221B2 (ja) |
BR (1) | BRPI1014873B1 (ja) |
CA (1) | CA2760008C (ja) |
CL (1) | CL2011002644A1 (ja) |
DK (1) | DK2451298T3 (ja) |
ES (1) | ES2421302T3 (ja) |
HK (1) | HK1169792A1 (ja) |
HR (1) | HRP20130550T1 (ja) |
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KR20170066395A (ko) * | 2014-10-02 | 2017-06-14 | 프로바이오티컬 에스.피.에이. | 식품, 음식물 및 화장품, 의료 기기 및 의약품을 포장하기 위한 자유수를 흡수 및 보유할 수 있고, 흡수된 자유수를 방출하지 않는 완전 수밀 다층 재료 |
CN111513331A (zh) * | 2020-04-16 | 2020-08-11 | 仙乐健康科技股份有限公司 | 一种包含益生菌的产品 |
CN113398874B (zh) * | 2021-06-17 | 2023-08-15 | 干霸干燥剂(深圳)有限公司 | 一种复合干燥剂及其制备方法 |
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